{"id":"https://openalex.org/W2742012201","doi":"https://doi.org/10.1158/1538-7445.am2017-1094","title":"Abstract 1094: Combining the pan-FGFR inhibitor AZD4547 with radiation in lung and head and neck squamous cell carcinoma","display_name":"Abstract 1094: Combining the pan-FGFR inhibitor AZD4547 with radiation in lung and head and neck squamous cell carcinoma","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2742012201","doi":"https://doi.org/10.1158/1538-7445.am2017-1094","mag":"2742012201"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-1094","doi":"https://doi.org/10.1158/1538-7445.am2017-1094","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-1094","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Andrew M. Baschnagel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Baschnagel","raw_affiliation_strings":["Univ. of Wisconsin School of Medicine, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin School of Medicine, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101479660","display_name":"Chunrong Li","orcid":"https://orcid.org/0000-0002-3015-8461","observed_orcids":["https://orcid.org/0000-0002-3015-8461"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunrong Li","raw_affiliation_strings":["Univ. of Wisconsin School of Medicine, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin School of Medicine, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060029481","display_name":"Alecia M. Morgan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alecia M. Morgan","raw_affiliation_strings":["Univ. of Wisconsin School of Medicine, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin School of Medicine, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028397295","display_name":"Sean R. Brennan","orcid":"https://orcid.org/0009-0009-8311-1999","observed_orcids":["https://orcid.org/0009-0009-8311-1999"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean R. Brennan","raw_affiliation_strings":["Univ. of Wisconsin School of Medicine, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin School of Medicine, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039718350","display_name":"Kalley A. Russo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalley A. Russo","raw_affiliation_strings":["Univ. of Wisconsin School of Medicine, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin School of Medicine, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014133933","display_name":"Paul M. Harari","orcid":"https://orcid.org/0000-0002-6207-5505","observed_orcids":["https://orcid.org/0000-0002-6207-5505"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Harari","raw_affiliation_strings":["Univ. of Wisconsin School of Medicine, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Wisconsin School of Medicine, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"1094","last_page":"1094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azd4547","display_name":"AZD4547","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fgfr-inhibitors","display_name":"FGFR inhibitors","score":0.6949999928474426},{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.656000018119812},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fgfr3","display_name":"FGFR3","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fgfr4","display_name":"FGFR4","score":0.8640000224113464},{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9430000185966492},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/combined-radiotherapy","display_name":"combined radiotherapy","score":0.7570000290870667},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8040000200271606},{"id":"https://openalex.org/keywords/fgfr-amplification","display_name":"FGFR amplification","score":0.7720000147819519},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.8740000128746033},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7192577123641968},{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.710673987865448},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6614521145820618},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.6173768043518066},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5690510869026184},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.49501103162765503},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48209908604621887},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.4563915431499481},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.45491623878479004},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.44612494111061096},{"id":"https://openalex.org/C49418065","wikidata":"https://www.wikidata.org/wiki/Q14914258","display_name":"Fibroblast growth factor receptor 1","level":4,"score":0.43415367603302},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.3887902498245239},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3679540157318115},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35289859771728516},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3325846791267395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3164026737213135},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.26552265882492065},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18704146146774292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17552772164344788},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1595570147037506},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-1094","doi":"https://doi.org/10.1158/1538-7445.am2017-1094","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-1094","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.75}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4297457244","https://openalex.org/W2031087011","https://openalex.org/W4210419513","https://openalex.org/W3195764138","https://openalex.org/W2288576450","https://openalex.org/W4297094043","https://openalex.org/W3206601542","https://openalex.org/W3003071079","https://openalex.org/W162241083","https://openalex.org/W2282820828"],"abstract_inverted_index":{"Abstract":[0],"The":[1,201],"fibroblast":[2],"growth":[3,247],"factor":[4],"receptors":[5],"(FGFR1,":[6],"FGR2,":[7],"FRG3,":[8],"FGR4)":[9],"are":[10,112,291],"frequently":[11],"altered":[12],"or":[13,228,261],"overexpressed":[14],"in":[15,38,43,58,72,99,123,127,149,209,264,283,285,297,334],"both":[16,128],"lung":[17,39,59,107,129,151,167,335],"and":[18,20,41,45,60,62,79,85,94,109,130,132,139,142,152,155,168,171,176,195,198,256,336,338],"head":[19,44,61,131,154,170,337],"neck":[21,46,63,133,156,172,339],"squamous":[22,340],"cell":[23,143,158,174,184,187,211,299,306,341],"carcinomas":[24],"(SCC).":[25],"Amplification":[26],"of":[27,90,106,121,192,207,239,254,281,346],"FGFR1":[28],"has":[29],"been":[30,51],"reported":[31],"to":[32,216,220,259,293],"be":[33],"as":[34,36,53],"high":[35],"22%":[37],"SCC":[40,47],"17%":[42],"(HNSCC).":[48],"FGFRs":[49,67],"have":[50],"identified":[52],"a":[54,83,103],"potential":[55],"therapeutic":[56],"target":[57],"cancers.":[64],"In":[65,231],"addition,":[66],"activate":[68],"multiple":[69],"pathways":[70],"involved":[71],"the":[73,91,118,252,265,279,328,347],"radiation":[74,126,255,260,282,333],"response":[75,280],"including":[76,301],"RAS/RAF/MAPK,":[77],"PI3K/AKT":[78],"STAT.":[80],"AZD4547":[81,122,146,208,221,241,257,276,331],"is":[82,95],"potent":[84],"selective":[86],"tyrosine":[87],"kinase":[88],"inhibitor":[89,330],"FGFR":[92,137,302],"family":[93],"currently":[96],"being":[97],"investigated":[98],"clinical":[100],"trials.":[101],"Since":[102],"substantial":[104],"portion":[105],"cancer":[108,134,157,173,305],"HNSCC":[110,183,269],"patients":[111],"treated":[113],"with":[114,125,145,226,242,251,332],"radiotherapy,":[115],"we":[116],"examined":[117],"anti-tumor":[119],"effects":[120,238],"combination":[124,253],"model":[135,287],"systems.":[136],"protein":[138,197,227],"RNA":[140,199,229],"expression":[141],"proliferation":[144],"were":[147,163,179],"evaluated":[148],"8":[150,153],"lines.":[159,307],"Clonogenic":[160],"survival":[161,234],"assays":[162,235],"performed":[164,180],"on":[165,181],"4":[166,169],"lines":[175,188,212,300],"xenograft":[177,270],"experiments":[178],"one":[182],"line.":[185],"These":[186,272],"demonstrated":[189],"varying":[190],"levels":[191],"FGFR1,":[193],"2":[194],"3":[196],"expression.":[200,230],"half":[202],"maximal":[203],"inhibitory":[204],"concentration":[205],"(IC50)":[206],"these":[210,295],"ranged":[213],"from":[214],"0.05":[215],"128":[217],"uM.":[218],"Sensitivity":[219],"did":[222],"not":[223],"correlate":[224],"directly":[225],"vitro":[232],"clonogenic":[233],"showed":[236],"limited":[237],"combining":[240],"radiation.":[243],"However,":[244],"significant":[245],"tumor":[246],"delay":[248],"was":[249],"observed":[250],"compared":[258],"drug":[262],"alone":[263],"SCC1483":[266],"FGFR2":[267],"expressing":[268],"model.":[271],"findings":[273,296],"suggest":[274],"that":[275],"can":[277],"augment":[278],"an":[284],"vivo":[286],"system.":[288],"Further":[289],"studies":[290],"underway":[292],"test":[294],"additional":[298],"dependent":[303],"amplified":[304],"Citation":[308],"Format:":[309],"Andrew":[310],"M.":[311,316,325],"Baschnagel,":[312],"Chunrong":[313],"Li,":[314],"Alecia":[315],"Morgan,":[317],"Sean":[318],"R.":[319],"Brennan,":[320],"Kalley":[321],"A.":[322],"Russo,":[323],"Paul":[324],"Harari.":[326],"Combining":[327],"pan-FGFR":[329],"carcinoma":[342],"[abstract].":[343],"In:":[344],"Proceedings":[345],"American":[348],"Association":[349],"for":[350],"Cancer":[351,364],"Research":[352],"Annual":[353],"Meeting":[354],"2017;":[355],"2017":[356],"Apr":[357],"1-5;":[358],"Washington,":[359],"DC.":[360],"Philadelphia":[361],"(PA):":[362],"AACR;":[363],"Res":[365],"2017;77(13":[366],"Suppl):Abstract":[367],"nr":[368],"1094.":[369],"doi:10.1158/1538-7445.AM2017-1094":[370]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
