{"id":"https://openalex.org/W2742399016","doi":"https://doi.org/10.2217/fon-2017-0117","title":"Immunomodulatory effects of current cancer treatment and the consequences for follow-up immunotherapeutics","display_name":"Immunomodulatory effects of current cancer treatment and the consequences for follow-up immunotherapeutics","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2742399016","doi":"https://doi.org/10.2217/fon-2017-0117","mag":"2742399016","pmid":"https://pubmed.ncbi.nlm.nih.gov/28776423"},"language":"en","primary_location":{"id":"doi:10.2217/fon-2017-0117","doi":"https://doi.org/10.2217/fon-2017-0117","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fon-2017-0117","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083431383","display_name":"Meghan J. Mooradian","orcid":"https://orcid.org/0000-0002-8289-8015","observed_orcids":["https://orcid.org/0000-0002-8289-8015"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan J Mooradian","raw_affiliation_strings":["Department of Medicine,Massachusetts General Hospital & Harvard Medical School, Boston,\rMA 02114,\rUSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,Massachusetts General Hospital & Harvard Medical School, Boston,\rMA 02114,\rUSA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008479799","display_name":"Ryan Joseph Sullivan","orcid":"https://orcid.org/0000-0001-5344-6645","observed_orcids":["https://orcid.org/0000-0001-5344-6645"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J Sullivan","raw_affiliation_strings":["Department of Medicine,Massachusetts General Hospital & Harvard Medical School, Boston,\rMA 02114,\rUSA","Fax: +1 617 724 3166"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,Massachusetts General Hospital & Harvard Medical School, Boston,\rMA 02114,\rUSA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Fax: +1 617 724 3166","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0864,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.13121054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"18","first_page":"1649","last_page":"1663"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pd-1-pd-l1","display_name":"PD-1/PD-L1","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cancer-immunity-cycle","display_name":"cancer-immunity cycle","score":0.6830000281333923},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8299999833106995},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9869999885559082},{"id":"https://openalex.org/keywords/durable-response","display_name":"durable response","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8650579452514648},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7590459585189819},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5675314664840698},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5410076975822449},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5290875434875488},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47371262311935425},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.47198420763015747},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.43994778394699097},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.43994471430778503},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.43387746810913086},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.41822880506515503},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4153459668159485},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.394480437040329},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37294667959213257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3347737789154053},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2217/fon-2017-0117","doi":"https://doi.org/10.2217/fon-2017-0117","is_oa":false,"landing_page_url":"https://doi.org/10.2217/fon-2017-0117","pdf_url":null,"source":{"id":"https://openalex.org/S174572715","display_name":"Future Oncology","issn_l":"1479-6694","issn":["1479-6694","1744-8301"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future Oncology","raw_type":"journal-article"},{"id":"pmid:28776423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28776423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Future oncology (London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W289544031","https://openalex.org/W1536480181","https://openalex.org/W1605743112","https://openalex.org/W1940241680","https://openalex.org/W1965370740","https://openalex.org/W1971620413","https://openalex.org/W1973488436","https://openalex.org/W1976841472","https://openalex.org/W1982488143","https://openalex.org/W1986013003","https://openalex.org/W1986462840","https://openalex.org/W1994993231","https://openalex.org/W1996810856","https://openalex.org/W1997944395","https://openalex.org/W2019405807","https://openalex.org/W2027345033","https://openalex.org/W2037036587","https://openalex.org/W2038325530","https://openalex.org/W2039123767","https://openalex.org/W2039664986","https://openalex.org/W2040956995","https://openalex.org/W2049553585","https://openalex.org/W2061440101","https://openalex.org/W2061824209","https://openalex.org/W2071069178","https://openalex.org/W2072853625","https://openalex.org/W2076743146","https://openalex.org/W2079068389","https://openalex.org/W2079315541","https://openalex.org/W2086437355","https://openalex.org/W2089187782","https://openalex.org/W2092055002","https://openalex.org/W2094481139","https://openalex.org/W2096387850","https://openalex.org/W2097995306","https://openalex.org/W2098414192","https://openalex.org/W2103675014","https://openalex.org/W2103767560","https://openalex.org/W2103959341","https://openalex.org/W2104347254","https://openalex.org/W2106747061","https://openalex.org/W2108789863","https://openalex.org/W2109274792","https://openalex.org/W2111415894","https://openalex.org/W2113510389","https://openalex.org/W2114671410","https://openalex.org/W2114903025","https://openalex.org/W2115975916","https://openalex.org/W2116376943","https://openalex.org/W2118546263","https://openalex.org/W2121820529","https://openalex.org/W2123363005","https://openalex.org/W2124427232","https://openalex.org/W2124446900","https://openalex.org/W2128035403","https://openalex.org/W2128565827","https://openalex.org/W2130211103","https://openalex.org/W2131783235","https://openalex.org/W2132923173","https://openalex.org/W2135445993","https://openalex.org/W2136364651","https://openalex.org/W2136443494","https://openalex.org/W2136700890","https://openalex.org/W2136731993","https://openalex.org/W2142996956","https://openalex.org/W2149244682","https://openalex.org/W2149748445","https://openalex.org/W2150145041","https://openalex.org/W2152897456","https://openalex.org/W2160834915","https://openalex.org/W2162222767","https://openalex.org/W2162856391","https://openalex.org/W2166662937","https://openalex.org/W2186491612","https://openalex.org/W2192699773","https://openalex.org/W2201977796","https://openalex.org/W2258329728","https://openalex.org/W2299181842","https://openalex.org/W2329974159","https://openalex.org/W2335365056","https://openalex.org/W2412250098","https://openalex.org/W2427476638","https://openalex.org/W2464620827","https://openalex.org/W2513415897","https://openalex.org/W2520601585","https://openalex.org/W2526607882","https://openalex.org/W2529904548","https://openalex.org/W2533098748","https://openalex.org/W2552470435","https://openalex.org/W2554479252","https://openalex.org/W2560704457","https://openalex.org/W2567700874","https://openalex.org/W2602107020","https://openalex.org/W2609883123","https://openalex.org/W2626820697","https://openalex.org/W4244304327"],"related_works":["https://openalex.org/W2946112461","https://openalex.org/W2884525857","https://openalex.org/W2747016053","https://openalex.org/W2988625462","https://openalex.org/W2555713829","https://openalex.org/W4409365006","https://openalex.org/W3135376681","https://openalex.org/W4385406293","https://openalex.org/W3212402614","https://openalex.org/W2284926981"],"abstract_inverted_index":{"Recent":[0],"advances":[1],"in":[2,12,78],"the":[3,13,31,36,79,88,101,108,115],"use":[4,109],"of":[5,15,27,33,45,61,90,104,110],"immunotherapy":[6,91,105],"have":[7,19,48],"led":[8],"to":[9,52,74,92,113],"historic":[10],"advancements":[11],"field":[14],"oncology.":[16],"Checkpoint":[17],"inhibitors":[18],"demonstrated":[20],"significant":[21],"effectiveness":[22],"against":[23,35],"a":[24,43,49,58,93],"broadening":[25],"range":[26],"cancers.":[28],"However,":[29],"despite":[30],"success":[32],"antibodies":[34],"immune":[37],"regulators,":[38],"CTLA4":[39],"and":[40,84,106,118],"PD-L1/PD-1,":[41],"only":[42],"subset":[44],"patients":[46],"will":[47],"durable":[50],"response":[51],"these":[53],"therapies,":[54],"which":[55],"implies":[56],"that":[57,71],"broader":[59],"view":[60],"cancer":[62],"immunity":[63],"is":[64,67,82],"required.":[65],"It":[66],"becoming":[68],"increasingly":[69],"apparent":[70],"combination":[72,111],"therapy":[73,112],"target":[75],"multiple":[76],"events":[77],"cancer-immunity":[80],"cycle":[81],"needed":[83],"could":[85],"potentially":[86],"extend":[87],"benefit":[89],"larger":[94],"population.":[95],"In":[96],"this":[97],"review,":[98],"we":[99],"discuss":[100],"current":[102],"status":[103],"highlight":[107],"prime":[114],"tumor":[116],"microenvironment":[117],"thereby":[119],"improve":[120],"treatment":[121],"effect.":[122]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-17T00:00:00"}