{"id":"https://openalex.org/W2739629103","doi":"https://doi.org/10.1158/1538-7445.am2017-5738","title":"Abstract 5738: Tracking the genetic relationship between first and late-onset second urothelial cancers by mutational signature analysis","display_name":"Abstract 5738: Tracking the genetic relationship between first and late-onset second urothelial cancers by mutational signature analysis","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2739629103","doi":"https://doi.org/10.1158/1538-7445.am2017-5738","mag":"2739629103"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-5738","doi":"https://doi.org/10.1158/1538-7445.am2017-5738","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-5738","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xavier Castells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Xavier Castells","raw_affiliation_strings":["1International Agency for Research on Cancer, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1International Agency for Research on Cancer, Lyon, France;","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027145199","display_name":"Maude Ardin","orcid":"https://orcid.org/0009-0005-4798-9009","observed_orcids":["https://orcid.org/0009-0005-4798-9009"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Maude Ardin","raw_affiliation_strings":["1International Agency for Research on Cancer, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1International Agency for Research on Cancer, Lyon, France;","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016754309","display_name":"Sandrine Rorive","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sandrine Rorive","raw_affiliation_strings":["2Pathology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Pathology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058378249","display_name":"Nil\u00fcfer Broeders","orcid":"https://orcid.org/0000-0001-5377-9335","observed_orcids":["https://orcid.org/0000-0001-5377-9335"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nilufer Broeders","raw_affiliation_strings":["3Nephrology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Nephrology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104955885","display_name":"Yan Song","orcid":"https://orcid.org/0000-0002-5955-0205","observed_orcids":["https://orcid.org/0000-0002-5955-0205"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210141458","display_name":"Cancer Hospital of Chinese Academy of Medical Sciences","ror":"https://ror.org/03x937183","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Song","raw_affiliation_strings":["4Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China;","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210141458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083456718","display_name":"St\u00e9phanie Villar","orcid":"https://orcid.org/0009-0005-1502-670X","observed_orcids":["https://orcid.org/0009-0005-1502-670X"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stephanie Villar","raw_affiliation_strings":["1International Agency for Research on Cancer, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1International Agency for Research on Cancer, Lyon, France;","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112599268","display_name":"Christine Carreira","orcid":"https://orcid.org/0000-0002-2225-0348","observed_orcids":["https://orcid.org/0000-0002-2225-0348"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Carreira","raw_affiliation_strings":["1International Agency for Research on Cancer, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1International Agency for Research on Cancer, Lyon, France;","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112739237","display_name":"Pierre\u2010Paul Bringuier","orcid":"https://orcid.org/0000-0001-7865-060X","observed_orcids":["https://orcid.org/0000-0001-7865-060X"]},"institutions":[{"id":"https://openalex.org/I4210123600","display_name":"H\u00f4pital Edouard Herriot","ror":"https://ror.org/02qt1p572","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596","https://openalex.org/I4210123600"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Paul Bringuier","raw_affiliation_strings":["5H\u00f4pital Edouard Herriot, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5H\u00f4pital Edouard Herriot, Lyon, France;","institution_ids":["https://openalex.org/I4210123600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025018584","display_name":"Adriana Heguy","orcid":"https://orcid.org/0000-0002-2836-6683","observed_orcids":["https://orcid.org/0000-0002-2836-6683"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Heguy","raw_affiliation_strings":["6New York University Langone Medical Center, New York, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6New York University Langone Medical Center, New York, NY;","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086445625","display_name":"Thierry Quackels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Thierry Quackels","raw_affiliation_strings":["7Urology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Urology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001474630","display_name":"Thierry Roumegu\u00e8re","orcid":"https://orcid.org/0000-0002-5377-8137","observed_orcids":["https://orcid.org/0000-0002-5377-8137"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Thierry Roumeguere","raw_affiliation_strings":["7Urology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Urology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071554067","display_name":"Jo\u00eblle Nortier","orcid":"https://orcid.org/0000-0003-3609-8217","observed_orcids":["https://orcid.org/0000-0003-3609-8217"]},"institutions":[{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]},{"id":"https://openalex.org/I2802054198","display_name":"Erasmus Hospital","ror":"https://ror.org/05j1gs298","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2802054198"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Joelle Nortier","raw_affiliation_strings":["3Nephrology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Nephrology, Universit\u00e9 Libre de Bruxelles, Erasme University Hospital, Brussels, Belgium;","institution_ids":["https://openalex.org/I132053463","https://openalex.org/I2802054198"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061154196","display_name":"Ji\u0159\u00ed Zavadil","orcid":"https://orcid.org/0000-0003-0640-5562","observed_orcids":["https://orcid.org/0000-0003-0640-5562"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jiri Zavadil","raw_affiliation_strings":["1International Agency for Research on Cancer, Lyon, France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1International Agency for Research on Cancer, Lyon, France;","institution_ids":["https://openalex.org/I42237331"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"5738","last_page":"5738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aristolochic-acid","display_name":"aristolochic acid","score":0.8759999871253967},{"id":"https://openalex.org/keywords/aristolochic-acid-nephropathy","display_name":"aristolochic acid nephropathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8259999752044678},{"id":"https://openalex.org/keywords/secondary-malignancies","display_name":"secondary malignancies","score":0.6039999723434448},{"id":"https://openalex.org/keywords/mutational-signatures","display_name":"mutational signatures","score":0.7829999923706055},{"id":"https://openalex.org/keywords/upper-tract-urothelial-carcinoma","display_name":"upper tract urothelial carcinoma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/urothelial-bladder-cancer","display_name":"bladder urothelial carcinoma","score":0.8119999766349792},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.699999988079071},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6579999923706055},{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"non-negative matrix factorization","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2780813843","wikidata":"https://www.wikidata.org/wiki/Q424210","display_name":"Aristolochic acid","level":2,"score":0.7211726903915405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5934475064277649},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5782797932624817},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5209152102470398},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4551447033882141},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.4547514021396637},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.45062118768692017},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.43693268299102783},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.41184642910957336},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36401665210723877},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.35303932428359985},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32744690775871277},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3202463984489441},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2973442077636719},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.18105170130729675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15988188982009888},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1269058883190155}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-5738","doi":"https://doi.org/10.1158/1538-7445.am2017-5738","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-5738","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3012921809","https://openalex.org/W2117785761","https://openalex.org/W3202238776","https://openalex.org/W2119657975","https://openalex.org/W1647887351","https://openalex.org/W4295567520","https://openalex.org/W1862925265","https://openalex.org/W2969038107","https://openalex.org/W2048174013","https://openalex.org/W1972720153"],"abstract_inverted_index":{"Abstract":[0],"Exposure":[1],"to":[2,17,52,62,69,88,139,200,270,294],"aristolochic":[3,18],"acid":[4,19],"(AA,":[5],"IARC":[6],"Group":[7],"1":[8],"carcinogen)":[9],"present":[10],"in":[11,192,204,222,247,264,317],"some":[12],"traditional":[13],"herbal":[14],"medicines":[15],"leads":[16],"nephropathy":[20],"(AAN),":[21],"often":[22],"complicated":[23],"by":[24,335,379],"development":[25],"of":[26,30,39,44,56,94,106,149,161,170,216,260,273,313,386],"multiple":[27,40],"urothelial":[28,100,262,299,377],"carcinomas":[29,263,300],"sequential":[31],"onset.":[32],"We":[33],"used":[34],"genome-scale":[35],"mutational":[36,202,214,380],"signature":[37,215,220,381],"analysis":[38,93,382],"urinary":[41],"tract":[42,99,159],"tumors":[43,160],"AAN":[45,75,265],"cases":[46],"from":[47,146,154,277],"a":[48,124,134],"unique":[49],"patient":[50,163],"group":[51],"determine":[53],"the":[54,57,63,70,85,115,129,150,155,171,205,213,223,232,239,257,278,286,295,311,336,369,387],"relationships":[55],"patients\u2019":[58],"late-onset":[59,297,375],"second":[60,104,130,229,242,376],"cancers":[61,97,105,131,230,243,378],"AA":[64,89,217,324],"exposure":[65,87],"as":[66,68,226,228,288,290],"well":[67,227,289],"first":[71,96,224,240,373],"cancers.":[72],"Aristolactam-DNA":[73],"adduct-positive":[74],"patients":[76,121,266],"(n=4)":[77],"who":[78],"developed":[79],"cancer":[80,274],"within":[81],"8":[82],"years":[83,110],"following":[84,301],"initial":[86],"were":[90,144],"chosen":[91],"for":[92,390],"their":[95],"(upper":[98],"carcinomas,":[101],"UTUC)":[102],"and":[103,132,153,157,241,304,374],"delayed":[107,258],"onset":[108,259],"(1-9":[109],"after":[111],"first-cancer":[112],"diagnosis,":[113],"involving":[114,231],"bladder":[116,233,261,298,315],"or":[117,168,234,322],"ureteral":[118],"meatus).":[119],"All":[120],"had":[122,133],"received":[123],"kidney":[125,302],"transplant":[126],"before":[127],"developing":[128],"functional":[135],"renal":[136,151],"graft":[137],"prior":[138],"prophylactic":[140],"nephroureterectomy.":[141],"Genomic":[142],"DNAs":[143],"isolated":[145],"FFPE":[147],"sections":[148],"cortex":[152],"upper":[156],"lower":[158,235],"each":[162],"using":[164,182],"laser":[165],"capture":[166],"micro-dissection":[167],"macro-dissection":[169],"tumor":[172,206],"areas.":[173],"Low-coverage":[174],"(~15x)":[175],"exome":[176],"100-bp":[177],"paired-end":[178],"sequencing":[179],"was":[180,198],"performed":[181],"Illumina":[183],"HiSeq2500.":[184],"Customized":[185],"variant":[186],"calling":[187],"identified":[188],"somatic":[189,250],"variants":[190],"absent":[191],"non-tumor":[193],"tissues.":[194,207],"Non-negative":[195],"matrix":[196],"factorization":[197],"applied":[199],"extract":[201],"signatures":[203],"In":[208],"all":[209],"cases,":[210],"we":[211],"established":[212,321],"(the":[218],"COSMIC":[219],"22)":[221],"UTUC":[225,280,306],"ureter":[236],"(meatus).":[237],"Additionally,":[238],"harbored":[244],"considerable":[245],"overlaps":[246],"exposure-specific":[248],"(A>T)":[249],"mutations.":[251],"This":[252],"finding":[253],"provides":[254],"evidence":[255],"that":[256],"is":[267,332],"likely":[268],"due":[269],"distal":[271],"seeding":[272],"cells":[275],"originating":[276],"primary":[279,305],"tumors.":[281],"Our":[282,308],"first-of-its-kind":[283],"study":[284],"addresses":[285],"risk":[287],"mechanistic":[291],"factors":[292],"leading":[293],"second,":[296],"transplantation":[303],"development.":[307],"results":[309],"underline":[310],"importance":[312],"long-term":[314],"follow-up":[316],"high-risk":[318],"populations":[319],"with":[320],"suspected":[323],"exposure.":[325],"Funding:":[326],"IARC;":[327],"NYU":[328],"Genome":[329],"Technology":[330],"Center":[331],"partially":[333],"supported":[334],"NIH/NCI":[337],"(P30CA016087)":[338],"grant.":[339],"Citation":[340],"Format:":[341],"Xavier":[342],"Castells,":[343],"Maude":[344],"Ardin,":[345],"Sandrine":[346],"Rorive,":[347],"Nilufer":[348],"Broeders,":[349],"Yan":[350],"Song,":[351],"Stephanie":[352],"Villar,":[353],"Christine":[354],"Carreira,":[355],"Pierre-Paul":[356],"Bringuier,":[357],"Adriana":[358],"Heguy,":[359],"Thierry":[360,362],"Quackels,":[361],"Roumeguere,":[363],"Joelle":[364],"Nortier,":[365],"Jiri":[366],"Zavadil.":[367],"Tracking":[368],"genetic":[370],"relationship":[371],"between":[372],"[abstract].":[383],"In:":[384],"Proceedings":[385],"American":[388],"Association":[389],"Cancer":[391,404],"Research":[392],"Annual":[393],"Meeting":[394],"2017;":[395],"2017":[396],"Apr":[397],"1-5;":[398],"Washington,":[399],"DC.":[400],"Philadelphia":[401],"(PA):":[402],"AACR;":[403],"Res":[405],"2017;77(13":[406],"Suppl):Abstract":[407],"nr":[408],"5738.":[409],"doi:10.1158/1538-7445.AM2017-5738":[410]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2017-08-08T00:00:00"}
