{"id":"https://openalex.org/W2741979643","doi":"https://doi.org/10.1172/jci.insight.92409","title":"Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis","display_name":"Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis","publication_year":2017,"publication_date":"2017-08-02","ids":{"openalex":"https://openalex.org/W2741979643","doi":"https://doi.org/10.1172/jci.insight.92409","mag":"2741979643","pmid":"https://pubmed.ncbi.nlm.nih.gov/28768907","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5543914"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.92409","doi":"https://doi.org/10.1172/jci.insight.92409","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.92409","pdf_url":"http://insight.jci.org/articles/view/92409/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/92409/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051569735","display_name":"Yu Fukuda","orcid":"https://orcid.org/0000-0001-6182-540X","observed_orcids":["https://orcid.org/0000-0001-6182-540X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Fukuda","raw_affiliation_strings":["Department of Pharmaceutical Sciences,"],"raw_orcid":"https://orcid.org/0000-0001-6182-540X","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100319047","display_name":"Yao Wang","orcid":"https://orcid.org/0000-0003-4578-7401","observed_orcids":["https://orcid.org/0000-0003-4578-7401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yao Wang","raw_affiliation_strings":["Department of Pharmaceutical Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030796286","display_name":"Shangli Lian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shangli Lian","raw_affiliation_strings":["Department of Pharmaceutical Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"John Lynch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Lynch","raw_affiliation_strings":["Department of Pharmaceutical Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111697133","display_name":"Shinjiro Nagai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinjiro Nagai","raw_affiliation_strings":["Department of Pharmaceutical Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075082637","display_name":"Bruce Fanshawe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruce Fanshawe","raw_affiliation_strings":["Department of Pharmaceutical Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083920194","display_name":"Ayten Kandilci","orcid":"https://orcid.org/0000-0003-4209-4992","observed_orcids":["https://orcid.org/0000-0003-4209-4992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayten Kandilci","raw_affiliation_strings":["Department of Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082046547","display_name":"Laura J. Janke","orcid":"https://orcid.org/0000-0002-9871-6239","observed_orcids":["https://orcid.org/0000-0002-9871-6239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura J. Janke","raw_affiliation_strings":["Department of Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006819204","display_name":"Geoffrey A. M. Neale","orcid":"https://orcid.org/0000-0003-3776-0858","observed_orcids":["https://orcid.org/0000-0003-3776-0858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey Neale","raw_affiliation_strings":["Hartwell Center for Bioinformatics and Biotechnology,"],"raw_orcid":"https://orcid.org/0000-0003-3776-0858","affiliations":[{"raw_affiliation_string":"Hartwell Center for Bioinformatics and Biotechnology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026730026","display_name":"Yiping Fan","orcid":"https://orcid.org/0000-0002-8430-4620","observed_orcids":["https://orcid.org/0000-0002-8430-4620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yiping Fan","raw_affiliation_strings":["Department of Computational Biology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110023421","display_name":"Brian P. Sorrentino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian P. Sorrentino","raw_affiliation_strings":["Department of Hematology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018286109","display_name":"Martine F. Roussel","orcid":"https://orcid.org/0000-0002-1740-8139","observed_orcids":["https://orcid.org/0000-0002-1740-8139"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martine F. Roussel","raw_affiliation_strings":["Department of Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Tumor Cell Biology, St. Jude Children\u2019s Research Hospital, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026036897","display_name":"Gerard C. Grosveld","orcid":"https://orcid.org/0000-0002-6583-1265","observed_orcids":["https://orcid.org/0000-0002-6583-1265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerard Grosveld","raw_affiliation_strings":["Department of Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053239538","display_name":"John D. Schuetz","orcid":"https://orcid.org/0000-0003-0779-1303","observed_orcids":["https://orcid.org/0000-0003-0779-1303"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"John D. Schuetz","raw_affiliation_strings":["Department of Pharmaceutical Sciences,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053239538"],"corresponding_institution_ids":[],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":3.098,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.92338365,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"2","issue":"15","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6455000042915344,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.6455000042915344,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.32030001282691956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mycn","display_name":"MYCN","score":0.8619999885559082},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mitochondrial-oxygen-consumption","display_name":"mitochondrial oxygen consumption","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pediatric-acute-myeloid-leukemia","display_name":"pediatric acute myeloid leukemia","score":0.6460000276565552},{"id":"https://openalex.org/keywords/therapeutic-vulnerabilities","display_name":"therapeutic vulnerabilities","score":0.4090000092983246},{"id":"https://openalex.org/keywords/porphyrin-precursors","display_name":"porphyrin precursors","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.8040025234222412},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.693292498588562},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5344679951667786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5206679105758667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4974575340747833},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47756606340408325},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.43712669610977173},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4291321635246277},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.35439029335975647},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3290128707885742},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2466488480567932},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.22623726725578308},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13567420840263367}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1172/jci.insight.92409","doi":"https://doi.org/10.1172/jci.insight.92409","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.92409","pdf_url":"http://insight.jci.org/articles/view/92409/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmid:28768907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28768907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5543914","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5543914/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.92409","doi":"https://doi.org/10.1172/jci.insight.92409","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.92409","pdf_url":"http://insight.jci.org/articles/view/92409/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1306644764","display_name":null,"funder_award_id":"CA21865","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G678144411","display_name":null,"funder_award_id":"P30 CA21745","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7691710229","display_name":null,"funder_award_id":"38105","funder_id":"https://openalex.org/F4320313598","funder_display_name":"American Lebanese Syrian Associated Charities"},{"id":"https://openalex.org/G9000884403","display_name":"NORMAL & NEOPLASTIC GROWTH IN THE BRAIN","funder_award_id":"P01CA096832","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000905134","display_name":"Transporters and Medulloblastoma","funder_award_id":"R01CA194057","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309537","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93"},{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320313598","display_name":"American Lebanese Syrian Associated Charities","ror":"https://ror.org/03rx10x31"},{"id":"https://openalex.org/F4320327645","display_name":"Gebze Teknik \u00dcniversitesi","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2741979643.pdf","grobid_xml":"https://content.openalex.org/works/W2741979643.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1529447899","https://openalex.org/W1568785136","https://openalex.org/W1773238988","https://openalex.org/W1843371075","https://openalex.org/W1965496508","https://openalex.org/W1966856154","https://openalex.org/W1972343164","https://openalex.org/W1972764534","https://openalex.org/W1991509879","https://openalex.org/W1997380301","https://openalex.org/W2003605385","https://openalex.org/W2005377659","https://openalex.org/W2011957619","https://openalex.org/W2019276195","https://openalex.org/W2023620389","https://openalex.org/W2041580104","https://openalex.org/W2042821039","https://openalex.org/W2051253813","https://openalex.org/W2056486476","https://openalex.org/W2058255384","https://openalex.org/W2069658951","https://openalex.org/W2076980097","https://openalex.org/W2081959583","https://openalex.org/W2102991688","https://openalex.org/W2104711019","https://openalex.org/W2110065044","https://openalex.org/W2117888794","https://openalex.org/W2130410032","https://openalex.org/W2139290043","https://openalex.org/W2151489743","https://openalex.org/W2158217645","https://openalex.org/W2167583908","https://openalex.org/W2170989872","https://openalex.org/W2410715658","https://openalex.org/W6633823227"],"related_works":["https://openalex.org/W2352751497","https://openalex.org/W2942879335","https://openalex.org/W7128776338","https://openalex.org/W4402022795","https://openalex.org/W4416372936","https://openalex.org/W4401510162","https://openalex.org/W4312467070","https://openalex.org/W7145195652","https://openalex.org/W2041580104","https://openalex.org/W1988355001"],"abstract_inverted_index":{"The":[0],"increased":[1,40,94,140],"heme":[2,43,106,123,125],"biosynthesis":[3,107],"long":[4],"observed":[5],"in":[6,22,35,49,72,100,145,202],"leukemia":[7],"was":[8,183],"previously":[9],"of":[10,42,60,122,135,142,151,167,197],"unknown":[11],"significance.":[12],"Heme,":[13],"synthesized":[14],"from":[15,79,175],"porphyrin":[16,137,176,191,207],"precursors,":[17],"plays":[18],"a":[19,85,190,210],"central":[20],"role":[21,34],"oxygen":[23,95,110],"metabolism":[24],"and":[25,63,69,102,112,124,147],"mitochondrial":[26,109],"function,":[27],"yet":[28],"little":[29],"is":[30,131,209],"known":[31],"about":[32],"its":[33],"leukemogenesis.":[36,215],"Here,":[37],"we":[38],"show":[39,186],"expression":[41,59],"biosynthetic":[44],"genes,":[45],"including":[46],"UROD,":[47],"only":[48],"pediatric":[50],"AML":[51,158],"samples":[52],"that":[53,187,206],"have":[54],"high":[55],"MYCN":[56,64,86,162,214],"expression.":[57],"High":[58],"both":[61],"UROD":[62],"predicts":[65],"poor":[66],"overall":[67],"survival":[68,150],"unfavorable":[70],"outcomes":[71],"adult":[73],"AML.":[74],"Murine":[75],"leukemic":[76,143],"progenitors":[77,117,144],"derived":[78],"hematopoietic":[80],"progenitor":[81],"cells":[82],"(HPCs)":[83],"overexpressing":[84],"cDNA":[87],"(MYCN-HPCs)":[88],"require":[89],"heme/porphyrin":[90],"biosynthesis,":[91],"accompanied":[92],"by":[93,178],"consumption,":[96],"to":[97,185,213],"fully":[98],"engage":[99],"self-renewal":[101],"oncogenic":[103],"transformation.":[104],"Blocking":[105],"reduced":[108],"consumption":[111],"markedly":[113],"suppressed":[114],"self-renewal.":[115],"Leukemic":[116],"rely":[118],"on":[119],"balanced":[120],"production":[121],"intermediates,":[126],"the":[127,136,149,195],"porphyrins.":[128],"Porphyrin":[129],"homeostasis":[130,208],"required":[132],"because":[133],"absence":[134,196],"exporter,":[138],"ABCG2,":[139,198],"death":[141],"vitro":[146],"prolonged":[148],"mice":[152],"transplanted":[153],"with":[154,160,189,194],"Abcg2-KO":[155,171],"MYCN-HPCs.":[156],"Pediatric":[157],"patients":[159],"elevated":[161],"mRNA":[163],"display":[164],"strong":[165],"activation":[166],"TP53":[168],"target":[169],"genes.":[170],"MYCN-HPCs":[172],"were":[173],"rescued":[174],"toxicity":[177],"p53":[179],"loss.":[180],"This":[181],"vulnerability":[182],"exploited":[184],"treatment":[188],"precursor,":[192],"coupled":[193],"blocked":[199],"MYCN-driven":[200],"leukemogenesis":[201],"vivo,":[203],"thereby":[204],"demonstrating":[205],"pathway":[211],"crucial":[212]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2017-08-08T00:00:00"}
