{"id":"https://openalex.org/W2742364528","doi":null,"title":"Effects of PH20 Hyaluronidase Inhibition In Vivo Following Cerebral White Matter Injury","display_name":"Effects of PH20 Hyaluronidase Inhibition In Vivo Following Cerebral White Matter Injury","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2742364528","mag":"2742364528"},"language":"en","primary_location":{"id":"pmh:oai:commons.cu-portland.edu:theses-1165","doi":null,"is_oa":false,"landing_page_url":"https://commons.cu-portland.edu/theses/150","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Theses","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047480890","display_name":"Rachel E. Siltman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rachel E. Siltman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5047480890"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronidase-inhibition","display_name":"hyaluronidase inhibition","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cerebral-white-matter-injury","display_name":"cerebral white matter injury","score":0.875},{"id":"https://openalex.org/keywords/hypoxia-ischemia","display_name":"hypoxia-ischemia","score":0.890999972820282},{"id":"https://openalex.org/keywords/preterm-birth","display_name":"preterm birth","score":0.777999997138977},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/opc-proliferation","display_name":"OPC proliferation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.7409999966621399},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.878000020980835},{"id":"https://openalex.org/keywords/cerebral-palsy","display_name":"cerebral palsy","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5532643795013428},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.43219631910324097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4132479727268219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.139873206615448},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.0988842248916626},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09011414647102356},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:commons.cu-portland.edu:theses-1165","doi":null,"is_oa":false,"landing_page_url":"https://commons.cu-portland.edu/theses/150","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Undergraduate Theses","raw_type":"text"},{"id":"mag:2742364528","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.csp.edu/cgi/viewcontent.cgi?article=1011&context=cup_commons_undergrad","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1494362497","https://openalex.org/W1556848471","https://openalex.org/W1758608299","https://openalex.org/W1896545635","https://openalex.org/W1964544761","https://openalex.org/W1974208182","https://openalex.org/W1980471744","https://openalex.org/W1983660269","https://openalex.org/W2027830942","https://openalex.org/W2039476938","https://openalex.org/W2059021136","https://openalex.org/W2065056828","https://openalex.org/W2066556226","https://openalex.org/W2100592864","https://openalex.org/W2100837475","https://openalex.org/W2107625098","https://openalex.org/W2108005154","https://openalex.org/W2111447973","https://openalex.org/W2111622605","https://openalex.org/W2120787848","https://openalex.org/W2125886309","https://openalex.org/W2135776201","https://openalex.org/W2151417786","https://openalex.org/W2158698668","https://openalex.org/W2166266395","https://openalex.org/W2583795921"],"related_works":["https://openalex.org/W2038353477","https://openalex.org/W3160912981","https://openalex.org/W4384926758","https://openalex.org/W2614148033","https://openalex.org/W2420168557","https://openalex.org/W1966605185","https://openalex.org/W2769464088","https://openalex.org/W14251522","https://openalex.org/W2068355692","https://openalex.org/W2007075719"],"abstract_inverted_index":{"Human":[0],"infants":[1],"born":[2],"prematurely":[3],"between":[4],"23-32":[5],"weeks":[6],"have":[7,120],"a":[8,34,105,143,157,167,175,204],"predisposition":[9],"toward":[10],"sustaining":[11],"white":[12,27],"matter":[13,28],"injury":[14],"(WMI).":[15],"In":[16],"survivors":[17],"of":[18,33,36,57,66,74,97,108,134,172,188,251],"preterm":[19,170],"birth,":[20],"hypoxic-ischemic":[21],"(H-I)":[22],"damage":[23],"to":[24,55,72,82,130,136,161,219],"the":[25,30,75,109,194,214,248,258],"cerebral":[26,45],"is":[29,112,150],"leading":[31,54,71],"cause":[32],"spectrum":[35],"neurological":[37],"and":[38,41,84,95,174,230,255],"motor":[39],"deficits":[40],"in":[42,145,159,207,210,213,245,247,257],"severe":[43],"cases,":[44],"palsy":[46],"(CP).":[47],"H-I":[48,61,146,173],"triggers":[49],"extracellular":[50],"matrix":[51],"(ECM)":[52],"breakdown":[53,92],"production":[56],"inhibitory":[58],"ECM":[59,91],"components.":[60],"also":[62,192,243],"induces":[63],"vigorous":[64],"proliferation":[65,149,196,227],"oligodendrocyte":[67],"progenitor":[68],"cells":[69,209,254],"(OPCs)":[70],"accumulation":[73],"pre-oligodendrocytes":[76],"(preOLs).":[77],"However,":[78],"these":[79],"preOLs":[80,135,256],"fail":[81],"differentiate":[83],"generate":[85],"myelin":[86,98],"producing":[87],"oligodendrocytes":[88],"(OLs).":[89],"Mechanistically,":[90],"blocks":[93],"repair":[94],"regeneration":[96],"following":[99,123],"WMI":[100,211,259],"as":[101],"hyaluronic":[102],"acid":[103],"(HA),":[104],"major":[106],"component":[107],"brain":[110],"ECM,":[111],"digested":[113],"into":[114],"bioactive":[115],"fragments":[116],"(fHA).":[117],"Previous":[118],"studies":[119],"shown":[121],"that":[122],"WMI,":[124],"HA":[125],"degraded":[126],"by":[127,232],"PH20":[128,178,189,233],"hyaluronidase":[129,155,234],"fHA":[131,141],"prevents":[132],"differentiation":[133],"mature":[137],"OLs,":[138],"but":[139],"whether":[140,184,240],"plays":[142,156],"role":[144,158],"mediated":[147,186,231],"OPC":[148,163,195],"unknown.":[151],"To":[152],"determine":[153],"if":[154],"vivo":[160],"promote":[162],"proliferation,":[164],"we":[165],"utilized":[166],"neonatal":[168,200],"rodent":[169],"model":[171],"new":[176],"selective":[177],"inhibitor,":[179],"SuBr3.":[180],"Our":[181],"hypothesis":[182],"tests":[183],"SuBr3":[185,215,241],"inhibition":[187],"activity":[190],"will":[191,238],"attenuate":[193],"response":[197],"observed":[198],"after":[199],"WMI.":[201],"We":[202],"found":[203],"significant":[205],"decrease":[206],"Ki67+":[208],"lesions":[212],"treated":[216],"animals":[217],"relative":[218],"all":[220],"other":[221],"control":[222],"groups,":[223],"suggesting":[224],"total":[225,249],"cell":[226],"was":[228],"attenuated":[229],"activity.":[235],"Future":[236],"experiments":[237],"analyze":[239],"treatment":[242],"results":[244],"changes":[246],"pool":[250],"OL":[252],"lineage":[253],"lesions.":[260]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2017-08-17T00:00:00"}
