{"id":"https://openalex.org/W2737576138","doi":null,"title":"Investigation of Novel Progression-related Methylation Events and HOXD Genes in Prostate Cancer","display_name":"Investigation of Novel Progression-related Methylation Events and HOXD Genes in Prostate Cancer","publication_year":2012,"publication_date":"2012-12-17","ids":{"openalex":"https://openalex.org/W2737576138","mag":"2737576138"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/34773","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/34773","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0216a44d-8f4a-42ec-a14e-cb6a87e0ea39/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/0216a44d-8f4a-42ec-a14e-cb6a87e0ea39/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076255258","display_name":"Ken J. Kron","orcid":"https://orcid.org/0009-0008-8790-1130","observed_orcids":["https://orcid.org/0009-0008-8790-1130"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kenneth James Kron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076255258"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.16089999675750732,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9419999718666077},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.675000011920929},{"id":"https://openalex.org/keywords/hoxd3","display_name":"HOXD3","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hoxd8","display_name":"HOXD8","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta2","display_name":"TGF-beta2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.7419999837875366},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.8610000014305115},{"id":"https://openalex.org/keywords/erg-oncogene","display_name":"ERG oncogene","score":0.9409999847412109},{"id":"https://openalex.org/keywords/alternative-transcription-start-sites","display_name":"alternative transcription start sites","score":0.8989999890327454},{"id":"https://openalex.org/keywords/aggressive-prostate-cancer","display_name":"aggressive prostate cancer","score":0.5820000171661377},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7354394197463989},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5704147815704346},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5625830292701721},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5069754123687744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45992690324783325},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4231511950492859},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40800195932388306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38928329944610596},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3691467046737671},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3474592864513397},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3456963300704956},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34559667110443115},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32192614674568176},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14070504903793335}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/34773","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/34773","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0216a44d-8f4a-42ec-a14e-cb6a87e0ea39/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/34773","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/34773","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2737576138","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/34773/1/Kron_Kenneth_J_201211_PhD_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/34773","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/34773","pdf_url":"https://utoronto.scholaris.ca/bitstreams/0216a44d-8f4a-42ec-a14e-cb6a87e0ea39/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2737576138.pdf","grobid_xml":"https://content.openalex.org/works/W2737576138.grobid-xml"},"referenced_works_count":404,"referenced_works":["https://openalex.org/W106733404","https://openalex.org/W221956105","https://openalex.org/W259097864","https://openalex.org/W1479668491","https://openalex.org/W1479907808","https://openalex.org/W1480089533","https://openalex.org/W1484635826","https://openalex.org/W1489006980","https://openalex.org/W1492600479","https://openalex.org/W1495871951","https://openalex.org/W1498683119","https://openalex.org/W1504197144","https://openalex.org/W1504303645","https://openalex.org/W1519947104","https://openalex.org/W1521365533","https://openalex.org/W1526016744","https://openalex.org/W1527752038","https://openalex.org/W1529732178","https://openalex.org/W1537007105","https://openalex.org/W1546801263","https://openalex.org/W1553178519","https://openalex.org/W1580150455","https://openalex.org/W1605104953","https://openalex.org/W1659768997","https://openalex.org/W1669374546","https://openalex.org/W1755052449","https://openalex.org/W1829324904","https://openalex.org/W1909201457","https://openalex.org/W1929894216","https://openalex.org/W1935114338","https://openalex.org/W1935960420","https://openalex.org/W1954763554","https://openalex.org/W1964252337","https://openalex.org/W1964453634","https://openalex.org/W1966101011","https://openalex.org/W1966714489","https://openalex.org/W1967648719","https://openalex.org/W1967705369","https://openalex.org/W1967795194","https://openalex.org/W1968080519","https://openalex.org/W1968093710","https://openalex.org/W1968391853","https://openalex.org/W1969369561","https://openalex.org/W1969670934","https://openalex.org/W1969962178","https://openalex.org/W1970145665","https://openalex.org/W1971707389","https://openalex.org/W1972187255","https://openalex.org/W1972602074","https://openalex.org/W1973178391","https://openalex.org/W1973330264","https://openalex.org/W1974558929","https://openalex.org/W1974840866","https://openalex.org/W1975319922","https://openalex.org/W1975932796","https://openalex.org/W1976974916","https://openalex.org/W1977021269","https://openalex.org/W1977479343","https://openalex.org/W1977546001","https://openalex.org/W1977628468","https://openalex.org/W1979013814","https://openalex.org/W1979615853","https://openalex.org/W1979828679","https://openalex.org/W1980705179","https://openalex.org/W1980948407","https://openalex.org/W1981030303","https://openalex.org/W1981432474","https://openalex.org/W1981463058","https://openalex.org/W1982538300","https://openalex.org/W1982875955","https://openalex.org/W1984486655","https://openalex.org/W1984807040","https://openalex.org/W1985553475","https://openalex.org/W1986022997","https://openalex.org/W1986215058","https://openalex.org/W1987328113","https://openalex.org/W1988565128","https://openalex.org/W1989578834","https://openalex.org/W1991034124","https://openalex.org/W1993090879","https://openalex.org/W1994664175","https://openalex.org/W1995049733","https://openalex.org/W1995404520","https://openalex.org/W1995712429","https://openalex.org/W1996072637","https://openalex.org/W1996447938","https://openalex.org/W1996487270","https://openalex.org/W1997367235","https://openalex.org/W1997517088","https://openalex.org/W1997551392","https://openalex.org/W1998418245","https://openalex.org/W1998449659","https://openalex.org/W2001493074","https://openalex.org/W2002314865","https://openalex.org/W2002497918","https://openalex.org/W2003706637","https://openalex.org/W2005311687","https://openalex.org/W2005911388","https://openalex.org/W2006734639","https://openalex.org/W2006788765","https://openalex.org/W2007521294","https://openalex.org/W2008663430","https://openalex.org/W2009310531","https://openalex.org/W2009629707","https://openalex.org/W2011152373","https://openalex.org/W2011893030","https://openalex.org/W2012290967","https://openalex.org/W2012539595","https://openalex.org/W2012703849","https://openalex.org/W2013039468","https://openalex.org/W2013703886","https://openalex.org/W2015284016","https://openalex.org/W2015437876","https://openalex.org/W2015721758","https://openalex.org/W2016102517","https://openalex.org/W2016371780","https://openalex.org/W2016905895","https://openalex.org/W2017181717","https://openalex.org/W2017437369","https://openalex.org/W2018649033","https://openalex.org/W2018825948","https://openalex.org/W2019741112","https://openalex.org/W2019845113","https://openalex.org/W2020138426","https://openalex.org/W2020636054","https://openalex.org/W2021343970","https://openalex.org/W2021377019","https://openalex.org/W2021729903","https://openalex.org/W2022153909","https://openalex.org/W2022666574","https://openalex.org/W2022667041","https://openalex.org/W2022893667","https://openalex.org/W2022929878","https://openalex.org/W2023194603","https://openalex.org/W2023844789","https://openalex.org/W2023862781","https://openalex.org/W2024042273","https://openalex.org/W2025025874","https://openalex.org/W2026258422","https://openalex.org/W2026781584","https://openalex.org/W2027178459","https://openalex.org/W2027505569","https://openalex.org/W2027845674","https://openalex.org/W2028716069","https://openalex.org/W2028740907","https://openalex.org/W2029654103","https://openalex.org/W2029655340","https://openalex.org/W2030049101","https://openalex.org/W2032353251","https://openalex.org/W2033538744","https://openalex.org/W2034024919","https://openalex.org/W2034803929","https://openalex.org/W2035122273","https://openalex.org/W2035411415","https://openalex.org/W2039053594","https://openalex.org/W2039816251","https://openalex.org/W2039948198","https://openalex.org/W2040257851","https://openalex.org/W2042472927","https://openalex.org/W2042673698","https://openalex.org/W2042720616","https://openalex.org/W2042850301","https://openalex.org/W2043115441","https://openalex.org/W2043253380","https://openalex.org/W2044541726","https://openalex.org/W2046241907","https://openalex.org/W2046635710","https://openalex.org/W2047007815","https://openalex.org/W2047529648","https://openalex.org/W2048249977","https://openalex.org/W2049205984","https://openalex.org/W2049481073","https://openalex.org/W2051293191","https://openalex.org/W2051497916","https://openalex.org/W2051911149","https://openalex.org/W2052234466","https://openalex.org/W2053421436","https://openalex.org/W2056093951","https://openalex.org/W2056430416","https://openalex.org/W2056501152","https://openalex.org/W2058016005","https://openalex.org/W2059300246","https://openalex.org/W2060312754","https://openalex.org/W2060359736","https://openalex.org/W2060446375","https://openalex.org/W2060959147","https://openalex.org/W2061096768","https://openalex.org/W2062093164","https://openalex.org/W2062213137","https://openalex.org/W2062461447","https://openalex.org/W2063116472","https://openalex.org/W2063135470","https://openalex.org/W2063298842","https://openalex.org/W2063774348","https://openalex.org/W2063905114","https://openalex.org/W2063908773","https://openalex.org/W2064558301","https://openalex.org/W2065173155","https://openalex.org/W2065498897","https://openalex.org/W2067160234","https://openalex.org/W2068345721","https://openalex.org/W2070166913","https://openalex.org/W2070476377","https://openalex.org/W2071154937","https://openalex.org/W2071991599","https://openalex.org/W2072083009","https://openalex.org/W2072713007","https://openalex.org/W2073334593","https://openalex.org/W2073872690","https://openalex.org/W2074140050","https://openalex.org/W2074370703","https://openalex.org/W2074497971","https://openalex.org/W2075002639","https://openalex.org/W2076528339","https://openalex.org/W2077216446","https://openalex.org/W2077530603","https://openalex.org/W2077654571","https://openalex.org/W2077669730","https://openalex.org/W2077816244","https://openalex.org/W2078239104","https://openalex.org/W2078831976","https://openalex.org/W2079298594","https://openalex.org/W2079738717","https://openalex.org/W2080433813","https://openalex.org/W2080439368","https://openalex.org/W2081628690","https://openalex.org/W2081826437","https://openalex.org/W2082244421","https://openalex.org/W2082592723","https://openalex.org/W2084118479","https://openalex.org/W2084910388","https://openalex.org/W2085115464","https://openalex.org/W2087204337","https://openalex.org/W2087207490","https://openalex.org/W2089253191","https://openalex.org/W2089267023","https://openalex.org/W2090906911","https://openalex.org/W2091665689","https://openalex.org/W2092293354","https://openalex.org/W2093769888","https://openalex.org/W2093868062","https://openalex.org/W2093896423","https://openalex.org/W2094804958","https://openalex.org/W2095351770","https://openalex.org/W2095435908","https://openalex.org/W2095761465","https://openalex.org/W2095804402","https://openalex.org/W2096083625","https://openalex.org/W2096151138","https://openalex.org/W2096278234","https://openalex.org/W2096496280","https://openalex.org/W2096800294","https://openalex.org/W2096957390","https://openalex.org/W2097271805","https://openalex.org/W2097607520","https://openalex.org/W2097824911","https://openalex.org/W2098894238","https://openalex.org/W2100365251","https://openalex.org/W2100543217","https://openalex.org/W2100545040","https://openalex.org/W2100893713","https://openalex.org/W2101491950","https://openalex.org/W2101935162","https://openalex.org/W2102450081","https://openalex.org/W2103007980","https://openalex.org/W2103170395","https://openalex.org/W2103498170","https://openalex.org/W2103687167","https://openalex.org/W2103709190","https://openalex.org/W2103959341","https://openalex.org/W2103974482","https://openalex.org/W2104090970","https://openalex.org/W2107633226","https://openalex.org/W2107796128","https://openalex.org/W2107888520","https://openalex.org/W2108664872","https://openalex.org/W2109393109","https://openalex.org/W2110534364","https://openalex.org/W2110607976","https://openalex.org/W2110848383","https://openalex.org/W2111396792","https://openalex.org/W2111659024","https://openalex.org/W2111970888","https://openalex.org/W2112023494","https://openalex.org/W2112392983","https://openalex.org/W2112689533","https://openalex.org/W2113720631","https://openalex.org/W2114231927","https://openalex.org/W2114318954","https://openalex.org/W2114884175","https://openalex.org/W2116236561","https://openalex.org/W2116849210","https://openalex.org/W2117200840","https://openalex.org/W2117391818","https://openalex.org/W2117792530","https://openalex.org/W2117905749","https://openalex.org/W2117941530","https://openalex.org/W2118008591","https://openalex.org/W2118136541","https://openalex.org/W2118263555","https://openalex.org/W2119504728","https://openalex.org/W2120099188","https://openalex.org/W2120292596","https://openalex.org/W2121158863","https://openalex.org/W2121407255","https://openalex.org/W2121789453","https://openalex.org/W2122673439","https://openalex.org/W2122828786","https://openalex.org/W2122860896","https://openalex.org/W2123526148","https://openalex.org/W2124388527","https://openalex.org/W2124704116","https://openalex.org/W2127684282","https://openalex.org/W2127757047","https://openalex.org/W2127808005","https://openalex.org/W2128317694","https://openalex.org/W2129435292","https://openalex.org/W2129528814","https://openalex.org/W2129583552","https://openalex.org/W2130023402","https://openalex.org/W2130585127","https://openalex.org/W2131116203","https://openalex.org/W2131260081","https://openalex.org/W2131287825","https://openalex.org/W2132528779","https://openalex.org/W2133085589","https://openalex.org/W2133193835","https://openalex.org/W2133410632","https://openalex.org/W2133929387","https://openalex.org/W2134246254","https://openalex.org/W2134418991","https://openalex.org/W2135173272","https://openalex.org/W2135798683","https://openalex.org/W2135946283","https://openalex.org/W2136880604","https://openalex.org/W2137035181","https://openalex.org/W2137547257","https://openalex.org/W2138290270","https://openalex.org/W2139031916","https://openalex.org/W2139349205","https://openalex.org/W2139860898","https://openalex.org/W2140649141","https://openalex.org/W2141453591","https://openalex.org/W2141835013","https://openalex.org/W2142072350","https://openalex.org/W2142285790","https://openalex.org/W2142503898","https://openalex.org/W2145424250","https://openalex.org/W2145817734","https://openalex.org/W2147415210","https://openalex.org/W2147900600","https://openalex.org/W2148080736","https://openalex.org/W2148448794","https://openalex.org/W2148521032","https://openalex.org/W2148983297","https://openalex.org/W2149307190","https://openalex.org/W2149433387","https://openalex.org/W2149775776","https://openalex.org/W2150173948","https://openalex.org/W2153192886","https://openalex.org/W2153314120","https://openalex.org/W2153853712","https://openalex.org/W2155530804","https://openalex.org/W2156585356","https://openalex.org/W2157241157","https://openalex.org/W2157681363","https://openalex.org/W2158143138","https://openalex.org/W2158308119","https://openalex.org/W2158314261","https://openalex.org/W2159157093","https://openalex.org/W2159816734","https://openalex.org/W2160005424","https://openalex.org/W2161224111","https://openalex.org/W2161380492","https://openalex.org/W2161465043","https://openalex.org/W2161748901","https://openalex.org/W2161810908","https://openalex.org/W2163895012","https://openalex.org/W2164218164","https://openalex.org/W2164695251","https://openalex.org/W2165011173","https://openalex.org/W2165782799","https://openalex.org/W2165983722","https://openalex.org/W2166368669","https://openalex.org/W2166537866","https://openalex.org/W2167194518","https://openalex.org/W2168272873","https://openalex.org/W2168602111","https://openalex.org/W2170210082","https://openalex.org/W2170544517","https://openalex.org/W2171960879","https://openalex.org/W2172102403","https://openalex.org/W2178232667","https://openalex.org/W2215018676","https://openalex.org/W2317471234","https://openalex.org/W2317570906","https://openalex.org/W2321006064","https://openalex.org/W2322278092","https://openalex.org/W2323868208","https://openalex.org/W2422074834","https://openalex.org/W2473305333","https://openalex.org/W2482202957","https://openalex.org/W4245684785","https://openalex.org/W4300464738"],"related_works":["https://openalex.org/W2011893030","https://openalex.org/W2070166913","https://openalex.org/W3217650989","https://openalex.org/W2090979034","https://openalex.org/W2498735961","https://openalex.org/W3089736145","https://openalex.org/W7099115801","https://openalex.org/W2126956112","https://openalex.org/W1492898634","https://openalex.org/W1827491256"],"abstract_inverted_index":{"Aberrant":[0],"DNA":[1,59,230,285,311],"methylation":[2,44,60,109,133,161,195,231,253,286],"in":[3,14,33,93,122,134,224,272,274],"gene":[4,7,215],"promoters":[5],"causes":[6],"silencing":[8],"and":[9,18,49,101,114,116,142,148,184,193,220,254,295,300],"is":[10,302],"a":[11,34,42,69,281],"common":[12],"event":[13],"prostate":[15,54,65,74,290],"cancer":[16],"development":[17],"progression.":[19],"While":[20],"commonly":[21],"identified":[22],"methylated":[23],"genes":[24,86,239],"have":[25,40,263],"been":[26],"analyzed":[27],"for":[28,53],"their":[29],"potential":[30,152],"clinical":[31],"utility":[32],"variety":[35],"of":[36,72,84,97,108,112,120,124,138,158,206,258,283,298],"cancers,":[37],"few":[38],"studies":[39],"attempted":[41],"genome-wide":[43,70],"approach":[45],"to":[46,57,103,242],"discover":[47],"new":[48],"possibly":[50],"improved":[51],"biomarkers":[52],"cancer.\\nIn":[55],"order":[56],"identify":[58],"changes":[61],"associated":[62,197],"with":[63,198,226,235],"aggressive":[64,293],"cancer,":[66],"we":[67,176],"performed":[68],"analysis":[71],"40":[73],"cancers":[75,225,291],"using":[76,89,209],"Agilent":[77],"human":[78],"CpG":[79],"island":[80],"microarrays.":[81],"Methylation":[82],"profiles":[83],"candidate":[85],"were":[87,126,196,222,240],"validated":[88],"quantitative":[90],"MethyLight":[91],"technology":[92],"an":[94,203,273],"independent":[95,174,204],"series":[96],"219":[98],"radical":[99],"prostatectomies":[100],"compared":[102],"clinicopathological":[104],"parameters.":[105],"The":[106],"effects":[107],"on":[110,266],"expression":[111,166,216,236,260,297],"HOXD3":[113,141,185,192,219,299],"HOXD8":[115,121,194,221,259,301],"the":[117,135,173,249],"possible":[118],"role":[119],"progression":[123],"PCa":[125],"also":[127],"investigated.":[128],"\\nWe":[129],"discovered":[130],"previously":[131],"unidentified":[132],"HOXD":[136],"cluster":[137],"genes,":[139],"namely":[140],"HOXD8,":[143],"as":[144,146,151,167,186,188],"well":[145,187],"TGF\u03b22":[147,201],"GENE":[149,189],"X":[150],"prognostic":[153],"biomarkers.":[154],"Furthermore,":[155],"unsupervised":[156],"clustering":[157],"samples":[159],"by":[160,304],"signature":[162],"indicated":[163],"ERG":[164,199],"oncogene":[165],"significantly":[168],"different":[169],"between":[170,180,252],"clusters.":[171],"Within":[172],"cohort,":[175],"observed":[177],"strong":[178],"correlations":[179],"Gleason":[181],"score":[182],"(GS)":[183],"X,":[190],"while":[191,229],"expresson.":[200],"was":[202],"predictor":[205],"disease":[207],"recurrence":[208],"Cox":[210],"multivariate":[211],"regression":[212],"analysis.":[213],"In":[214],"studies,":[217],"both":[218],"elevated":[223],"poor":[227,250],"prognosis,":[228],"did":[232,261],"not":[233,262,308],"correlate":[234],"levels.":[237],"Both":[238],"found":[241],"contain":[243],"alternative":[244],"transcription":[245],"start":[246],"sites,":[247],"explaining":[248],"correlation":[251],"expression.":[255],"Finally,":[256],"knockdown":[257],"any":[264],"effect":[265],"viable":[267],"cells":[268],"or":[269],"cell":[270],"motility":[271],"vitro":[275],"model.":[276],"\\nThese":[277],"results":[278],"indicate":[279],"that":[280,296],"panel":[282],"novel":[284],"markers":[287],"distinguish":[288],"indolent":[289],"from":[292],"ones,":[294],"regulated":[303],"mechanisms":[305],"including,":[306],"but":[307],"dependent":[309],"on,":[310],"methylation.":[312]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2017-07-31T00:00:00"}
