{"id":"https://openalex.org/W2737873151","doi":"https://doi.org/10.3390/molecules22071211","title":"Synthesis, Antitumor Evaluation and Molecular Docking of New Morpholine Based Heterocycles","display_name":"Synthesis, Antitumor Evaluation and Molecular Docking of New Morpholine Based Heterocycles","publication_year":2017,"publication_date":"2017-07-20","ids":{"openalex":"https://openalex.org/W2737873151","doi":"https://doi.org/10.3390/molecules22071211","mag":"2737873151","pmid":"https://pubmed.ncbi.nlm.nih.gov/28726760","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6152077"},"language":"en","primary_location":{"id":"doi:10.3390/molecules22071211","doi":"https://doi.org/10.3390/molecules22071211","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules22071211","pdf_url":"https://www.mdpi.com/1420-3049/22/7/1211/pdf?version=1500553688","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/22/7/1211/pdf?version=1500553688","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039363446","display_name":"Zeinab A. Muhammad","orcid":"https://orcid.org/0000-0003-1711-8497","observed_orcids":["https://orcid.org/0000-0003-1711-8497"]},"institutions":[{"id":"https://openalex.org/I4210136593","display_name":"National Organization for Drug Control and Research","ror":"https://ror.org/0407ex783","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210136593","https://openalex.org/I4210160667","https://openalex.org/I4405259620"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Zeinab Muhammad","raw_affiliation_strings":["Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt","institution_ids":["https://openalex.org/I4210136593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002475341","display_name":"Mastoura Mohamed Edrees","orcid":"https://orcid.org/0000-0002-2301-7652","observed_orcids":["https://orcid.org/0000-0002-2301-7652"]},"institutions":[{"id":"https://openalex.org/I4210136593","display_name":"National Organization for Drug Control and Research","ror":"https://ror.org/0407ex783","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210136593","https://openalex.org/I4210160667","https://openalex.org/I4405259620"]},{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Mastoura Edrees","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia","Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-2301-7652","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]},{"raw_affiliation_string":"Department of Organic Chemistry, National Organization for Drug Control and Research (NODCAR), Giza 12311, Egypt","institution_ids":["https://openalex.org/I4210136593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027201395","display_name":"Rasha A. M. Faty","orcid":"https://orcid.org/0000-0002-9259-1797","observed_orcids":["https://orcid.org/0000-0002-9259-1797"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rasha Faty","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075917911","display_name":"Sobhi M. Gomha","orcid":"https://orcid.org/0000-0002-7739-2837","observed_orcids":["https://orcid.org/0000-0002-7739-2837"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Sobhi Gomha","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-7739-2837","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt","institution_ids":["https://openalex.org/I145487455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073689703","display_name":"Seham Soliman Alterary","orcid":"https://orcid.org/0000-0002-4176-2840","observed_orcids":["https://orcid.org/0000-0002-4176-2840"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Seham Alterary","raw_affiliation_strings":["Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038486773","display_name":"Yahia N. Mabkhot","orcid":"https://orcid.org/0000-0002-9762-0323","observed_orcids":["https://orcid.org/0000-0002-9762-0323","https://orcid.org/0000-0002-2120-7567"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Yahia Mabkhot","raw_affiliation_strings":["Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-9762-0323","affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038486773","https://openalex.org/A5075917911"],"corresponding_institution_ids":["https://openalex.org/I145487455","https://openalex.org/I28022161"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.9535,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.66974439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"7","first_page":"1211","last_page":"1211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13208","display_name":"Synthesis of heterocyclic compounds","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morpholine-derivatives","display_name":"morpholine derivatives","score":0.6930000185966492},{"id":"https://openalex.org/keywords/hydrazonoyl-chlorides","display_name":"hydrazonoyl chlorides","score":0.8289999961853027},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.800000011920929},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7850000262260437},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8669999837875366},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7450000047683716},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2781056017","wikidata":"https://www.wikidata.org/wiki/Q410243","display_name":"Morpholine","level":2,"score":0.8680624961853027},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7269073128700256},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5815843939781189},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.566945493221283},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.538673460483551},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5286185145378113},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5045019388198853},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.4984004497528076},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.43104827404022217},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4241583049297333},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4190228581428528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2394639551639557},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.17826640605926514},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.17481300234794617},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16326594352722168},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08756375312805176},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072283","descriptor_name":"A549 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047188","descriptor_name":"Chalcones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/molecules22071211","doi":"https://doi.org/10.3390/molecules22071211","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules22071211","pdf_url":"https://www.mdpi.com/1420-3049/22/7/1211/pdf?version=1500553688","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5174887","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6152077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:28726760","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28726760","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6152077","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6152077/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:338a433166c44227a95b33885ddb34d9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/338a433166c44227a95b33885ddb34d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 22, Iss 7, p 1211 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules22071211","doi":"https://doi.org/10.3390/molecules22071211","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules22071211","pdf_url":"https://www.mdpi.com/1420-3049/22/7/1211/pdf?version=1500553688","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2256046612","display_name":null,"funder_award_id":"PRG-1437-29","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"}],"funders":[{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2737873151.pdf","grobid_xml":"https://content.openalex.org/works/W2737873151.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1966004473","https://openalex.org/W1975567389","https://openalex.org/W1983606421","https://openalex.org/W1985304583","https://openalex.org/W1988935135","https://openalex.org/W1989945031","https://openalex.org/W2009397812","https://openalex.org/W2012719103","https://openalex.org/W2013009346","https://openalex.org/W2014291309","https://openalex.org/W2015993339","https://openalex.org/W2022879641","https://openalex.org/W2023093323","https://openalex.org/W2024138049","https://openalex.org/W2035073862","https://openalex.org/W2037203845","https://openalex.org/W2046787132","https://openalex.org/W2062136458","https://openalex.org/W2066603944","https://openalex.org/W2078611034","https://openalex.org/W2081255946","https://openalex.org/W2114918609","https://openalex.org/W2135732933","https://openalex.org/W2145121667","https://openalex.org/W2154993472","https://openalex.org/W2160230313","https://openalex.org/W2165751339","https://openalex.org/W2171347612","https://openalex.org/W2332096832","https://openalex.org/W2340948639","https://openalex.org/W2396930286","https://openalex.org/W2507133975","https://openalex.org/W2508288073","https://openalex.org/W2513209884","https://openalex.org/W2513773378","https://openalex.org/W2949539907","https://openalex.org/W2951677317","https://openalex.org/W2952186301","https://openalex.org/W2952538710","https://openalex.org/W2952648435","https://openalex.org/W4235342104","https://openalex.org/W6681656546"],"related_works":["https://openalex.org/W2795591870","https://openalex.org/W4390011727","https://openalex.org/W4322743530","https://openalex.org/W3025084345","https://openalex.org/W2765989577","https://openalex.org/W4408287408","https://openalex.org/W2616405345","https://openalex.org/W2762405039","https://openalex.org/W1520878054","https://openalex.org/W4411969420"],"abstract_inverted_index":{"A":[0],"series":[1,16],"of":[2,17,52,61,68,118],"new":[3],"morpholinylchalcones":[4],"was":[5],"prepared":[6],"and":[7,55,58,83,98,106,127],"then":[8],"used":[9],"as":[10],"building":[11],"blocks":[12],"for":[13,41,74],"constructing":[14],"a":[15],"7-morpholino-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones":[18],"via":[19],"their":[20,62],"reaction":[21],"with":[22,28,91],"6-aminothiouracil.":[23],"The":[24,38],"latter":[25],"thiones":[26],"reacted":[27],"the":[29,35,43,50,59,69,92,99,112,140,158],"appropriate":[30],"hydrazonoyl":[31],"chloride":[32],"to":[33],"give":[34],"corresponding":[36],"pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones.":[37],"assigned":[39],"structures":[40],"all":[42],"newly":[44],"synthesized":[45,70],"compounds":[46,71,103],"were":[47,64,72],"confirmed":[48],"on":[49],"basis":[51],"elemental":[53],"analyses":[54],"spectral":[56],"data":[57],"mechanisms":[60],"formation":[63],"also":[65],"discussed.":[66],"Most":[67],"tested":[73],"in":[75],"vitro":[76],"activity":[77,138,160],"against":[78,111,139],"human":[79,84],"lung":[80],"cancer":[81],"(A-549)":[82],"hepatocellular":[85],"carcinoma":[86],"(HepG-2)":[87],"cell":[88,114,142],"lines":[89,143],"compared":[90],"employed":[93],"standard":[94],"antitumor":[95],"drug":[96],"(cisplatin)":[97],"results":[100],"revealed":[101],"that":[102],"8,":[104],"4e":[105],"7b":[107,135],"have":[108],"promising":[109,137],"activities":[110],"A-549":[113],"line":[115],"(IC50":[116,144],"values":[117],"2.78":[119],"\u00b1":[120,124,129,147],"0.86":[121],"\u03bcg/mL,":[122,131],"5.37":[123],"0.95":[125],"\u03bcg/mL":[126],"5.70":[128],"0.91":[130],"respectively)":[132],"while":[133],"compound":[134],"has":[136],"HepG-2":[141],"=":[145],"3.54":[146],"1.11":[148],"\u03bcg/mL).":[149],"Moreover,":[150],"computational":[151],"studies":[152],"using":[153],"MOE":[154],"2014.09":[155],"software":[156],"supported":[157],"biological":[159],"results.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2017-07-31T00:00:00"}