{"id":"https://openalex.org/W2741542068","doi":"https://doi.org/10.1161/01.str.32.suppl_1.323-b","title":"Intravenous TPA for Ischemic Stroke Patients: Houston Experience 1996\u20132000","display_name":"Intravenous TPA for Ischemic Stroke Patients: Houston Experience 1996\u20132000","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2741542068","doi":"https://doi.org/10.1161/01.str.32.suppl_1.323-b","mag":"2741542068"},"language":"en","primary_location":{"id":"mag:2741542068","doi":"https://doi.org/10.1161/01.str.32.suppl_1.323-b","is_oa":false,"landing_page_url":"http://stroke.ahajournals.org/content/32/Suppl_1/323.3","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Stroke","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026886390","display_name":"James C. Grotta","orcid":"https://orcid.org/0000-0002-3667-4248","observed_orcids":["https://orcid.org/0000-0002-3667-4248"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James C. Grotta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3667-4248","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060351508","display_name":"Andrei V. Alexandrov","orcid":"https://orcid.org/0000-0001-8871-1023","observed_orcids":["https://orcid.org/0000-0001-8871-1023","https://orcid.org/0000-0002-4060-6766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrei V. Alexandrov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8871-1023","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067201014","display_name":"William Scott Burgin","orcid":"https://orcid.org/0000-0001-5376-8302","observed_orcids":["https://orcid.org/0000-0001-5376-8302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Scott Burgin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5376-8302","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Megan Long","orcid":"https://orcid.org/0000-0002-4052-1746","observed_orcids":["https://orcid.org/0000-0002-4052-1746"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Megan Long","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4052-1746","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091463744","display_name":"Ashraf El\u2010Mitwalli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashraf El\u2010Mitwalli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078127863","display_name":"Morgan S. Campbell","orcid":"https://orcid.org/0009-0000-4659-4818","observed_orcids":["https://orcid.org/0009-0000-4659-4818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morgan Campbell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-4659-4818","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079153413","display_name":"Lewis B. Morgenstern","orcid":"https://orcid.org/0000-0002-5787-592X","observed_orcids":["https://orcid.org/0000-0002-5787-592X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lewis B. Morgenstern","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000578550","display_name":"Marc D. Malkoff","orcid":"https://orcid.org/0000-0002-6665-3114","observed_orcids":["https://orcid.org/0000-0002-6665-3114"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Malkoff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6665-3114","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2508,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.65740951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":null,"first_page":"323","last_page":"323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intravenous-tissue-plasminogen-activator","display_name":"intravenous tissue plasminogen activator","score":0.9589999914169312},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9629999995231628},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.8799999952316284},{"id":"https://openalex.org/keywords/thrombolysis-safety","display_name":"thrombolysis safety","score":0.8180000185966492},{"id":"https://openalex.org/keywords/door-to-needle-time","display_name":"door-to-needle time","score":0.9100000262260437},{"id":"https://openalex.org/keywords/protocol-violations","display_name":"protocol violations","score":0.6669999957084656},{"id":"https://openalex.org/keywords/stroke-mortality","display_name":"stroke mortality","score":0.4690000116825104},{"id":"https://openalex.org/keywords/nihss","display_name":"NIHSS","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9770206212997437},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.5286429524421692},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5185418725013733},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5066105127334595},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.5056748390197754},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4813400208950043},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.4593719244003296},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.4519042372703552},{"id":"https://openalex.org/C2909817843","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Fibrinolytic agent","level":3,"score":0.446514755487442},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4173155426979065},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.28875455260276794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.251171350479126},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.11933165788650513},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2741542068","doi":"https://doi.org/10.1161/01.str.32.suppl_1.323-b","is_oa":false,"landing_page_url":"http://stroke.ahajournals.org/content/32/Suppl_1/323.3","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Stroke","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8899999856948853,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161256482","https://openalex.org/W1998257407","https://openalex.org/W2148750186","https://openalex.org/W2069334904","https://openalex.org/W2405216978","https://openalex.org/W1975054153","https://openalex.org/W2271907165","https://openalex.org/W2001380059","https://openalex.org/W1858397219","https://openalex.org/W1974638135"],"abstract_inverted_index":{"40":[0],"Background:":[4],"Implementation":[6],"of":[7,35,60,93,134,188,244,254,263,276,284,292],"intravenous":[8],"(IV)":[9],"tissue":[11],"plasminogen":[12],"activator":[13],"(TPA)":[14],"therapy":[15,278],"with":[16,24,64,76,132,165,251],"the":[17,58,69,84,273,282,285,290,293],"NINDS":[18,85],"protocol":[19],"has":[20,29],"been":[22],"reported":[23],"variable":[25],"safety.":[26],"Our":[27],"center":[28],"an":[30],"experienced":[31],"stroke":[33,38,67],"team":[34,287],"fellows":[36],"and":[37,45,100,191,219],"faculty":[39],"servicing":[40],"one":[41],"University":[42],"hospital":[44,215],"three":[46],"community":[47],"hospitals.":[48],"Methods:":[50],"We":[52,270],"report":[53],"our":[55],"experience":[56],"in":[57,185,195,241],"treatment":[59],"269":[61,94],"consecutive":[62],"patients":[63,95,135,190,197],"ischemic":[66],"within":[68,137],"first":[70],"3":[71],"hours":[72,203],"after":[73],"symptom":[74],"onset":[75],"0.9":[77,245],"mg/kg":[79,246],"IV":[80],"TPA":[81,121,240,264,277],"according":[82],"to":[83,171,268],"protocol.":[86],"Results:":[88],"A":[90],"total":[92],"were":[96,183],"treated":[97,136],"between":[98,161],"1/96":[99],"6/00:":[101],"median":[102],"age":[103],"69":[104],"(range":[106,128,147,157],"24\u201393":[107],"years,":[108],"females":[109],"48%).":[110],"Pre-treatment":[111],"NIHSS":[112,204,221],"was":[113,123,144,155,198,206,217,223],"14\u00b16":[114],"(median":[116,208,226],"14,":[117],"range":[118,210,228],"4\u201333":[119],"points).":[120,212],"bolus":[122],"given":[124,250],"at":[125,181],"137":[126],"min":[127],"30\u2013180":[130],"minutes)":[131],"28%":[133],"2":[138],"hours.":[139],"Median":[140],"door-to-needle":[142],"time":[143],"68":[145],"minutes":[146],"10\u2013129":[148],"minutes).":[149],"Overall":[150],"symptomatic":[152,192,255],"ICH":[153,193,256],"rate":[154,194],"4.5%":[156],"2.6%":[158],"-":[159],"8.7%":[160],"hospitals,":[162],"ns),":[164],"a":[166,242,252],"decline":[167],"noted":[168],"from":[169,266],"1996":[170,267],"2000":[172],"(Table).":[173],"Protocol":[174],"violations":[176],"(excessive":[177],"blood":[178],"pressure,":[179],"seizure":[180],"onset)":[182],"found":[184],"13%":[187],"all":[189],"these":[196],"15%.":[200],"At":[201],"24":[202],"score":[205,222],"9\u00b18":[207],"8,":[209],"0\u201336":[211],"In":[214],"mortality":[216],"15%":[218],"discharge":[220],"6\u00b17":[224],"3,":[227],"0\u201336).":[229],"Long-term":[230],"follow-up":[231],"will":[232],"be":[233,248],"reported.":[234,260],"Conclusions:":[237],"Intravenous":[239],"dose":[243],"can":[247],"risk":[253],"lower":[257],"than":[258,288],"previously":[259],"Safety":[262],"improved":[265],"2000.":[269],"conclude":[271],"that":[272],"safety":[274],"depends":[279],"more":[280],"on":[281],"expertise":[283],"treating":[286],"type":[291],"hospital.":[295]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-08-08T00:00:00"}
