{"id":"https://openalex.org/W2739802012","doi":null,"title":"Original Article Associations of LIN-28B/let-7a/IGF-II axis haplotypes with disease survival in epithelial ovarian cancer","display_name":"Original Article Associations of LIN-28B/let-7a/IGF-II axis haplotypes with disease survival in epithelial ovarian cancer","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2739802012","mag":"2739802012"},"language":"en","primary_location":{"id":"mag:2739802012","doi":null,"is_oa":false,"landing_page_url":"http://www.ajceog.us/files/ajceog0008820.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101569049","display_name":"Lingeng Lu","orcid":"https://orcid.org/0000-0001-9871-0809","observed_orcids":["https://orcid.org/0000-0001-9871-0809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingeng Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9871-0809","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029949952","display_name":"Dionyssios Katsaros","orcid":"https://orcid.org/0000-0002-8267-1494","observed_orcids":["https://orcid.org/0000-0002-8267-1494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dionyssios Katsaros","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8267-1494","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082729565","display_name":"Evan Risch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evan Risch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101453053","display_name":"Qian Deng","orcid":"https://orcid.org/0000-0003-0176-5673","observed_orcids":["https://orcid.org/0000-0003-0176-5673"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qian Deng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0176-5673","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089876284","display_name":"Nicoletta Biglia","orcid":"https://orcid.org/0000-0003-1009-5309","observed_orcids":["https://orcid.org/0000-0003-1009-5309","https://orcid.org/0000-0002-1939-018X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicoletta Biglia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1009-5309","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107839676","display_name":"Elisa Picardo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisa Picardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048721156","display_name":"Marco Mitidieri","orcid":"https://orcid.org/0000-0002-8872-9968","observed_orcids":["https://orcid.org/0000-0002-8872-9968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco Mitidieri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8872-9968","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006714908","display_name":"Harvey A. Risch","orcid":"https://orcid.org/0000-0001-5337-3941","observed_orcids":["https://orcid.org/0000-0001-5337-3941"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harvey A. Risch","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5337-3941","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074071367","display_name":"Herbert Yu","orcid":"https://orcid.org/0000-0003-3950-4815","observed_orcids":["https://orcid.org/0000-0003-3950-4815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Herbert Yu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3950-4815","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043162785","display_name":"Anna Siwy-Hudowska","orcid":"https://orcid.org/0000-0002-3026-853X","observed_orcids":["https://orcid.org/0000-0002-3026-853X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Siwy-Hudowska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2071,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.496676,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-ovarian-cancer","display_name":"epithelial ovarian cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/let-7a","display_name":"let-7a","score":0.9819999933242798},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.996999979019165},{"id":"https://openalex.org/keywords/haplotype-association","display_name":"haplotype association","score":0.7310000061988831},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9309999942779541},{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.6230000257492065},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8119999766349792},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7260000109672546},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.984000027179718}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7916106581687927},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.7353245615959167},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.598713219165802},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5667232871055603},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.544672966003418},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5006413459777832},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4987173080444336},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4916897416114807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43917155265808105},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4124252200126648},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4111438989639282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27903926372528076},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2519899606704712},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.07267555594444275}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2739802012","doi":null,"is_oa":false,"landing_page_url":"http://www.ajceog.us/files/ajceog0008820.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W14098964","https://openalex.org/W144423133","https://openalex.org/W1544882311","https://openalex.org/W1578805649","https://openalex.org/W1584107383","https://openalex.org/W1920303762","https://openalex.org/W1964901903","https://openalex.org/W1966111737","https://openalex.org/W1972570808","https://openalex.org/W1973816411","https://openalex.org/W1976810487","https://openalex.org/W1976840283","https://openalex.org/W1979045752","https://openalex.org/W1983031223","https://openalex.org/W1985140771","https://openalex.org/W1986589033","https://openalex.org/W1994786666","https://openalex.org/W1998564647","https://openalex.org/W2002448742","https://openalex.org/W2004714113","https://openalex.org/W2005608256","https://openalex.org/W2006722291","https://openalex.org/W2006797972","https://openalex.org/W2009229545","https://openalex.org/W2009733794","https://openalex.org/W2010352552","https://openalex.org/W2010831747","https://openalex.org/W2019167811","https://openalex.org/W2023372666","https://openalex.org/W2028169705","https://openalex.org/W2029038784","https://openalex.org/W2030714059","https://openalex.org/W2034203463","https://openalex.org/W2034815318","https://openalex.org/W2037995476","https://openalex.org/W2039153962","https://openalex.org/W2044766199","https://openalex.org/W2047333918","https://openalex.org/W2048348557","https://openalex.org/W2049909920","https://openalex.org/W2052360319","https://openalex.org/W2063462827","https://openalex.org/W2065899119","https://openalex.org/W2067213721","https://openalex.org/W2069053277","https://openalex.org/W2074498980","https://openalex.org/W2081835397","https://openalex.org/W2082447405","https://openalex.org/W2082947145","https://openalex.org/W2085463723","https://openalex.org/W2088738576","https://openalex.org/W2089001345","https://openalex.org/W2089171551","https://openalex.org/W2094323986","https://openalex.org/W2097626332","https://openalex.org/W2110666579","https://openalex.org/W2112740613","https://openalex.org/W2113427027","https://openalex.org/W2114896726","https://openalex.org/W2115322004","https://openalex.org/W2116588813","https://openalex.org/W2127951115","https://openalex.org/W2129545382","https://openalex.org/W2132194692","https://openalex.org/W2134823582","https://openalex.org/W2135518377","https://openalex.org/W2137649483","https://openalex.org/W2138069158","https://openalex.org/W2142489285","https://openalex.org/W2144038313","https://openalex.org/W2145702684","https://openalex.org/W2146169914","https://openalex.org/W2146221021","https://openalex.org/W2162001800","https://openalex.org/W2162818680","https://openalex.org/W2165151551","https://openalex.org/W2167116536","https://openalex.org/W2167122992","https://openalex.org/W2171186404","https://openalex.org/W2172157901","https://openalex.org/W2330878435","https://openalex.org/W2404630393"],"related_works":["https://openalex.org/W2029979054","https://openalex.org/W2204086933","https://openalex.org/W2034815318","https://openalex.org/W2106973450","https://openalex.org/W1979301062","https://openalex.org/W3141682987","https://openalex.org/W1995324662","https://openalex.org/W2114896726","https://openalex.org/W2151174073","https://openalex.org/W7166048472"],"abstract_inverted_index":{"The":[0,180],"axis":[1,88,248],"of":[2,103,127,169,237,246],"LIN-28B,":[3],"let-7a":[4,63,107,131],"and":[5,27,98,108,129,132,157,214,241],"IGF-II":[6,30],"has":[7,249],"been":[8],"shown":[9],"to":[10,33,234],"be":[11,34],"involved":[12],"in":[13,25,29,46,60,75,111,145,149],"human":[14],"diseases.":[15],"Several":[16],"func-":[17],"tional":[18],"intronic":[19],"single":[20],"nucleotide":[21],"polymorphisms":[22],"(SNPs)":[23],"rs314276":[24,144],"LIN-28B":[26,146],"rs4320932":[28],"are":[31,231],"found":[32,123],"associated":[35,153,165],"with":[36,91,154,166],"epithelial":[37],"ovarian":[38],"cancer":[39],"(EOC)":[40],"or":[41,48,64],"its":[42],"risk":[43,168],"factors.":[44],"SNPs":[45,74],"pri-":[47],"pre-miRNAs":[49],"may":[50],"affect":[51],"miRNA":[52],"expression,":[53],"but":[54,142],"it":[55],"is":[56,68],"unclear":[57],"whether":[58],"rs731085":[59,104,128,148],"let-7a-3":[61],"influences":[62],"pri-/pre-let-7a-3":[65,109,133],"levels.":[66],"It":[67],"also":[69],"not":[70],"known":[71],"if":[72],"these":[73,96],"combination":[76],"have":[77],"a":[78,176],"joint":[79],"effect":[80,102,253],"on":[81,106,254],"EOC.":[82],"Here":[83],"we":[84],"analyzed":[85],"the":[86,101,125,161,172,211,220,228,235,243,247],"LIN-28B/let-7a/IGF-II":[87],"haplotype-specific":[89,229],"association":[90,121],"EOC":[92,114],"survival":[93],"by":[94],"genotyping":[95],"SNPs,":[97,240],"mainly":[99],"assessed":[100],"genotype":[105,126],"expression":[110],"211":[112],"primary":[113],"samples.":[115],"No":[116],"statistically":[117],"signifi":[118],"-":[119],"cant":[120],"was":[122,151,164,175],"between":[124],"both":[130],"expressions.":[134],"Multivariate":[135],"Cox":[136],"regression":[137],"analyses":[138],"showed":[139],"that":[140,227,242],"rs4320932,":[141,193],"neither":[143],"nor":[147],"let-7a-3,":[150],"significantly":[152],"patient":[155,255],"overall":[156,256],"progression-free":[158],"survival.":[159,257],"Furthermore,":[160],"haplotype":[162,173,212,221,244],"G-C-C":[163,213,245],"increased":[167],"death,":[170],"while":[171],"G-C-T":[174],"favorable":[177],"prognostic":[178],"indicator.":[179],"adjusted":[181],"hazard":[182],"ratios":[183],"for":[184,192,198,204,210,219],"death":[185],"(HRs)":[186],"were":[187],"1.64":[188],"(95%":[189,195,201,207,216],"CI:":[190,196,202,208,217],"1.19-2.26)":[191],"1.13":[194],"0.84-1.51)":[197],"rs314276,":[199],"0.89":[200],"0.66-1.21)":[203],"rs731085,":[205],"7.48":[206],"1.01-55.7)":[209],"0.14":[215],"0.03-0.70)":[218],"G-C-T,":[222],"respectively.":[223],"These":[224],"results":[225],"suggest":[226],"effects":[230],"stronger":[232],"compared":[233],"sum":[236],"three":[238],"individual":[239],"an":[250],"unfavor-":[251],"able":[252]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-08-08T00:00:00"}
