{"id":"https://openalex.org/W2739745603","doi":"https://doi.org/10.1158/1538-7445.am2017-1888","title":"Abstract 1888: 3D matrix confinement triggers vascular mimicry through a conserved migratory and transcriptional response","display_name":"Abstract 1888: 3D matrix confinement triggers vascular mimicry through a conserved migratory and transcriptional response","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2739745603","doi":"https://doi.org/10.1158/1538-7445.am2017-1888","mag":"2739745603"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-1888","doi":"https://doi.org/10.1158/1538-7445.am2017-1888","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-1888","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Daniel Ortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Ortiz","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088713741","display_name":"Brian Tsui","orcid":"https://orcid.org/0000-0001-8017-5895","observed_orcids":["https://orcid.org/0000-0001-8017-5895"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Tsui","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033692701","display_name":"Tyler Goshia","orcid":"https://orcid.org/0000-0002-8533-2340","observed_orcids":["https://orcid.org/0000-0002-8533-2340"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Goshia","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017954175","display_name":"Colleen Ricker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colleen Ricker","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101461760","display_name":"Hannah K. Carter","orcid":"https://orcid.org/0000-0002-1729-2463","observed_orcids":["https://orcid.org/0000-0002-1729-2463"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Carter","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025879044","display_name":"Stephanie I. Fraley","orcid":"https://orcid.org/0000-0003-1548-4442","observed_orcids":["https://orcid.org/0000-0003-1548-4442"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie I. Fraley","raw_affiliation_strings":["University of California, San Diego, La Jolla, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, La Jolla, CA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"1888","last_page":"1888"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasculogenic-mimicry","display_name":"vasculogenic mimicry","score":0.9909999966621399},{"id":"https://openalex.org/keywords/3d-collagen-matrix","display_name":"3D collagen matrix","score":0.8600000143051147},{"id":"https://openalex.org/keywords/collective-cell-migration","display_name":"collective cell migration","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mesenchymal-migration","display_name":"mesenchymal migration","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6579999923706055},{"id":"https://openalex.org/keywords/transcriptional-response","display_name":"transcriptional response","score":0.7440000176429749},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6930000185966492},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6703726649284363},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.6659084558486938},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6122175455093384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5780153274536133},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5252894163131714},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5063613653182983},{"id":"https://openalex.org/C2779944901","wikidata":"https://www.wikidata.org/wiki/Q25324157","display_name":"Vasculogenic mimicry","level":4,"score":0.49292683601379395},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44935253262519836},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4394950270652771},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.36729490756988525},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2783608138561249},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18557602167129517},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1802886724472046}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-1888","doi":"https://doi.org/10.1158/1538-7445.am2017-1888","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-1888","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2769533324","https://openalex.org/W3104740673","https://openalex.org/W7066594956","https://openalex.org/W2888232470","https://openalex.org/W2080522575","https://openalex.org/W2060066380","https://openalex.org/W2594848467","https://openalex.org/W3130807913","https://openalex.org/W2594567071","https://openalex.org/W2003859924"],"abstract_inverted_index":{"Abstract":[0],"An":[1],"initial":[2],"step":[3],"in":[4,23,34,45,99,134,242,255,269],"solid":[5],"tumor":[6,12,40,244],"metastasis":[7,79],"involves":[8],"the":[9,26,65,189,251,279,313],"migration":[10,20,36,69,74,98,125],"of":[11,29,67,90,116,164,192,230,258,312],"cells":[13,41,120,145,165,174,220,259],"through":[14,302],"extracellular":[15],"matrix.":[16],"Several":[17],"cancer":[18,96,119],"cell":[19,97,128,137],"strategies":[21],"exist":[22],"vivo,":[24],"and":[25,51,60,71,93,168,180,233,264,306],"local":[27],"properties":[28],"collagen":[30,88,108,194],"fibers":[31],"are":[32],"implicated":[33],"modulating":[35],"behaviors.":[37],"Yet,":[38],"individual":[39],"also":[42,175],"display":[43],"heterogeneity":[44,62],"their":[46],"intrinsic":[47,59],"ability":[48],"to":[49,56,64,78,126,187,204,267],"migrate":[50],"metastasize.":[52],"It":[53],"remains":[54],"unclear":[55],"what":[57],"extent":[58],"extrinsic":[61],"contribute":[63,76],"emergence":[66],"distinct":[68],"phenotypes":[70,75],"whether":[72],"certain":[73],"more":[77],"than":[80],"others.":[81],"To":[82],"study":[83],"this,":[84],"we":[85,185],"generated":[86],"3D":[87,270,296],"matrices":[89,101],"varying":[91],"densities":[92],"monitored":[94],"single":[95,123],"these":[100,142],"with":[102,130,149],"time-lapse":[103],"microscopy.":[104],"We":[105],"observed":[106],"a":[107,131,154,222,256,261,303],"density":[109],"threshold":[110],"at":[111,278],"2.5mg/ml,":[112],"above":[113],"which":[114],"86%":[115],"MDA-MB-231":[117],"breast":[118],"transition":[121],"from":[122,260],"mesenchymal":[124],"collective":[127],"migration,":[129],"50%":[132],"increase":[133],"persistence":[135],"after":[136],"division.":[138],"After":[139],"seven":[140],"days,":[141],"collectively":[143,218],"migrating":[144,178,219],"created":[146],"networks":[147],"coated":[148],"basement":[150],"membrane":[151],"molecules":[152],"resembling":[153],"clinical":[155],"phenotype":[156,253],"known":[157],"as":[158],"vascular":[159,231,300],"mimicry":[160,301],"(VM).The":[161],"remaining":[162],"14%":[163],"migrated":[166],"randomly":[167],"eventually":[169],"formed":[170],"spheroids.":[171],"HT-1080":[172],"fibrosarcoma":[173],"responded":[176],"similarly,":[177],"persistently":[179],"forming":[181],"cellular":[182],"networks.":[183],"Next":[184],"sought":[186],"identify":[188],"physical":[190],"feature":[191],"high-density":[193],"driving":[195],"VM.":[196,206],"Neither":[197],"hypoxia":[198],"or":[199],"matrix":[200,209,297],"stiffness":[201],"was":[202,275],"sufficient":[203],"induce":[205],"However,":[207],"PEG-induced":[208],"confinement":[210,268,298],"triggered":[211],"VM":[212,252],"network":[213],"formation.":[214],"RNA":[215],"sequencing":[216],"revealed":[217],"up-regulated":[221],"conserved":[223,262,304],"transcriptional":[224,263,307],"program":[225],"significantly":[226],"enriched":[227],"for":[228,316],"annotations":[229],"development":[232],"motility":[234],"regulation":[235],"processes.":[236],"This":[237,273],"gene":[238],"module":[239],"predicted":[240],"survival":[241],"human":[243],"transcriptome":[245],"datasets.":[246],"Our":[247],"results":[248],"suggest":[249],"that":[250],"arises":[254],"subpopulation":[257],"migratory":[265,305],"response":[266,308],"collagen.":[271],"Note:":[272],"abstract":[274],"not":[276],"presented":[277],"meeting.":[280],"Citation":[281],"Format:":[282],"Daniel":[283],"Ortiz,":[284],"Brian":[285],"Tsui,":[286],"Tyler":[287],"Goshia,":[288],"Colleen":[289],"Ricker,":[290],"Hannah":[291],"Carter,":[292],"Stephanie":[293],"I.":[294],"Fraley.":[295],"triggers":[299],"[abstract].":[309],"In:":[310],"Proceedings":[311],"American":[314],"Association":[315],"Cancer":[317,330],"Research":[318],"Annual":[319],"Meeting":[320],"2017;":[321],"2017":[322],"Apr":[323],"1-5;":[324],"Washington,":[325],"DC.":[326],"Philadelphia":[327],"(PA):":[328],"AACR;":[329],"Res":[331],"2017;77(13":[332],"Suppl):Abstract":[333],"nr":[334],"1888.":[335],"doi:10.1158/1538-7445.AM2017-1888":[336]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2017-08-08T00:00:00"}