{"id":"https://openalex.org/W2739733367","doi":"https://doi.org/10.1158/1538-7445.am2017-3191","title":"Abstract 3191: Daytime blue-enriched LED light-induced circadian amplification of the nighttime melatonin signal increases sorafenib sensitivity in human hepatocellular carcinoma via enhanced suppression of the Warburg effect","display_name":"Abstract 3191: Daytime blue-enriched LED light-induced circadian amplification of the nighttime melatonin signal increases sorafenib sensitivity in human hepatocellular carcinoma via enhanced suppression of the Warburg effect","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2739733367","doi":"https://doi.org/10.1158/1538-7445.am2017-3191","mag":"2739733367"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-3191","doi":"https://doi.org/10.1158/1538-7445.am2017-3191","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-3191","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108445496","display_name":"Robert T. Dauchy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Dauchy","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079244519","display_name":"David T. Pointer","orcid":"https://orcid.org/0000-0002-0174-981X","observed_orcids":["https://orcid.org/0000-0002-0174-981X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Pointer","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033174111","display_name":"Aaron E. Hoffman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron E. Hoffman","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037460127","display_name":"Melissa A. Wren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa A. Wren-Dail","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102242095","display_name":"Shulin Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shulin Xiang","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697783","display_name":"Lin Yuan","orcid":"https://orcid.org/0000-0002-6583-7333","observed_orcids":["https://orcid.org/0000-0002-6583-7333"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Yuan","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016402426","display_name":"David E. Blask","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Blask","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043142422","display_name":"Victoria P. Belancio","orcid":"https://orcid.org/0000-0003-2293-6988","observed_orcids":["https://orcid.org/0000-0003-2293-6988"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria P. Belancio","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046305632","display_name":"Steven M. Hill","orcid":"https://orcid.org/0000-0002-5909-692X","observed_orcids":["https://orcid.org/0000-0002-5909-692X"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Hill","raw_affiliation_strings":["Tulane Univ. School of Medicine, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tulane Univ. School of Medicine, New Orleans, LA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"3191","last_page":"3191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.621999979019165},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.7519999742507935},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/warburg-effect","display_name":"Warburg effect","score":0.996999979019165},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-glucose-uptake","display_name":"tumor glucose uptake","score":0.5920000076293945},{"id":"https://openalex.org/keywords/lactic-acid-production","display_name":"lactic acid production","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hepg2-xenograft","display_name":"HepG2 xenograft","score":0.7990000247955322},{"id":"https://openalex.org/keywords/phototherapy","display_name":"phototherapy","score":0.5490000247955322},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.503000020980835},{"id":"https://openalex.org/keywords/pineal-gland","display_name":"pineal gland","score":0.6420000195503235},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8260969519615173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6881965398788452},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.6647953987121582},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6611118316650391},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5997552871704102},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5626243352890015},{"id":"https://openalex.org/C109156525","wikidata":"https://www.wikidata.org/wiki/Q56770304","display_name":"Warburg effect","level":4,"score":0.44046080112457275},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.37929216027259827},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33363717794418335},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2893248498439789},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.190342515707016}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-3191","doi":"https://doi.org/10.1158/1538-7445.am2017-3191","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-3191","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2415536161","https://openalex.org/W2087356637","https://openalex.org/W2034139851","https://openalex.org/W4285206599","https://openalex.org/W3018861914","https://openalex.org/W2769323635","https://openalex.org/W4361816912","https://openalex.org/W1970460092","https://openalex.org/W1980459335","https://openalex.org/W2280419820"],"abstract_inverted_index":{"Abstract":[0],"Over":[1],"36,000":[2],"people":[3],"in":[4,15,31,41,61,80,104,219,241,259,280,363,449],"the":[5,17,28,37,42,52,58,69,75,97,128,148,260,274,291,307,334,343,359,372,386,405,442,457,464],"United":[6],"States":[7],"will":[8],"be":[9],"diagnosed":[10],"with":[11],"hepatocellular":[12,451],"carcinoma":[13,452],"(HCC)":[14],"2016,":[16],"second":[18],"leading":[19],"cause":[20],"of":[21,51,118,147,230,336,404,441,456,463],"cancer":[22,83],"death":[23],"worldwide.":[24],"Metabolic":[25],"pathways":[26],"within":[27],"liver":[29],"and":[30,63,85,172,195,226,232,238,268,318,338,346,375,384],"HCC":[32],"are":[33,358],"highly":[34],"regulated":[35],"by":[36,57,102,312,398],"central":[38],"circadian":[39,53,71,99,368,389,439],"clock":[40],"suprachiastmatic":[43],"nucleus":[44],"(SCN).":[45],"The":[46],"SCN":[47],"drives":[48],"nighttime":[49,70,98,129,137,213,367,443],"production":[50,270],"anti-cancer":[54],"hormone":[55],"melatonin":[56,72,100,130,214,390,401,444],"pineal":[59],"gland":[60],"rats":[62,105,124,282,299],"humans.":[64],"We":[65],"have":[66],"shown":[67],"that":[68,86,255],"signal":[73,101,131,391,445],"suppresses":[74],"Warburg":[76,149,292,308,344,373,406,458],"effect":[77,293,309,345,374,459],"(aerobic":[78],"glycolysis)":[79],"human":[81,450],"breast":[82],"xenografts":[84],"blue-enriched":[87,436],"light":[88],"(460-480":[89],"nm)":[90],"from":[91],"LEDs":[92],"at":[93,252,273],"daytime":[94,116],"(bLAD),":[95],"amplifies":[96,127],"7-fold":[103,217],"over":[106],"cool":[107],"white":[108],"fluorescent":[109],"(CWF)":[110],"lighting.":[111],"Here":[112],"we":[113],"tested":[114],"whether":[115],"exposure":[117],"tissue-isolated":[119],"HepG2":[120,377],"xenograft-bearing":[121],"male":[122],"nude":[123],"to":[125,132,136,154,223,245,352,361,395],"bLAD":[126,177,303,337,339],"increase":[133],"tumor":[134,250,354,378,393],"sensitivity":[135,394,448],"administered":[138],"sorafenib":[139,284,341,369,447],"(FDA-approved":[140],"multi-kinase":[141],"inhibitor)":[142],"treatment":[143],"via":[144,453],"enhancing":[145,399],"suppression":[146,403,455],"effect.":[150,407],"Animals":[151],"were":[152,207,216,235,277],"randomized":[153],"6":[155],"subgroups":[156],"(n":[157],"=":[158],"4):":[159],"CWF":[160,324,381],"Groups":[161,178,220,224],"I,":[162],"12":[163],"h":[164,166],"light:12":[165],"dark":[167],"(LD,12:12)":[168],"(CWF":[169,174],"+":[170,175,182,186,190,198,200,304,325,340],"vehicle)":[171],"II":[173],"sorafenib);":[176],"III":[179,243],"(LD,12bLAD:12)":[180],"(bLAD":[181,185,189,197],"vehicle),":[183],"IV":[184],"sorafenib),":[187],"V":[188],"S20928":[191,199,331],"MT1/MT2":[192],"receptor":[193,329],"blocker),":[194],"VI":[196],"sorafenib).":[201],"Drug":[202],"treatments":[203],"began":[204],"when":[205],"tumors":[206,349],"2.5":[208],"g":[209],"estimated":[210],"weight.":[211],"Plasma":[212],"levels":[215],"higher":[218,258],"III-VI,":[221],"compared":[222,244],"I":[225],"II.":[227],"Tumor":[228,265],"latency-to-onset":[229],"growth":[231,233],"rates":[234],"markedly":[236],"delayed":[237],"decreased,":[239],"respectively,":[240,322],"Group":[242,246],"I.":[247],"Sorafenib":[248],"induced":[249,376],"regression":[251,379,397],"a":[253,400],"rate":[254],"was":[256,294,310],"2-fold":[257],"bLAD-":[261],"vs":[262,285,297,323],"CWF-exposed":[263,281,298],"rats.":[264,327],"glucose":[266],"uptake":[267],"lactate":[269],"(Warburg":[271],"effect)":[272],"mid-dark":[275],"phase":[276],"significantly":[278,295],"reduced":[279,311],"receiving":[283,300],"vehicle.":[286,301],"In":[287,302],"vehicle-treated":[288],"bLAD-exposed":[289],"rats,":[290,306],"decreased":[296],"sorafenib-treated":[305,326],"an":[313],"additional":[314],"51%":[315],"(glucose":[316],"uptake)":[317],"89%":[319],"(lactate":[320],"production),":[321],"Melatonin":[328],"blocker":[330],"completely":[332,350],"prevented":[333],"effects":[335],"on":[342],"made":[347],"these":[348],"resistant":[351],"sorafenib-induced":[353,396],"regression.":[355],"These":[356],"findings":[357],"first":[360],"show":[362],"vivo":[364],"that:":[365],"1)":[366],"therapy":[370],"inhibited":[371],"under":[380],"lighting":[382],"conditions,":[383],"2)":[385],"bLAD-amplified":[387],"nocturnal":[388],"increased":[392],"receptor-mediated":[402],"Citation":[408],"Format:":[409],"Robert":[410],"T.":[411,414],"Dauchy,":[412],"David":[413,426],"Pointer,":[415],"Aaron":[416],"E.":[417,427],"Hoffman,":[418],"Melissa":[419],"A.":[420],"Wren-Dail,":[421],"Shulin":[422],"Xiang,":[423],"Lin":[424],"Yuan,":[425],"Blask,":[428],"Victoria":[429],"P.":[430],"Belancio,":[431],"Steven":[432],"M.":[433],"Hill.":[434],"Daytime":[435],"LED":[437],"light-induced":[438],"amplification":[440],"increases":[446],"enhanced":[454],"[abstract].":[460],"In:":[461],"Proceedings":[462],"American":[465],"Association":[466],"for":[467],"Cancer":[468,481],"Research":[469],"Annual":[470],"Meeting":[471],"2017;":[472],"2017":[473],"Apr":[474],"1-5;":[475],"Washington,":[476],"DC.":[477],"Philadelphia":[478],"(PA):":[479],"AACR;":[480],"Res":[482],"2017;77(13":[483],"Suppl):Abstract":[484],"nr":[485],"3191.":[486],"doi:10.1158/1538-7445.AM2017-3191":[487]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
