{"id":"https://openalex.org/W2740728522","doi":"https://doi.org/10.1158/1538-7445.am2017-1839","title":"Abstract 1839: TGFBR1*6A mouse model mimics human breast cancer development and progression","display_name":"Abstract 1839: TGFBR1*6A mouse model mimics human breast cancer development and progression","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2740728522","doi":"https://doi.org/10.1158/1538-7445.am2017-1839","mag":"2740728522"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-1839","doi":"https://doi.org/10.1158/1538-7445.am2017-1839","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-1839","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069512564","display_name":"Michael J. Pennison","orcid":"https://orcid.org/0000-0002-1384-5091","observed_orcids":["https://orcid.org/0000-0002-1384-5091"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael James Pennison","raw_affiliation_strings":["Wake Forest Baptist Medical Center, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Baptist Medical Center, Winston-Salem, NC","institution_ids":["https://openalex.org/I1282516798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100376910","display_name":"Minghui Wang","orcid":"https://orcid.org/0000-0003-3644-7325","observed_orcids":["https://orcid.org/0000-0003-3644-7325","https://orcid.org/0000-0002-8272-2888"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minghui Wang","raw_affiliation_strings":["Wake Forest Baptist Medical Center, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Baptist Medical Center, Winston-Salem, NC","institution_ids":["https://openalex.org/I1282516798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086391254","display_name":"Hugo Jimenez","orcid":"https://orcid.org/0000-0002-4234-7075","observed_orcids":["https://orcid.org/0000-0002-4234-7075"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugo Jimenez","raw_affiliation_strings":["Wake Forest Baptist Medical Center, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Baptist Medical Center, Winston-Salem, NC","institution_ids":["https://openalex.org/I1282516798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042254050","display_name":"Boris Pasche","orcid":"https://orcid.org/0000-0002-3750-7898","observed_orcids":["https://orcid.org/0000-0002-3750-7898"]},"institutions":[{"id":"https://openalex.org/I1282516798","display_name":"Atrium Health Wake Forest Baptist","ror":"https://ror.org/04v8djg66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282516798","https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris Pasche","raw_affiliation_strings":["Wake Forest Baptist Medical Center, Winston-Salem, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest Baptist Medical Center, Winston-Salem, NC","institution_ids":["https://openalex.org/I1282516798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1282516798"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"1839","last_page":"1839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tgf-beta-type-i-receptor","display_name":"TGF-beta type I receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6620000004768372},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.6119999885559082},{"id":"https://openalex.org/keywords/mmtv-neu-transgenic-mice","display_name":"MMTV-neu transgenic mice","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-suppressor-signaling","display_name":"tumor suppressor signaling","score":0.6150000095367432},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6150000095367432},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mouse-model-of-breast-cancer","display_name":"mouse model of breast cancer","score":0.6890000104904175},{"id":"https://openalex.org/keywords/genetic-susceptibility-to-cancer","display_name":"genetic susceptibility to cancer","score":0.5709999799728394},{"id":"https://openalex.org/keywords/tumor-volume","display_name":"tumor volume","score":0.40299999713897705},{"id":"https://openalex.org/keywords/mammary-gland","display_name":"mammary gland","score":0.3330000042915344}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6784197688102722},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6778439879417419},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6181309819221497},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5871762633323669},{"id":"https://openalex.org/C2776187077","wikidata":"https://www.wikidata.org/wiki/Q1888235","display_name":"Mammary tumor","level":4,"score":0.5715426206588745},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.529353678226471},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5130382776260376},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.49589332938194275},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.48034989833831787},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4775334596633911},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4614194333553314},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.388563871383667},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36981236934661865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36421313881874084},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31243598461151123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3030968904495239},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2353224754333496},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21624064445495605}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-1839","doi":"https://doi.org/10.1158/1538-7445.am2017-1839","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-1839","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3179776943","https://openalex.org/W4382048831","https://openalex.org/W7071250711","https://openalex.org/W1988852157","https://openalex.org/W2057476303","https://openalex.org/W1576254015","https://openalex.org/W2040257806","https://openalex.org/W2101195856","https://openalex.org/W1501678287","https://openalex.org/W7097955868"],"abstract_inverted_index":{"Abstract":[0],"Transforming":[1],"Growth":[2],"Factor-\u00df":[3],"(TGF-\u03b2)":[4],"is":[5,58,71],"one":[6],"of":[7,31,85,104,114,142,187,196,216,225,232,241,265,277,333,341,368],"the":[8,21,32,82,115,331,337,369],"most":[9],"commonly":[10],"altered":[11],"cellular":[12],"signaling":[13,65,91],"pathways":[14],"in":[15,48,66,76,310,336],"human":[16,120,298,359],"cancer.":[17,343],"Our":[18,285],"group":[19],"was":[20,249,259],"first":[22],"to":[23,167,175,178,324,328],"discover":[24],"TGFBR1*6A":[25,355],"(*6A),":[26],"a":[27,102,140,322],"common":[28],"hypomorphic":[29],"variant":[30],"type":[33],"I":[34],"TGF-\u00df":[35,90],"receptor":[36],"(TGFBR1),":[37],"which":[38],"has":[39],"been":[40],"associated":[41,59,302],"with":[42,60,73,119,135,303],"increased":[43],"risk":[44],"for":[45,193,205,372],"breast":[46,93,299,342,360],"cancer":[47,94,300,361],"multiple":[49,282],"epidemiological":[50],"studies.":[51,316],"Functional":[52],"analysis":[53,195],"also":[54],"suggests":[55,287],"that":[56,246,288,295],"*6A":[57,86,126,304],"decreased":[61,307],"tumor":[62,68,158,169],"suppressive":[63],"TGF-\u03b2":[64],"early":[67],"development":[69,95,338,362],"and":[70,87,96,127,132,155,202,230,243,255,305,339,363],"involved":[72],"promoting":[74],"tumorigenesis":[75],"advanced":[77],"carcinomas.":[78],"To":[79],"better":[80,329],"understand":[81,330],"functional":[83],"impact":[84],"constitutively":[88,306],"reduced":[89],"on":[92],"progression,":[97],"we":[98,289],"have":[99,290],"recently":[100],"developed":[101,220,237,247,269,281,291],"series":[103],"transgenic":[105,148,292],"knock-in":[106],"mouse":[107,116,149,293,318,356],"model":[108,357],"variants":[109,131,335],"by":[110,314],"replacing":[111],"exon":[112,121],"1":[113,122],"Tgfbr1":[117],"sequence":[118],"sequences":[123],"harboring":[124],"both":[125],"wild-type":[128],"(*9A)":[129],"TGFBR1":[130,308,334],"crossed":[133],"them":[134],"MMTVneu":[136],"mice.":[137],"We":[138],"generated":[139],"total":[141],"5":[143],"FVB":[144],"double":[145],"and/or":[146],"triple":[147],"strains:":[150],"MMTVneu;9A/9A,":[151],"MMTVneu;6A/6A,":[152],"MMTVneu;9A/6A,":[153],"MMTVneu;*9A/-,":[154],"MMTVneu;6A/-.":[156],"Following":[157],"development,":[159],"measurements":[160],"were":[161,173,191,203],"performed":[162,210],"three":[163],"times":[164],"per":[165],"week":[166],"determine":[168],"volume.":[170],"All":[171],"mice":[172,218,227,234,245,253,267,279],"allowed":[174],"live":[176],"up":[177],"18":[179],"months":[180],"(548":[181],"days)":[182],"or":[183,271],"until":[184],"they":[185],"died":[186],"natural":[188],"causes.":[189],"Specimens":[190],"collected":[192],"later":[194],"blood,":[197],"tumors,":[198,222,273],"normal":[199],"mammary":[200,221],"tissue,":[201],"evaluated":[204],"lung":[206],"metastases.":[207],"Statistical":[208],"comparisons":[209],"using":[211],"Student\u2019s":[212],"t-test.":[213],"Only":[214],"34.4%":[215],"MMTVneu;9A/9A":[217,252,278],"(11/32)":[219],"while":[223,274],"80%":[224],"MMTVneu;6A/6A":[226,266],"(24/30;":[228],"p=0.0002)":[229],"62.5%":[231],"MMTVneu;6A/-":[233],"(19/32,":[235],"p=0.046)":[236],"tumors.":[238],"The":[239],"percentage":[240],"MMTVneu;9A/6A":[242],"MMTVneu;*9A/-":[244],"tumors":[248,283],"higher":[250],"than":[251],"(48.3%":[254],"50%,":[256],"respectively)":[257],"but":[258],"not":[260],"statistically":[261],"significant.":[262],"Additionally,":[263],"66.7%":[264],"(20/30)":[268],"2":[270],"more":[272],"only":[275],"25%":[276],"(8/32)":[280],"(p=0.0007).":[284],"data":[286],"strains":[294],"accurately":[296],"mimic":[297],"susceptibility":[301],"expression":[309],"humans,":[311],"as":[312],"evidenced":[313],"other":[315],"These":[317],"models":[319],"may":[320],"be":[321],"tool":[323],"provide":[325],"invaluable":[326],"insight":[327],"role":[332],"progression":[340,364],"Citation":[344],"Format:":[345],"Michael":[346],"James":[347],"Pennison,":[348],"Minghui":[349],"Wang,":[350],"Hugo":[351],"Jimenez,":[352],"Boris":[353],"Pasche.":[354],"mimics":[358],"[abstract].":[365],"In:":[366],"Proceedings":[367],"American":[370],"Association":[371],"Cancer":[373,386],"Research":[374],"Annual":[375],"Meeting":[376],"2017;":[377],"2017":[378],"Apr":[379],"1-5;":[380],"Washington,":[381],"DC.":[382],"Philadelphia":[383],"(PA):":[384],"AACR;":[385],"Res":[387],"2017;77(13":[388],"Suppl):Abstract":[389],"nr":[390],"1839.":[391],"doi:10.1158/1538-7445.AM2017-1839":[392]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2017-08-08T00:00:00"}