{"id":"https://openalex.org/W2741664375","doi":null,"title":"colorectal cancer and potential effects on therapy in the CAPRI GOIM trial","display_name":"colorectal cancer and potential effects on therapy in the CAPRI GOIM trial","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2741664375","mag":"2741664375"},"language":"en","primary_location":{"id":"mag:2741664375","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Fabiana_Tatangelo/publication/274702225_Heterogeneity_of_KRAS_NRAS_BRAF_and_PIK3CA_mutations_in_metastatic_colorectal_cancer_and_potential_effects_on_therapy_in_the_CAPRI_GOIM_trial/links/552784c10cf2520617a71712.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003014678","display_name":"Nicola Normanno","orcid":"https://orcid.org/0000-0002-7158-2605","observed_orcids":["https://orcid.org/0000-0002-7158-2605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola Normanno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7158-2605","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036367394","display_name":"Anna Maria Rachiglio","orcid":"https://orcid.org/0000-0002-4144-7066","observed_orcids":["https://orcid.org/0000-0002-4144-7066"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Maria Rachiglio","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4144-7066","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002867055","display_name":"Matilde Lambiase","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matilde Lambiase","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006208754","display_name":"Erika Martinelli","orcid":"https://orcid.org/0000-0002-0291-475X","observed_orcids":["https://orcid.org/0000-0002-0291-475X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Martinelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039134651","display_name":"Francesca Fenizia","orcid":"https://orcid.org/0000-0003-0523-1919","observed_orcids":["https://orcid.org/0000-0003-0523-1919"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesca Fenizia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0523-1919","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002520057","display_name":"Ciro Esposito","orcid":"https://orcid.org/0000-0002-8858-6848","observed_orcids":["https://orcid.org/0000-0002-8858-6848","https://orcid.org/0000-0002-7906-1097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ciro Esposito","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8858-6848","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020655022","display_name":"Teresa Troiani","orcid":"https://orcid.org/0000-0002-0646-4901","observed_orcids":["https://orcid.org/0000-0002-0646-4901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Troiani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0646-4901","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020635495","display_name":"Daniele Rizzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniele Rizzi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005851993","display_name":"Fabiana Tatangelo","orcid":"https://orcid.org/0000-0002-9943-6079","observed_orcids":["https://orcid.org/0000-0002-9943-6079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabiana Tatangelo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9943-6079","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023150524","display_name":"Gerardo Botti","orcid":"https://orcid.org/0000-0002-6287-733X","observed_orcids":["https://orcid.org/0000-0002-6287-733X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerardo Botti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046559582","display_name":"Evaristo Maiello","orcid":"https://orcid.org/0000-0003-3890-3435","observed_orcids":["https://orcid.org/0000-0003-3890-3435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evaristo Maiello","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3890-3435","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054605837","display_name":"Giuseppe Colucci","orcid":"https://orcid.org/0000-0002-2379-8751","observed_orcids":["https://orcid.org/0000-0002-2379-8751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe Colucci","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2379-8751","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056034569","display_name":"Fortunato Ciardiello","orcid":"https://orcid.org/0000-0002-3369-4841","observed_orcids":["https://orcid.org/0000-0002-3369-4841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fortunato Ciardiello","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3369-4841","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F Magrassi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Magrassi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025069722","display_name":"Italia Meridionale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Italia Meridionale","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.972000002861023},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/braf-mutation","display_name":"BRAF mutation","score":1.0},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":1.0},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":0.9319999814033508},{"id":"https://openalex.org/keywords/folfiri","display_name":"FOLFIRI","score":0.9990000128746033},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.6370000243186951},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7960000038146973},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.9581562280654907},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.7377088069915771},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6309165358543396},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.5233016610145569},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5057809352874756},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4963098168373108},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4800502061843872},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46734386682510376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4638773202896118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4453135132789612},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4372977614402771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41205182671546936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25125980377197266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17251056432724}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2741664375","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Fabiana_Tatangelo/publication/274702225_Heterogeneity_of_KRAS_NRAS_BRAF_and_PIK3CA_mutations_in_metastatic_colorectal_cancer_and_potential_effects_on_therapy_in_the_CAPRI_GOIM_trial/links/552784c10cf2520617a71712.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1888056807","https://openalex.org/W2005348280","https://openalex.org/W2010873488","https://openalex.org/W2014881369","https://openalex.org/W2038624343","https://openalex.org/W2041993682","https://openalex.org/W2085633477","https://openalex.org/W2100543432","https://openalex.org/W2119746400","https://openalex.org/W2121765653","https://openalex.org/W2125974203","https://openalex.org/W2128937710","https://openalex.org/W2131371081","https://openalex.org/W2135449254","https://openalex.org/W2135672185","https://openalex.org/W2145217386","https://openalex.org/W2146437121","https://openalex.org/W2162247266","https://openalex.org/W2165708858","https://openalex.org/W2262414037"],"related_works":["https://openalex.org/W2155014687","https://openalex.org/W2341678242","https://openalex.org/W1897062612","https://openalex.org/W2128937710","https://openalex.org/W2301065828","https://openalex.org/W2162247266","https://openalex.org/W1981415796","https://openalex.org/W2764170205","https://openalex.org/W2885510545","https://openalex.org/W2802937318"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],":":[2,42,124],"Evidence":[3],"suggests":[4],"that":[5,65,84,144],"metastatic":[6],"colorectal":[7],"carcinoma":[8],"(mCRC)":[9],"has":[10],"a":[11,19,120,192,233],"high":[12],"level":[13],"of":[14,22,50,69,103,116,136,141,150,194,236],"intra-tumor":[15],"heterogeneity.":[16],"We":[17],"performed":[18],"quantitative":[20,67],"assessment":[21,68],"tumor":[23],"heterogeneity":[24],"for":[25,77,160],"KRAS,":[26],"NRAS,":[27],"BRAF":[28,172],"and":[29,40,131,138,180,226],"PIK3CA":[30,181,240],"mutations,":[31],"in":[32,53,106,145,171,208,239],"order":[33],"to":[34,113,198],"assess":[35],"potential":[36],"clinical":[37],"implications.":[38],"Patients":[39],"Methods":[41],"Tumor":[43],"samples":[44],"(n.182)":[45],"from":[46],"the":[47,78,91,101,114,148,200],"CAPRI-GOIM":[48],"trial":[49],"first-line":[51],"cetuximab+FOLFIRI":[52],"KRAS":[54,126,209],"exon-2":[55],"wild-type":[56],"mCRC":[57],"patients":[58,211,216],"were":[59,158,224],"assessed":[60],"by":[61,97,99],"next":[62],"generation":[63],"sequencing":[64],"allows":[66],"mutant":[70,104,154,189,201,210],"genes.":[71],"Mutant":[72],"allelic":[73],"frequency":[74,102,235],"was":[75,95,206],"normalized":[76],"neoplastic":[79,107,117,151,195],"cell":[80],"content":[81],"and,":[82],"assuming":[83],"somatic":[85],"mutations":[86,238],"usually":[87],"affect":[88],"one":[89],"allele,":[90],"Heterogeneity":[92],"Score":[93],"(HS)":[94],"calculated":[96],"multiplying":[98],"2":[100],"alleles":[105],"cells.":[108],"Therefore,":[109],"HS":[110,127,214],"virtually":[111],"corresponds":[112],"fraction":[115,193],"cells":[118,152,196],"carrying":[119],"specific":[121],"mutation.":[122],"Results":[123],"The":[125,203],"ranged":[128],"between":[129],"12":[130],"260":[132],"with":[133,212,243],"mean":[134,165,176,185],"value":[135,140],"87,1":[137],"median":[139,167,178,187,219],"84,4,":[142],"suggesting":[143],"most":[146],"CRC":[147],"majority":[149],"carry":[153,199],"KRAS.":[155],"Similar":[156],"findings":[157],"observed":[159],"NRAS":[161],"(HS":[162,173,182],"range":[163,174,183],"35,5-146,7;":[164],"102,8;":[166],"117,1).":[168],"In":[169],"contrast,":[170],"17,1-120;":[175],"54,8;":[177],"54,3)":[179],"14,3-120;":[184],"59,5;":[186],"47,3)":[188],"cases":[190],"only":[191],"seem":[197],"allele.":[202],"response":[204],"rate":[205],"70%":[207],"an":[213],"33":[215],"(high-KRAS;":[217],"n.35);":[218],"progression":[220],"free":[221],"survival":[222],"(PFS)":[223],"7,97":[225],"8,37":[227],"months,":[228],"respectively.":[229],"Low-KRAS":[230],"tumors":[231],"had":[232],"higher":[234],"additional":[237],"as":[241],"compared":[242],"high-KRAS":[244],"(6/10":[245],"vs":[246],"8/35).":[247]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-08-08T00:00:00"}
