{"id":"https://openalex.org/W2738725848","doi":"https://doi.org/10.1161/circresaha.117.311185","title":"Mast Cells Granular Contents Are Crucial for Deep Vein Thrombosis in Mice","display_name":"Mast Cells Granular Contents Are Crucial for Deep Vein Thrombosis in Mice","publication_year":2017,"publication_date":"2017-07-25","ids":{"openalex":"https://openalex.org/W2738725848","doi":"https://doi.org/10.1161/circresaha.117.311185","mag":"2738725848","pmid":"https://pubmed.ncbi.nlm.nih.gov/28739590","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5623089"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.117.311185","doi":"https://doi.org/10.1161/circresaha.117.311185","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.117.311185","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1161/circresaha.117.311185","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040971522","display_name":"Tatyana Ponomaryov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1308923049","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Tatyana Ponomaryov","raw_affiliation_strings":["From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","institution_ids":["https://openalex.org/I1308923049"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089386271","display_name":"Holly Payne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1308923049","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Holly Payne","raw_affiliation_strings":["From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","institution_ids":["https://openalex.org/I1308923049"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053843507","display_name":"Larissa Fabritz","orcid":"https://orcid.org/0000-0002-9241-1733","observed_orcids":["https://orcid.org/0000-0002-9241-1733"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1308923049","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Larissa Fabritz","raw_affiliation_strings":["From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","institution_ids":["https://openalex.org/I1308923049"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032584210","display_name":"Denisa D. Wagner","orcid":"https://orcid.org/0000-0002-4494-413X","observed_orcids":["https://orcid.org/0000-0002-4494-413X"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1308923049","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Denisa D. Wagner","raw_affiliation_strings":["From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","institution_ids":["https://openalex.org/I1308923049"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049683399","display_name":"Alexander G. Brill","orcid":"https://orcid.org/0000-0002-4558-0390","observed_orcids":["https://orcid.org/0000-0002-4558-0390","https://orcid.org/0000-0002-3224-3651"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1308923049","display_name":"University Hospitals Birmingham NHS Foundation Trust","ror":"https://ror.org/014ja3n03","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Alexander Brill","raw_affiliation_strings":["From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, United Kingdom (T.P., H.P., L.F., A.B.); Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.); Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children\u2019s Hospital, MA; and Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I79619799"]},{"raw_affiliation_string":"Department of Cardiology, University Hospital Birmingham, United Kingdom (L.F.)","institution_ids":["https://openalex.org/I1308923049"]},{"raw_affiliation_string":"Department of Pediatrics, Harvard Medical School, Boston, MA (D.D.W., A.B.)","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Program in Cellular and Molecular Medicine (D.D.W., A.B.) and Division of Hematology/Oncology (D.D.W., A.B.), Boston Children's Hospital, MA","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049683399"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1308923049","https://openalex.org/I136199984","https://openalex.org/I79619799"],"apc_list":null,"apc_paid":{"value":4964,"currency":"EUR","value_usd":5353},"fwci":3.8665,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.94681518,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"121","issue":"8","first_page":"941","last_page":"950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.16519999504089355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mast-cell-deficient-mice","display_name":"mast cell-deficient mice","score":0.8379999995231628},{"id":"https://openalex.org/keywords/inferior-vena-cava-stenosis","display_name":"inferior vena cava stenosis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pulmonary-embolism","display_name":"pulmonary embolism","score":0.7839999794960022},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/platelet-recruitment","display_name":"platelet recruitment","score":0.8420000076293945},{"id":"https://openalex.org/keywords/soluble-p-selectin","display_name":"soluble P-selectin","score":0.9039999842643738},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/compound-48-80","display_name":"compound 48/80","score":0.9679999947547913},{"id":"https://openalex.org/keywords/weibel-palade-bodies","display_name":"Weibel-Palade bodies","score":0.8740000128746033},{"id":"https://openalex.org/keywords/venous-thrombosis-prophylaxis","display_name":"venous thrombosis prevention","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.6669597625732422},{"id":"https://openalex.org/C2778959117","wikidata":"https://www.wikidata.org/wiki/Q430892","display_name":"Deep vein","level":3,"score":0.49628883600234985},{"id":"https://openalex.org/C2779655021","wikidata":"https://www.wikidata.org/wiki/Q1907811","display_name":"Mast (botany)","level":3,"score":0.49609121680259705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41113513708114624},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3496483266353607},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29185742139816284},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.286670982837677},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27017027139663696}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014682","descriptor_name":"Vena Cava, Inferior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014682","descriptor_name":"Vena Cava, Inferior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014682","descriptor_name":"Vena Cava, Inferior","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015550","descriptor_name":"Cell Degranulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019009","descriptor_name":"Proto-Oncogene Proteins c-kit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020246","descriptor_name":"Venous Thrombosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D020302","descriptor_name":"Weibel-Palade Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051149","descriptor_name":"Selenoprotein P","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1161/circresaha.117.311185","doi":"https://doi.org/10.1161/circresaha.117.311185","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.117.311185","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4561962","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5623089","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5623089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5623089","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circ Res","raw_type":"Text"},{"id":"pmid:28739590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28739590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ff0aba52-8283-409c-99e2-8cd00b9bfa10","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5623089","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ponomaryov, T, Payne, H, Fabritz, L, Wagner, D D & Brill, A 2017, 'Mast cells granular contents are crucial for deep vein thrombosis in mice', Circulation Research, vol. 121, no. 8, pp. 941-950. https://doi.org/10.1161/CIRCRESAHA.117.311185","raw_type":"article"},{"id":"pmh:oai:dash.harvard.edu:1/34492147","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492147","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1161/circresaha.117.311185","doi":"https://doi.org/10.1161/circresaha.117.311185","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.117.311185","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G158052130","display_name":"The role of mast cells in deep vein thrombosis","funder_award_id":"PG/13/60/30406","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"},{"id":"https://openalex.org/G792597866","display_name":"How inflammation and thrombosis fuel disease and aging: Focus on NETs","funder_award_id":"R35HL135765","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W109772865","https://openalex.org/W174012016","https://openalex.org/W191284529","https://openalex.org/W1512958442","https://openalex.org/W1561015496","https://openalex.org/W1685305421","https://openalex.org/W1789276389","https://openalex.org/W1878226039","https://openalex.org/W1964292893","https://openalex.org/W1966613914","https://openalex.org/W1974704824","https://openalex.org/W1974725320","https://openalex.org/W1981646849","https://openalex.org/W1981719472","https://openalex.org/W1981961781","https://openalex.org/W1994749414","https://openalex.org/W1997625941","https://openalex.org/W2006276782","https://openalex.org/W2019323469","https://openalex.org/W2028482524","https://openalex.org/W2038163300","https://openalex.org/W2043306284","https://openalex.org/W2059540883","https://openalex.org/W2064369146","https://openalex.org/W2065331625","https://openalex.org/W2068917842","https://openalex.org/W2079113776","https://openalex.org/W2081682917","https://openalex.org/W2091439605","https://openalex.org/W2099894481","https://openalex.org/W2101675655","https://openalex.org/W2102339256","https://openalex.org/W2106301295","https://openalex.org/W2107721410","https://openalex.org/W2109669564","https://openalex.org/W2109963121","https://openalex.org/W2126683943","https://openalex.org/W2133313098","https://openalex.org/W2135782176","https://openalex.org/W2140994013","https://openalex.org/W2143811534","https://openalex.org/W2146959518","https://openalex.org/W2152502508","https://openalex.org/W2158485980","https://openalex.org/W2167377974","https://openalex.org/W2171168738","https://openalex.org/W2172191543","https://openalex.org/W2282197705","https://openalex.org/W2294236942","https://openalex.org/W2372521228","https://openalex.org/W2401886842","https://openalex.org/W2491061016","https://openalex.org/W4229688459"],"related_works":["https://openalex.org/W1997625941","https://openalex.org/W4319461047","https://openalex.org/W2805579393","https://openalex.org/W1994749414","https://openalex.org/W2578853149","https://openalex.org/W2571180398","https://openalex.org/W146864541","https://openalex.org/W2172191543","https://openalex.org/W2610970982","https://openalex.org/W4382141316"],"abstract_inverted_index":{"RATIONALE:":[0],"Deep":[1],"vein":[2,177],"thrombosis":[3,206],"(DVT)":[4],"and":[5,17,43,103,132,203,218],"its":[6],"complication":[7],"pulmonary":[8],"embolism":[9],"have":[10],"high":[11],"morbidity":[12],"reducing":[13],"quality":[14],"of":[15,23,36,67,77,89,106,114,119,128,134,155,184,248],"life":[16],"leading":[18],"to":[19,32,136,237],"death.":[20],"Cellular":[21],"mechanisms":[22],"DVT":[24,41,51,60,143,199,213,249],"initiation":[25,42],"remain":[26],"poorly":[27],"understood.":[28],"OBJECTIVE:":[29],"We":[30,72],"sought":[31],"determine":[33],"the":[34,68,100,104,137],"role":[35],"mast":[37],"cells":[38],"(MCs)":[39],"in":[40,90,99,147,158,162,180,200,207,226,250],"validate":[44],"MCs":[45,81,93,96,108,115,211,232],"as":[46],"a":[47,57,192],"potential":[48,244],"target":[49],"for":[50,80,246],"prevention.":[52],"METHODS":[53],"AND":[54],"RESULTS:":[55],"In":[56],"mouse":[58],"model,":[59],"was":[61],"induced":[62],"by":[63,229],"partial":[64],"ligation":[65],"(stenosis)":[66],"inferior":[69,138],"vena":[70,139],"cava.":[71],"demonstrated":[73],"that":[74],"2":[75],"strains":[76],"mice":[78],"deficient":[79],"were":[82,97,145],"completely":[83],"protected":[84],"from":[85,196],"DVT.":[86,124],"Adoptive":[87],"transfer":[88],"vitro":[91],"differentiated":[92],"restored":[94,205],"thrombosis.":[95,111],"present":[98],"venous":[101],"wall,":[102],"number":[105],"granule-containing":[107],"decreased":[109],"with":[110],"Pharmacological":[112],"depletion":[113],"granules":[116],"or":[117,190],"prevention":[118,247],"MC":[120,165,188],"degranulation":[121],"also":[122],"reduced":[123,146],"Basal":[125],"plasma":[126,153],"levels":[127,154],"von":[129],"Willebrand":[130],"factor":[131],"recruitment":[133],"platelets":[135],"cava":[140],"wall":[141],"after":[142],"induction":[144],"MC-deficient":[148,163,208],"mice.":[149,164],"Stenosis":[150],"application":[151,183],"increased":[152],"soluble":[156],"P-selectin":[157],"wild-type":[159,201],"but":[160],"not":[161,234],"releasate":[166],"elevated":[167],"ICAM-1":[168],"(intercellular":[169],"adhesion":[170],"molecule-1)":[171],"expression":[172],"on":[173],"HUVEC":[174],"(human":[175],"umbilical":[176],"endothelial":[178,216],"cells)":[179],"vitro.":[181],"Topical":[182],"compound":[185],"48/80,":[186],"an":[187],"secretagogue,":[189],"histamine,":[191],"Weibel-Palade":[193,219],"body":[194,220],"secretagogue":[195],"MCs,":[197],"potentiated":[198],"mice,":[202],"histamine":[204],"animals.":[209],"CONCLUSIONS:":[210],"exacerbate":[212],"likely":[214],"through":[215],"activation":[217],"release,":[221],"which":[222],"is,":[223],"at":[224],"least":[225],"part,":[227],"mediated":[228],"histamine.":[230],"Because":[231],"do":[233],"directly":[235],"contribute":[236],"normal":[238],"hemostasis,":[239],"they":[240],"can":[241],"be":[242],"considered":[243],"targets":[245],"humans.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2017-07-31T00:00:00"}
