{"id":"https://openalex.org/W2741379995","doi":"https://doi.org/10.1158/1078-0432.ccr-17-0143","title":"Exposure\u2013Response of Veliparib to Inform Phase II Trial Design in Refractory or Relapsed Patients with Hematological Malignancies","display_name":"Exposure\u2013Response of Veliparib to Inform Phase II Trial Design in Refractory or Relapsed Patients with Hematological Malignancies","publication_year":2017,"publication_date":"2017-07-27","ids":{"openalex":"https://openalex.org/W2741379995","doi":"https://doi.org/10.1158/1078-0432.ccr-17-0143","mag":"2741379995","pmid":"https://pubmed.ncbi.nlm.nih.gov/28751440","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5837045"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-17-0143","doi":"https://doi.org/10.1158/1078-0432.ccr-17-0143","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-17-0143","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5837045","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052331821","display_name":"Shailly Mehrotra","orcid":"https://orcid.org/0009-0007-0047-538X","observed_orcids":["https://orcid.org/0009-0007-0047-538X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shailly Mehrotra","raw_affiliation_strings":["1Center for Translational Medicine, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Translational Medicine, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050047645","display_name":"Mathangi Gopalakrishnan","orcid":"https://orcid.org/0000-0003-2881-9870","observed_orcids":["https://orcid.org/0000-0003-2881-9870"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mathangi Gopalakrishnan","raw_affiliation_strings":["1Center for Translational Medicine, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Translational Medicine, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083885025","display_name":"Jogarao V. S. Gobburu","orcid":"https://orcid.org/0000-0002-8348-4295","observed_orcids":["https://orcid.org/0000-0002-8348-4295"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jogarao Gobburu","raw_affiliation_strings":["1Center for Translational Medicine, University of Maryland, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Center for Translational Medicine, University of Maryland, Baltimore, Maryland","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020575293","display_name":"Jiuping Jay Ji","orcid":"https://orcid.org/0000-0002-5287-6157","observed_orcids":["https://orcid.org/0000-0002-5287-6157"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiuping Ji","raw_affiliation_strings":["2Frederick National Laboratory for Cancer Research, Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Frederick National Laboratory for Cancer Research, Frederick, Maryland","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079274832","display_name":"Jacqueline M. Greer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline M. Greer","raw_affiliation_strings":["3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046042179","display_name":"Richard Piekarz","orcid":"https://orcid.org/0000-0002-3591-7893","observed_orcids":["https://orcid.org/0000-0002-3591-7893"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Piekarz","raw_affiliation_strings":["4Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040758762","display_name":"Judith E. Karp","orcid":"https://orcid.org/0000-0003-4754-127X","observed_orcids":["https://orcid.org/0000-0003-4754-127X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith E. Karp","raw_affiliation_strings":["3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland","5Department of Oncology, Johns Hopkins University, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"5Department of Oncology, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045709974","display_name":"Keith William Pratz","orcid":"https://orcid.org/0000-0002-1284-8266","observed_orcids":["https://orcid.org/0000-0002-1284-8266"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith W. Pratz","raw_affiliation_strings":["3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland","5Department of Oncology, Johns Hopkins University, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"5Department of Oncology, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015341987","display_name":"Michelle A. Rudek","orcid":"https://orcid.org/0000-0001-5739-6868","observed_orcids":["https://orcid.org/0000-0001-5739-6868"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michelle A. Rudek","raw_affiliation_strings":["3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland","5Department of Oncology, Johns Hopkins University, Baltimore, Maryland","6Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]},{"raw_affiliation_string":"5Department of Oncology, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"6Department of Medicine, Division of Clinical Pharmacology, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5015341987","https://openalex.org/A5050047645"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I145311948","https://openalex.org/I4210164401"],"apc_list":null,"apc_paid":null,"fwci":0.4681,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6581973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"23","issue":"21","first_page":"6421","last_page":"6429"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/veliparib","display_name":"veliparib","score":1.0},{"id":"https://openalex.org/keywords/exposure-response-analysis","display_name":"exposure-response analysis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8240000009536743},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9190000295639038},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/objective-response","display_name":"objective response","score":0.6470000147819519},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mucositis","display_name":"mucositis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dose-selection","display_name":"dose selection","score":0.6240000128746033},{"id":"https://openalex.org/keywords/phase-ii-trial-design","display_name":"phase II trial design","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2781312401","wikidata":"https://www.wikidata.org/wiki/Q7919041","display_name":"Veliparib","level":5,"score":0.7947906255722046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6491948962211609},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6255455613136292},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6158667206764221},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5514576435089111},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5013439655303955},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4267634153366089},{"id":"https://openalex.org/C2777334693","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Maximum tolerated dose","level":3,"score":0.4267134666442871},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1515982449054718},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.08955597877502441},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019772","descriptor_name":"Topotecan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019772","descriptor_name":"Topotecan","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-17-0143","doi":"https://doi.org/10.1158/1078-0432.ccr-17-0143","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-17-0143","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:28751440","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28751440","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:europepmc.org:5156140","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5837045","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5837045","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5837045","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5156140","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5837045","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G155039108","display_name":null,"funder_award_id":"U01 CA070095 and UM1CA186691","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2700320199","display_name":"Phase I Clinical Trials of New Anti-Cancer Targeted Therapies","funder_award_id":"U01CA070095","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5110292763","display_name":"Wisconsin and New Jersey Alliance in Precision Experimental Therapeutics","funder_award_id":"UM1CA186716","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6405609260","display_name":"Institute for Clinical and Translational Research","funder_award_id":"UL1TR001079","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7832261492","display_name":null,"funder_award_id":"P30 CA006973 and UL1 TR 001079","funder_id":"https://openalex.org/F4320333181","funder_display_name":"Sidney Kimmel Comprehensive Cancer Center"},{"id":"https://openalex.org/G9000884540","display_name":"The Johns Hopkins Translational Science Team and Consortium for ETCTN Studies","funder_award_id":"UM1CA186691","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000911005","display_name":"Regional Oncology Research Center","funder_award_id":"P30CA006973","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333181","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20"},{"id":"https://openalex.org/F4320334039","display_name":"Sidney Kimmel Center for Prostate and Urologic Cancers","ror":"https://ror.org/037e5pc19"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W70081261","https://openalex.org/W1928092242","https://openalex.org/W1977180561","https://openalex.org/W1998626781","https://openalex.org/W2024447346","https://openalex.org/W2040624495","https://openalex.org/W2083133947","https://openalex.org/W2117954942","https://openalex.org/W2118883481","https://openalex.org/W2160649777","https://openalex.org/W2163840401","https://openalex.org/W2181166720","https://openalex.org/W2287857102","https://openalex.org/W2296857019","https://openalex.org/W2298676218","https://openalex.org/W2507983749","https://openalex.org/W2584631269","https://openalex.org/W2921614528"],"related_works":["https://openalex.org/W2901175244","https://openalex.org/W2970540816","https://openalex.org/W2584631269","https://openalex.org/W2801863679","https://openalex.org/W2613198872","https://openalex.org/W2789896032","https://openalex.org/W4246169005","https://openalex.org/W3207103941","https://openalex.org/W4223541458","https://openalex.org/W2521377778"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"A":[2],"phase":[3,36],"I":[4],"trial":[5,38],"of":[6,59,102,106,112,145,149,180,228],"veliparib":[7,60,207,224],"in":[8,21,122,130,158,166,192,237,246],"combination":[9,238],"with":[10,23,68,118,125,132,138,161,168,174,188,239],"topotecan":[11],"plus":[12],"carboplatin":[13],"(T+C)":[14],"demonstrated":[15],"a":[16,226],"33%":[17],"objective":[18,27,114],"response":[19,75,115],"rate":[20],"patients":[22,131,167],"hematological":[24],"malignancies.":[25],"The":[26,95,110,178],"is":[28,241],"to":[29,33,54,243],"perform":[30],"exposure\u2013response":[31],"analysis":[32,144],"inform":[34],"the":[35,217],"II":[37],"design.":[39],"Experimental":[40],"Design:":[41],"Pharmacokinetic,":[42],"efficacy,":[43],"and":[44,76,79,89,104,136],"safety":[45],"data":[46],"from":[47],"95":[48],"patients,":[49],"who":[50],"were":[51,70,93,98,116],"administered":[52],"10":[53],"100":[55],"mg":[56,203,230],"b.i.d.":[57,231],"doses":[58,199],"for":[61,72,154,232],"either":[62],"8,":[63],"14,":[64],"or":[65],"21":[66],"days":[67,127,163,236],"T+C,":[69],"utilized":[71],"exposure\u2013efficacy":[73,197],"(objective":[74],"overall":[77,146],"survival)":[78],"exposure\u2013safety":[80],"(\u2265grade":[81],"3":[82,183],"mucositis)":[83],"analysis.":[84],"Multivariate":[85],"cox":[86],"proportional":[87],"hazards":[88],"logistic":[90],"regression":[91],"analyses":[92],"conducted.":[94],"covariates":[96],"evaluated":[97],"disease":[99],"status,":[100],"duration":[101],"treatment,":[103,128,164],"number":[105],"prior":[107,140,176],"therapies.":[108,141,177],"Results:":[109],"odds":[111,179],"having":[113,181],"1.08-fold":[117],"1,000":[119,155,189],"ng/hr/mL":[120,156],"increase":[121,157,191],"AUC,":[123,159],"1.8-fold":[124],">8":[126,162],"2.8-fold":[129],"myeloproliferative":[133],"neoplasms":[134],"(MPN),":[135],"0.5-fold":[137],"\u22652":[139,175],"Based":[142,220],"on":[143,221],"survival,":[147],"hazard":[148],"death":[150],"decreased":[151],"by":[152,172,186],"1.5%":[153],"39%":[160],"44%":[165],"MPN,":[169],"while":[170],"increased":[171,185],"19%":[173],"\u2265grade":[182],"mucositis":[184],"29%":[187],"ng.h/mL":[190],"AUC.":[193],"Conclusions:":[194],"Despite":[195],"shallow":[196],"relationship,":[198],"lower":[200],"than":[201],"80":[202,229],"do":[204],"not":[205],"exceed":[206],"single":[208],"agent":[209],"preclinical":[210],"IC50.":[211],"Shallow":[212],"exposure\u2013mucositis":[213],"relationship":[214],"also":[215],"supports":[216],"80-mg":[218],"dose.":[219],"benefit/risk":[222],"assessment,":[223],"at":[225,233],"dose":[227],"least":[234],"14":[235],"T+C":[240],"recommended":[242],"be":[244],"studied":[245],"MPN":[247],"patients.":[248],"Clin":[249],"Cancer":[250],"Res;":[251],"23(21);":[252],"6421\u20139.":[253],"\u00a92017":[254],"AACR.":[255]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-08T00:00:00"}
