{"id":"https://openalex.org/W2742019054","doi":"https://doi.org/10.1158/1538-7445.am2017-5013","title":"Abstract 5013: A 3D culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer","display_name":"Abstract 5013: A 3D culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2742019054","doi":"https://doi.org/10.1158/1538-7445.am2017-5013","mag":"2742019054"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-5013","doi":"https://doi.org/10.1158/1538-7445.am2017-5013","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-5013","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090179644","display_name":"Bhuminder Singh","orcid":"https://orcid.org/0000-0003-1357-2158","observed_orcids":["https://orcid.org/0000-0003-1357-2158"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhuminder Singh","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055801372","display_name":"Cunxi Li","orcid":"https://orcid.org/0000-0003-1264-042X","observed_orcids":["https://orcid.org/0000-0003-1264-042X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cunxi Li","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036988988","display_name":"Ramona Graves\u2010Deal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramona Graves-Deal","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062062195","display_name":"Haiting Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiting Ma","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060746658","display_name":"Alina Starchenko","orcid":"https://orcid.org/0000-0003-2265-7508","observed_orcids":["https://orcid.org/0000-0003-2265-7508"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alina Starchenko","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007726440","display_name":"William Fry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William H. Fry","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001475437","display_name":"Yuanyuan Lu","orcid":"https://orcid.org/0000-0003-0194-8074","observed_orcids":["https://orcid.org/0000-0003-0194-8074","https://orcid.org/0009-0005-2649-8913"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanyuan Lu","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100423359","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0003-1588-3208","observed_orcids":["https://orcid.org/0000-0003-1588-3208","https://orcid.org/0009-0000-3185-5384"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041399222","display_name":"Galina T. Bogatcheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galina Bogatcheva","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035769058","display_name":"Mohseen P. Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohseen P. Khan","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050233317","display_name":"Ginger L. Milne","orcid":"https://orcid.org/0000-0003-3890-151X","observed_orcids":["https://orcid.org/0000-0003-3890-151X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ginger L. Milne","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084130453","display_name":"Shilin Zhao","orcid":"https://orcid.org/0000-0002-3921-3965","observed_orcids":["https://orcid.org/0000-0002-3921-3965"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shilin Zhao","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042841835","display_name":"Gregory Daniel Ayers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D. Ayers","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061465255","display_name":"Nenggan Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nenggan Li","raw_affiliation_strings":["2Jiaen Genetics Laboratory, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Jiaen Genetics Laboratory, Beijing, China;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087826096","display_name":"Mary Kay Washington","orcid":"https://orcid.org/0000-0002-9589-7695","observed_orcids":["https://orcid.org/0000-0002-9589-7695"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary K. Washington","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113849367","display_name":"Timothy Joseph Yeatman","orcid":"https://orcid.org/0000-0002-7487-0784","observed_orcids":["https://orcid.org/0000-0002-7487-0784"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J. Yeatman","raw_affiliation_strings":["3Gibbs Cancer Center & Research Institute, Spartanburg, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Gibbs Cancer Center & Research Institute, Spartanburg, SC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043640546","display_name":"Oliver Gene McDonald","orcid":"https://orcid.org/0000-0002-6602-7535","observed_orcids":["https://orcid.org/0000-0002-6602-7535"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oliver G. McDonald","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319741","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0002-0037-1042","observed_orcids":["https://orcid.org/0000-0002-0037-1042"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Liu","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046249010","display_name":"Robert J. Coffey","orcid":"https://orcid.org/0000-0002-2180-3844","observed_orcids":["https://orcid.org/0000-0002-2180-3844"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Coffey","raw_affiliation_strings":["1Vanderbilt University Medical Center, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Vanderbilt University Medical Center, Nashville, TN;","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"5013","last_page":"5013"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cetuximab-resistance","display_name":"cetuximab resistance","score":0.9200000166893005},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8790000081062317},{"id":"https://openalex.org/keywords/met-tyrosine-kinase","display_name":"MET tyrosine kinase","score":0.828000009059906},{"id":"https://openalex.org/keywords/crizotinib","display_name":"crizotinib","score":0.9319999814033508},{"id":"https://openalex.org/keywords/versican","display_name":"versican","score":0.9020000100135803},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.7789999842643738},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.47600001096725464},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.5830000042915344},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.43799999356269836},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.8848304748535156},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6831066012382507},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6069216728210449},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5402881503105164},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5318728685379028},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48312923312187195},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.47309592366218567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4547036588191986},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33037668466567993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32639873027801514},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3092119097709656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1715686321258545}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-5013","doi":"https://doi.org/10.1158/1538-7445.am2017-5013","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-5013","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2597422592","https://openalex.org/W3083434439","https://openalex.org/W4231090214","https://openalex.org/W3180589295","https://openalex.org/W2914971500","https://openalex.org/W4282982241","https://openalex.org/W4311092962","https://openalex.org/W4409628231","https://openalex.org/W7000170636","https://openalex.org/W2326995704"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"previously":[2],"reported":[3],"that":[4,184],"single":[5],"cells":[6],"from":[7],"a":[8,178,205,216,223,233,300],"human":[9,179],"colorectal":[10,310],"cancer":[11,311],"(CRC)":[12],"cell":[13],"line":[14],"(HCA-7)":[15],"formed":[16],"either":[17],"hollow":[18],"single-layered":[19],"polarized":[20],"cysts":[21,40],"or":[22],"solid":[23],"spiky":[24,42,67],"masses":[25,43],"when":[26],"plated":[27],"within":[28],"type-I":[29],"collagen":[30],"in":[31,123,147,155,167,172,227,309],"3D.":[32,148],"To":[33,128],"begin":[34],"in-depth":[35],"analyses":[36],"into":[37],"whether":[38],"clonal":[39],"and":[41,55,66,69,74,81,100,110,134,140,145,162,174,196,200,222,242,306],"possessed":[44],"divergent":[45],"malignant":[46],"properties,":[47],"individual":[48],"colonies":[49],"of":[50,91,108,113,143,150,177,219,303,315],"each":[51],"morphology":[52],"were":[53,70],"isolated":[54],"expanded.":[56],"The":[57],"lines":[58],"thus":[59],"derived":[60],"faithfully":[61],"retained":[62],"the":[63,114,151,158,163,316],"parental":[64],"cystic":[65],"morphologies":[68],"termed":[71],"CC":[72,80,133,144,156],"(cystic)":[73],"SC":[75,82,94,124,146,168],"(spiky),":[76],"respectively.":[77],"Although":[78],"both":[79],"expressed":[83],"EGF":[84],"receptor":[85],"(EGFR),":[86],"cetuximab":[87,122,126,220,304],"strongly":[88,191],"inhibited":[89],"growth":[90,98],"CC,":[92],"whereas":[93],"was":[95,102,157,169],"resistant":[96],"to":[97,104,121,237],"inhibition":[99],"this":[101,210,231],"coupled":[103],"increased":[105],"tyrosine":[106,117],"phosphorylation":[107],"MET":[109],"RON.":[111],"Addition":[112],"dual":[115],"MET/RON":[116],"kinase":[118],"inhibitor,":[119],"crizotinib,":[120],"restored":[125],"sensitivity.":[127],"characterize":[129],"genome-wide":[130],"divergence":[131],"between":[132],"SC,":[135],"we":[136,213],"performed":[137],"comprehensive":[138],"genomic":[139],"transcriptomic":[141],"analysis":[142],"One":[149],"most":[152,164],"upregulated":[153,165],"genes":[154,244,308],"tumor":[159],"suppressor":[160],"15-PGDH/HPGD":[161],"gene":[166],"versican":[170],"(VCAN)":[171],"3D":[173,211,296],"xenografts.":[175],"Analysis":[176],"CRC":[180],"tissue":[181],"microarray":[182],"showed":[183],"epithelial,":[185],"but":[186],"not":[187],"stromal,":[188],"VCAN":[189,199],"staining":[190,203],"correlated":[192],"with":[193,209],"reduced":[194],"survival,":[195],"combined":[197],"epithelial":[198],"absent":[201],"HPGD":[202],"portended":[204],"poorer":[206],"prognosis.":[207],"Thus,":[208],"system,":[212],"have":[214],"identified":[215],"new":[217,301],"mode":[218,302],"resistance":[221,305],"potential":[224],"prognostic":[225],"marker":[226],"CRC.":[228,246],"As":[229],"such,":[230],"represents":[232],"potentially":[234],"powerful":[235],"system":[236,298],"identify":[238],"additional":[239],"therapeutic":[240],"sensitivities":[241],"disease-relevant":[243,307],"for":[245,319],"Citation":[247],"Format:":[248],"Bhuminder":[249],"Singh,":[250],"Cunxi":[251],"Li,":[252,280],"Ramona":[253],"Graves-Deal,":[254],"Haiting":[255],"Ma,":[256],"Alina":[257],"Starchenko,":[258],"William":[259],"H.":[260],"Fry,":[261],"Yuanyuan":[262],"Lu,":[263],"Yang":[264],"Wang,":[265],"Galina":[266],"Bogatcheva,":[267],"Mohseen":[268],"P.":[269],"Khan,":[270],"Ginger":[271],"L.":[272],"Milne,":[273],"Shilin":[274],"Zhao,":[275],"Gregory":[276],"D.":[277],"Ayers,":[278],"Nenggan":[279],"Mary":[281],"K.":[282],"Washington,":[283,328],"Timothy":[284],"J.":[285,293],"Yeatman,":[286],"Oliver":[287],"G.":[288],"McDonald,":[289],"Qi":[290],"Liu,":[291],"Robert":[292],"Coffey.":[294],"A":[295],"culture":[297],"identifies":[299],"[abstract].":[312],"In:":[313],"Proceedings":[314],"American":[317],"Association":[318],"Cancer":[320,333],"Research":[321],"Annual":[322],"Meeting":[323],"2017;":[324],"2017":[325],"Apr":[326],"1-5;":[327],"DC.":[329],"Philadelphia":[330],"(PA):":[331],"AACR;":[332],"Res":[334],"2017;77(13":[335],"Suppl):Abstract":[336],"nr":[337],"5013.":[338],"doi:10.1158/1538-7445.AM2017-5013":[339]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2017-08-08T00:00:00"}
