{"id":"https://openalex.org/W2740509136","doi":"https://doi.org/10.1158/1538-7445.am2017-4416","title":"Abstract 4416: Studies on role of acyl-CoA cholesterol acyltransferase (ACAT) expression in ovarian/endometrial cancer progression - An invitro study","display_name":"Abstract 4416: Studies on role of acyl-CoA cholesterol acyltransferase (ACAT) expression in ovarian/endometrial cancer progression - An invitro study","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2740509136","doi":"https://doi.org/10.1158/1538-7445.am2017-4416","mag":"2740509136"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-4416","doi":"https://doi.org/10.1158/1538-7445.am2017-4416","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-4416","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041428301","display_name":"Vijayalakshmi N. Ayyagari","orcid":"https://orcid.org/0000-0003-1001-7044","observed_orcids":["https://orcid.org/0000-0003-1001-7044"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijayalakshmi N. Ayyagari","raw_affiliation_strings":["1Southern Illinois Univ., Springfield, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Illinois Univ., Springfield, IL;","institution_ids":["https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101977732","display_name":"Xinjia Wang","orcid":"https://orcid.org/0000-0003-1417-0089","observed_orcids":["https://orcid.org/0000-0003-1417-0089"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinjia Wang","raw_affiliation_strings":["1Southern Illinois Univ., Springfield, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Southern Illinois Univ., Springfield, IL;","institution_ids":["https://openalex.org/I196729704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005661299","display_name":"Laurent Brard","orcid":"https://orcid.org/0000-0003-0065-1826","observed_orcids":["https://orcid.org/0000-0003-0065-1826"]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurent Brard","raw_affiliation_strings":["2Southern Illinois Univ. Simmons Cancer Inst., Springfield, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Southern Illinois Univ. Simmons Cancer Inst., Springfield, IL","institution_ids":["https://openalex.org/I196729704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I196729704"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"4416","last_page":"4416"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acyl-coa-cholesterol-acyltransferase","display_name":"acyl-CoA:cholesterol acyltransferase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/acat1","display_name":"ACAT1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":1.0},{"id":"https://openalex.org/keywords/cholesteryl-esters","display_name":"cholesterol esters","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cholesterol-metabolism","display_name":"cholesterol metabolism","score":0.7429999709129333},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6890000104904175},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5640000104904175},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9259999990463257},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C37002583","wikidata":"https://www.wikidata.org/wiki/Q418755","display_name":"Sterol O-acyltransferase","level":4,"score":0.7730914354324341},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.6313588619232178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5871813893318176},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5852203369140625},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5749227404594421},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.5228036642074585},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5121393203735352},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.4824669659137726},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4775077700614929},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.45233771204948425},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4384400248527527},{"id":"https://openalex.org/C2776448209","wikidata":"https://www.wikidata.org/wiki/Q415555","display_name":"Cholesteryl ester","level":4,"score":0.4328756332397461},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4232769012451172},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4109801948070526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37965282797813416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33538147807121277},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3027368187904358},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.14466506242752075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1211070716381073},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.06938862800598145}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-4416","doi":"https://doi.org/10.1158/1538-7445.am2017-4416","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-4416","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3001832391","https://openalex.org/W119371096","https://openalex.org/W4411475143","https://openalex.org/W2065959557","https://openalex.org/W1476631167","https://openalex.org/W4391576335","https://openalex.org/W2292257040","https://openalex.org/W2344747184","https://openalex.org/W2031540681","https://openalex.org/W4223470676"],"abstract_inverted_index":{"Abstract":[0],"INTRODUCTION:":[1],"Cancer":[2,296,309],"progression":[3,239,283],"and":[4,17,37,47,62,85,107,141,152,163,175,179,194,209,214,234,240],"tumorigenesis":[5],"have":[6,29],"been":[7,30],"linked":[8],"to":[9,221],"alterations":[10],"in":[11,20,32,43,45,68,93,110,114,166,177,212,237,250,280],"cellular":[12],"metabolic":[13],"pathways":[14,140],"of":[15,25,79,81,88,105,124,126,138,156,169,204,232,242,253,274,291],"lipid":[16,69],"cholesterol":[18,26,54,59,108,112,127,235,276],"synthesis":[19],"many":[21],"cancers.":[22,49],"Increased":[23],"levels":[24,165,211],"esters":[27,109,236],"(CE)":[28,67],"reported":[31],"breast":[33],"cancer,":[34,39],"leukemia,":[35],"glioma":[36],"prostate":[38],"but":[40],"not":[41],"exploited":[42],"detail":[44],"ovarian":[46,180,213,243],"endometrial":[48,171,215],"Inside":[50],"cells,":[51],"excess":[52],"free":[53],"is":[55],"esterified":[56],"by":[57,130,188],"acyl-CoA":[58,275],"acyltransferase":[60,277],"(ACAT)":[61,278],"stored":[63],"as":[64,91,219],"cholesteryl":[65],"ester":[66,73],"droplets":[70],"(LDs).":[71],"Cholesteryl":[72],"accumulation":[74],"may":[75,248],"be":[76],"a":[77,167],"consequence":[78],"loss":[80],"tumor":[82],"suppressor":[83],"PTEN":[84],"subsequent":[86,142],"activation":[87],"PI3K/AKT":[89],"pathway":[90],"observed":[92],"pancreatic":[94],"cancer.":[95,244,261],"In":[96],"the":[97,103,122,161,238,251,292],"present":[98],"study,":[99],"we":[100],"focused":[101],"on":[102,144,230,272],"role":[104,273],"ACAT":[106,157,184,233],"altered":[111],"metabolism":[113],"ovarian/endometrial":[115,145,260,281],"cancer":[116,146,172,181,216,282],"cell":[117,150,173,217],"lines.":[118],"METHODS:":[119],"We":[120],"studied":[121,159],"effect":[123,143],"abrogation":[125],"esterification":[128],"either":[129],"an":[131,201],"ACAT-1":[132,205],"inhibitor/shRNA":[133],"knockdown":[134],"or":[135,256],"via":[136],"inhibition":[137],"PI3K/AKT/mTOR":[139],"cells":[147],"proliferation,":[148],"invasion,":[149],"migration":[151],"tumorigenesis.":[153],"The":[154],"expression":[155,185,203,279],"was":[158,186],"at":[160,206],"protein":[162,208],"mRNA":[164,210],"panel":[168],"ovarian/":[170],"lines":[174,218],"also":[176,226],"normal":[178],"clinical":[182],"samples.":[183],"assessed":[187],"western":[189],"blotting,":[190],"ELISA,":[191],"quantitative":[192],"RT-PCR":[193],"immunostaining":[195],"techniques.":[196],"RESULTS:":[197],"Our":[198,224],"results":[199,225],"reveal":[200],"elevated":[202],"both":[207],"compared":[220],"primary":[222],"cells.":[223],"provide":[227],"preliminary":[228],"data":[229],"involvement":[231],"metastasis":[241],"CONCLUSION:":[245],"These":[246],"studies":[247],"aid":[249],"development":[252],"new":[254],"biomarkers":[255],"treatment":[257],"targets":[258],"for":[259,295],"Citation":[262],"Format:":[263],"Vijayalakshmi":[264],"N.":[265],"Ayyagari,":[266],"Xinjia":[267],"Wang,":[268],"Laurent":[269],"Brard.":[270],"Studies":[271],"-":[284],"An":[285],"invitro":[286],"study":[287],"[abstract].":[288],"In:":[289],"Proceedings":[290],"American":[293],"Association":[294],"Research":[297],"Annual":[298],"Meeting":[299],"2017;":[300],"2017":[301],"Apr":[302],"1-5;":[303],"Washington,":[304],"DC.":[305],"Philadelphia":[306],"(PA):":[307],"AACR;":[308],"Res":[310],"2017;77(13":[311],"Suppl):Abstract":[312],"nr":[313],"4416.":[314],"doi:10.1158/1538-7445.AM2017-4416":[315]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2017-08-08T00:00:00"}