{"id":"https://openalex.org/W2740294142","doi":"https://doi.org/10.1158/1538-7445.am2017-141","title":"Abstract 141: CD44 positive and sorafenib resistant hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128","display_name":"Abstract 141: CD44 positive and sorafenib resistant hepatocellular carcinomas respond to the ATP-competitive mTOR inhibitor INK128","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2740294142","doi":"https://doi.org/10.1158/1538-7445.am2017-141","mag":"2740294142"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-141","doi":"https://doi.org/10.1158/1538-7445.am2017-141","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-141","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053949796","display_name":"Mohamed Ali Badawi","orcid":"https://orcid.org/0000-0001-9033-2436","observed_orcids":["https://orcid.org/0000-0001-9033-2436"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed Badawi","raw_affiliation_strings":["1College of Pharmacy, The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1College of Pharmacy, The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384996","display_name":"Jihye Kim","orcid":"https://orcid.org/0000-0002-5719-8180","observed_orcids":["https://orcid.org/0000-0002-5719-8180"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihye Kim","raw_affiliation_strings":["1College of Pharmacy, The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1College of Pharmacy, The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051581077","display_name":"Dhruvitkumar S. Sutaria","orcid":"https://orcid.org/0000-0001-8149-3481","observed_orcids":["https://orcid.org/0000-0001-8149-3481"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhruvitkumar Sutaria","raw_affiliation_strings":["1College of Pharmacy, The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1College of Pharmacy, The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011005834","display_name":"Tasneem Motiwala","orcid":"https://orcid.org/0000-0002-5863-7704","observed_orcids":["https://orcid.org/0000-0002-5863-7704"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tasneem Motiwala","raw_affiliation_strings":["2College of Medicine, The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2College of Medicine, The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008534741","display_name":"Ryan Reyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Reyes","raw_affiliation_strings":["2College of Medicine, The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2College of Medicine, The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024388674","display_name":"Nissar Ahmad Wani","orcid":"https://orcid.org/0000-0002-9248-9039","observed_orcids":["https://orcid.org/0000-0002-9248-9039"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nissar Wani","raw_affiliation_strings":["2College of Medicine, The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2College of Medicine, The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113522352","display_name":"Samson T. Jacob","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samson Jacob","raw_affiliation_strings":["2College of Medicine, The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2College of Medicine, The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066257150","display_name":"Mitch A. Phelps","orcid":"https://orcid.org/0000-0002-1615-5280","observed_orcids":["https://orcid.org/0000-0002-1615-5280"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitch Phelps","raw_affiliation_strings":["1College of Pharmacy, The Ohio State University, Columbus, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1College of Pharmacy, The Ohio State University, Columbus, OH;","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001854674","display_name":"Thomas D. Schmittgen","orcid":"https://orcid.org/0000-0002-2812-8546","observed_orcids":["https://orcid.org/0000-0002-2812-8546"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Schmittgen","raw_affiliation_strings":["3College of Pharmacy, University of Florida, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3College of Pharmacy, University of Florida, Gainesville, FL","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"141","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.08810000121593475,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.9739999771118164},{"id":"https://openalex.org/keywords/sorafenib-resistance","display_name":"sorafenib resistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ink128","display_name":"INK128","score":0.9620000123977661},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9620000123977661},{"id":"https://openalex.org/keywords/4e-bp1-phosphorylation","display_name":"4E-BP1 phosphorylation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5529999732971191},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.44999998807907104},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.7940000295639038},{"id":"https://openalex.org/keywords/huh7-cells","display_name":"Huh7 cells","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.9038031101226807},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.7948280572891235},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7925388813018799},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6315308213233948},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.45804187655448914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4437614381313324},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.42257726192474365},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41579023003578186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35965317487716675},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31792569160461426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26001405715942383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11527803540229797},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.11363354325294495}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-141","doi":"https://doi.org/10.1158/1538-7445.am2017-141","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-141","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2803195783","https://openalex.org/W6992104532","https://openalex.org/W7127368140","https://openalex.org/W2063488708","https://openalex.org/W2072061998","https://openalex.org/W2799303607","https://openalex.org/W2020903165","https://openalex.org/W1971464262","https://openalex.org/W3091458331","https://openalex.org/W2516154528"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"PI3K/AKT/mTOR":[2],"pathway":[3],"is":[4],"activated":[5],"in":[6,60,84,125,173,186,214],"about":[7],"50%":[8],"of":[9,93,110,119,162,207,212,254],"patients":[10,190],"with":[11,76],"hepatocellular":[12,242],"carcinoma":[13],"(HCC).":[14],"Allosteric":[15],"mTOR":[16,46,50,130,157,182,248],"inhibitors,":[17],"also":[18,202],"known":[19],"as":[20,209],"rapalogs,":[21],"fail":[22],"to":[23,32,38,89,106,154,169,199,245],"show":[24],"any":[25],"significant":[26],"clinical":[27],"utility.":[28],"In":[29],"an":[30,167],"effort":[31],"identify":[33],"new":[34],"pathways":[35],"and":[36,55,63,69,72,98,100,139,148,164,194,239],"compounds":[37],"treat":[39],"advanced":[40,188],"HCC,":[41],"we":[42],"considered":[43],"the":[44,102,107,143,155,204,246,255],"ATP-competitive":[45,49,181,247],"inhibitor":[47,158,249],"INK128.":[48,111],"inhibitors":[51,131,183],"attenuate":[52],"both":[53],"mTORC1":[54],"mTORC2.":[56],"We":[57],"evaluated":[58],"INK128":[59,112,135,163,250],"sorafenib":[61,78,149,165,240],"sensitive":[62,105],"insensitive":[64,196],"HCC":[65,71,126,145,151,175,189],"cell":[66,74],"lines,":[67],"CD44low":[68],"CD44high":[70,147,174],"those":[73],"lines":[75],"acquired":[77],"resistance.":[79],"CD44":[80,94,114,208,237],"was":[81],"significantly":[82],"increased":[83],"Huh7":[85],"cells":[86,103,127,152],"made":[87],"resistant":[88,150,198,241],"sorafenib.":[90,200],"Forced":[91],"expression":[92,115],"enhanced":[95],"cellular":[96],"proliferation":[97],"migration,":[99],"rendered":[101],"more":[104],"anti-proliferative":[108,138,171],"effects":[109,141],"suppressed":[113],"by":[116],"blocking":[117],"phosphorylation":[118],"eukaryotic":[120],"translation":[121],"initiation":[122],"factor":[123],"4EBP1":[124],"while":[128],"allosteric":[129,156],"do":[132],"not.":[133],"Moreover,":[134],"exhibited":[136],"potent":[137],"anti-migration":[140],"on":[142],"mesenchymal-like":[144],"cells,":[146],"compared":[153],"everolimus.":[159],"Combination":[160],"studies":[161],"showed":[166],"additive":[168],"synergistic":[170],"effect":[172],"cells.":[176],"Our":[177],"findings":[178],"suggest":[179],"that":[180],"are":[184,195],"effective":[185],"treating":[187],"who":[191],"express":[192],"CD44,":[193],"or":[197],"It":[201],"highlights":[203],"potential":[205],"use":[206],"a":[210],"biomarker":[211],"response":[213],"these":[215],"patients.":[216],"Citation":[217],"Format:":[218],"Mohamed":[219],"Badawi,":[220],"Jihye":[221],"Kim,":[222],"Dhruvitkumar":[223],"Sutaria,":[224],"Tasneem":[225],"Motiwala,":[226],"Ryan":[227],"Reyes,":[228],"Nissar":[229],"Wani,":[230],"Samson":[231],"Jacob,":[232],"Mitch":[233],"Phelps,":[234],"Thomas":[235],"Schmittgen.":[236],"positive":[238],"carcinomas":[243],"respond":[244],"[abstract].":[251],"In:":[252],"Proceedings":[253],"American":[256],"Association":[257],"for":[258],"Cancer":[259,272],"Research":[260],"Annual":[261],"Meeting":[262],"2017;":[263],"2017":[264],"Apr":[265],"1-5;":[266],"Washington,":[267],"DC.":[268],"Philadelphia":[269],"(PA):":[270],"AACR;":[271],"Res":[273],"2017;77(13":[274],"Suppl):Abstract":[275],"nr":[276],"141.":[277],"doi:10.1158/1538-7445.AM2017-141":[278]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2017-08-08T00:00:00"}
