{"id":"https://openalex.org/W2740106368","doi":null,"title":"ORIGINAL COMMUNICATION The \u2018carnivore connection \u2019 \u2014 evolutionary aspects of insulin resistance","display_name":"ORIGINAL COMMUNICATION The \u2018carnivore connection \u2019 \u2014 evolutionary aspects of insulin resistance","publication_year":2014,"publication_date":"2014-11-24","ids":{"openalex":"https://openalex.org/W2740106368","mag":"2740106368"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.452.3533","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.452.3533","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.medicinabiomolecular.com.br/biblioteca/pdfs/Doencas/do-1196.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080414613","display_name":"Stephen Colagiuri","orcid":"https://orcid.org/0000-0002-2398-4781","observed_orcids":["https://orcid.org/0000-0002-2398-4781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Colagiuri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"J Br","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Br","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.7753999829292297,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.07169999927282333,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10140","display_name":"Food composition and properties","score":0.0215000007301569,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hyperinsulinemia","display_name":"hyperinsulinemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dietary-protein","display_name":"dietary protein","score":0.7850000262260437},{"id":"https://openalex.org/keywords/dietary-carbohydrates","display_name":"dietary carbohydrates","score":0.9470000267028809},{"id":"https://openalex.org/keywords/glycemic-index","display_name":"glycemic index","score":0.9929999709129333},{"id":"https://openalex.org/keywords/human-evolution","display_name":"human evolution","score":0.8399999737739563},{"id":"https://openalex.org/keywords/agrarian-change","display_name":"agricultural transformation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/grain-milling","display_name":"grain milling","score":0.7689999938011169},{"id":"https://openalex.org/keywords/postprandial-insulin-response","display_name":"postprandial insulin response","score":0.8360000252723694},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/fast-food","display_name":"fast food","score":0.777999997138977},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8185653686523438},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5905160903930664},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5536441206932068},{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.5180513858795166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4722054898738861},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4578917920589447},{"id":"https://openalex.org/C2778977261","wikidata":"https://www.wikidata.org/wiki/Q11358","display_name":"Carbohydrate","level":2,"score":0.45616111159324646},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45367002487182617},{"id":"https://openalex.org/C163528473","wikidata":"https://www.wikidata.org/wiki/Q81875","display_name":"Carnivore","level":3,"score":0.45253026485443115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32331228256225586},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.11585715413093567},{"id":"https://openalex.org/C188382862","wikidata":"https://www.wikidata.org/wiki/Q170430","display_name":"Predation","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.452.3533","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.452.3533","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.medicinabiomolecular.com.br/biblioteca/pdfs/Doencas/do-1196.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W133939314","https://openalex.org/W1541471661","https://openalex.org/W1885559565","https://openalex.org/W1941327923","https://openalex.org/W1961916049","https://openalex.org/W1969536836","https://openalex.org/W1969572070","https://openalex.org/W1969636761","https://openalex.org/W1975334244","https://openalex.org/W1982549240","https://openalex.org/W1984513597","https://openalex.org/W1988289916","https://openalex.org/W2010832954","https://openalex.org/W2020215578","https://openalex.org/W2022005733","https://openalex.org/W2039169534","https://openalex.org/W2040431516","https://openalex.org/W2043028234","https://openalex.org/W2047590837","https://openalex.org/W2061437752","https://openalex.org/W2062078854","https://openalex.org/W2063389678","https://openalex.org/W2066721691","https://openalex.org/W2076585242","https://openalex.org/W2087553815","https://openalex.org/W2096773810","https://openalex.org/W2110952210","https://openalex.org/W2114738717","https://openalex.org/W2114978780","https://openalex.org/W2133137653","https://openalex.org/W2137407934","https://openalex.org/W2142914825","https://openalex.org/W2146731250","https://openalex.org/W2160234571","https://openalex.org/W2162546421","https://openalex.org/W2166449535","https://openalex.org/W2166577999","https://openalex.org/W2169708340","https://openalex.org/W2258420576","https://openalex.org/W2271821329","https://openalex.org/W2319850088","https://openalex.org/W2327628147","https://openalex.org/W2330340155","https://openalex.org/W2330505590","https://openalex.org/W2409415881"],"related_works":["https://openalex.org/W2059001716","https://openalex.org/W1973736650","https://openalex.org/W1969636761","https://openalex.org/W2103282062","https://openalex.org/W2066589657","https://openalex.org/W2150370135","https://openalex.org/W312672453","https://openalex.org/W2170013846","https://openalex.org/W2107166987","https://openalex.org/W2189276495"],"abstract_inverted_index":{"Insulin":[0,71],"resistance":[1,23,68,72,180],"is":[2,5,24,31,183],"common":[3,185],"and":[4,14,51,53,69,75,102,132,157,160,181,201,220],"determined":[6],"by":[7],"physiological":[8],"(aging,":[9],"physical":[10],"fitness),":[11],"pathological":[12],"(obesity)":[13],"genetic":[15],"factors.":[16],"The":[17,37,140,149],"metabolic":[18],"compensatory":[19],"response":[20],"to":[21,32,210],"insulin":[22,67,161,179,234],"hyperinsulinaemia,":[25],"the":[26,46,54,57,64,79,95,98,103,118,144,193,197,221,231],"primary":[27],"purpose":[28],"of":[29,48,60,66,97,105,120,146,151,178,187,199,216,233],"which":[30,82,87],"maintain":[33],"normal":[34],"glucose":[35],"tolerance.":[36],"\u2018carnivore":[38],"connection":[39],"\u2019":[40,205],"postulates":[41],"a":[42,88,114,128,184,226],"critical":[43],"role":[44],"for":[45],"quantity":[47,119],"dietary":[49,61,107,147],"protein":[50],"carbohydrate":[52,62,108,121,125],"change":[55],"in":[56,63,113,117,137,214,229],"glycaemic":[58,130,159],"index":[59,131],"evolution":[65],"hyperinsulinaemia.":[70],"offered":[73],"survival":[74],"reproductive":[76],"advantages":[77],"during":[78,86],"Ice":[80,100],"Ages":[81],"dominated":[83],"human":[84],"evolution,":[85],"high-protein":[89],"low-carbohydrate":[90],"diet":[91],"was":[92],"consumed.":[93],"Following":[94],"end":[96],"last":[99,194],"Age":[101],"advent":[104],"agriculture,":[106],"increased.":[109],"Although":[110],"this":[111],"resulted":[112],"sharp":[115],"increase":[116],"consumed,":[122],"these":[123],"traditional":[124],"foods":[126,204],"had":[127],"low":[129],"produced":[133],"only":[134],"modest":[135],"increases":[136],"plasma":[138],"insulin.":[139],"industrial":[141],"revolution":[142],"changed":[143],"quality":[145],"carbohydrate.":[148],"milling":[150],"cereals":[152],"made":[153],"starch":[154],"more":[155],"digestible":[156],"postprandial":[158],"responses":[162],"increased":[163],"2":[164],"\u2013":[165],"3":[166],"fold":[167],"compared":[168],"with":[169],"coarsely":[170],"ground":[171],"flour":[172],"or":[173],"whole":[174],"grains.":[175],"This":[176],"combination":[177],"hyperinsulinaemia":[182],"feature":[186],"many":[188],"modern":[189],"day":[190],"diseases.":[191],"Over":[192],"50":[195],"y":[196],"explosion":[198],"convenience":[200],"takeaway":[202],"\u2018fast":[203],"has":[206,224],"exposed":[207],"most":[208],"populations":[209],"caloric":[211],"intakes":[212],"far":[213],"excess":[215],"daily":[217],"energy":[218],"requirements":[219],"resulting":[222],"obesity":[223],"been":[225],"major":[227],"factor":[228],"increasing":[230],"prevalence":[232],"resistance.":[235]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}