{"id":"https://openalex.org/W2739585247","doi":"https://doi.org/10.1158/1538-7445.am2017-2987","title":"Abstract 2987: Validation and clinical feasibility of a comprehensive genomic profiling assay to identify likely immunotherapy responders through tumor mutational burden (TMB)","display_name":"Abstract 2987: Validation and clinical feasibility of a comprehensive genomic profiling assay to identify likely immunotherapy responders through tumor mutational burden (TMB)","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2739585247","doi":"https://doi.org/10.1158/1538-7445.am2017-2987","mag":"2739585247"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2017-2987","doi":"https://doi.org/10.1158/1538-7445.am2017-2987","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-2987","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088627335","display_name":"Daniel S. Lieber","orcid":"https://orcid.org/0000-0001-7190-9383","observed_orcids":["https://orcid.org/0000-0001-7190-9383"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel S. Lieber","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark R. Kennedy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Kennedy","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025067315","display_name":"Douglas Buckner Johnson","orcid":"https://orcid.org/0000-0002-6390-773X","observed_orcids":["https://orcid.org/0000-0002-6390-773X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas B. Johnson","raw_affiliation_strings":["2Vanderbilt University, Nashville, TN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Vanderbilt University, Nashville, TN;","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050435057","display_name":"Jonathan E. Rosenberg","orcid":"https://orcid.org/0000-0003-2637-4249","observed_orcids":["https://orcid.org/0000-0003-2637-4249"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan E. Rosenberg","raw_affiliation_strings":["3Memorial Sloan Kettering Cancer Center, New York, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Memorial Sloan Kettering Cancer Center, New York, MA;","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001204975","display_name":"Marcin Kowanetz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcin Kowanetz","raw_affiliation_strings":["4Genentech, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Genentech, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000119117","display_name":"Joel R. Greenbowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel R. Greenbowe","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071731260","display_name":"Garrett Michael Frampton","orcid":"https://orcid.org/0000-0002-2361-2750","observed_orcids":["https://orcid.org/0000-0002-2361-2750"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett M. Frampton","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023777752","display_name":"Caitlin F. Connelly","orcid":"https://orcid.org/0000-0003-2687-9845","observed_orcids":["https://orcid.org/0000-0003-2687-9845"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin F. Connelly","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062019987","display_name":"Alexa Betzig Schrock","orcid":"https://orcid.org/0000-0003-0106-9096","observed_orcids":["https://orcid.org/0000-0003-0106-9096"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa B. Schrock","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070221807","display_name":"Jeffrey S. Ross","orcid":"https://orcid.org/0000-0001-5865-6828","observed_orcids":["https://orcid.org/0000-0001-5865-6828"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Ross","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113642947","display_name":"Philip J. Stephens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Stephens","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088809839","display_name":"Siraj Mahamed Ali","orcid":"https://orcid.org/0000-0001-7477-4023","observed_orcids":["https://orcid.org/0000-0001-7477-4023"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siraj M. Ali","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111578811","display_name":"Vincent A. Miller","orcid":"https://orcid.org/0000-0003-1667-3771","observed_orcids":["https://orcid.org/0000-0003-1667-3771"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent A. Miller","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002641296","display_name":"David A. Fabrizio","orcid":"https://orcid.org/0000-0001-8088-9476","observed_orcids":["https://orcid.org/0000-0001-8088-9476"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Fabrizio","raw_affiliation_strings":["1Foundation Medicine, Inc., Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Foundation Medicine, Inc., Cambridge, MA;","institution_ids":["https://openalex.org/I4392738181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"13_Supplement","first_page":"2987","last_page":"2987"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.996999979019165},{"id":"https://openalex.org/keywords/comprehensive-genomic-profiling","display_name":"comprehensive genomic profiling","score":0.7919999957084656},{"id":"https://openalex.org/keywords/immunotherapy-response-prediction","display_name":"immunotherapy response prediction","score":0.7820000052452087},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7599999904632568},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.5839999914169312},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9490000009536743},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tumor-purity","display_name":"tumor purity","score":0.847000002861023},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6510000228881836},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6140000224113464},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.4880000054836273},{"id":"https://openalex.org/keywords/assay-validation","display_name":"assay validation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/foundation-medicine","display_name":"Foundation Medicine","score":0.46399998664855957},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.5220000147819519},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.38100001215934753}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5450518131256104},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.49306127429008484},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.485825777053833},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4264981746673584},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.42071324586868286},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.4200384318828583},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.4195341467857361},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.41490858793258667},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4011392295360565},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34858405590057373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3389853835105896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3161529302597046},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3049056828022003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28290629386901855},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.27166005969047546},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2107052505016327},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.19264033436775208}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2017-2987","doi":"https://doi.org/10.1158/1538-7445.am2017-2987","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2017-2987","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2592955236","https://openalex.org/W2890651241","https://openalex.org/W2898462015","https://openalex.org/W4248547935","https://openalex.org/W4391512518","https://openalex.org/W2886136951","https://openalex.org/W2794003569","https://openalex.org/W2913484031","https://openalex.org/W2996276574","https://openalex.org/W2726345695"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Patients":[2],"across":[3,73,141,282,387],"a":[4,28,58,91,167,189,237,283,343,388,447],"range":[5,284],"of":[6,23,49,76,96,170,210,218,239,285,345,362,391,446,465],"disease":[7],"types":[8],"have":[9,350],"demonstrated":[10],"robust":[11],"and":[12,68,89,102,109,137,149,248,259,279,315,333,337,352,396,443],"durable":[13],"responses":[14],"using":[15],"checkpoint":[16],"inhibitor":[17],"therapies":[18],"(CPITs).":[19],"Given":[20],"the":[21,47,161,255,354,381,466],"limitations":[22],"immuno-histochemical":[24],"based":[25,121],"testing,":[26],"identifying":[27],"unified,":[29],"quantitative":[30],"metric":[31],"to":[32,36,87,118,165,223,270,310,379,384,452],"determine":[33,119,176],"potential":[34],"response":[35,67,269,383],"CPITs":[37,72,311,386],"remains":[38],"an":[39,74,115,264],"urgent":[40],"need.":[41],"Tumor":[42],"mutational":[43,287,356,459],"burden":[44,288,357,460],"(TMB)":[45,358,461],"measures":[46],"number":[48,390],"somatic":[50,139],"protein":[51],"coding":[52,162],"mutations":[53,171],"per":[54,172],"target":[55,163],"sequence":[56],"in":[57,106,236,312],"tumor":[59,212,286,297,355,458],"specimen.":[60],"This":[61],"measure":[62,276],"has":[63],"been":[64],"associated":[65,267,306],"with":[66,268,292,307],"survival":[69,235,309],"for":[70,469],"multiple":[71],"array":[75],"indications.":[77],"In":[78],"this":[79],"study":[80],"we":[81,178,253,325],"describe":[82],"Foundation":[83,273],"Medicine\u2019s":[84,274],"(FMI)":[85],"work":[86],"develop":[88],"validate":[90],"TMB":[92,120,130,180,232,258,275,303,332,375],"result":[93],"as":[94,293,295,360],"part":[95,361],"our":[97,125,183,363],"comprehensive":[98,126,184,364,448],"genomic":[99,127,185,366,449],"profiling":[100,128,186,367,450],"assays":[101],"summarize":[103],"clinical":[104,203,370,444],"feasibility":[105,227,371,445],"NSCLC,":[107,313,394],"melanoma":[108,242,314,395],"bladder":[110,316,397],"cancer.":[111,317,398],"Methods":[112],"We":[113,349],"developed":[114,351],"analysis":[116],"method":[117,194],"on":[122,195,290],"data":[123,319],"from":[124,182,221,320],"assays.":[129,368],"is":[131,158],"calculated":[132],"by":[133,160,230],"counting":[134],"all":[135],"synonymous":[136],"non-synonymous":[138],"variants":[140],"315":[142],"or":[143,151],"405":[144],"genes,":[145],"excluding":[146],"germline":[147],"alterations":[148],"known":[150],"likely":[152,382,454],"driver":[153],"alterations.":[154],"The":[155],"mutation":[156,168],"count":[157],"normalized":[159],"territory":[164],"achieve":[166],"density":[169],"megabase":[173],"(mut/Mb).":[174],"To":[175],"accuracy,":[177],"compared":[179],"values":[181,289],"assay":[187,451],"against":[188],"CLIA-validated":[190],"whole-exome":[191],"sequencing":[192],"(WES)":[193],"29":[196],"patients.":[197,251],"Precision":[198],"was":[199,214,228,304],"assessed":[200,229],"over":[201,321],"10":[202],"samples":[204,291,336],"replicated":[205],"4-6":[206],"times.":[207],"Lower":[208],"limit":[209],"sample":[211],"purity":[213],"determined":[215],"through":[216,457],"dilutions":[217],"tumor/normal":[219],"pairs":[220],"80%":[222],"5%":[224],"tumor.":[225],"Clinical":[226],"analyzing":[231],"versus":[233],"immunotherapy-based":[234],"cohort":[238,300],"65":[240],"metastatic":[241],"patients,":[243],"150":[244],"urothelial":[245],"carcinoma":[246],"patients":[247],"463":[249],"NSCLC":[250],"Additionally,":[252],"examined":[254],"relationship":[256],"between":[257,330],"microsatellite":[260],"instability":[261],"status":[262],"(MSI),":[263],"independent":[265],"biomarker":[266,359],"CPITs.":[271],"Results":[272],"provides":[277],"accurate":[278],"precise":[280],"results":[281,372],"little":[294],"20%":[296],"purity.":[298],"Using":[299,318],"specific":[301],"thresholds,":[302],"significantly":[305],"improved":[308],"40,000":[322],"patient":[323],"samples,":[324],"also":[326],"show":[327,338],"significant":[328],"overlap":[329],"high":[331,334],"MSI":[335],"that":[339,374],"MSI-High":[340],"specimens":[341],"represent":[342],"subset":[344],"TMB-High":[346],"specimens.":[347],"Conclusions":[348],"validated":[353],"cancer":[365],"Initial":[369],"demonstrate":[373],"can":[376],"be":[377],"used":[378],"predict":[380],"anti-PD-1/PD-L1":[385],"growing":[389],"indications":[392],"including":[393],"Citation":[399],"Format:":[400],"Daniel":[401],"S.":[402,428],"Lieber,":[403],"Mark":[404],"R.":[405,416],"Kennedy,":[406],"Douglas":[407],"B.":[408,425],"Johnson,":[409],"Jonathan":[410],"E.":[411],"Rosenberg,":[412],"Marcin":[413],"Kowanetz,":[414],"Joel":[415],"Greenbowe,":[417],"Garrett":[418],"M.":[419,434],"Frampton,":[420],"Caitlin":[421],"F.":[422],"Connelly,":[423],"Alexa":[424],"Schrock,":[426],"Jeffrey":[427],"Ross,":[429],"Philip":[430],"J.":[431],"Stephens,":[432],"Siraj":[433],"Ali,":[435],"Vincent":[436],"A.":[437,440],"Miller,":[438],"David":[439],"Fabrizio.":[441],"Validation":[442],"identify":[453],"immunotherapy":[455],"responders":[456],"[abstract].":[462],"In:":[463],"Proceedings":[464],"American":[467],"Association":[468],"Cancer":[470,483],"Research":[471],"Annual":[472],"Meeting":[473],"2017;":[474],"2017":[475],"Apr":[476],"1-5;":[477],"Washington,":[478],"DC.":[479],"Philadelphia":[480],"(PA):":[481],"AACR;":[482],"Res":[484],"2017;77(13":[485],"Suppl):Abstract":[486],"nr":[487],"2987.":[488],"doi:10.1158/1538-7445.AM2017-2987":[489]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2017-08-08T00:00:00"}