{"id":"https://openalex.org/W2741490597","doi":"https://doi.org/10.1158/1538-7445.am2017-5298","title":"Abstract 5298: Lung cancer risk and scarring on imaging and histology in the National Lung Screening Trial","display_name":"Abstract 5298: Lung cancer risk and scarring on imaging and histology in the National Lung Screening Trial","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2741490597","doi":"https://doi.org/10.1158/1538-7445.am2017-5298","mag":"2741490597"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-5298","doi":"https://doi.org/10.1158/1538-7445.am2017-5298","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-5298","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061481561","display_name":"Alison L. Van Dyke","orcid":"https://orcid.org/0000-0002-8591-9467","observed_orcids":["https://orcid.org/0000-0002-8591-9467"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison L. Van Dyke","raw_affiliation_strings":["National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105778913","display_name":"Christine D. Berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine D. Berg","raw_affiliation_strings":["National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019329822","display_name":"Neil E. Caporaso","orcid":"https://orcid.org/0000-0001-7562-4609","observed_orcids":["https://orcid.org/0000-0001-7562-4609"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil E. Caporaso","raw_affiliation_strings":["National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009110617","display_name":"Hormuzd A. Katki","orcid":"https://orcid.org/0000-0003-2002-0095","observed_orcids":["https://orcid.org/0000-0003-2002-0095"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hormuzd A. Katki","raw_affiliation_strings":["National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019860962","display_name":"Anil K. Chaturvedi","orcid":"https://orcid.org/0000-0003-2696-8899","observed_orcids":["https://orcid.org/0000-0003-2696-8899"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil K. Chaturvedi","raw_affiliation_strings":["National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035778053","display_name":"Eric A. Engels","orcid":"https://orcid.org/0000-0003-0203-6958","observed_orcids":["https://orcid.org/0000-0003-0203-6958"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric A. Engels","raw_affiliation_strings":["National Cancer Institute, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, Rockville, MD","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"5298","last_page":"5298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13759","display_name":"Medical Imaging and Pathology Studies","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6129999756813049},{"id":"https://openalex.org/keywords/lung-cancer-screening","display_name":"lung cancer screening","score":0.6209999918937683},{"id":"https://openalex.org/keywords/low-dose-computed-tomography","display_name":"low-dose CT","score":0.9409999847412109},{"id":"https://openalex.org/keywords/national-lung-screening-trial","display_name":"National Lung Screening Trial","score":0.8619999885559082},{"id":"https://openalex.org/keywords/lung-cancer-risk","display_name":"lung cancer risk","score":0.6460000276565552},{"id":"https://openalex.org/keywords/heavy-smokers","display_name":"heavy smokers","score":0.5479999780654907},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.8040000200271606},{"id":"https://openalex.org/keywords/pneumonia-history","display_name":"pneumonia history","score":0.6660000085830688},{"id":"https://openalex.org/keywords/lung-cancer-histology","display_name":"lung cancer histology","score":0.49399998784065247}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9455859661102295},{"id":"https://openalex.org/C2778321237","wikidata":"https://www.wikidata.org/wiki/Q17125886","display_name":"National Lung Screening Trial","level":4,"score":0.8381844758987427},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7736325263977051},{"id":"https://openalex.org/C2777405583","wikidata":"https://www.wikidata.org/wiki/Q6704277","display_name":"Lung cancer screening","level":3,"score":0.6776219606399536},{"id":"https://openalex.org/C2777642821","wikidata":"https://www.wikidata.org/wiki/Q206060","display_name":"Scars","level":2,"score":0.6132254600524902},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5162106156349182},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4979097843170166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47286033630371094},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.429598331451416},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.32459136843681335},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30251121520996094}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-5298","doi":"https://doi.org/10.1158/1538-7445.am2017-5298","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-5298","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2153772720","https://openalex.org/W2739946210","https://openalex.org/W4408011383","https://openalex.org/W2022897925","https://openalex.org/W2482351703","https://openalex.org/W4245957820","https://openalex.org/W2297980830","https://openalex.org/W3079676645","https://openalex.org/W2560856906","https://openalex.org/W3127694095"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"The":[2,355,385],"contribution":[3,377],"of":[4,82,100,144,149,169,234,249,297,367,378,382,410,423,464],"pulmonary":[5,141],"scars":[6,209,311],"to":[7,14,115,331,380],"lung":[8,16,28,31,41,51,87,92,124,150,158,223,268,286,362,383],"cancer":[9,32,42,52,159,224,252,269,363,447],"development":[10,381],"and":[11,40,89,122,146,177,189,219,323,360,390,413,449,453],"the":[12,44,117,163,206,247,399,407,421,456,465],"degree":[13],"which":[15],"cancers":[17,88,93,125,235,287,299,415],"cause":[18],"a":[19,50,365],"scarring":[20,29,39,64,84,121,186,191,227,244,262,291,329,339,344,359,379,389,391,397,412,418,450],"response":[21],"are":[22],"unclear.":[23],"Also":[24],"unknown":[25],"is":[26,372],"how":[27],"impacts":[30],"screening.":[33,424],"Methods:":[34],"We":[35],"evaluated":[36,157],"associations":[37],"between":[38,119,184,357,387],"in":[43,212,288,294,314,455],"National":[45,457],"Lung":[46,164,290,446,458],"Screening":[47,165,459],"Trial":[48,460],"(NLST),":[49],"screening":[53,69,96,259],"trial":[54],"among":[55,335],"current":[56],"or":[57,231],"former,":[58],"heavy":[59],"smokers,":[60],"55-74":[61],"years-old.":[62],"Baseline":[63],"(presence":[65],"vs.":[66,346],"absence)":[67],"on":[68,95,187,392,451],"low":[70],"dose":[71],"computed":[72],"tomography":[73],"(LDCT)":[74],"scan":[75],"was":[76,263,292],"assessed":[77],"at":[78],"baseline":[79],"(T0).":[80],"Associations":[81,183],"T0":[83,101,120,185,208,226,261,338,343,358,388,411],"with":[85,90,265,300,337,374],"screen-detected":[86],"interval-detected":[91,251],"missed":[94],"within":[97],"3":[98,370],"years":[99,128,371],"screen":[102],"were":[103,113,192,210,281,312],"analyzed":[104],"using":[105],"multinomial":[106],"logistic":[107,195],"regression.":[108,196],"Cox":[109],"proportional":[110],"hazards":[111],"models":[112,132],"used":[114],"analyze":[116],"relationship":[118,386],"incident":[123,222,267,361],"diagnosed":[126],">3":[127],"after":[129],"T0.":[130],"Regression":[131],"included":[133],"age,":[134],"sex,":[135],"race,":[136],"smoking":[137],"history,":[138],"chronic":[139],"obstructive":[140],"disease,":[142],"history":[143,148],"pneumonia,":[145],"family":[147],"cancer.":[151,384],"A":[152],"thoracic":[153],"pathologist":[154],"(first":[155],"author)":[156],"pathology":[160],"slides":[161,280],"from":[162,205],"Study":[166],"(LSS)":[167],"subset":[168],"NLST":[170],"for":[171,283,468],"scar":[172],"grade":[173],"(none,":[174,179],"sparse,":[175],"dense)":[176],"maturity":[178],"immature,":[180],"intermediate,":[181],"mature).":[182],"LDCT":[188,199],"histological":[190],"examined":[193],"by":[194],"Results:":[197],"NLST\u2019s":[198],"arm":[200],"enrolled":[201],"26,722":[202],"participants":[203],"(65%":[204],"LSS).":[207],"present":[211],"132":[213],"(22%)":[214,302],"screen-detected,":[215],"12":[216],"(29%)":[217],"interval-detected,":[218],"94":[220],"(26%)":[221],"cases.":[225],"did":[228],"not":[229],"increase":[230,246],"decrease":[232,420],"screen-detection":[233],"[odds":[236],"ratio":[237,272],"(OR)":[238],"95%":[239],"CI:":[240],"1.03":[241],"(0.84-1.26)].":[242],"However,":[243],"might":[245],"chance":[248],"an":[250,375,403],"[OR":[253,349],"(95%":[254,274,350],"CI):":[255,275,351],"1.54":[256],"(0.76-3.12)].":[257],"After":[258],"stopped,":[260],"associated":[264],"increased":[266],"risk":[270,448],"[hazard":[271],"(HR)":[273],"1.27":[276],"(1.00-1.62);":[277],"P=0.048].":[278],"Pathology":[279],"available":[282],"258":[284],"(38%)":[285],"LSS.":[289],"found":[293,313],"172":[295],"(67%)":[296],"these":[298],"58":[301],"being":[303],"characterized":[304],"as":[305],"mature":[306],"scars.":[307],"On":[308],"microscopic":[309,393],"review,":[310],"80":[315],"(66%)":[316],"ADC,":[317],"46":[318],"(82%)":[319],"squamous":[320],"cell":[321],"carcinomas,":[322],"20":[324],"(51%)":[325],"bronchioloalveolar":[326],"carcinomas.":[327],"Microscopic":[328],"tended":[330],"be":[332],"more":[333,368],"frequent":[334],"cases":[336],"than":[340,369],"those":[341],"without":[342],"(75%":[345],"64%;":[347],"P=0.10)":[348],"1.89":[352],"(0.98-3.86)].":[353],"Conclusion:":[354],"association":[356,409],"over":[364],"period":[366],"consistent":[373],"etiologic":[376,404],"evaluation":[394],"suggests":[395,416],"that":[396,417],"preceded":[398],"cancer,":[400],"further":[401],"supporting":[402],"relationship.":[405],"Finally,":[406],"borderline":[408],"interval":[414],"may":[419],"sensitivity":[422],"Citation":[425],"Format:":[426],"Alison":[427],"L.":[428],"Van":[429],"Dyke,":[430],"Christine":[431],"D.":[432],"Berg,":[433],"Neil":[434],"E.":[435],"Caporaso,":[436],"Hormuzd":[437],"A.":[438,444],"Katki,":[439],"Anil":[440],"K.":[441],"Chaturvedi,":[442],"Eric":[443],"Engels.":[445],"imaging":[452],"histology":[454],"[abstract].":[461],"In:":[462],"Proceedings":[463],"American":[466],"Association":[467],"Cancer":[469,482],"Research":[470],"Annual":[471],"Meeting":[472],"2017;":[473],"2017":[474],"Apr":[475],"1-5;":[476],"Washington,":[477],"DC.":[478],"Philadelphia":[479],"(PA):":[480],"AACR;":[481],"Res":[483],"2017;77(13":[484],"Suppl):Abstract":[485],"nr":[486],"5298.":[487],"doi:10.1158/1538-7445.AM2017-5298":[488]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2017-08-08T00:00:00"}
