{"id":"https://openalex.org/W2742229347","doi":"https://doi.org/10.1002/rth2.12032","title":"Reduced dosing of enoxaparin for venous thromboembolism in overweight and obese adolescents: a single institution retrospective review","display_name":"Reduced dosing of enoxaparin for venous thromboembolism in overweight and obese adolescents: a single institution retrospective review","publication_year":2017,"publication_date":"2017-08-10","ids":{"openalex":"https://openalex.org/W2742229347","doi":"https://doi.org/10.1002/rth2.12032","mag":"2742229347","pmid":"https://pubmed.ncbi.nlm.nih.gov/30046689","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6058273"},"language":"en","primary_location":{"id":"doi:10.1002/rth2.12032","doi":"https://doi.org/10.1002/rth2.12032","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rth2.12032","pdf_url":"http://www.rpthjournal.org/article/S2475037922021719/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.rpthjournal.org/article/S2475037922021719/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029985024","display_name":"Stephanie Hoffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Hoffman","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082143007","display_name":"Chi L. Braunreiter","orcid":"https://orcid.org/0000-0002-6861-5189","observed_orcids":["https://orcid.org/0000-0002-6861-5189"]},"institutions":[{"id":"https://openalex.org/I4210130567","display_name":"Helen DeVos Children's Hospital","ror":"https://ror.org/03bk8p931","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130567","https://openalex.org/I4392738273"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chi Braunreiter","raw_affiliation_strings":["Helen DeVos Children's Hospital, Grand Rapids, MI, USA","Michigan State University College of Human Medicine, Grand Rapids, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helen DeVos Children's Hospital, Grand Rapids, MI, USA","institution_ids":["https://openalex.org/I4210130567"]},{"raw_affiliation_string":"Michigan State University College of Human Medicine, Grand Rapids, MI, USA","institution_ids":["https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082143007"],"corresponding_institution_ids":["https://openalex.org/I4210130567","https://openalex.org/I87216513"],"apc_list":{"value":2250,"currency":"USD","value_usd":2250},"apc_paid":{"value":2250,"currency":"USD","value_usd":2250},"fwci":1.0462,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81197655,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"2","first_page":"188","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11929","display_name":"Cerebral Venous Sinus Thrombosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enoxaparin","display_name":"enoxaparin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/venous-thromboembolism","display_name":"venous thromboembolism","score":0.9190000295639038},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/adolescent-overweight","display_name":"adolescent overweight","score":0.8859999775886536},{"id":"https://openalex.org/keywords/low-molecular-weight-heparin","display_name":"low molecular weight heparin","score":0.953000009059906},{"id":"https://openalex.org/keywords/anti-xa-levels","display_name":"anti-Xa levels","score":0.7860000133514404},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.7260000109672546},{"id":"https://openalex.org/keywords/thrombus-progression","display_name":"thrombus progression","score":0.8159999847412109},{"id":"https://openalex.org/keywords/anticoagulation-outcomes","display_name":"anticoagulation outcomes","score":0.7059999704360962}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.9585775136947632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9166010618209839},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.9075179100036621},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6491377949714661},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5194979906082153},{"id":"https://openalex.org/C2991741193","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thromboembolism","level":3,"score":0.4378516674041748},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4153573215007782},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41064897179603577},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.14959537982940674}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1002/rth2.12032","doi":"https://doi.org/10.1002/rth2.12032","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rth2.12032","pdf_url":"http://www.rpthjournal.org/article/S2475037922021719/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5011907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6058273","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6058273","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6058273","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Pract Thromb Haemost","raw_type":"Text"},{"id":"pmid:30046689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30046689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and practice in thrombosis and haemostasis","raw_type":"Journal Article"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/138884","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2027.42/138884","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1002/rth2.12032","doi":"https://doi.org/10.1002/rth2.12032","is_oa":true,"landing_page_url":"https://doi.org/10.1002/rth2.12032","pdf_url":"http://www.rpthjournal.org/article/S2475037922021719/pdf","source":{"id":"https://openalex.org/S4210185368","display_name":"Research and Practice in Thrombosis and Haemostasis","issn_l":"2475-0379","issn":["2475-0379"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research and Practice in Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2742229347.pdf","grobid_xml":"https://content.openalex.org/works/W2742229347.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1509399724","https://openalex.org/W1512088449","https://openalex.org/W1560605300","https://openalex.org/W1574141134","https://openalex.org/W2000941640","https://openalex.org/W2001497857","https://openalex.org/W2013537866","https://openalex.org/W2013984355","https://openalex.org/W2023989540","https://openalex.org/W2033873973","https://openalex.org/W2041773027","https://openalex.org/W2054446352","https://openalex.org/W2057415381","https://openalex.org/W2057593812","https://openalex.org/W2076895726","https://openalex.org/W2085346056","https://openalex.org/W2106459062","https://openalex.org/W2106528571","https://openalex.org/W2131451413","https://openalex.org/W2132775754","https://openalex.org/W2146595375","https://openalex.org/W2151402544","https://openalex.org/W2152073293","https://openalex.org/W2155104514","https://openalex.org/W2158604269","https://openalex.org/W2169109838","https://openalex.org/W2169845753","https://openalex.org/W2419228228","https://openalex.org/W2468777891","https://openalex.org/W3145112846"],"related_works":["https://openalex.org/W4396639882","https://openalex.org/W2158604269","https://openalex.org/W2970400610","https://openalex.org/W2572373151","https://openalex.org/W3199022576","https://openalex.org/W2946423528","https://openalex.org/W2968597804","https://openalex.org/W2108919700","https://openalex.org/W4392859764","https://openalex.org/W4410158772"],"abstract_inverted_index":{"Unlabelled":[0],"Box":[1],"\u2022Data":[2],"is":[3,40,176,183],"scarce":[4],"on":[5,164,180],"enoxaparin":[6,22,28,48,207,352],"dosing":[7,231,271,290,350],"for":[8,49,63,79,94,140,237],"obese":[9,17,52,160,174,200,224,252,285,357],"adolescents":[10,18,53,201,225,286,358],"with":[11,20,54,66,81,96,264,269,335,359],"venous":[12,156],"thromboembolism":[13],"(VTE).":[14],"\u2022Overweight":[15],"and":[16,51,69,74,84,99,111,126,178,195,199,223,251,259,280,284,346,356],"treated":[19,268],"reduced":[21,204,270,349],"dose":[23,169,238,317],"(RD)":[24,272],"were":[25,267,303],"reviewed.":[26],"\u2022Initial":[27],"doses":[29,205],"calculated":[30],"using":[31],"actual":[32],"body":[33],"weight":[34],"may":[35],"be":[36],"greater":[37],"than":[38],"what":[39],"needed.":[41],"\u2022Trials":[42],"are":[43,240,340],"warranted":[44,341],"to":[45,59,166,190,217,221,232,282,305,342,353],"evaluate":[46,343],"RD":[47,293,311,322],"overweight":[50,198,222,250,283,355],"VTE.":[55,360],"We":[56,243],"would":[57],"like":[58],"thank":[60,90],"Beth":[61],"Sandon\u2010Kleiboer":[62],"her":[64],"help":[65],"data":[67,163],"collection":[68],"Alan":[70],"T.":[71],"Davis,":[72],"PhD,":[73,78],"Tracy":[75],"J.":[76],"Koehler,":[77],"assistance":[80,95],"statistical":[82],"support":[83],"manuscript":[85],"preparation.":[86],"The":[87,104,147,162,213],"authors":[88,105],"also":[89],"Beyond":[91,120],"Words,":[92,121],"Inc.,":[93,122],"the":[97,109,141,144,168,209,255,310,344],"editing":[98,127],"preparation":[100],"of":[101,113,143,170,197,206,211,249,257,273,329,348,351],"this":[102,114,129],"manuscript.":[103],"maintained":[106],"control":[107],"over":[108],"direction":[110],"content":[112,142],"article":[115],"during":[116,319],"its":[117,133],"development.":[118],"Although":[119],"supplied":[123],"professional":[124],"writing":[125],"services,":[128],"does":[130],"not":[131,315],"indicate":[132],"endorsement":[134],"of,":[135],"agreement":[136],"with,":[137],"or":[138],"responsibility":[139],"article.":[145],"Background":[146],"global":[148],"obesity":[149],"epidemic":[150],"has":[151],"created":[152],"new":[153],"challenges,":[154],"including":[155],"thromboembolisms":[157],"(VTE)":[158],"in":[159,173],"adolescents.":[161],"whether":[165],"reduce":[167],"low\u2010molecular":[171],"heparin":[172],"adults":[175],"conflicting,":[177],"information":[179],"adolescent":[181],"patients":[182,253,294,307,323,331],"scarce.":[184],"Objectives":[185],"Our":[186],"primary":[187],"goal":[188,215],"was":[189,216],"describe":[191],"dosing,":[192,277],"anti\u2010Xa":[193,278,300],"levels,":[194,279],"outcomes":[196,220,281],"who":[202,226,266,287],"received":[203,227,288],"at":[208],"initiation":[210],"therapy.":[212],"secondary":[214],"compare":[218],"their":[219,276],"standard":[228,289],"1":[229],"mg/kg":[230],"determine":[233],"if":[234],"future":[235],"trials":[236,339],"reduction":[239],"warranted.":[241],"Patients/Methods":[242],"performed":[244],"a":[245],"retrospective":[246],"cohort":[247],"study":[248],"between":[254],"ages":[256],"12":[258],"18":[260],"years":[261],"old":[262],"diagnosed":[263],"VTE":[265],"enoxaparin,":[274],"comparing":[275],"(SD).":[291],"Results":[292],"(n=19)":[295],"achieved":[296],"therapeutic":[297],"mean":[298],"initial":[299],"levels":[301],"that":[302],"similar":[304],"SD":[306],"(n=11).":[308],"Of":[309],"patients,":[312],"53%":[313],"did":[314],"require":[316],"adjustments":[318],"treatment.":[320],"Two":[321],"had":[324],"thrombus":[325],"progression.":[326],"A":[327],"total":[328],"25":[330],"ultimately":[332],"completed":[333],"therapy":[334],"RD.":[336],"Conclusions":[337],"Future":[338],"efficacy":[345],"safety":[347],"treat":[354]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-17T00:00:00"}
