{"id":"https://openalex.org/W2741732829","doi":"https://doi.org/10.1158/1538-7445.am2017-175","title":"Abstract 175: Combination of plasmonic photothermal therapy with surgery applied to naturally occurring mammary tumors in canines and felines: clinical outcomes and molecular studies","display_name":"Abstract 175: Combination of plasmonic photothermal therapy with surgery applied to naturally occurring mammary tumors in canines and felines: clinical outcomes and molecular studies","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2741732829","doi":"https://doi.org/10.1158/1538-7445.am2017-175","mag":"2741732829"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-175","doi":"https://doi.org/10.1158/1538-7445.am2017-175","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-175","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039065690","display_name":"Moustafa R. K. Ali","orcid":"https://orcid.org/0000-0002-2027-1006","observed_orcids":["https://orcid.org/0000-0002-2027-1006"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moustafa R. Ali","raw_affiliation_strings":["1Georgia Inst. of Technology, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgia Inst. of Technology, Atlanta, GA;","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060796246","display_name":"Haithem A. M. A. Farghali","orcid":"https://orcid.org/0000-0002-3311-1335","observed_orcids":["https://orcid.org/0000-0002-3311-1335"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Haithem A. Farghali","raw_affiliation_strings":["2Veterinary Medicine, Cairo University, Cairo, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Veterinary Medicine, Cairo University, Cairo, Egypt;","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004712047","display_name":"Hala Ragab Khalil Ali","orcid":"https://orcid.org/0000-0001-5879-2176","observed_orcids":["https://orcid.org/0000-0001-5879-2176"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hala R. Ali","raw_affiliation_strings":["2Veterinary Medicine, Cairo University, Cairo, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Veterinary Medicine, Cairo University, Cairo, Egypt;","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043057301","display_name":"Ahmed H. Osman","orcid":"https://orcid.org/0000-0002-1967-3251","observed_orcids":["https://orcid.org/0000-0002-1967-3251"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed H. Osman","raw_affiliation_strings":["2Veterinary Medicine, Cairo University, Cairo, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Veterinary Medicine, Cairo University, Cairo, Egypt;","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yousef A. Soliman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Yousef A. Soliman","raw_affiliation_strings":["2Veterinary Medicine, Cairo University, Cairo, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Veterinary Medicine, Cairo University, Cairo, Egypt;","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034298207","display_name":"Yue Wu","orcid":"https://orcid.org/0000-0001-7680-9285","observed_orcids":["https://orcid.org/0000-0001-7680-9285"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Wu","raw_affiliation_strings":["1Georgia Inst. of Technology, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgia Inst. of Technology, Atlanta, GA;","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108143608","display_name":"Ibrahim M. Ibrahim","orcid":"https://orcid.org/0000-0001-7875-7538","observed_orcids":["https://orcid.org/0000-0001-7875-7538"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ibrahim M. Ibrahim","raw_affiliation_strings":["2Veterinary Medicine, Cairo University, Cairo, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Veterinary Medicine, Cairo University, Cairo, Egypt;","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089898054","display_name":"Salah Abdel Karim Selim","orcid":"https://orcid.org/0000-0003-0607-4732","observed_orcids":["https://orcid.org/0000-0003-0607-4732"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Salah A. Selim","raw_affiliation_strings":["2Veterinary Medicine, Cairo University, Cairo, Egypt;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Veterinary Medicine, Cairo University, Cairo, Egypt;","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010399375","display_name":"Dong Moon Shin","orcid":"https://orcid.org/0000-0002-8245-4174","observed_orcids":["https://orcid.org/0000-0002-8245-4174"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong M. Shin","raw_affiliation_strings":["3Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025158613","display_name":"Mostafa A. El\u2010Sayed","orcid":"https://orcid.org/0000-0002-7674-8424","observed_orcids":["https://orcid.org/0000-0002-7674-8424"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mostafa A. El-Sayed","raw_affiliation_strings":["1Georgia Inst. of Technology, Atlanta, GA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Georgia Inst. of Technology, Atlanta, GA;","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"175","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.5625,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.35249999165534973,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmonic-photothermal-therapy","display_name":"plasmonic photothermal therapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gold-nanorods","display_name":"gold nanorods","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mammary-adenocarcinoma","display_name":"mammary adenocarcinoma","score":0.9100000262260437},{"id":"https://openalex.org/keywords/canine-mammary-tumors","display_name":"canine mammary tumors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/feline-mammary-tumors","display_name":"feline mammary tumors","score":1.0},{"id":"https://openalex.org/keywords/mastectomy","display_name":"mastectomy","score":0.6129999756813049},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tumor-gene-expression","display_name":"cancer gene expression","score":0.5149999856948853},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.41499999165534973},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.35899999737739563},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.375},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7467840313911438},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6145955324172974},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.5990673899650574},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.5547835230827332},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.513950526714325},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.48482099175453186},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4415789544582367},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4338533282279968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26363736391067505}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-175","doi":"https://doi.org/10.1158/1538-7445.am2017-175","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-175","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2521751549","https://openalex.org/W2479538421","https://openalex.org/W2950137561","https://openalex.org/W4416893343","https://openalex.org/W2129166766","https://openalex.org/W6990536856","https://openalex.org/W4313224709","https://openalex.org/W2944530150","https://openalex.org/W4404797018","https://openalex.org/W2887660804"],"abstract_inverted_index":{"Abstract":[0],"Plasmonic":[1],"Photothermal":[2],"Therapy":[3],"(PPTT)":[4],"is":[5,25,36,73],"a":[6,37,82,175,283],"cancer":[7,32,86,286,367],"therapy":[8,267,474],"where":[9],"gold":[10],"nanorods":[11],"(AuNRs)":[12],"are":[13,363],"injected":[14,65],"at":[15,122],"the":[16,123,127,132,150,215,219,353,415,425,496],"tumor":[17,189,229,274,385,402],"site":[18],"and":[19,98,101,113,142,196,293,301,318,324,348,373,405,437,485,489],"near-infrared":[20],"light":[21],"(safe":[22],"to":[23,27,41,60,104,202,226,351,478],"bio-system)":[24],"applied":[26,102,477],"generate":[28],"localized":[29,46],"heat":[30],"causing":[31,67,231],"cell":[33],"death.":[34],"PPTT":[35,55,97,227,247,300,429],"potentially":[38],"good":[39],"alternative":[40],"replace":[42],"traditional":[43],"surgery":[44,244,302,431,476],"for":[45,49,154,257,268,365,432,499],"tumors.":[47],"However,":[48,79,260],"large":[50,92,433],"tumors":[51,107,434,482],"(volume":[52],"\u226510":[53],"cm3),":[54],"could":[56,116],"be":[57],"ineffective":[58],"due":[59],"an":[61],"uneven":[62],"distribution":[63],"of":[64,70,85,91,111,171,285,297,356,427,471,495],"AuNRs":[66],"possible":[68],"inhomogeneity":[69],"heat.":[71],"Surgery":[72],"frequently":[74],"recommended":[75],"in":[76,108,208,316,321,435,483],"those":[77],"cases.":[78,259],"it":[80,103],"carries":[81],"high":[83],"risk":[84],"recurrence.":[87],"For":[88,126],"effective":[89],"treatment":[90,298,350,381],"tumors,":[93],"we":[94,130],"combined":[95],"both":[96],"surgical":[99],"resection":[100],"naturally":[105,479],"occurring":[106,480],"mammary":[109,481],"glands":[110],"dogs":[112,436],"cats,":[114],"which":[115,400,408,413],"realistically":[117],"represent":[118],"their":[119],"human":[120],"equivalents":[121],"molecular":[124,490],"level.":[125],"experimental":[128],"design,":[129],"divided":[131,192],"animals":[133,151],"into":[134,193],"three":[135,161,217],"different":[136],"groups.":[137],"20":[138],"cases":[139,162,181,207,240,262],"(7":[140],"cats":[141],"13":[143],"dogs)":[144],"were":[145,152,163,182,241,375,393],"all":[146,170],"diagnosed":[147],"with":[148,184,243,475],"adenocarcinoma;":[149],"monitored":[153],"1-2":[155],"years":[156,335],"after":[157,266,294,310,336,349,380,396,430],"treatments.":[158],"Group":[159,178,237],"(I):":[160],"solely":[164],"treated":[165,183,242],"by":[166,246],"mastectomy":[167,185],"(control":[168],"group);":[169],"them":[172],"died":[173,263],"within":[174,234],"few":[176],"weeks.":[177],"(II):":[179],"five":[180],"first.":[186],"Then,":[187],"each":[188],"wound":[190,221],"was":[191,200,223,411],"two":[194,206,295,345,378],"halves,":[195],"only":[197],"one":[198,235],"half":[199,220],"exposed":[201,225],"PPTT.":[203],"After":[204],"treatment,":[205],"this":[209],"group":[210],"rendered":[211],"complete":[212,252],"remission.":[213],"In":[214,326,420],"other":[216],"cases,":[218],"that":[222,362],"not":[224],"had":[228],"recurrence":[230,256],"animal":[232],"death":[233],"year.":[236],"(III):":[238],"12":[239],"followed":[245],"treatment.":[248,337,397],"This":[249],"regime":[250],"showed":[251,282,312,330],"remission":[253],"without":[254],"any":[255],"eight":[258],"four":[261],"4-12":[264],"months":[265],"reasons":[269],"such":[270,369,388],"as":[271,370,389],"pneumonia":[272],"(no":[273],"found,":[275],"based":[276],"on":[277],"X":[278],"ray).":[279],"Histopathology":[280],"results":[281],"decrease":[284],"grades":[287,290],"before":[288,347],"(variant":[289],"from":[291],"1-4)":[292],"weeks":[296,346,379],"via":[299],"(grade":[303],"0).":[304],"Blood":[305],"tests":[306],"(conducted":[307],"1":[308],"year":[309],"therapy)":[311],"no":[313,331],"obvious":[314],"change":[315],"liver":[317],"kidney":[319],"functions":[320],"groups":[322],"II":[323],"III.":[325],"addition,":[327],"X-ray":[328],"diffraction":[329],"metastasis":[332],"1-":[333],"2":[334],"We":[338],"have":[339],"performed":[340],"quantitative,":[341],"real":[342],"time-PCR":[343],"analysis":[344],"study":[352,423],"expression":[354],"levels":[355],"several":[357],"important":[358],"genes.":[359],"The":[360],"genes":[361],"responsible":[364],"repairing":[366],"cells":[368,387],"BRCA1,":[371],"BRCA2,":[372],"CD163-IL-10":[374],"significantly":[376],"diminished":[377],"(group":[382],"III).":[383],"Furthermore,":[384],"microenvironment":[386],"tumor-associated":[390],"macrophages":[391],"(TAMs)":[392],"greatly":[394],"altered":[395],"TAM":[398,406],"1,":[399],"retards":[401],"growth,":[403],"augmented,":[404],"2,":[407],"promotes":[409],"tumorigenesis,":[410],"diminished,":[412],"explains":[414],"animals\u2019":[416],"increased":[417],"survival":[418],"rate.":[419],"conclusion,":[421],"our":[422],"demonstrates":[424],"feasibility":[426],"applying":[428],"cats.":[438],"Citation":[439],"Format:":[440],"Moustafa":[441],"R.":[442,448],"Ali,":[443,449],"Haithem":[444],"A.":[445,454,462,468],"Farghali,":[446],"Hala":[447],"Ahmed":[450],"H.":[451],"Osman,":[452],"Yousef":[453],"Soliman,":[455],"Yue":[456],"Wu,":[457],"Ibrahim":[458],"M.":[459,465],"Ibrahim,":[460],"Salah":[461],"Selim,":[463],"Dong":[464],"Shin,":[466],"Mostafa":[467],"El-Sayed.":[469],"Combination":[470],"plasmonic":[472],"photothermal":[473],"canines":[484],"felines:":[486],"clinical":[487],"outcomes":[488],"studies":[491],"[abstract].":[492],"In:":[493],"Proceedings":[494],"American":[497],"Association":[498],"Cancer":[500,513],"Research":[501],"Annual":[502],"Meeting":[503],"2017;":[504],"2017":[505],"Apr":[506],"1-5;":[507],"Washington,":[508],"DC.":[509],"Philadelphia":[510],"(PA):":[511],"AACR;":[512],"Res":[514],"2017;77(13":[515],"Suppl):Abstract":[516],"nr":[517],"175.":[518],"doi:10.1158/1538-7445.AM2017-175":[519]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-08-08T00:00:00"}