{"id":"https://openalex.org/W2742004115","doi":"https://doi.org/10.18632/oncotarget.19714","title":"Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGF\u03b21-independent manner","display_name":"Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGF\u03b21-independent manner","publication_year":2017,"publication_date":"2017-07-31","ids":{"openalex":"https://openalex.org/W2742004115","doi":"https://doi.org/10.18632/oncotarget.19714","mag":"2742004115","pmid":"https://pubmed.ncbi.nlm.nih.gov/29137281","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5669907"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.19714","doi":"https://doi.org/10.18632/oncotarget.19714","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19714","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19714&path%5B%5D=62974","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19714&path%5B%5D=62974","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079888845","display_name":"Razan Sheta","orcid":"https://orcid.org/0009-0008-2403-4922","observed_orcids":["https://orcid.org/0009-0008-2403-4922"]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Razan Sheta","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404756","display_name":"Zhi\u2010Qiang Wang","orcid":"https://orcid.org/0000-0003-2658-8781","observed_orcids":["https://orcid.org/0000-0003-2658-8781"]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Zhi-Qiang Wang","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053934915","display_name":"Magdalena Bachvarova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Magdalena Bachvarova","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087341200","display_name":"Marie Plante","orcid":"https://orcid.org/0000-0002-2298-7913","observed_orcids":["https://orcid.org/0000-0002-2298-7913"]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie Plante","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Obstetrics and Gynecology, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jean Gregoire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jean Gregoire","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Obstetrics and Gynecology, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022422757","display_name":"Marie\u2010Claude Renaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie-Claude Renaud","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Obstetrics and Gynecology, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038025657","display_name":"Alexandra Sebastianelli","orcid":"https://orcid.org/0009-0004-5620-6507","observed_orcids":["https://orcid.org/0009-0004-5620-6507"]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alexandra Sebastianelli","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Obstetrics and Gynecology, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110685823","display_name":"St\u00e9phane Gobeil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139308","display_name":"Centre hospitalier de l'Universit\u00e9 Laval","ror":"https://ror.org/041v96n47","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4210139308","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I4405256986","display_name":"Centre de recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval","ror":"https://ror.org/04rgqcd02","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256986","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stephane Gobeil","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, CHUL, Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, CHUL, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210139308","https://openalex.org/I4405256986"]},{"raw_affiliation_string":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019869174","display_name":"Chantale Morin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chantale Morin","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101615019","display_name":"Elizabeth A. Macdonald","orcid":"https://orcid.org/0000-0002-3154-9632","observed_orcids":["https://orcid.org/0000-0002-3154-9632"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Elizabeth Macdonald","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039075996","display_name":"Barbara C. Vanderhyden","orcid":"https://orcid.org/0000-0002-7644-7189","observed_orcids":["https://orcid.org/0000-0002-7644-7189"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Barbara Vanderhyden","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091028771","display_name":"Dimcho R Bachvarov","orcid":"https://orcid.org/0000-0001-6509-9599","observed_orcids":["https://orcid.org/0000-0001-6509-9599"]},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210121051","https://openalex.org/I4210139015","https://openalex.org/I4405257837","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dimcho Bachvarov","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L\u2019H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.047,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.76828712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"47","first_page":"82506","last_page":"82530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.15870000422000885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hic-5","display_name":"Hic-5","score":0.9869999885559082},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mesenchymal-epithelial-transition","display_name":"mesenchymal-epithelial transition","score":0.925000011920929},{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/rhoa-rock-signaling-pathway","display_name":"RhoA/ROCK signaling","score":0.9010000228881836},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.7419999837875366},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.48899999260902405},{"id":"https://openalex.org/keywords/high-grade-serous-ovarian-carcinoma","display_name":"high-grade serous ovarian cancer","score":0.746999979019165},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.8340068459510803},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6811514496803284},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5857228636741638},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.5430407524108887},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5123351812362671},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.49643951654434204},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4672057032585144},{"id":"https://openalex.org/C2776364838","wikidata":"https://www.wikidata.org/wiki/Q7391779","display_name":"SNAI1","level":5,"score":0.43864572048187256},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4311044216156006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4297953248023987},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40831226110458374},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3300836980342865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31998133659362793},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.30791744589805603},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24138599634170532},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.18632/oncotarget.19714","doi":"https://doi.org/10.18632/oncotarget.19714","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19714","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19714&path%5B%5D=62974","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmid:29137281","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29137281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5669907","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5669907/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.19714","doi":"https://doi.org/10.18632/oncotarget.19714","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19714","pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=19714&path%5B%5D=62974","source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2742004115.pdf","grobid_xml":"https://content.openalex.org/works/W2742004115.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W181553447","https://openalex.org/W205625670","https://openalex.org/W442531429","https://openalex.org/W1480706413","https://openalex.org/W1566905203","https://openalex.org/W1591779307","https://openalex.org/W1592723497","https://openalex.org/W1601840114","https://openalex.org/W1760215417","https://openalex.org/W1839613638","https://openalex.org/W1894633050","https://openalex.org/W1930571801","https://openalex.org/W1964644808","https://openalex.org/W1964674342","https://openalex.org/W1964847767","https://openalex.org/W1968826282","https://openalex.org/W1969086878","https://openalex.org/W1969601692","https://openalex.org/W1972494704","https://openalex.org/W1977000581","https://openalex.org/W1979538859","https://openalex.org/W1985841620","https://openalex.org/W1988692017","https://openalex.org/W1997140903","https://openalex.org/W2000099153","https://openalex.org/W2001071540","https://openalex.org/W2004408232","https://openalex.org/W2005286886","https://openalex.org/W2005958259","https://openalex.org/W2006187225","https://openalex.org/W2006487228","https://openalex.org/W2013480667","https://openalex.org/W2015707566","https://openalex.org/W2016884409","https://openalex.org/W2017897725","https://openalex.org/W2026591084","https://openalex.org/W2032091934","https://openalex.org/W2033871653","https://openalex.org/W2035478190","https://openalex.org/W2036395582","https://openalex.org/W2038468856","https://openalex.org/W2040380803","https://openalex.org/W2040935952","https://openalex.org/W2045394733","https://openalex.org/W2045474213","https://openalex.org/W2046364610","https://openalex.org/W2046681055","https://openalex.org/W2053362297","https://openalex.org/W2056852515","https://openalex.org/W2057968053","https://openalex.org/W2059080364","https://openalex.org/W2059338137","https://openalex.org/W2059918221","https://openalex.org/W2061587104","https://openalex.org/W2063232779","https://openalex.org/W2065180481","https://openalex.org/W2070040271","https://openalex.org/W2078637086","https://openalex.org/W2083543572","https://openalex.org/W2094535521","https://openalex.org/W2097999618","https://openalex.org/W2101158706","https://openalex.org/W2103992634","https://openalex.org/W2106268127","https://openalex.org/W2108770100","https://openalex.org/W2110264417","https://openalex.org/W2111154069","https://openalex.org/W2112005444","https://openalex.org/W2115792588","https://openalex.org/W2116119295","https://openalex.org/W2118650242","https://openalex.org/W2120841541","https://openalex.org/W2123883227","https://openalex.org/W2124653487","https://openalex.org/W2127034758","https://openalex.org/W2127190481","https://openalex.org/W2130839996","https://openalex.org/W2135016021","https://openalex.org/W2137761999","https://openalex.org/W2138885372","https://openalex.org/W2140740264","https://openalex.org/W2143017330","https://openalex.org/W2150136461","https://openalex.org/W2152625770","https://openalex.org/W2155756738","https://openalex.org/W2155884268","https://openalex.org/W2158734599","https://openalex.org/W2159762082","https://openalex.org/W2162647319","https://openalex.org/W2164202885","https://openalex.org/W2165899098","https://openalex.org/W2166607774","https://openalex.org/W2168259018","https://openalex.org/W2171059311","https://openalex.org/W2175423389","https://openalex.org/W2213547537","https://openalex.org/W2238490809","https://openalex.org/W2259128731","https://openalex.org/W2264528830","https://openalex.org/W2275445498","https://openalex.org/W2312739661","https://openalex.org/W2319829547","https://openalex.org/W2322357954","https://openalex.org/W2406858132","https://openalex.org/W2422262505","https://openalex.org/W2434647794","https://openalex.org/W2519895466","https://openalex.org/W2559292455","https://openalex.org/W2590020652","https://openalex.org/W2921883081","https://openalex.org/W3028515504"],"related_works":["https://openalex.org/W2112005444","https://openalex.org/W3149873436","https://openalex.org/W7212007374","https://openalex.org/W4205930877","https://openalex.org/W2965642174","https://openalex.org/W2889164950","https://openalex.org/W2127034758","https://openalex.org/W2734401595","https://openalex.org/W6939830530","https://openalex.org/W4409410359"],"abstract_inverted_index":{"The":[0],"molecular":[1],"basis":[2],"of":[3,53,61,108,116,121,148,156,181,191,203,224,236,240],"epithelial":[4,59,99],"ovarian":[5,33],"cancer":[6],"(EOC)":[7],"dissemination":[8],"is":[9,35,80,88,217],"still":[10],"poorly":[11],"understood.We":[12],"have":[13],"previously":[14],"identified":[15],"the":[16,94,137,218,222,233],"hydrogen":[17],"peroxide-inducible":[18],"clone-5":[19],"(Hic-5)":[20],"gene":[21],"as":[22,49,168,170],"hypomethylated":[23],"in":[24,58,70,82,93,110,136,166,178,184,188,205,226,231],"high-grade":[25],"(HG)":[26],"serous":[27],"EOC":[28,71,95,138,185,237],"tumors,":[29],"compared":[30],"to":[31,131],"normal":[32,63],"tissues.Hic-5":[34],"a":[36,50,154,200,209],"focal":[37],"adhesion":[38],"scaffold":[39],"protein":[40],"and":[41,64,85,125,128,162,175,196,228],"has":[42,72],"been":[43,73],"primarily":[44],"studied":[45],"for":[46,199],"its":[47,68,229],"role":[48,69,202,223,230],"key":[51],"mediator":[52],"TGF-\u03b2-induced":[54],"epithelialto-mesenchymal":[55],"transition":[56,150],"(EMT)":[57],"cells":[60,112,139,186,238],"both":[62],"malignant":[65],"origin;":[66],"however,":[67],"never":[74],"investigated.Here":[75],"we":[76],"demonstrate":[77],"that":[78,86],"Hic-5":[79,87,109,134,182,204,225],"overexpressed":[81],"advanced":[83],"EOC,":[84,227],"upregulated":[89],"upon":[90],"TGF\u03b21":[91,242],"treatment":[92],"cell":[96,173],"line":[97],"with":[98,103,119,140],"morphology":[100,142],"(A2780s),":[101],"associated":[102],"EMT":[104,114,207],"induction.However,":[105],"ectopic":[106],"expression":[107,183],"A2780s":[111],"induces":[113],"independently":[115,239],"TGF\u03b21,":[117],"accompanied":[118,145],"enhancement":[120],"cellular":[122],"proliferation":[123],"rate":[124],"migratory/invasive":[126],"capacity":[127],"increased":[129,163],"resistance":[130],"chemotherapeutic":[132],"drugs.Moreover,":[133],"knockdown":[135],"mesenchymal":[141,234],"(SKOV3)":[143],"was":[144,197],"by":[146,153],"induction":[147],"mesenchymalto-epithelial":[149],"(MET),":[151],"followed":[152],"reduction":[155],"their":[157],"proliferative,":[158],"migratory/":[159],"invasive":[160],"capacity,":[161],"drugs":[164],"sensitivity":[165],"vitro,":[167],"well":[169],"enhanced":[171],"tumor":[172],"colonization":[174],"metastatic":[176],"growth":[177],"vivo.The":[179],"modulation":[180],"resulted":[187],"altered":[189],"regulation":[190],"numerous":[192],"EMT-related":[193],"canonical":[194],"pathways":[195],"indicative":[198],"possible":[201],"controlling":[206],"through":[208],"RhoA/":[210],"ROCK":[211],"mediated":[212],"mechanism.To":[213],"our":[214],"knowledge,":[215],"this":[216],"first":[219],"report":[220],"examining":[221],"maintaining":[232],"phenotype":[235],"exogenous":[241],"treatment.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-08-08T00:00:00"}
