{"id":"https://openalex.org/W2740111909","doi":"https://doi.org/10.1158/1538-7445.am2017-3498","title":"Abstract 3498: Characterization of a novel metastatic lung cancer associated lncRNA","display_name":"Abstract 3498: Characterization of a novel metastatic lung cancer associated lncRNA","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2740111909","doi":"https://doi.org/10.1158/1538-7445.am2017-3498","mag":"2740111909"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-3498","doi":"https://doi.org/10.1158/1538-7445.am2017-3498","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-3498","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024040432","display_name":"Nicole M. A. White","orcid":"https://orcid.org/0000-0003-3928-9502","observed_orcids":["https://orcid.org/0000-0003-3928-9502"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole M. White","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017617254","display_name":"Emily B. Rozycki","orcid":"https://orcid.org/0009-0008-4651-0176","observed_orcids":["https://orcid.org/0009-0008-4651-0176"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily B. Rozycki","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076346004","display_name":"Ha X. Dang","orcid":"https://orcid.org/0000-0002-9342-9249","observed_orcids":["https://orcid.org/0000-0002-9342-9249"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ha X. Dang","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028616783","display_name":"Christopher A. Maher","orcid":"https://orcid.org/0000-0002-9035-603X","observed_orcids":["https://orcid.org/0000-0002-9035-603X","https://orcid.org/0009-0005-1728-4614","https://orcid.org/0000-0002-1628-7857"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. Maher","raw_affiliation_strings":["Washington University School of Medicine, Saint Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington University School of Medicine, Saint Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"3498","last_page":"3498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.8529999852180481},{"id":"https://openalex.org/keywords/lung-cancer-metastasis","display_name":"lung cancer metastasis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ezh2","display_name":"EZH2","score":0.7409999966621399},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/h3k27-methylation","display_name":"H3K27 methylation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/epigenetic-gene-repression","display_name":"epigenetic gene repression","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mall","display_name":"malls","score":0.49300000071525574},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.7868436574935913},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6616334319114685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6473117470741272},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6179488301277161},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5748710036277771},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5282591581344604},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.5222609639167786},{"id":"https://openalex.org/C50171091","wikidata":"https://www.wikidata.org/wiki/Q17917770","display_name":"EZH2","level":4,"score":0.5040756464004517},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46103835105895996},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39207926392555237},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.303941011428833},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21836304664611816},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18744230270385742},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16416215896606445}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-3498","doi":"https://doi.org/10.1158/1538-7445.am2017-3498","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-3498","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3159024074","https://openalex.org/W3193581912","https://openalex.org/W4282942918","https://openalex.org/W2885317814","https://openalex.org/W4285046322","https://openalex.org/W2767606698","https://openalex.org/W4413094485","https://openalex.org/W2741589533","https://openalex.org/W3006402852","https://openalex.org/W3007471236"],"abstract_inverted_index":{"Abstract":[0],"Lung":[1,95],"cancer":[2,96,118,255],"is":[3,29,47,131],"the":[4,11,30,56,122,223,262],"leading":[5],"cause":[6],"of":[7,13,33,58,125,166,204,222,250,261],"death":[8],"worldwide":[9],"with":[10,16,134,182,233],"majority":[12],"patients":[14],"presenting":[15],"metastasis":[17,183],"and":[18,140,163,173,220],"moreover,":[19],"developing":[20],"resistance":[21],"to":[22,69,83,144,152,171,190,226,228],"current":[23],"treatments.":[24],"One":[25],"promising":[26],"therapeutic":[27],"area":[28],"novel":[31,252],"class":[32],"long":[34,72],"noncoding":[35],"RNAs":[36,74],"(lncRNAs).":[37],"While":[38],"emerging":[39],"evidence":[40],"implicates":[41],"them":[42],"in":[43,51,60,79,157,184,193,206],"cancer,":[44,62],"lncRNA":[45,257],"biology":[46],"still":[48],"largely":[49],"unexplored":[50],"tumor":[52,138,208],"metastasis.":[53,146,234],"To":[54],"elucidate":[55],"function":[57],"lncRNAs":[59],"lung":[61,87,117,158,254],"our":[63],"lab":[64],"used":[65],"transcriptome":[66],"sequencing":[67],"(RNA-Seq)":[68],"discover":[70],"120":[71],"non-coding":[73],"(lncRNAs)":[75],"that":[76,121],"are":[77],"enriched":[78,103],"metastatic":[80,100,253],"tumors":[81,101,196],"compared":[82],"their":[84],"corresponding":[85],"primary":[86],"tumors,":[88],"which":[89],"we":[90,148,187],"have":[91,149],"named":[92],"Metastasis":[93],"Associated":[94],"LncRNAs":[97],"(MALLs).":[98],"Notably,":[99],"were":[102],"for":[104,265],"differentially":[105],"expressed":[106],"protein-coding":[107],"genes":[108,143,180,231],"targeted":[109],"by":[110],"Polycomb":[111],"Repressive":[112],"Complex":[113],"2":[114],"(PRC2).":[115],"In":[116],"studies":[119],"show":[120],"catalytic":[123],"subunit":[124],"PRC2,":[126],"EZH2":[127],"(an":[128],"H3K27":[129],"methylase),":[130],"overexpressed,":[132],"associates":[133],"poor":[135],"prognosis,":[136],"promotes":[137,161,213],"progression,":[139],"epigenetically":[141,229],"represses":[142,176],"promote":[145],"Specifically,":[147],"found":[150,188],"MALL-1":[151,189,205,212],"be":[153,191],"(i)":[154],"highly":[155],"up-regulated":[156],"cancer;":[159],"(ii)":[160],"proliferation":[162],"migration/invasion,":[164],"hallmarks":[165],"oncogenic":[167,202],"phenotypes;":[168],"(iii)":[169],"binds":[170],"EZH2;":[172],"(iv)":[174],"cooperatively":[175],"well-known":[177],"PRC2":[178,224],"target":[179],"associated":[181,232,256],"patients.":[185],"Further,":[186],"altered":[192],"multiple":[194],"solid":[195,207],"thus":[197],"suggesting":[198],"a":[199,251],"critical":[200],"conserved":[201],"role":[203],"progression.":[209],"We":[210],"believe":[211],"aggressive":[214],"disease":[215],"through":[216],"its":[217],"interactions":[218],"with,":[219],"recruitment":[221],"complex":[225],"chromatin,":[227],"modify":[230],"Citation":[235],"Format:":[236],"Nicole":[237],"M.":[238],"White,":[239],"Emily":[240],"B.":[241],"Rozycki,":[242],"Ha":[243],"X.":[244],"Dang,":[245],"Christopher":[246],"A.":[247],"Maher.":[248],"Characterization":[249],"[abstract].":[258],"In:":[259],"Proceedings":[260],"American":[263],"Association":[264],"Cancer":[266,279],"Research":[267],"Annual":[268],"Meeting":[269],"2017;":[270],"2017":[271],"Apr":[272],"1-5;":[273],"Washington,":[274],"DC.":[275],"Philadelphia":[276],"(PA):":[277],"AACR;":[278],"Res":[280],"2017;77(13":[281],"Suppl):Abstract":[282],"nr":[283],"3498.":[284],"doi:10.1158/1538-7445.AM2017-3498":[285]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2017-08-08T00:00:00"}