{"id":"https://openalex.org/W2742450412","doi":"https://doi.org/10.18632/oncotarget.20231","title":"Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model","display_name":"Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model","publication_year":2017,"publication_date":"2017-08-12","ids":{"openalex":"https://openalex.org/W2742450412","doi":"https://doi.org/10.18632/oncotarget.20231","mag":"2742450412","pmid":"https://pubmed.ncbi.nlm.nih.gov/29156737","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5689627"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.20231","doi":"https://doi.org/10.18632/oncotarget.20231","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.20231","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncotarget.20231","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110514735","display_name":"Kei Kawaguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Kei Kawaguchi","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA","Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan","Department of Surgery, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081080411","display_name":"Kentaro Igarashi","orcid":"https://orcid.org/0000-0003-2278-1736","observed_orcids":["https://orcid.org/0000-0003-2278-1736"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kentaro Igarashi","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA","Department of Surgery, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023556030","display_name":"Shukuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shukuan Li","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109489759","display_name":"Qinghong Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinghong Han","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuying Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuying Tan","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017915063","display_name":"Tasuku Kiyuna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tasuku Kiyuna","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA","Department of Surgery, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084841997","display_name":"Kentaro Miyake","orcid":"https://orcid.org/0000-0002-4680-4317","observed_orcids":["https://orcid.org/0000-0002-4680-4317"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kentaro Miyake","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA","Department of Surgery, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060520190","display_name":"Takashi Murakami","orcid":"https://orcid.org/0000-0002-9429-5705","observed_orcids":["https://orcid.org/0000-0002-9429-5705"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takashi Murakami","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA","Department of Surgery, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039301683","display_name":"Bartosz Chmielowski","orcid":"https://orcid.org/0000-0002-2374-3320","observed_orcids":["https://orcid.org/0000-0002-2374-3320"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bartosz Chmielowski","raw_affiliation_strings":["Division of Hematology-Oncology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002607014","display_name":"Scott D. Nelson","orcid":"https://orcid.org/0000-0002-8435-5065","observed_orcids":["https://orcid.org/0000-0002-8435-5065"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott D. Nelson","raw_affiliation_strings":["Department of Pathology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047314223","display_name":"Tara A. Russell","orcid":"https://orcid.org/0000-0002-3912-3601","observed_orcids":["https://orcid.org/0000-0002-3912-3601"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tara A. Russell","raw_affiliation_strings":["Division of Surgical Oncology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070052371","display_name":"Sarah Dry","orcid":"https://orcid.org/0000-0002-1858-5225","observed_orcids":["https://orcid.org/0000-0002-1858-5225"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah M. Dry","raw_affiliation_strings":["Department of Pathology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100326032","display_name":"Yunfeng Li","orcid":"https://orcid.org/0000-0003-3254-8487","observed_orcids":["https://orcid.org/0000-0003-3254-8487"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunfeng Li","raw_affiliation_strings":["Department of Pathology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086139902","display_name":"Michiaki Unno","orcid":"https://orcid.org/0000-0002-2145-6416","observed_orcids":["https://orcid.org/0000-0002-2145-6416"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiaki Unno","raw_affiliation_strings":["Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077449490","display_name":"Fritz C. Eilber","orcid":"https://orcid.org/0000-0003-3336-9333","observed_orcids":["https://orcid.org/0000-0003-3336-9333"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fritz C. Eilber","raw_affiliation_strings":["Division of Surgical Oncology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Surgical Oncology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["AntiCancer, Inc., San Diego, CA, USA","Department of Surgery, University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer, Inc., San Diego, CA, USA","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.0271,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.99339061,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"8","issue":"49","first_page":"85516","last_page":"85525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.6567000150680542,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.13979999721050262,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-methioninase","display_name":"recombinant methioninase","score":0.996999979019165},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/braf-v600e-melanoma","display_name":"BRAF V600E melanoma","score":0.9440000057220459},{"id":"https://openalex.org/keywords/methionine-dependence","display_name":"methionine dependence","score":0.9279999732971191},{"id":"https://openalex.org/keywords/methionine-deprivation","display_name":"methionine deprivation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/metabolic-targeting","display_name":"metabolic targeting","score":0.6729999780654907},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/patient-derived-orthotopic-xenograft","display_name":"patient-derived orthotopic xenograft","score":0.9769999980926514},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.47200000286102295},{"id":"https://openalex.org/keywords/melanoma-metastasis","display_name":"melanoma metastasis","score":0.3700000047683716},{"id":"https://openalex.org/keywords/clinical-trial-design","display_name":"clinical trial design","score":0.34200000762939453},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.4339999854564667},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.32899999618530273}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.8674263954162598},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7196915149688721},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6952067017555237},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4820576608181},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.4567273259162903},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4506422281265259},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4468838572502136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41923829913139343},{"id":"https://openalex.org/C2776470698","wikidata":"https://www.wikidata.org/wiki/Q21851559","display_name":"V600E","level":4,"score":0.412118136882782},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3249349594116211},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.26684826612472534},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.19731545448303223},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17291802167892456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10039833188056946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0967203676700592},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.18632/oncotarget.20231","doi":"https://doi.org/10.18632/oncotarget.20231","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.20231","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4603859","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5689627","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5689627","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5689627","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"},{"id":"pmid:29156737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29156737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt30g181d3","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/30g181d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, vol 8, iss 49","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt30g181d3","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/30g181d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget, vol 8, iss 49","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.20231","doi":"https://doi.org/10.18632/oncotarget.20231","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.20231","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G501255456","display_name":"Establishment of a patient-like mouse models of soft-tissue sarcoma sub-types","funder_award_id":"R43CA213649","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W249545773","https://openalex.org/W279302623","https://openalex.org/W347202097","https://openalex.org/W1239224350","https://openalex.org/W1492549565","https://openalex.org/W1530556189","https://openalex.org/W1544424898","https://openalex.org/W1569875761","https://openalex.org/W1592125379","https://openalex.org/W1805852575","https://openalex.org/W1848282561","https://openalex.org/W1896165692","https://openalex.org/W1963404410","https://openalex.org/W1965110439","https://openalex.org/W1969705513","https://openalex.org/W1978391889","https://openalex.org/W1980325735","https://openalex.org/W1992331783","https://openalex.org/W1997855844","https://openalex.org/W1998139955","https://openalex.org/W1998296205","https://openalex.org/W1999839653","https://openalex.org/W2000710160","https://openalex.org/W2009313952","https://openalex.org/W2012110463","https://openalex.org/W2014252256","https://openalex.org/W2014844807","https://openalex.org/W2015556936","https://openalex.org/W2027818468","https://openalex.org/W2028701135","https://openalex.org/W2046367925","https://openalex.org/W2052625497","https://openalex.org/W2057881489","https://openalex.org/W2059921126","https://openalex.org/W2072823493","https://openalex.org/W2081193330","https://openalex.org/W2096870516","https://openalex.org/W2107117572","https://openalex.org/W2122134113","https://openalex.org/W2128542677","https://openalex.org/W2131746764","https://openalex.org/W2132970134","https://openalex.org/W2139283055","https://openalex.org/W2159118239","https://openalex.org/W2272577140","https://openalex.org/W2278568674","https://openalex.org/W2294356527","https://openalex.org/W2306887830","https://openalex.org/W2332572212","https://openalex.org/W2342246138","https://openalex.org/W2342714720","https://openalex.org/W2347178913","https://openalex.org/W2408339495","https://openalex.org/W2418346118","https://openalex.org/W2419037363","https://openalex.org/W2444538184","https://openalex.org/W2516251801","https://openalex.org/W2527335053","https://openalex.org/W2550476383","https://openalex.org/W2568046113","https://openalex.org/W2572657810","https://openalex.org/W2593558254","https://openalex.org/W2602989667","https://openalex.org/W2605117891"],"related_works":["https://openalex.org/W2771508138","https://openalex.org/W2772407589","https://openalex.org/W2914543600","https://openalex.org/W2889504957","https://openalex.org/W2942752966","https://openalex.org/W2550476383","https://openalex.org/W2572657810","https://openalex.org/W2626307008","https://openalex.org/W2527335053","https://openalex.org/W2912655939"],"abstract_inverted_index":{"//":[0],"Kei":[1],"Kawaguchi":[2],"1,":[3,9,26,37,75],"2,":[4],"3":[5,65,95],",":[6,11,15,19,23,28,32,34,39,43,48,53,58,62,66],"Kentaro":[7,29],"Igarashi":[8],"2":[10,27,33,38,76,84],"Shukuan":[12],"Li":[13,60],"1":[14,18,22,31,77],"Qinghong":[16],"Han":[17],"Yuying":[20],"Tan":[21],"Tasuku":[24],"Kiyuna":[25],"Miyake":[30],"Takashi":[35],"Murakami":[36],"Bartosz":[40],"Chmielowski":[41],"4":[42,107],"Scott":[44],"D.":[45],"Nelson":[46],"5":[47,57,61,118],"Tara":[49],"A.":[50],"Russell":[51],"6":[52,70,129],"Sarah":[54],"M.":[55,73,144],"Dry":[56],"Yunfeng":[59],"Michiaki":[63],"Unno":[64],"Fritz":[67,148],"C.":[68,149],"Eilber":[69],"and":[71,326],"Robert":[72,143],"Hoffman":[74],"AntiCancer,":[78],"Inc.,":[79],"San":[80,91],"Diego,":[81,92],"CA,":[82,93,116,127,139],"USA":[83,94,117,128,140],"Department":[85,96,119],"of":[86,89,97,101,109,112,120,123,131,135,225,233,258,324,350],"Surgery,":[87,98],"University":[88,111,122,134],"California,":[90,113,124,136],"Graduate":[99],"School":[100],"Medicine,":[102],"Tohoku":[103],"University,":[104],"Sendai,":[105],"Japan":[106],"Division":[108,130],"Hematology-Oncology,":[110],"Los":[114,125,137],"Angeles,":[115,126,138],"Pathology,":[121],"Surgical":[132],"Oncology,":[133],"Correspondence":[141],"to:":[142],"Hoffman,":[145],"email:":[146,151],"all@anticancer.com":[147],"Eilber,":[150],"fceilber@mednet.ucla.edu":[152],"Keywords:":[153],"recombinant":[154,209],"methioninase,":[155],"methionine":[156,179,181,204],"dependence,":[157,182],"metabolic":[158,188],"targeting,":[159],"temozolomide,":[160],"melanoma":[161,228,240,249],"Received:":[162],"June":[163],"06,":[164,168],"2017":[165,169,173],"Accepted:":[166],"July":[167],"Published:":[170],"August":[171],"12,":[172],"ABSTRACT":[174],"An":[175],"excessive":[176],"requirement":[177],"for":[178],"termed":[180],"appears":[183],"to":[184,229,303],"be":[185,200],"a":[186,216,238,355],"general":[187],"defect":[189],"in":[190,235,354,363],"cancer.":[191],"We":[192],"have":[193],"previously":[194],"shown":[195],"that":[196],"cancer-cell":[197],"growth":[198,301],"can":[199],"selectively":[201],"arrested":[202],"by":[203],"deprivation":[205],"such":[206,366],"as":[207,367],"with":[208,237],"methioninase":[210],"(rMETase).":[211],"The":[212,341],"present":[213,246,342],"study":[214,247,343],"used":[215],"previously-established":[217],"patient-derived":[218],"orthotopic":[219],"xenograft":[220],"(PDOX)":[221],"nude":[222],"mouse":[223,251],"model":[224],"BRAF":[226],"V600E-mutant":[227],"determine":[230],"the":[231,245,321,345,348],"efficacy":[232,349],"rMETase":[234,273,284,327,351,370],"combination":[236,281,322,352],"first-line":[239,373],"drug,":[241],"temozolomide":[242],"(TEM).":[243],"In":[244],"40":[248],"PDOX":[250,356],"models":[252],"were":[253],"randomized":[254],"into":[255],"four":[256],"groups":[257],"10":[259],"mice":[260],"each:":[261],"untreated":[262,304],"control":[263,305],"(n=10);":[264],"TEM":[265,282,325],"(25":[266],"mg/kg,":[267,287],"oral":[268,288],"14":[269,277,293,317],"consecutive":[270,278,294],"days,":[271,279,295],"n=10);":[272,280],"(100":[274],"units,":[275,291],"intraperitoneal":[276,292],"+":[283],"(TEM:":[285,306,335],"25":[286],"rMETase:":[289,309,338],"100":[290],"n=10).":[296],"All":[297],"treatments":[298],"inhibited":[299],"tumor":[300],"compared":[302],"p":[307,310,313,336,339],"=0.0081,":[308],"=0.0037,":[311],"TEM-rMETase:":[312],"=0.0024)":[314],"on":[315],"day":[316],"after":[318],"initiation.":[319],"However,":[320],"therapy":[323,353],"was":[328],"significantly":[329],"more":[330],"efficacious":[331],"than":[332],"either":[333],"mono-therapy":[334],"=0.0051,":[337],"=0.0051).":[340],"is":[344],"first":[346],"demonstrating":[347],"model,":[357],"suggesting":[358],"potential":[359],"clinical":[360],"development,":[361],"especially":[362],"recalcitrant":[364],"cancers":[365],"melanoma,":[368],"where":[369],"may":[371],"enhance":[372],"therapy.":[374]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-17T00:00:00"}
