{"id":"https://openalex.org/W2738960566","doi":"https://doi.org/10.1016/j.arth.2017.07.024","title":"Local Infiltration Analgesia With Liposomal Bupivacaine Improves Pain Scores and Reduces Opioid Use After Total Knee Arthroplasty: Results of a Randomized Controlled Trial","display_name":"Local Infiltration Analgesia With Liposomal Bupivacaine Improves Pain Scores and Reduces Opioid Use After Total Knee Arthroplasty: Results of a Randomized Controlled Trial","publication_year":2017,"publication_date":"2017-07-25","ids":{"openalex":"https://openalex.org/W2738960566","doi":"https://doi.org/10.1016/j.arth.2017.07.024","mag":"2738960566","pmid":"https://pubmed.ncbi.nlm.nih.gov/28802777"},"language":"en","primary_location":{"id":"doi:10.1016/j.arth.2017.07.024","doi":"https://doi.org/10.1016/j.arth.2017.07.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.arth.2017.07.024","pdf_url":"http://www.arthroplastyjournal.org/article/S088354031730640X/pdf","source":{"id":"https://openalex.org/S48915936","display_name":"The Journal of Arthroplasty","issn_l":"0883-5403","issn":["0883-5403","1532-8406"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Arthroplasty","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.arthroplastyjournal.org/article/S088354031730640X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108083499","display_name":"Michael A. Mont","orcid":"https://orcid.org/0000-0003-4303-5556","observed_orcids":["https://orcid.org/0000-0003-4303-5556"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Mont","raw_affiliation_strings":["Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020196725","display_name":"Walter B. Beaver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130327","display_name":"OrthoCarolina","ror":"https://ror.org/03446fm19","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210130327"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter B. Beaver","raw_affiliation_strings":["Department of Orthopaedic Surgery, OrthoCarolina Hip & Knee Center, Charlotte, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, OrthoCarolina Hip & Knee Center, Charlotte, North Carolina","institution_ids":["https://openalex.org/I4210130327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008507259","display_name":"Stanley H. Dysart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114111","display_name":"Pinnacle Orthopedics","ror":"https://ror.org/025xp7q94","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley H. Dysart","raw_affiliation_strings":["Department of Orthopaedic Surgery, Pinnacle Orthopedics, Marietta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Pinnacle Orthopedics, Marietta, Georgia","institution_ids":["https://openalex.org/I4210114111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088978300","display_name":"John W. Barrington","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John W. Barrington","raw_affiliation_strings":["Department of Orthopaedic Surgery, Joint Replacement Center of Texas, Baylor Medical Center Frisco, Plano, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Joint Replacement Center of Texas, Baylor Medical Center Frisco, Plano, Texas","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010426945","display_name":"Daniel J. Del Gaizo","orcid":"https://orcid.org/0000-0002-6662-1104","observed_orcids":["https://orcid.org/0000-0002-6662-1104"]},"institutions":[{"id":"https://openalex.org/I4210123841","display_name":"University of North Carolina Hospitals","ror":"https://ror.org/0355zfr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1333535994","https://openalex.org/I4210123841"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Del Gaizo","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of North Carolina Hospitals, Chapel Hill, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of North Carolina Hospitals, Chapel Hill, North Carolina","institution_ids":["https://openalex.org/I4210123841"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5108083499"],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":{"value":4650,"currency":"USD","value_usd":4650},"fwci":19.6906,"has_fulltext":true,"cited_by_count":166,"citation_normalized_percentile":{"value":0.99682608,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"33","issue":"1","first_page":"90","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/local-infiltration-analgesia","display_name":"local infiltration analgesia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/liposomal-bupivacaine","display_name":"liposomal bupivacaine","score":1.0},{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":0.9929999709129333},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9129999876022339},{"id":"https://openalex.org/keywords/opioid-consumption","display_name":"opioid consumption","score":0.9739999771118164},{"id":"https://openalex.org/keywords/multimodal-pain-therapy","display_name":"multimodal pain management","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9643746614456177},{"id":"https://openalex.org/C2781328992","wikidata":"https://www.wikidata.org/wiki/Q422806","display_name":"Bupivacaine","level":2,"score":0.7336136698722839},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.7237998843193054},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6705176830291748},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.6414929628372192},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.6269099116325378},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5254111289978027},{"id":"https://openalex.org/C3017871827","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee arthroplasty","level":2,"score":0.5154464840888977},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30762994289398193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15745222568511963},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000698","descriptor_name":"Analgesia","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000779","descriptor_name":"Anesthetics, Local","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002045","descriptor_name":"Bupivacaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006987","descriptor_name":"Hypesthesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006987","descriptor_name":"Hypesthesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006987","descriptor_name":"Hypesthesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Pain, Postoperative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Pain, Postoperative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019645","descriptor_name":"Arthroplasty, Replacement, Knee","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059408","descriptor_name":"Pain Management","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.arth.2017.07.024","doi":"https://doi.org/10.1016/j.arth.2017.07.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.arth.2017.07.024","pdf_url":"http://www.arthroplastyjournal.org/article/S088354031730640X/pdf","source":{"id":"https://openalex.org/S48915936","display_name":"The Journal of Arthroplasty","issn_l":"0883-5403","issn":["0883-5403","1532-8406"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Arthroplasty","raw_type":"journal-article"},{"id":"pmid:28802777","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28802777","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of arthroplasty","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.arth.2017.07.024","doi":"https://doi.org/10.1016/j.arth.2017.07.024","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.arth.2017.07.024","pdf_url":"http://www.arthroplastyjournal.org/article/S088354031730640X/pdf","source":{"id":"https://openalex.org/S48915936","display_name":"The Journal of Arthroplasty","issn_l":"0883-5403","issn":["0883-5403","1532-8406"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Arthroplasty","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6899999976158142}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320314485","display_name":"Pacira Pharmaceuticals","ror":null},{"id":"https://openalex.org/F4320319667","display_name":"Pacira BioSciences","ror":"https://ror.org/00xrkf913"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2738960566.pdf","grobid_xml":"https://content.openalex.org/works/W2738960566.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1848732933","https://openalex.org/W1878911017","https://openalex.org/W1971174434","https://openalex.org/W2008661754","https://openalex.org/W2012950152","https://openalex.org/W2087705479","https://openalex.org/W2091984592","https://openalex.org/W2117937929","https://openalex.org/W2119177577","https://openalex.org/W2134877306","https://openalex.org/W2156074554","https://openalex.org/W2253312057","https://openalex.org/W2257876134","https://openalex.org/W2259082347","https://openalex.org/W2268908362","https://openalex.org/W2280290829","https://openalex.org/W2287021665","https://openalex.org/W2302570558","https://openalex.org/W2338326288","https://openalex.org/W2339304020","https://openalex.org/W2345067312","https://openalex.org/W2396999924","https://openalex.org/W2401664538","https://openalex.org/W2404460296","https://openalex.org/W2463686975","https://openalex.org/W2503782971","https://openalex.org/W2561186204","https://openalex.org/W2590739949","https://openalex.org/W2591605610","https://openalex.org/W2604969244","https://openalex.org/W3129745663","https://openalex.org/W4211036686"],"related_works":["https://openalex.org/W1984168887","https://openalex.org/W3151283371","https://openalex.org/W2025058623","https://openalex.org/W2030413770","https://openalex.org/W2120947904","https://openalex.org/W2130726670","https://openalex.org/W2062112351","https://openalex.org/W2113880444","https://openalex.org/W2414740429","https://openalex.org/W2094718577"],"abstract_inverted_index":{"Background":[0],"Local":[1],"infiltration":[2,94],"analgesia":[3],"(LIA)":[4],"with":[5,30,38,73,79,87,148,175,227,240,254],"liposomal":[6],"bupivacaine":[7,80,88],"(LB)":[8],"in":[9,189],"patients":[10,200,257],"undergoing":[11],"total":[12,129,166],"knee":[13],"arthroplasty":[14],"(TKA)":[15],"has":[16],"yielded":[17],"mixed":[18],"results.":[19],"The":[20,105],"PILLAR":[21],"study,":[22],"which":[23],"was":[24,146,172],"designed":[25],"to":[26,53,71,207,234,250],"minimize":[27],"limitations":[28],"associated":[29],"previous":[31],"studies,":[32],"compared":[33],"the":[34,112,196],"effects":[35],"of":[36,49,115,139,191,198],"LIA":[37,72,86,226,239],"or":[39,85],"without":[40,152,179],"LB":[41,74,149,153,180,192,228,241],"on":[42,225],"pain":[43,100,119,143],"scores,":[44],"opioid":[45,55,130,167,209,246,252],"consumption,":[46,247],"including":[47],"proportion":[48],"opioid-free":[50,199,256],"patients,":[51],"time":[52,206,249],"first":[54,208,251],"rescue,":[56,253],"and":[57,96,128,150,176,205,248,258],"safety":[58,261],"after":[59],"primary":[60],"unilateral":[61],"TKA.":[62,235],"Methods":[63],"Patients":[64],"(":[65,201,211],"N":[66],"=":[67,162,185,213],"140)":[68],"were":[69,103,109,193,216],"randomized":[70],"266":[75],"mg/20":[76],"mL":[77],"(admixed":[78],"HCl":[81,89],"0.5%,":[82,90],"20":[83,91],"mL)":[84],"mL.":[92],"Standardized":[93],"techniques":[95,232],"a":[97],"standardized":[98],"multimodal":[99],"management":[101],"protocol":[102],"used.":[104],"coprimary":[106],"efficacy":[107],"endpoints":[108],"area":[110],"under":[111],"curve":[113],"(AUC)":[114],"visual":[116,140],"analog":[117,141],"scale":[118,142],"intensity":[120,144],"scores":[121],"12-48":[122,125,138],"hours":[123,133,170],"(AUC":[124],")":[126],"postsurgery":[127,171],"consumption":[131,168],"0-48":[132,169],"postsurgery.":[134],"Results":[135],"Mean":[136],"AUC":[137],"score":[145],"180.8":[147],"209.3":[151],"(least":[154],"squares":[155],"[LS]":[156],"mean":[157,165],"treatment":[158],"difference":[159],"\u221226.88,":[160],"P":[161,184,202,212],".0381).":[163],"LS":[164],"18.7":[173],"mg":[174,178],"84.9":[177],"(LS":[181],"ratio":[182],"0.220,":[183],".0048).":[186],"Significant":[187],"differences":[188],"favor":[190],"observed":[194],"for":[195],"percentage":[197],"<":[203],".01)":[204],"rescue":[210],".0230).":[214],"Treatments":[215],"similarly":[217],"well":[218],"tolerated.":[219],"Conclusion":[220],"This":[221],"study":[222],"provides":[223],"data":[224],"administered":[229],"using":[230],"optimal":[231],"specific":[233],"In":[236],"this":[237],"setting,":[238],"significantly":[242],"improved":[243],"postsurgical":[244],"pain,":[245],"more":[255],"no":[259],"unexpected":[260],"concerns.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-21T09:56:26.102985","created_date":"2025-10-10T00:00:00"}