{"id":"https://openalex.org/W2739602575","doi":"https://doi.org/10.3390/ijms18081657","title":"Polycomb Repressor Complex 2 in Genomic Instability and Cancer","display_name":"Polycomb Repressor Complex 2 in Genomic Instability and Cancer","publication_year":2017,"publication_date":"2017-07-30","ids":{"openalex":"https://openalex.org/W2739602575","doi":"https://doi.org/10.3390/ijms18081657","mag":"2739602575","pmid":"https://pubmed.ncbi.nlm.nih.gov/28758948","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5578047"},"language":"en","primary_location":{"id":"doi:10.3390/ijms18081657","doi":"https://doi.org/10.3390/ijms18081657","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18081657","pdf_url":"https://www.mdpi.com/1422-0067/18/8/1657/pdf?version=1501414396","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/18/8/1657/pdf?version=1501414396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022903359","display_name":"Zoe Veneti","orcid":"https://orcid.org/0009-0008-8535-6511","observed_orcids":["https://orcid.org/0009-0008-8535-6511"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Zoe Veneti","raw_affiliation_strings":["Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005980034","display_name":"Kalliopi K. Gkouskou","orcid":"https://orcid.org/0000-0002-8785-3051","observed_orcids":["https://orcid.org/0000-0002-8785-3051"]},"institutions":[{"id":"https://openalex.org/I40479246","display_name":"Technological Educational Institute of Athens","ror":"https://ror.org/044m46d61","country_code":"GR","type":"education","lineage":["https://openalex.org/I40479246","https://openalex.org/I4210094138"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kalliopi Gkouskou","raw_affiliation_strings":["Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological and Educational Institute of Athens, 12243 Athens, Greece","Embiodiagnostics Ltd., 71202 Heraklion, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratories, Faculty of Health and Caring Professions, Technological and Educational Institute of Athens, 12243 Athens, Greece","institution_ids":["https://openalex.org/I40479246"]},{"raw_affiliation_string":"Embiodiagnostics Ltd., 71202 Heraklion, Greece","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071694950","display_name":"Aristides G. Eliopoulos","orcid":"https://orcid.org/0000-0002-6403-6761","observed_orcids":["https://orcid.org/0000-0002-6403-6761"]},"institutions":[{"id":"https://openalex.org/I142617266","display_name":"University of Crete","ror":"https://ror.org/00dr28g20","country_code":"GR","type":"education","lineage":["https://openalex.org/I142617266"]},{"id":"https://openalex.org/I8901234","display_name":"Foundation for Research and Technology Hellas","ror":"https://ror.org/052rphn09","country_code":"GR","type":"facility","lineage":["https://openalex.org/I8901234"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Aristides Eliopoulos","raw_affiliation_strings":["Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 70013 Heraklion, Greece","Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, 70013 Heraklion, Greece","institution_ids":["https://openalex.org/I8901234"]},{"raw_affiliation_string":"Molecular and Cellular Biology Laboratory, Division of Basic Sciences, University of Crete Medical School, 71003 Heraklion, Greece","institution_ids":["https://openalex.org/I142617266"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071694950"],"corresponding_institution_ids":["https://openalex.org/I142617266","https://openalex.org/I8901234"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.4461,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.41023899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"8","first_page":"1657","last_page":"1657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.9369999766349792},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-1","display_name":"PRC1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.781000018119812},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.824999988079071},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/tumor-suppressor-gene-expression","display_name":"tumor suppressor gene expression","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":1.0},{"id":"https://openalex.org/keywords/dna-replication-fidelity","display_name":"DNA replication fidelity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dietary-intervention","display_name":"dietary intervention","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.876539409160614},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.7833662033081055},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6726540923118591},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6483178734779358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5850175619125366},{"id":"https://openalex.org/C2777116130","wikidata":"https://www.wikidata.org/wiki/Q4082046","display_name":"Polycomb-group proteins","level":5,"score":0.5656087398529053},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4730740487575531},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.47292643785476685},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.4636363387107849},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.44863763451576233},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4371795058250427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37668493390083313},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.34045350551605225},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.333404004573822},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.3181857168674469},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.31068336963653564},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.17788049578666687}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms18081657","doi":"https://doi.org/10.3390/ijms18081657","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18081657","pdf_url":"https://www.mdpi.com/1422-0067/18/8/1657/pdf?version=1501414396","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4479624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5578047","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5578047","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5578047","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:28758948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28758948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ac458c1e9d33454aafbd7201eb0f08a7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ac458c1e9d33454aafbd7201eb0f08a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 18, Iss 8, p 1657 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms18081657","doi":"https://doi.org/10.3390/ijms18081657","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms18081657","pdf_url":"https://www.mdpi.com/1422-0067/18/8/1657/pdf?version=1501414396","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321916","display_name":"State Scholarships Foundation","ror":"https://ror.org/023z3dm33"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2739602575.pdf","grobid_xml":"https://content.openalex.org/works/W2739602575.grobid-xml"},"referenced_works_count":150,"referenced_works":["https://openalex.org/W1491640607","https://openalex.org/W1528589025","https://openalex.org/W1532953497","https://openalex.org/W1600190890","https://openalex.org/W1834568190","https://openalex.org/W1873710893","https://openalex.org/W1896434730","https://openalex.org/W1907727697","https://openalex.org/W1930112233","https://openalex.org/W1963736125","https://openalex.org/W1969485334","https://openalex.org/W1971313898","https://openalex.org/W1972591504","https://openalex.org/W1975678442","https://openalex.org/W1975860179","https://openalex.org/W1977090021","https://openalex.org/W1978251248","https://openalex.org/W1978780879","https://openalex.org/W1982538300","https://openalex.org/W1986531534","https://openalex.org/W1995275377","https://openalex.org/W1995652309","https://openalex.org/W1996487270","https://openalex.org/W1997325237","https://openalex.org/W2001730700","https://openalex.org/W2003613216","https://openalex.org/W2004286348","https://openalex.org/W2004380688","https://openalex.org/W2006788765","https://openalex.org/W2007171597","https://openalex.org/W2008105436","https://openalex.org/W2008376266","https://openalex.org/W2008435686","https://openalex.org/W2009557362","https://openalex.org/W2012028536","https://openalex.org/W2014359105","https://openalex.org/W2014634026","https://openalex.org/W2015863218","https://openalex.org/W2016644845","https://openalex.org/W2017157480","https://openalex.org/W2017444114","https://openalex.org/W2017492512","https://openalex.org/W2018963502","https://openalex.org/W2019828472","https://openalex.org/W2020230403","https://openalex.org/W2024373518","https://openalex.org/W2028101001","https://openalex.org/W2030246401","https://openalex.org/W2031400410","https://openalex.org/W2035208208","https://openalex.org/W2035488182","https://openalex.org/W2037914568","https://openalex.org/W2038676786","https://openalex.org/W2039948198","https://openalex.org/W2045852033","https://openalex.org/W2048074675","https://openalex.org/W2048183749","https://openalex.org/W2048222359","https://openalex.org/W2050419281","https://openalex.org/W2052609775","https://openalex.org/W2052741109","https://openalex.org/W2053823153","https://openalex.org/W2056212435","https://openalex.org/W2057129764","https://openalex.org/W2059581278","https://openalex.org/W2059971436","https://openalex.org/W2061846271","https://openalex.org/W2062484760","https://openalex.org/W2062586342","https://openalex.org/W2064538938","https://openalex.org/W2064871244","https://openalex.org/W2068091527","https://openalex.org/W2070604281","https://openalex.org/W2071988722","https://openalex.org/W2075453277","https://openalex.org/W2075808226","https://openalex.org/W2076266762","https://openalex.org/W2079298594","https://openalex.org/W2082559623","https://openalex.org/W2084295010","https://openalex.org/W2085124573","https://openalex.org/W2085183370","https://openalex.org/W2086333179","https://openalex.org/W2086365180","https://openalex.org/W2092062739","https://openalex.org/W2092761963","https://openalex.org/W2100365251","https://openalex.org/W2102153391","https://openalex.org/W2105154348","https://openalex.org/W2106599226","https://openalex.org/W2109613178","https://openalex.org/W2112983880","https://openalex.org/W2113634596","https://openalex.org/W2114318954","https://openalex.org/W2117532914","https://openalex.org/W2118136541","https://openalex.org/W2121250734","https://openalex.org/W2125496315","https://openalex.org/W2128064256","https://openalex.org/W2131836848","https://openalex.org/W2135871242","https://openalex.org/W2137334102","https://openalex.org/W2137623566","https://openalex.org/W2138867046","https://openalex.org/W2139793965","https://openalex.org/W2142804235","https://openalex.org/W2145163779","https://openalex.org/W2147370638","https://openalex.org/W2148416479","https://openalex.org/W2150135551","https://openalex.org/W2150645494","https://openalex.org/W2153463588","https://openalex.org/W2153537703","https://openalex.org/W2153824687","https://openalex.org/W2153877395","https://openalex.org/W2154170224","https://openalex.org/W2154229063","https://openalex.org/W2155979487","https://openalex.org/W2159249303","https://openalex.org/W2159295674","https://openalex.org/W2163217325","https://openalex.org/W2163913910","https://openalex.org/W2171439874","https://openalex.org/W2181751096","https://openalex.org/W2202440832","https://openalex.org/W2272538773","https://openalex.org/W2274757775","https://openalex.org/W2290001148","https://openalex.org/W2296837482","https://openalex.org/W2297999483","https://openalex.org/W2320983896","https://openalex.org/W2322316999","https://openalex.org/W2340171624","https://openalex.org/W2343932903","https://openalex.org/W2386671561","https://openalex.org/W2473146109","https://openalex.org/W2509824916","https://openalex.org/W2511049107","https://openalex.org/W2515546929","https://openalex.org/W2519181983","https://openalex.org/W2522895022","https://openalex.org/W2588361345","https://openalex.org/W2588561047","https://openalex.org/W2590723071","https://openalex.org/W2595991151","https://openalex.org/W2603804628","https://openalex.org/W2604498317","https://openalex.org/W2720029603","https://openalex.org/W6665930068","https://openalex.org/W6677307833"],"related_works":["https://openalex.org/W2017295967","https://openalex.org/W4389981876","https://openalex.org/W2502703983","https://openalex.org/W2531569648","https://openalex.org/W4388782371","https://openalex.org/W2946544352","https://openalex.org/W2988405541","https://openalex.org/W4293001313","https://openalex.org/W3108237288","https://openalex.org/W2567961077"],"abstract_inverted_index":{"Polycomb":[0],"repressor":[1],"complexes":[2],"PRC1":[3],"and":[4,9,12,29,39,60,79,92],"PRC2":[5,50],"regulate":[6],"chromatin":[7],"compaction":[8],"gene":[10,54],"expression,":[11,55],"are":[13],"widely":[14],"recognized":[15],"for":[16,89],"their":[17],"fundamental":[18],"contributions":[19],"to":[20,36,86],"developmental":[21],"processes.":[22],"Herein,":[23],"we":[24],"summarize":[25],"the":[26,46,56,61,71,75,90],"existing":[27],"evidence":[28],"molecular":[30],"mechanisms":[31],"linking":[32],"PRC-mediated":[33],"epigenetic":[34],"aberrations":[35],"genomic":[37],"instability":[38],"malignancy,":[40],"with":[41],"a":[42],"particular":[43],"focus":[44],"on":[45],"role":[47],"of":[48,63,70,77,94],"deregulated":[49],"in":[51,74],"tumor":[52],"suppressor":[53],"DNA":[57,64],"damage":[58],"response,":[59],"fidelity":[62],"replication.":[65],"We":[66],"also":[67],"discuss":[68],"some":[69],"recent":[72],"advances":[73],"development":[76],"pharmacological":[78],"dietary":[80],"interventions":[81],"affecting":[82],"PRC2,":[83],"which":[84],"point":[85],"promising":[87],"applications":[88],"prevention":[91],"management":[93],"human":[95],"malignancies.":[96]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-08-08T00:00:00"}