{"id":"https://openalex.org/W2742380604","doi":"https://doi.org/10.1016/j.coi.2017.07.011","title":"Known unknowns: how might the persistent herpesvirome shape immunity and aging?","display_name":"Known unknowns: how might the persistent herpesvirome shape immunity and aging?","publication_year":2017,"publication_date":"2017-08-04","ids":{"openalex":"https://openalex.org/W2742380604","doi":"https://doi.org/10.1016/j.coi.2017.07.011","mag":"2742380604","pmid":"https://pubmed.ncbi.nlm.nih.gov/28780492","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5682194"},"language":"en","primary_location":{"id":"doi:10.1016/j.coi.2017.07.011","doi":"https://doi.org/10.1016/j.coi.2017.07.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coi.2017.07.011","pdf_url":null,"source":{"id":"https://openalex.org/S170047187","display_name":"Current Opinion in Immunology","issn_l":"0952-7915","issn":["0952-7915","1879-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5682194","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036273449","display_name":"Janko Nikolich\u2010\u017dugich","orcid":"https://orcid.org/0000-0001-5830-5323","observed_orcids":["https://orcid.org/0000-0001-5830-5323"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janko Nikolich-Zugich","raw_affiliation_strings":["Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States. Electronic address: nikolich@email.arizona.edu","Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States. Electronic address: nikolich@email.arizona.edu","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065542116","display_name":"Felicia D. Goodrum","orcid":"https://orcid.org/0000-0002-6646-7290","observed_orcids":["https://orcid.org/0000-0002-6646-7290"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felicia Goodrum","raw_affiliation_strings":["Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036878633","display_name":"Kenneth S. Knox","orcid":"https://orcid.org/0000-0002-5261-6558","observed_orcids":["https://orcid.org/0000-0002-5261-6558"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4405259572","display_name":"University of Arizona College of Medicine- Phoenix","ror":"https://ror.org/02drhvq25","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Knox","raw_affiliation_strings":["Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States; University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, United States","Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States","University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States; University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, United States","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4405259572"]},{"raw_affiliation_string":"Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, United States","institution_ids":["https://openalex.org/I4405259572"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020932497","display_name":"Megan J. Smithey","orcid":"https://orcid.org/0000-0001-8890-3228","observed_orcids":["https://orcid.org/0000-0001-8890-3228"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Megan J Smithey","raw_affiliation_strings":["Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States. Electronic address: smithey@email.arizona.edu","Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States"],"raw_orcid":"https://orcid.org/0000-0003-2346-3967","affiliations":[{"raw_affiliation_string":"Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States. Electronic address: smithey@email.arizona.edu","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ 85724, United States","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020932497","https://openalex.org/A5036273449"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":0.9406,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.6875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"48","issue":null,"first_page":"23","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.7310000061988831},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.8920000195503235},{"id":"https://openalex.org/keywords/herpesviruses","display_name":"herpesvirus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/endogenous-viral-elements","display_name":"endogenous viral elements","score":0.8880000114440918},{"id":"https://openalex.org/keywords/virome","display_name":"virome","score":0.6460000276565552},{"id":"https://openalex.org/keywords/microbiome","display_name":"microbiome","score":0.6579999923706055},{"id":"https://openalex.org/keywords/virus-host-interactions","display_name":"host-virus interaction","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C190743605","wikidata":"https://www.wikidata.org/wiki/Q17027885","display_name":"Human virome","level":4,"score":0.9179525375366211},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.8014684319496155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7650599479675293},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7348812818527222},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5460642576217651},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5234265327453613},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.47508683800697327},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.33320504426956177},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3319453001022339},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3285883665084839},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20960301160812378},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.20210188627243042},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.1094808280467987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07596045732498169}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006564","descriptor_name":"Herpesviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017735","descriptor_name":"Virus Latency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.coi.2017.07.011","doi":"https://doi.org/10.1016/j.coi.2017.07.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.coi.2017.07.011","pdf_url":null,"source":{"id":"https://openalex.org/S170047187","display_name":"Current Opinion in Immunology","issn_l":"0952-7915","issn":["0952-7915","1879-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Immunology","raw_type":"journal-article"},{"id":"pmid:28780492","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28780492","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5109128","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5682194","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5682194","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5682194","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Opin Immunol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5109128","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5682194","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2481170185","display_name":null,"funder_award_id":"N01-AI-000017","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5947311558","display_name":"IMPACT OF CMV UPON T-CELL AGING AND IMMUNE DEFENSE","funder_award_id":"R01AG048021","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6733631288","display_name":"T cell Homeostasis and Function in Immune Senescence","funder_award_id":"R01AG020719","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000868808","display_name":"Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic Cells","funder_award_id":"R37AI079059","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1544333260","https://openalex.org/W1605851537","https://openalex.org/W1904456060","https://openalex.org/W1910012553","https://openalex.org/W1932638060","https://openalex.org/W1960462362","https://openalex.org/W1969586306","https://openalex.org/W1976936948","https://openalex.org/W1978279708","https://openalex.org/W1978297432","https://openalex.org/W1988969261","https://openalex.org/W1992390228","https://openalex.org/W1998779041","https://openalex.org/W2003437843","https://openalex.org/W2011601656","https://openalex.org/W2013544175","https://openalex.org/W2015035889","https://openalex.org/W2020381478","https://openalex.org/W2023880399","https://openalex.org/W2031041877","https://openalex.org/W2032911889","https://openalex.org/W2039113659","https://openalex.org/W2040977485","https://openalex.org/W2041919004","https://openalex.org/W2063892379","https://openalex.org/W2071107745","https://openalex.org/W2073368255","https://openalex.org/W2084814249","https://openalex.org/W2086927598","https://openalex.org/W2087562777","https://openalex.org/W2087991160","https://openalex.org/W2088177247","https://openalex.org/W2098132870","https://openalex.org/W2099468505","https://openalex.org/W2102330096","https://openalex.org/W2103532807","https://openalex.org/W2103849595","https://openalex.org/W2105019625","https://openalex.org/W2105928329","https://openalex.org/W2107472847","https://openalex.org/W2115364134","https://openalex.org/W2116687125","https://openalex.org/W2116934424","https://openalex.org/W2121017194","https://openalex.org/W2122859436","https://openalex.org/W2123183493","https://openalex.org/W2129477930","https://openalex.org/W2129738847","https://openalex.org/W2131362770","https://openalex.org/W2132466754","https://openalex.org/W2133576690","https://openalex.org/W2135879492","https://openalex.org/W2137522671","https://openalex.org/W2144241990","https://openalex.org/W2154123565","https://openalex.org/W2159039255","https://openalex.org/W2159360702","https://openalex.org/W2161593765","https://openalex.org/W2270045649","https://openalex.org/W2285594441","https://openalex.org/W2461330194","https://openalex.org/W2558386355","https://openalex.org/W2603415762","https://openalex.org/W2626113915","https://openalex.org/W2626351472","https://openalex.org/W2660682167","https://openalex.org/W2682925396","https://openalex.org/W6644954920","https://openalex.org/W6739250107"],"related_works":["https://openalex.org/W7214234194","https://openalex.org/W7128428835","https://openalex.org/W2936416251","https://openalex.org/W1751391168","https://openalex.org/W2725483392","https://openalex.org/W4220931524","https://openalex.org/W6982589442","https://openalex.org/W2009730316","https://openalex.org/W7196959987","https://openalex.org/W3162338434"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-08-17T00:00:00"}