{"id":"https://openalex.org/W2741387793","doi":null,"title":"CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension","display_name":"CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2741387793","mag":"2741387793"},"language":"en","primary_location":{"id":"mag:2741387793","doi":null,"is_oa":false,"landing_page_url":"http://ajplung.physiology.org/content/ajplung/310/1/L40.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"paratext","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076647130","display_name":"Adeleye James Afolayan","orcid":"https://orcid.org/0000-0001-9886-6694","observed_orcids":["https://orcid.org/0000-0001-9886-6694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adeleye J. Afolayan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9886-6694","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111835579","display_name":"Annie Eis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annie Eis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075205259","display_name":"Maxwell Alexander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maxwell Alexander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058871054","display_name":"Teresa Michalkiewicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Michalkiewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068363919","display_name":"Ru\u2010Jeng Teng","orcid":"https://orcid.org/0000-0003-4321-2452","observed_orcids":["https://orcid.org/0000-0003-4321-2452"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ru\u2010Jeng Teng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4321-2452","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003732931","display_name":"Satyan Lakshminrusimha","orcid":"https://orcid.org/0000-0001-6098-2155","observed_orcids":["https://orcid.org/0000-0001-6098-2155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satyan Lakshminrusimha","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6098-2155","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043220616","display_name":"Girija Ganesh Konduri","orcid":"https://orcid.org/0000-0002-3602-1538","observed_orcids":["https://orcid.org/0000-0002-3602-1538"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Girija G. Konduri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3602-1538","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040861741","display_name":"Afolayan AJ","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Afolayan AJ","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091670505","display_name":"Eis A","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eis A","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5117515557","display_name":"Teng Rj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ru\u2010Jeng Teng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4321-2452","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":true,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9467999935150146,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/persistent-pulmonary-hypertension-of-the-newborn","display_name":"persistent pulmonary hypertension of the newborn","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7110000252723694},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.6890000104904175},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pgc-1","display_name":"PGC-1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/inhaled-nitric-oxide","display_name":"inhaled nitric oxide","score":0.8790000081062317},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.847000002861023},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8640000224113464},{"id":"https://openalex.org/keywords/pulmonary-artery-endothelial-cells","display_name":"pulmonary artery endothelial cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.7390176057815552},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6725722551345825},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.655807614326477},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6215112805366516},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5158783197402954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4891693890094757},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4876796007156372},{"id":"https://openalex.org/C2908688039","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Nitric Oxide Synthase Type III","level":5,"score":0.47645309567451477},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.45772653818130493},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.4223771393299103},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3379017114639282},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.333065003156662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29985910654067993},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1489744782447815}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2741387793","doi":null,"is_oa":false,"landing_page_url":"http://ajplung.physiology.org/content/ajplung/310/1/L40.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1493762666","https://openalex.org/W1821918060","https://openalex.org/W1902133904","https://openalex.org/W1965380611","https://openalex.org/W1972482985","https://openalex.org/W1982233191","https://openalex.org/W1982339972","https://openalex.org/W1990967318","https://openalex.org/W1997312454","https://openalex.org/W1998091253","https://openalex.org/W2002179772","https://openalex.org/W2014830922","https://openalex.org/W2015989606","https://openalex.org/W2022479328","https://openalex.org/W2025029680","https://openalex.org/W2028680679","https://openalex.org/W2029657737","https://openalex.org/W2029658224","https://openalex.org/W2039495243","https://openalex.org/W2039765184","https://openalex.org/W2058768220","https://openalex.org/W2065246627","https://openalex.org/W2086990113","https://openalex.org/W2113515610","https://openalex.org/W2121863476","https://openalex.org/W2123476161","https://openalex.org/W2129166389","https://openalex.org/W2133444149","https://openalex.org/W2133517534","https://openalex.org/W2133737628","https://openalex.org/W2157199218","https://openalex.org/W2158905364","https://openalex.org/W2168578600","https://openalex.org/W2169001678","https://openalex.org/W2184995059","https://openalex.org/W2187540790","https://openalex.org/W2526700131"],"related_works":["https://openalex.org/W2204266269","https://openalex.org/W1807776544","https://openalex.org/W2029658224","https://openalex.org/W2412446159","https://openalex.org/W2201641158","https://openalex.org/W2105017863","https://openalex.org/W2039495243","https://openalex.org/W1977473534","https://openalex.org/W139593119","https://openalex.org/W2156158174"],"abstract_inverted_index":{"Afolayan":[0],"AJ,":[1],"Eis":[2],"A,":[3],"Alexander":[4],"M,":[5],"Michalkiewicz":[6],"T,":[7],"Teng":[8],"RJ,":[9],"Lakshminrusimha":[10],"S,":[11],"Konduri":[12],"GG.":[13],"Decreased":[14],"endothelial":[15,74,116],"nitric":[16,75,109],"oxide":[17,76,110],"synthase":[18,77],"expression":[19],"and":[20,27,84,121,144,149,168,176,224,231,249,251,279,290],"function":[21,85],"contribute":[22],"to":[23,80],"impaired":[24,81],"mitochondrial":[25,65,82,132,180,254,280],"biogenesis":[26,83],"oxidative":[28,277],"stress":[29,278],"in":[30,54,86,147,184,195,198,257,266,282],"fetal":[31,154],"lambs":[32,101,123,155,203],"with":[33,102,107,124,159,187,192,205,234,273],"persistent":[34,55],"pulmonary":[35,56,114],"hypertension.":[36],"Am":[37],"J":[38],"Physiol":[39,43],"Lung":[40],"Cell":[41],"Mol":[42],"310:":[44],"L40\u2013L49,":[45],"2016.":[46],"First":[47],"published":[48],"October":[49],"30,":[50],"2015;":[51],"doi:10.1152/ajplung.00392.2014.\u2014Impaired":[52],"vasodilation":[53],"hypertension":[57],"of":[58,90,152,164,170,201,214,242,260,292],"the":[59,69,199,253],"newborn":[60],"(PPHN)":[61],"is":[62],"characterized":[63],"by":[64,93,288],"dysfunction.":[66],"We":[67,98,112,129,269],"investigated":[68],"hypothesis":[70],"that":[71,271],"a":[72,87],"decreased":[73,131,183,252,262],"level":[78],"leads":[79],"lamb":[88],"model":[89],"PPHN":[91,100,122,153,202,207],"induced":[92],"prenatal":[94],"ductus":[95],"arteriosus":[96],"constriction.":[97],"ventilated":[99],"100%":[103,188,274],"O2":[104,189,275],"alone":[105],"or":[106],"inhaled":[108],"(iNO).":[111],"treated":[113],"artery":[115],"cells":[117],"(PAECs)":[118],"from":[119],"normal":[120],"detaNONOate,":[125],"an":[126],"NO":[127],"donor.":[128],"observed":[130],"(mt)":[133],"DNA":[134],"copy":[135,219],"number,":[136,220],"electron":[137],"transport":[138],"chain":[139],"(ETC)":[140],"complex":[141],"subunit":[142,222],"levels,":[143,223],"ATP":[145,225],"levels":[146,169,241,256,265],"PAECs":[148],"lung":[150],"tissue":[151],"at":[156],"baseline":[157],"compared":[158,204],"gestation":[160],"matched":[161],"controls.":[162],"Phosphorylation":[163],"AMP-activated":[165],"kinase":[166],"(AMPK)":[167],"peroxisome":[171],"proliferator-activated":[172],"receptorcoactivator":[173],"1(PGC-1":[174],")":[175],"sirtuin-1,":[177],"which":[178,211,284],"facilitate":[179],"biogenesis,":[181],"were":[182],"PPHN.":[185],"Ventilation":[186],"was":[190],"associated":[191],"larger":[193],"decreases":[194],"ETC":[196,221,263],"subunits":[197],"lungs":[200],"unventilated":[206],"lambs.":[208],"iNO":[209,289],"administration,":[210],"facilitated":[212],"weaning":[213,291],"FIO2,":[215],"partly":[216,286],"restored":[217],"mtDNA":[218],"levels.":[226],"DetaNONOate":[227],"increased":[228,240],"eNOS":[229,261],"phosphorylation":[230],"its":[232],"interaction":[233],"heat":[235],"shock":[236],"protein":[237,264],"90":[238],"(HSP90);":[239],"superoxide":[243,255],"dismutase":[244],"2":[245],"(SOD2)":[246],"mRNA,":[247],"protein,":[248],"activity;":[250],"PPHN-PAECs.":[258],"Knockdown":[259],"control":[267],"PAECs.":[268],"conclude":[270],"ventilation":[272],"amplifies":[276],"dysfunction":[281],"PPHN,":[283],"are":[285],"improved":[287],"oxygen.":[293]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-08T00:00:00"}