{"id":"https://openalex.org/W2742084573","doi":"https://doi.org/10.1128/jvi.01084-17","title":"High-Risk Alphapapillomavirus Oncogenes Impair the Homologous Recombination Pathway","display_name":"High-Risk Alphapapillomavirus Oncogenes Impair the Homologous Recombination Pathway","publication_year":2017,"publication_date":"2017-08-03","ids":{"openalex":"https://openalex.org/W2742084573","doi":"https://doi.org/10.1128/jvi.01084-17","mag":"2742084573","pmid":"https://pubmed.ncbi.nlm.nih.gov/28768872","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5625488"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01084-17","doi":"https://doi.org/10.1128/jvi.01084-17","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01084-17","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5625488","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015794770","display_name":"Nicholas A. Wallace","orcid":"https://orcid.org/0000-0002-3971-716X","observed_orcids":["https://orcid.org/0000-0002-3971-716X"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas A. Wallace","raw_affiliation_strings":["Division of Biology, Kansas State University, Manhattan, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, Kansas State University, Manhattan, Kansas, USA","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091302158","display_name":"Sujita Khanal","orcid":"https://orcid.org/0000-0003-3196-0058","observed_orcids":["https://orcid.org/0000-0003-3196-0058"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sujita Khanal","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028549110","display_name":"Kristin L. Robinson","orcid":"https://orcid.org/0009-0008-2840-6762","observed_orcids":["https://orcid.org/0009-0008-2840-6762"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristin L. Robinson","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088342196","display_name":"Sebastian O. Wendel","orcid":"https://orcid.org/0000-0002-5515-0968","observed_orcids":["https://orcid.org/0000-0002-5515-0968"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian O. Wendel","raw_affiliation_strings":["Division of Biology, Kansas State University, Manhattan, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biology, Kansas State University, Manhattan, Kansas, USA","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079537035","display_name":"Joshua J. Messer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua J. Messer","raw_affiliation_strings":["James E. Rogers College of Law, University of Arizona, Tucson, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"James E. Rogers College of Law, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013624819","display_name":"Denise A. Galloway","orcid":"https://orcid.org/0000-0002-6713-6127","observed_orcids":["https://orcid.org/0000-0002-6713-6127"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise A. Galloway","raw_affiliation_strings":["Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1363,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.95515785,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"91","issue":"20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5917999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.4043000042438507,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hpv-e6","display_name":"E6 oncoprotein","score":0.7540000081062317},{"id":"https://openalex.org/keywords/hpv-e7","display_name":"E7 oncoprotein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9419999718666077},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9290000200271606},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7459999918937683},{"id":"https://openalex.org/keywords/oropharyngeal-cancer","display_name":"oropharyngeal cancer","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dna-repair-foci","display_name":"DNA repair foci","score":0.7390000224113464},{"id":"https://openalex.org/keywords/viral-oncogenes","display_name":"viral oncogenes","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8530068397521973},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.8035972118377686},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.8007930517196655},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.7834991812705994},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.7396156787872314},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6727097630500793},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.5660358667373657},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.48723307251930237},{"id":"https://openalex.org/C122917832","wikidata":"https://www.wikidata.org/wiki/Q2065945","display_name":"Non-homologous end joining","level":4,"score":0.4454202353954315},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4449884593486786},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44168993830680847},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4310791492462158},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42521148920059204},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42418813705444336},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3555957078933716}],"mesh":[{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050725","descriptor_name":"Papillomavirus E7 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051135","descriptor_name":"Rad51 Recombinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052685","descriptor_name":"Alphapapillomavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059765","descriptor_name":"Homologous Recombination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.01084-17","doi":"https://doi.org/10.1128/jvi.01084-17","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01084-17","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5625488","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5625488","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:28768872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28768872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5625488","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5625488","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1409126743","display_name":"Chromosome Metabolism and Cancer Training Grant","funder_award_id":"T32CA009657","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4029147574","display_name":"Human Papillomavirus and Polyomavirus Associated Malignancies.","funder_award_id":"R35CA209979","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5083911033","display_name":null,"funder_award_id":"T32 CA0096547","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7651521412","display_name":"HPV: Biology, Clinical Significance and Epidemiology","funder_award_id":"P01CA042792","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000869322","display_name":"Kansas IDeA Network of Biomedical Research Excellence 5","funder_award_id":"P20GM103418","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G928597882","display_name":"Interactions of HPV Oncogenes With the p53 Pathway","funder_award_id":"R01CA064795","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9942295","display_name":"CD22 Regulation of B Lymphocyte Function and Survival","funder_award_id":"R01CA096547","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W140061535","https://openalex.org/W1539426772","https://openalex.org/W1619509351","https://openalex.org/W1841331176","https://openalex.org/W1875984885","https://openalex.org/W1972651021","https://openalex.org/W1974875034","https://openalex.org/W1974894607","https://openalex.org/W1985804387","https://openalex.org/W1998248450","https://openalex.org/W2006317761","https://openalex.org/W2015732442","https://openalex.org/W2017474562","https://openalex.org/W2024254896","https://openalex.org/W2029816972","https://openalex.org/W2038500217","https://openalex.org/W2039382131","https://openalex.org/W2041801904","https://openalex.org/W2042049210","https://openalex.org/W2042785538","https://openalex.org/W2045504097","https://openalex.org/W2045751302","https://openalex.org/W2051409228","https://openalex.org/W2053440993","https://openalex.org/W2054690913","https://openalex.org/W2056909284","https://openalex.org/W2058812851","https://openalex.org/W2060763328","https://openalex.org/W2070721957","https://openalex.org/W2082643905","https://openalex.org/W2085429487","https://openalex.org/W2086480947","https://openalex.org/W2095317270","https://openalex.org/W2098765233","https://openalex.org/W2101988823","https://openalex.org/W2103770333","https://openalex.org/W2109664448","https://openalex.org/W2110143309","https://openalex.org/W2111065008","https://openalex.org/W2114404734","https://openalex.org/W2115459564","https://openalex.org/W2117184512","https://openalex.org/W2122098145","https://openalex.org/W2137278881","https://openalex.org/W2139721691","https://openalex.org/W2141201649","https://openalex.org/W2141509764","https://openalex.org/W2142793899","https://openalex.org/W2148028028","https://openalex.org/W2149166037","https://openalex.org/W2157899948","https://openalex.org/W2163840401","https://openalex.org/W2165948908","https://openalex.org/W2166826534","https://openalex.org/W2168892058","https://openalex.org/W2169642388","https://openalex.org/W2170008898","https://openalex.org/W2170939558","https://openalex.org/W2216406530","https://openalex.org/W2261971875","https://openalex.org/W2393644277","https://openalex.org/W2405232734","https://openalex.org/W3128343078","https://openalex.org/W6684715665"],"related_works":["https://openalex.org/W4391145752","https://openalex.org/W4220668624","https://openalex.org/W2790279538","https://openalex.org/W2053440993","https://openalex.org/W3203223682","https://openalex.org/W4317870995","https://openalex.org/W7099448235","https://openalex.org/W3098459592","https://openalex.org/W4318825258","https://openalex.org/W4387728577"],"abstract_inverted_index":{"ABSTRACT":[0],"Persistent":[1],"high-risk":[2],"genus":[3],"human":[4],"Alphapapillomavirus":[5],"(HPV)":[6],"infections":[7],"cause":[8],"nearly":[9],"every":[10],"cervical":[11,38],"carcinoma":[12],"and":[13,75,83,96,100,168,255,296,322],"a":[14,46,139,145,203,248,327,371],"subset":[15],"of":[16,37,49,58,69,89,105,138,150,177,196,210,235,244,260,269,306,312,337,347,354,367,374,388],"tumors":[17,39],"in":[18,64,131,228,257,317],"the":[19,23,29,50,70,87,103,106,125,132,136,151,188,224,233,242,258,261,266,276,307,365,368,386],"oropharyngeal":[20],"tract.":[21],"During":[22],"decades":[24],"required":[25,77],"for":[26,78,251,345],"HPV-associated":[27,79,229],"tumorigenesis,":[28],"cellular":[30],"genome":[31,263],"becomes":[32],"significantly":[33],"destabilized.":[34],"Our":[35,377],"analysis":[36],"from":[40,165,315],"four":[41],"separate":[42],"data":[43,215,378],"sets":[44],"found":[45],"significant":[47],"upregulation":[48],"homologous-recombination":[51],"(HR)":[52],"pathway":[53,108],"genes.":[54],"The":[55,118,310,335],"increased":[56,208],"abundance":[57],"HR":[59,90,107,122,299,325,338],"proteins":[60,91],"can":[61],"be":[62,162,200,343],"replicated":[63],"primary":[65],"cells":[66,318],"by":[67,115,123,158,231,264,339,363],"expression":[68],"two":[71],"HPV":[72,81,119,154,172,220,245,253,294,320,340,348,357,369,383],"oncogenes":[73,120,221,282,341,358],"(E6":[74],"E7)":[76],"transformation.":[80],"E6":[82,99,155,254,295,321,384],"E7":[84,101,173,256,297,323],"also":[85],"enhanced":[86],"ability":[88,104],"to":[92,109,127,142,161,181,190,199,223,285,300,361],"form":[93],"repair":[94,114,157,192,234,268,289,355],"foci,":[95],"yet":[97],"both":[98,166,252,280],"reduce":[102],"complete":[110],"double-strand":[111],"break":[112],"(DSB)":[113],"about":[116],"50%.":[117],"hinder":[121],"allowing":[124],"process":[126],"begin":[128],"at":[129,302],"points":[130],"cell":[133,308],"cycle":[134],"when":[135],"lack":[137],"sister":[140],"chromatid":[141],"serve":[143],"as":[144],"homologous":[146,267],"template":[147],"prevents":[148],"completion":[149],"repair.":[152],"Further,":[153,351],"attenuates":[156],"causing":[159],"RAD51":[160,179,313],"mislocalized":[163],"away":[164,314],"transient":[167,182],"persistent":[169],"DSBs,":[170],"whereas":[171],"is":[174,275],"only":[175],"capable":[176],"impairing":[178],"localization":[180],"lesions.":[183],"Finally,":[184],"we":[185],"show":[186,292],"that":[187,205,219,279,293],"inability":[189],"robustly":[191],"DSBs":[193,316],"causes":[194],"some":[195],"these":[197,214],"lesions":[198],"more":[201],"persistent,":[202],"phenotype":[204],"correlates":[206],"with":[207],"integration":[209,366,387],"episomal":[211],"DNA.":[212,237],"Together,":[213],"support":[216,379],"our":[217,272],"hypothesis":[218],"contribute":[222,360],"genomic":[225],"instability":[226],"observed":[227],"malignancies":[230],"attenuating":[232],"damaged":[236],"IMPORTANCE":[238],"This":[239],"study":[240],"expands":[241],"understanding":[243],"biology,":[246],"establishing":[247],"direct":[249],"role":[250],"destabilization":[259],"host":[262],"blocking":[265],"DSBs.":[270],"To":[271],"knowledge,":[273],"this":[274,287,352,380],"first":[277],"time":[278],"viral":[281],"were":[283],"shown":[284],"disrupt":[286],"DSB":[288],"pathway.":[290],"We":[291],"allow":[298],"initiate":[301],"an":[303],"inappropriate":[304],"part":[305],"cycle.":[309],"mislocalization":[311],"expressing":[319],"hinders":[324],"through":[326],"distinct":[328],"mechanism.":[329],"These":[330],"observations":[331],"have":[332],"broad":[333],"implications.":[334],"impairment":[336],"may":[342,359],"targeted":[344],"treatment":[346],"+":[349],"malignancies.":[350],"attenuation":[353],"suggests":[356],"tumorigenesis":[362],"promoting":[364],"genome,":[370],"common":[372],"feature":[373],"HPV-transformed":[375],"cells.":[376],"idea":[381],"since":[382],"stimulates":[385],"episomes.":[389]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-08T00:00:00"}
