{"id":"https://openalex.org/W2740733004","doi":"https://doi.org/10.1158/1538-7445.am2017-710","title":"Abstract 710: Identification of autoantibody to ECH1 & HNRNPA2B1 as potential biomarkers in the early detection of lung cancer","display_name":"Abstract 710: Identification of autoantibody to ECH1 & HNRNPA2B1 as potential biomarkers in the early detection of lung cancer","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2740733004","doi":"https://doi.org/10.1158/1538-7445.am2017-710","mag":"2740733004"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-710","doi":"https://doi.org/10.1158/1538-7445.am2017-710","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-710","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000885936","display_name":"Liping Dai","orcid":"https://orcid.org/0000-0002-5531-1776","observed_orcids":["https://orcid.org/0000-0002-5531-1776"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liping Dai","raw_affiliation_strings":["1Zhengzhou University, Zhengzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Zhengzhou University, Zhengzhou, China;","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079894628","display_name":"Jitian Li","orcid":"https://orcid.org/0000-0001-9857-3226","observed_orcids":["https://orcid.org/0000-0001-9857-3226"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jitian Li","raw_affiliation_strings":["2the University of Texas at El Paso, El Paso, TX;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2the University of Texas at El Paso, El Paso, TX;","institution_ids":["https://openalex.org/I164936912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034728230","display_name":"Jun-Chieh James Tsay","orcid":"https://orcid.org/0000-0002-2282-2510","observed_orcids":["https://orcid.org/0000-0002-2282-2510"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun-Chieh J. Tsay","raw_affiliation_strings":["3New York University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3New York University, New York, NY;","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411441","display_name":"Xiao Wang","orcid":"https://orcid.org/0000-0001-8824-6280","observed_orcids":["https://orcid.org/0000-0001-8824-6280"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Wang","raw_affiliation_strings":["1Zhengzhou University, Zhengzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Zhengzhou University, Zhengzhou, China;","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024082250","display_name":"John S. Munger","orcid":"https://orcid.org/0000-0002-9679-2983","observed_orcids":["https://orcid.org/0000-0002-9679-2983"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Munger","raw_affiliation_strings":["3New York University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3New York University, New York, NY;","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091299701","display_name":"Harvey Ira Pass","orcid":"https://orcid.org/0000-0003-3222-3471","observed_orcids":["https://orcid.org/0000-0003-3222-3471"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey Pass","raw_affiliation_strings":["3New York University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3New York University, New York, NY;","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008330886","display_name":"William N. Rom","orcid":"https://orcid.org/0000-0002-8793-7028","observed_orcids":["https://orcid.org/0000-0002-8793-7028"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William N. Rom","raw_affiliation_strings":["3New York University, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3New York University, New York, NY;","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065446697","display_name":"Eng M. Tan","orcid":"https://orcid.org/0000-0002-8711-3248","observed_orcids":["https://orcid.org/0000-0002-8711-3248"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eng M. Tan","raw_affiliation_strings":["4The Scripps Research Institute, San Diego, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4The Scripps Research Institute, San Diego, CA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100646259","display_name":"Jianying Zhang","orcid":"https://orcid.org/0000-0003-2938-9526","observed_orcids":["https://orcid.org/0000-0003-2938-9526"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Ying Zhang","raw_affiliation_strings":["1Zhengzhou University, Zhengzhou, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Zhengzhou University, Zhengzhou, China;","institution_ids":["https://openalex.org/I38877650"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"710","last_page":"710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9700000286102295},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hnrnpa2b1","display_name":"HNRNPA2B1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.800000011920929},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.7110000252723694},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.8259999752044678},{"id":"https://openalex.org/keywords/preclinical-detection","display_name":"preclinical detection","score":0.6800000071525574},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.9190000295639038},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.718999981880188},{"id":"https://openalex.org/keywords/34-kda-protein","display_name":"34 kDa protein","score":0.6499999761581421},{"id":"https://openalex.org/keywords/cancer-immunotherapy-targets","display_name":"cancer immunotherapy targets","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.9609774351119995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6761950850486755},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5655267238616943},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5555428266525269},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.5476835370063782},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5048254132270813},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.45371612906455994},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.44717785716056824},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4453924298286438},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.44227397441864014},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4180796146392822},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40771424770355225},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.334665447473526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12864065170288086},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.12071141600608826},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09057164192199707}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-710","doi":"https://doi.org/10.1158/1538-7445.am2017-710","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-710","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2599100097","https://openalex.org/W2762161655","https://openalex.org/W2997781325","https://openalex.org/W2207667586","https://openalex.org/W2761050422","https://openalex.org/W2490949080","https://openalex.org/W2980702511","https://openalex.org/W2023167125","https://openalex.org/W2989806903","https://openalex.org/W4389053551"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Identification":[2,293],"of":[3,8,20,67,101,125,129,133,156,160,164,187,191,195,242,256,264,294,307,313],"biomarkers":[4,237,302],"for":[5,238,317],"early":[6,240,305],"detection":[7,241,306],"lung":[9,308],"cancer":[10,309],"(LC)":[11],"may":[12],"lead":[13],"to":[14,29,83,116,151,182,216,296],"more":[15],"effective":[16],"treatment":[17],"and":[18,76,109,131,141,162,166,193,204,221,231,260,267],"reduction":[19],"mortality.":[21],"Methods:":[22],"Serological":[23],"proteome":[24],"analysis":[25],"(SERPA)":[26],"was":[27,248],"used":[28,234],"identify":[30],"proteins":[31,97],"around":[32],"34":[33,102],"kDa,":[34],"which":[35],"had":[36],"been":[37],"previously":[38],"recognized":[39],"by":[40,61,250],"autoantibody":[41,50,87,115,181,206,295],"in":[42,52,91,135,197,229,303],"sera":[43,53],"from":[44,54,138],"LC":[45,56,69,137,199,217,230],"patients.":[46],"We":[47],"have":[48],"validated":[49],"response":[51],"90":[55],"patients,":[57],"89":[58],"normal":[59,79,139,202],"controls":[60,80],"using":[62,177],"immunoassay.":[63],"Another":[64],"independent":[65],"cohort":[66],"25":[68],"patients":[70],"with":[71,98,127,145,158,170,189,200],"219":[72],"serial":[73],"serum":[74],"samples":[75],"56":[77],"matched":[78,201],"were":[81,104],"examined":[82],"evaluate":[84],"whether":[85],"the":[86,92,112,122,239,251,261,304,314],"can":[88,232],"be":[89,209,233],"detected":[90,210],"preclinical":[93,179],"stage.":[94],"Results:":[95],"The":[96],"molecular":[99],"weight":[100],"kDa":[103],"identified":[105],"as":[106,235,300],"ECH1,":[107],"GAPDH":[108],"HNRNPA2B1.":[110],"In":[111],"validation":[113],"study,":[114],"ECH1":[117,183,220,297],"achieved":[118],"an":[119,154,185],"area":[120],"under":[121],"curve":[123],"(AUC)":[124],"0.799":[126],"sensitivity":[128,159,190],"62.2%":[130],"specificity":[132,163,194],"95.5%":[134],"discriminating":[136],"individuals,":[140],"showed":[142,167,184],"negative":[143,168],"correlation":[144,169],"tumor":[146],"size":[147],"(rs=0.-256,":[148],"p=0.023).":[149],"Autoantibody":[150],"HNRNPA2B1":[152,222,299],"performed":[153],"AUC":[155,186],"0.874":[157],"72.2%":[161],"95.5%,":[165],"lymph":[171],"node":[172],"metastasis":[173],"(rs=0.-279,":[174],"P=0.012).":[175],"By":[176],"longitudinal":[178],"samples,":[180],"0.763":[188],"60.0%":[192],"89.3%":[196],"distinguishing":[198],"controls,":[203],"elevated":[205],"levels":[207],"could":[208],"greater":[211],"than":[212],"two":[213],"years":[214],"prior":[215],"diagnosis.":[218],"Conclusions:":[219],"are":[223],"autoantigens":[224],"that":[225],"elicit":[226],"autoimmune":[227],"responses":[228],"potential":[236,301],"LC.":[243],"Funding":[244],"support:":[245],"This":[246],"work":[247],"supported":[249],"National":[252,262],"Natural":[253],"Science":[254],"Foundation":[255],"China":[257],"(81672917,":[258],"81372371)":[259],"Institutes":[263],"Health":[265],"(SC1CA166016":[266],"U01CA086137).":[268],"Citation":[269],"Format:":[270],"Liping":[271],"Dai,":[272],"Jitian":[273],"Li,":[274],"Jun-Chieh":[275],"J.":[276],"Tsay,":[277],"Xiao":[278],"Wang,":[279],"John":[280],"S.":[281],"Munger,":[282],"Harvey":[283],"Pass,":[284],"William":[285],"N.":[286],"Rom,":[287],"Eng":[288],"M.":[289],"Tan,":[290],"Jian-Ying":[291],"Zhang.":[292],"&":[298],"[abstract].":[310],"In:":[311],"Proceedings":[312],"American":[315],"Association":[316],"Cancer":[318,331],"Research":[319],"Annual":[320],"Meeting":[321],"2017;":[322],"2017":[323],"Apr":[324],"1-5;":[325],"Washington,":[326],"DC.":[327],"Philadelphia":[328],"(PA):":[329],"AACR;":[330],"Res":[332],"2017;77(13":[333],"Suppl):Abstract":[334],"nr":[335],"710.":[336],"doi:10.1158/1538-7445.AM2017-710":[337]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-08-08T00:00:00"}
