{"id":"https://openalex.org/W274201170","doi":null,"title":"Transient functional expression of alphaVbeta 3 on vascular cells during wound repair.","display_name":"Transient functional expression of alphaVbeta 3 on vascular cells during wound repair.","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W274201170","mag":"274201170","pmid":"https://pubmed.ncbi.nlm.nih.gov/8623913","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861547"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1544436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861547","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861547","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111853222","display_name":"Richard A.F. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Clark","raw_affiliation_strings":["Department of Dermatology, State University of New York at Stony Brook, 11794-8165, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, State University of New York at Stony Brook, 11794-8165, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080650253","display_name":"Marcia G. Tonnesen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M G Tonnesen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021540608","display_name":"James O. Gailit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Gailit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111533687","display_name":"David A. Cheresh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Cheresh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.6273,"has_fulltext":false,"cited_by_count":196,"citation_normalized_percentile":{"value":0.958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"148","issue":"5","first_page":"1407","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alphavbeta3","display_name":"integrin \u03b1v\u03b23","score":0.9399999976158142},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6309999823570251},{"id":"https://openalex.org/keywords/granulation-tissue","display_name":"granulation tissue","score":0.796999990940094},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7839999794960022},{"id":"https://openalex.org/keywords/capillary-sprouting","display_name":"capillary sprouting","score":0.9049999713897705},{"id":"https://openalex.org/keywords/fibrin-clot","display_name":"fibrin clot","score":0.9300000071525574},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.753000020980835},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9480000138282776},{"id":"https://openalex.org/keywords/integrin-antagonists","display_name":"integrin antagonists","score":0.6990000009536743},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.7239999771118164},{"id":"https://openalex.org/keywords/skin-wounds","display_name":"skin wounds","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2776055305","wikidata":"https://www.wikidata.org/wiki/Q1543255","display_name":"Granulation tissue","level":3,"score":0.8798808455467224},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7725298404693604},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7346309423446655},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.7139121890068054},{"id":"https://openalex.org/C164144092","wikidata":"https://www.wikidata.org/wiki/Q6587033","display_name":"Vitronectin","level":4,"score":0.6370166540145874},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6322262287139893},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5555101037025452},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.4966736435890198},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.4800378084182739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4230199158191681},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40767326951026917},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3786601424217224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37070250511169434},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2730717062950134},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25557655096054077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20140978693962097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13267379999160767},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1289718747138977}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005337","descriptor_name":"Fibrin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006097","descriptor_name":"Granulation Tissue","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013556","descriptor_name":"Swine, Miniature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D019030","descriptor_name":"Receptors, Vitronectin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019096","descriptor_name":"Vitronectin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1544436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861547","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1861547","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861547","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:8623913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8623913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:274201170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8623913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1544436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861547","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G243309107","display_name":"Integrin alpha v beta 3 promotes resistance to EGF receptor inhibitors","funder_award_id":"R01CA045726","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W166803931","https://openalex.org/W1577857859","https://openalex.org/W1967194093","https://openalex.org/W1977621167","https://openalex.org/W1991011809","https://openalex.org/W1995282093","https://openalex.org/W1999794993","https://openalex.org/W2001753204","https://openalex.org/W2006878196","https://openalex.org/W2021655686","https://openalex.org/W2029773366","https://openalex.org/W2031768006","https://openalex.org/W2039920167","https://openalex.org/W2044725419","https://openalex.org/W2044806537","https://openalex.org/W2045243608","https://openalex.org/W2047476232","https://openalex.org/W2048286821","https://openalex.org/W2052083000","https://openalex.org/W2058651524","https://openalex.org/W2074012988","https://openalex.org/W2085804760","https://openalex.org/W2087342203","https://openalex.org/W2091241505","https://openalex.org/W2107943664","https://openalex.org/W2139084649","https://openalex.org/W2144712422","https://openalex.org/W2160760873","https://openalex.org/W2164249174","https://openalex.org/W2172144171","https://openalex.org/W2314203153","https://openalex.org/W2412891350","https://openalex.org/W4211002736","https://openalex.org/W4232671899","https://openalex.org/W4255042798"],"related_works":["https://openalex.org/W2030160629","https://openalex.org/W2029773366","https://openalex.org/W2287029392","https://openalex.org/W1593531624","https://openalex.org/W2398689555","https://openalex.org/W81760698","https://openalex.org/W2033746699","https://openalex.org/W2075560919","https://openalex.org/W2027214472","https://openalex.org/W2045243608"],"abstract_inverted_index":{"During":[0,65],"early":[1],"granulation":[2,66,102,145,163,182],"tissue":[3,67,103,146,164,183],"formation":[4,104,184],"of":[5,21,31,53,59,98,112],"wound":[6,26,149],"repair,":[7],"new":[8,57],"capillaries":[9,58],"invade":[10],"the":[11,25,39,51,77,82,110,148,154,162],"fibrin":[12,79],"clot,":[13],"a":[14,106,130,173,186],"process":[15],"that":[16,118,169],"undoubtedly":[17],"requires":[18],"an":[19],"interaction":[20],"vascular":[22,40],"cells":[23],"with":[24,129],"provisional":[27],"matrix":[28],"composed":[29],"mainly":[30],"fibrin,":[32],"fibronectin,":[33],"and":[34,122,150,181],"vitronectin.":[35],"Integrin":[36],"alphaVbeta3":[37,69,99,119,155,171],"is":[38],"cell":[41],"receptor":[42,55],"for":[43],"these":[44,91],"wound-associated":[45],"adhesive":[46],"proteins.":[47],"Therefore,":[48],"we":[49],"investigated":[50],"expression":[52,160],"this":[54,142],"on":[56,73],"healing":[60,187],"full-thickness":[61],"cutaneous":[62],"porcine":[63],"wounds.":[64],"formation,":[68],"was":[70],"expressed":[71],"specifically":[72,100],"capillary":[74],"sprouts":[75],"invading":[76],"central":[78],"clot":[80],"whereas":[81],"closely":[83],"related":[84],"integrin":[85,170],"alphaVbeta5":[86],"failed":[87],"to":[88,90],"localize":[89],"cells.":[92],"Cyclic":[93],"peptides":[94],"or":[95,158],"antibody":[96],"antagonists":[97],"inhibited":[101],"in":[105,161,185],"transient":[107],"manner":[108],"during":[109,178],"period":[111],"invasive":[113,151,179],"angiogenesis.":[114],"Immunolocalization":[115],"studies":[116],"revealed":[117],"became":[120],"aggregated":[121],"lost":[123],"from":[124],"sprouting":[125],"vessels":[126],"after":[127],"treatment":[128],"peptide":[131],"antagonist.":[132],"In":[133],"contrast,":[134],"beta":[135],"1":[136],"integrins":[137],"were":[138],"not":[139],"modulated":[140],"by":[141],"treatment.":[143],"Once":[144],"filled":[147],"angiogenesis":[152,180],"terminated,":[153],"showed":[156],"little":[157],"no":[159],"microvasculature.":[165],"These":[166],"data":[167],"demonstrate":[168],"plays":[172],"fundamental,":[174],"but":[175],"transient,":[176],"role":[177],"wound.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}