{"id":"https://openalex.org/W2738655447","doi":"https://doi.org/10.3389/fnagi.2017.00245","title":"Differential Roles of Environmental Enrichment in Alzheimer\u2019s Type of Neurodegeneration and Physiological Aging","display_name":"Differential Roles of Environmental Enrichment in Alzheimer\u2019s Type of Neurodegeneration and Physiological Aging","publication_year":2017,"publication_date":"2017-07-26","ids":{"openalex":"https://openalex.org/W2738655447","doi":"https://doi.org/10.3389/fnagi.2017.00245","mag":"2738655447","pmid":"https://pubmed.ncbi.nlm.nih.gov/28798684","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5526976"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2017.00245","doi":"https://doi.org/10.3389/fnagi.2017.00245","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2017.00245","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2017.00245/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2017.00245/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005141736","display_name":"Vladimir V. Salmin","orcid":"https://orcid.org/0000-0003-4441-9025","observed_orcids":["https://orcid.org/0000-0003-4441-9025"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir V. Salmin","raw_affiliation_strings":["Department of Medical and Biological Physics, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Biological Physics, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017225731","display_name":"Yulia K. Komleva","orcid":"https://orcid.org/0000-0001-5742-8356","observed_orcids":["https://orcid.org/0000-0001-5742-8356"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yulia K. Komleva","raw_affiliation_strings":["Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]},{"raw_affiliation_string":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109047907","display_name":"Natalia V. Kuvacheva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia V. Kuvacheva","raw_affiliation_strings":["Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]},{"raw_affiliation_string":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053205504","display_name":"Andrey V. Morgun","orcid":"https://orcid.org/0000-0002-9644-5500","observed_orcids":["https://orcid.org/0000-0002-9644-5500"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Andrey V. Morgun","raw_affiliation_strings":["Department of Pediatrics, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070963914","display_name":"\u0415. \u0414. \u0425\u0438\u043b\u0430\u0436\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-9718-1260","observed_orcids":["https://orcid.org/0000-0002-9718-1260"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena D. Khilazheva","raw_affiliation_strings":["Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]},{"raw_affiliation_string":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084047325","display_name":"Olga L. Lopatina","orcid":"https://orcid.org/0000-0002-7884-2721","observed_orcids":["https://orcid.org/0000-0002-7884-2721"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga L. Lopatina","raw_affiliation_strings":["Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]},{"raw_affiliation_string":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005509008","display_name":"\u0415. \u0410. \u041f\u043e\u0436\u0438\u043b\u0435\u043d\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-7857-0490","observed_orcids":["https://orcid.org/0000-0001-7857-0490"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Elena A. Pozhilenkova","raw_affiliation_strings":["Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]},{"raw_affiliation_string":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103213525","display_name":"Konstantin A. Shapovalov","orcid":"https://orcid.org/0000-0002-8510-919X","observed_orcids":["https://orcid.org/0000-0002-8510-919X"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Konstantin A. Shapovalov","raw_affiliation_strings":["Department of Medical and Biological Physics, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical and Biological Physics, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102719188","display_name":"Yu. A. Uspenskaya","orcid":"https://orcid.org/0000-0003-4386-9753","observed_orcids":["https://orcid.org/0000-0003-4386-9753"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yulia A. Uspenskaya","raw_affiliation_strings":["Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016722675","display_name":"Alla B. Salmina","orcid":"https://orcid.org/0000-0003-4012-6348","observed_orcids":["https://orcid.org/0000-0003-4012-6348"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alla B. Salmina","raw_affiliation_strings":["Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]},{"raw_affiliation_string":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia","institution_ids":["https://openalex.org/I4210090231"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016722675"],"corresponding_institution_ids":["https://openalex.org/I4210090231"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.9308,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.85561726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"245","last_page":"245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/environmental-enrichment","display_name":"environmental enrichment","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/adult-neurogenesis","display_name":"adult neurogenesis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.7879999876022339},{"id":"https://openalex.org/keywords/neurosphere-formation","display_name":"neurosphere formation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neuroprotective-strategies","display_name":"neuroprotective strategies","score":0.652999997138977},{"id":"https://openalex.org/keywords/pax6","display_name":"Pax6","score":0.5379999876022339},{"id":"https://openalex.org/keywords/ngn2","display_name":"Ngn2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/neurod1","display_name":"NeuroD1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/neun","display_name":"NeuN","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/impedance-spectroscopy","display_name":"impedance spectroscopy","score":0.47999998927116394},{"id":"https://openalex.org/keywords/aged-rats","display_name":"aged rats","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.8612768054008484},{"id":"https://openalex.org/C2781100881","wikidata":"https://www.wikidata.org/wiki/Q21123811","display_name":"NeuN","level":3,"score":0.770738422870636},{"id":"https://openalex.org/C53927964","wikidata":"https://www.wikidata.org/wiki/Q3054611","display_name":"Environmental enrichment","level":2,"score":0.7564013004302979},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7414753437042236},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6999432444572449},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6353037357330322},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.622394323348999},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6151027679443359},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5746537446975708},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5600388050079346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.553983211517334},{"id":"https://openalex.org/C162746124","wikidata":"https://www.wikidata.org/wiki/Q7002675","display_name":"Neurosphere","level":5,"score":0.47258031368255615},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.2780390977859497},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.25319162011146545},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21599441766738892},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20546773076057434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16216135025024414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15253198146820068},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12296950817108154},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnagi.2017.00245","doi":"https://doi.org/10.3389/fnagi.2017.00245","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2017.00245","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2017.00245/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5526976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5526976","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Aging Neurosci","raw_type":"Text"},{"id":"pmid:28798684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28798684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in aging neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a4dd7fbe8ba44434866e3def560050e3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a4dd7fbe8ba44434866e3def560050e3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 9 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2017.00245","doi":"https://doi.org/10.3389/fnagi.2017.00245","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2017.00245","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnagi.2017.00245/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2738655447.pdf","grobid_xml":"https://content.openalex.org/works/W2738655447.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W51964316","https://openalex.org/W145265252","https://openalex.org/W605396897","https://openalex.org/W1520624253","https://openalex.org/W1524688016","https://openalex.org/W1526640848","https://openalex.org/W1530064533","https://openalex.org/W1545082774","https://openalex.org/W1567578874","https://openalex.org/W1577872131","https://openalex.org/W1589552381","https://openalex.org/W1716345204","https://openalex.org/W1911628067","https://openalex.org/W1925906507","https://openalex.org/W1965648790","https://openalex.org/W1967137091","https://openalex.org/W1970697771","https://openalex.org/W1978453599","https://openalex.org/W2010432189","https://openalex.org/W2019779766","https://openalex.org/W2020256588","https://openalex.org/W2024782827","https://openalex.org/W2025042523","https://openalex.org/W2043031260","https://openalex.org/W2045066990","https://openalex.org/W2048279924","https://openalex.org/W2048499770","https://openalex.org/W2049590463","https://openalex.org/W2055804501","https://openalex.org/W2060025652","https://openalex.org/W2066746555","https://openalex.org/W2068201611","https://openalex.org/W2072024872","https://openalex.org/W2075943282","https://openalex.org/W2077599130","https://openalex.org/W2083482927","https://openalex.org/W2088200315","https://openalex.org/W2089771991","https://openalex.org/W2092717795","https://openalex.org/W2094573053","https://openalex.org/W2106831544","https://openalex.org/W2109500726","https://openalex.org/W2120030821","https://openalex.org/W2135046848","https://openalex.org/W2139411299","https://openalex.org/W2141070041","https://openalex.org/W2143023796","https://openalex.org/W2148778462","https://openalex.org/W2153900148","https://openalex.org/W2158186731","https://openalex.org/W2160626501","https://openalex.org/W2164528882","https://openalex.org/W2166184830","https://openalex.org/W2174079611","https://openalex.org/W2296995756","https://openalex.org/W2322460682","https://openalex.org/W2337071721","https://openalex.org/W2346727851","https://openalex.org/W2409842303","https://openalex.org/W2462368251","https://openalex.org/W2492926495","https://openalex.org/W2530627152","https://openalex.org/W2537214690","https://openalex.org/W2566457502"],"related_works":["https://openalex.org/W1978610757","https://openalex.org/W1976212770","https://openalex.org/W4295078807","https://openalex.org/W2071004833","https://openalex.org/W1981559763","https://openalex.org/W2041320147","https://openalex.org/W1997170399","https://openalex.org/W2796425517","https://openalex.org/W2596881535","https://openalex.org/W2344798939"],"abstract_inverted_index":{"Impairment":[0],"of":[1,18,34,75,86,97,110,122,140,157,164,171,183,215,235],"hippocampal":[2,79,87,184,236],"adult":[3,142,191],"neurogenesis":[4,80],"in":[5,24,62,81,90,137,153,168,174,189,195,208,226,232,239,241,245,256],"aging":[6,102],"or":[7,32,144,247],"degenerating":[8],"brain":[9,19,50,101,258],"is":[10],"a":[11,45],"well-known":[12],"phenomenon":[13],"caused":[14],"by":[15],"the":[16,25,29,73,107,120,138,162,196,201,209,223,233],"shortage":[17],"stem":[20,35,126],"cell":[21,36,172],"pool,":[22],"alterations":[23],"local":[26],"microenvironment":[27],"within":[28],"neurogenic":[30,237],"niches,":[31],"deregulation":[33],"development.":[37],"Environmental":[38],"enrichment":[39,77,117,217],"(EE)":[40],"has":[41],"been":[42],"proposed":[43],"as":[44],"potent":[46],"tool":[47],"to":[48,52,57,200,264],"restore":[49,180],"functions,":[51],"prevent":[53],"aging-associated":[54],"neurodegeneration,":[55],"and":[56,64,83,99,130],"cure":[58],"neuronal":[59],"deficits":[60],"seen":[61],"neurodevelopmental":[63],"neurodegenerative":[65],"disorders.":[66],"Here":[67],"we":[68],"report":[69],"our":[70],"data":[71],"on":[72,78],"effects":[74],"environmental":[76,116,216],"vivo":[82],"neurosphere-forming":[84,181],"capacity":[85,182],"stem/progenitor":[88,185],"cells":[89,129,186],"vitro.":[91],"Two":[92],"models":[93],"-":[94],"Alzheimer\u2019s":[95,147,202],"type":[96],"neurodegeneration":[98],"physiological":[100],"\u2013":[103],"were":[104],"chosen":[105],"for":[106,125,161],"comparative":[108],"analysis":[109,163],"EE":[111,178,228],"effects.":[112],"We":[113],"found":[114],"that":[115,177],"greatly":[118],"affects":[119],"expression":[121],"markers":[123],"specific":[124],"cells,":[127],"progenitor":[128],"differentiated":[131],"neurons":[132],"(Pax6,":[133],"Ngn2,":[134],"NeuroD1,":[135],"NeuN)":[136],"hippocampus":[139],"young":[141,190,248],"rats":[143,145,211],"with":[146,222],"disease":[148,203],"model":[149,160,204],"but":[150,206,243],"less":[151],"efficiently":[152,188],"aged":[154,210,265],"animals.":[155],"Application":[156],"time-lag":[158],"mathematical":[159],"impedance":[165],"traces":[166],"obtained":[167,225],"real-time":[169],"monitoring":[170],"proliferation":[173],"vitro":[175,240],"revealed":[176],"could":[179,259],"more":[187],"animals":[192],"(4-fold":[193],"greater":[194],"control":[197],"group":[198],"comparing":[199],"group)":[205],"not":[207,244,260],"(no":[212],"positive":[213],"effect":[214],"at":[218],"all).":[219],"In":[220],"accordance":[221],"results":[224],"vivo,":[227],"was":[229],"almost":[230],"ineffective":[231],"recovery":[234],"reserve":[238],"aged,":[242],"amyloid-treated":[246],"adult,":[249],"rats.":[250],"Therefore,":[251],"EE-based":[252],"neuroprotective":[253],"strategies":[254],"effective":[255],"A\u03b2-affected":[257],"be":[261],"directly":[262],"extrapolated":[263],"brain.":[266]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-07-31T00:00:00"}