{"id":"https://openalex.org/W2737547155","doi":null,"title":"Dendritic cell function in the setting of chronic hepatitis cinfection and changes during antiviral treatment","display_name":"Dendritic cell function in the setting of chronic hepatitis cinfection and changes during antiviral treatment","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2737547155","mag":"2737547155"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:18568","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18568/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075490243","display_name":"Ioannis Pachiadakis","orcid":"https://orcid.org/0000-0002-6876-2322","observed_orcids":["https://orcid.org/0000-0002-6876-2322"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ioannis Pachiadakis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6876-2322","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075490243"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8539999723434448},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/hcv-viraemia","display_name":"HCV viraemia","score":0.675000011920929},{"id":"https://openalex.org/keywords/hcv-core-protein","display_name":"HCV core protein","score":0.906000018119812},{"id":"https://openalex.org/keywords/ethanol-intake","display_name":"ethanol consumption","score":0.5640000104904175},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pegylated-interferon-alpha","display_name":"pegylated interferon-alpha","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cd4-t-cell-proliferation","display_name":"CD4+ T cell proliferation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8209999799728394},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/innate-immune-defects","display_name":"innate immune defects","score":0.5429999828338623},{"id":"https://openalex.org/keywords/hcv-rna","display_name":"HCV RNA","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.7239586710929871},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6680771112442017},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6268886923789978},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6159177422523499},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5578709244728088},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.49860715866088867},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.4979276657104492},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4623497724533081},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43497171998023987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4194944500923157}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:18568","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18568/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Masters thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:2737547155","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/18568/","pdf_url":null,"source":{"id":"https://openalex.org/S4306519268","display_name":"Masters thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Masters thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":414,"referenced_works":["https://openalex.org/W124239641","https://openalex.org/W319524242","https://openalex.org/W1483162601","https://openalex.org/W1486797447","https://openalex.org/W1488377901","https://openalex.org/W1491342045","https://openalex.org/W1494401243","https://openalex.org/W1499978168","https://openalex.org/W1502937057","https://openalex.org/W1505139021","https://openalex.org/W1506258653","https://openalex.org/W1511803520","https://openalex.org/W1514540900","https://openalex.org/W1515466910","https://openalex.org/W1517310071","https://openalex.org/W1519633296","https://openalex.org/W1534496719","https://openalex.org/W1536488163","https://openalex.org/W1542447311","https://openalex.org/W1548411824","https://openalex.org/W1568579274","https://openalex.org/W1578472914","https://openalex.org/W1582747522","https://openalex.org/W1588809288","https://openalex.org/W1589719720","https://openalex.org/W1630111658","https://openalex.org/W1633418194","https://openalex.org/W1635062911","https://openalex.org/W1640867508","https://openalex.org/W1645159332","https://openalex.org/W1659380298","https://openalex.org/W1661544713","https://openalex.org/W1665466173","https://openalex.org/W1678764202","https://openalex.org/W1711829680","https://openalex.org/W1777081626","https://openalex.org/W1784997902","https://openalex.org/W1847011379","https://openalex.org/W1858348078","https://openalex.org/W1877659824","https://openalex.org/W1902746983","https://openalex.org/W1914975684","https://openalex.org/W1928772928","https://openalex.org/W1932966137","https://openalex.org/W1933670444","https://openalex.org/W1950162085","https://openalex.org/W1957867949","https://openalex.org/W1958363133","https://openalex.org/W1960538598","https://openalex.org/W1964508470","https://openalex.org/W1964662152","https://openalex.org/W1964804566","https://openalex.org/W1965794222","https://openalex.org/W1967911919","https://openalex.org/W1969072247","https://openalex.org/W1972346208","https://openalex.org/W1972776583","https://openalex.org/W1973452228","https://openalex.org/W1974159345","https://openalex.org/W1974733477","https://openalex.org/W1974750479","https://openalex.org/W1975179263","https://openalex.org/W1975273858","https://openalex.org/W1975588465","https://openalex.org/W1975714746","https://openalex.org/W1976045232","https://openalex.org/W1976049896","https://openalex.org/W1976615867","https://openalex.org/W1977036616","https://openalex.org/W1977779856","https://openalex.org/W1977799278","https://openalex.org/W1978171344","https://openalex.org/W1978644579","https://openalex.org/W1979003966","https://openalex.org/W1979132095","https://openalex.org/W1979919755","https://openalex.org/W1980138671","https://openalex.org/W1980215946","https://openalex.org/W1980272197","https://openalex.org/W1980273234","https://openalex.org/W1980318677","https://openalex.org/W1980563261","https://openalex.org/W1980768668","https://openalex.org/W1981649463","https://openalex.org/W1981746803","https://openalex.org/W1981900811","https://openalex.org/W1981932944","https://openalex.org/W1982906491","https://openalex.org/W1984015030","https://openalex.org/W1984150038","https://openalex.org/W1985970818","https://openalex.org/W1986178107","https://openalex.org/W1986315531","https://openalex.org/W1986505810","https://openalex.org/W1986649246","https://openalex.org/W1987553806","https://openalex.org/W1987598047","https://openalex.org/W1988468641","https://openalex.org/W1990058709","https://openalex.org/W1990283625","https://openalex.org/W1990458269","https://openalex.org/W1991020851","https://openalex.org/W1991236592","https://openalex.org/W1991330340","https://openalex.org/W1992212684","https://openalex.org/W1992239172","https://openalex.org/W1992484212","https://openalex.org/W1992603628","https://openalex.org/W1992649586","https://openalex.org/W1992958037","https://openalex.org/W1992987492","https://openalex.org/W1993437521","https://openalex.org/W1993690048","https://openalex.org/W1994194561","https://openalex.org/W1994391392","https://openalex.org/W1994838458","https://openalex.org/W1995332691","https://openalex.org/W1996518557","https://openalex.org/W1998597340","https://openalex.org/W1998670692","https://openalex.org/W1999730899","https://openalex.org/W2000115037","https://openalex.org/W2001338276","https://openalex.org/W2001675155","https://openalex.org/W2001945066","https://openalex.org/W2002442746","https://openalex.org/W2003020329","https://openalex.org/W2003579943","https://openalex.org/W2004151652","https://openalex.org/W2005113160","https://openalex.org/W2006772331","https://openalex.org/W2007198955","https://openalex.org/W2007498454","https://openalex.org/W2007509612","https://openalex.org/W2008152503","https://openalex.org/W2009219530","https://openalex.org/W2012033859","https://openalex.org/W2012628280","https://openalex.org/W2012808888","https://openalex.org/W2013816787","https://openalex.org/W2015199158","https://openalex.org/W2015489330","https://openalex.org/W2016525911","https://openalex.org/W2016862474","https://openalex.org/W2017017909","https://openalex.org/W2019628123","https://openalex.org/W2022057836","https://openalex.org/W2022901323","https://openalex.org/W2022986271","https://openalex.org/W2024043429","https://openalex.org/W2025412364","https://openalex.org/W2026101939","https://openalex.org/W2027545702","https://openalex.org/W2028161109","https://openalex.org/W2028207476","https://openalex.org/W2029757145","https://openalex.org/W2030333875","https://openalex.org/W2031477951","https://openalex.org/W2033125798","https://openalex.org/W2033649274","https://openalex.org/W2035580952","https://openalex.org/W2036764167","https://openalex.org/W2037368492","https://openalex.org/W2038481383","https://openalex.org/W2039544146","https://openalex.org/W2040173732","https://openalex.org/W2040597422","https://openalex.org/W2042994480","https://openalex.org/W2044193462","https://openalex.org/W2045733748","https://openalex.org/W2045904546","https://openalex.org/W2046178003","https://openalex.org/W2046399828","https://openalex.org/W2047352444","https://openalex.org/W2047711008","https://openalex.org/W2047803539","https://openalex.org/W2048143404","https://openalex.org/W2050466666","https://openalex.org/W2050997685","https://openalex.org/W2051246044","https://openalex.org/W2054019820","https://openalex.org/W2057064398","https://openalex.org/W2057318017","https://openalex.org/W2059280966","https://openalex.org/W2059530064","https://openalex.org/W2060483294","https://openalex.org/W2061299331","https://openalex.org/W2062174742","https://openalex.org/W2062717261","https://openalex.org/W2063029767","https://openalex.org/W2063557216","https://openalex.org/W2063654789","https://openalex.org/W2064304037","https://openalex.org/W2064593553","https://openalex.org/W2066116844","https://openalex.org/W2068128206","https://openalex.org/W2068487155","https://openalex.org/W2070968956","https://openalex.org/W2071136569","https://openalex.org/W2071670416","https://openalex.org/W2072681498","https://openalex.org/W2073723790","https://openalex.org/W2074188269","https://openalex.org/W2074717986","https://openalex.org/W2075503360","https://openalex.org/W2076361525","https://openalex.org/W2076815050","https://openalex.org/W2077654197","https://openalex.org/W2078503333","https://openalex.org/W2078887917","https://openalex.org/W2078937761","https://openalex.org/W2079724990","https://openalex.org/W2080921782","https://openalex.org/W2082521416","https://openalex.org/W2082544214","https://openalex.org/W2082892689","https://openalex.org/W2082944999","https://openalex.org/W2082958692","https://openalex.org/W2083798679","https://openalex.org/W2084446925","https://openalex.org/W2087122183","https://openalex.org/W2087651812","https://openalex.org/W2087877207","https://openalex.org/W2088024377","https://openalex.org/W2088165891","https://openalex.org/W2088304195","https://openalex.org/W2089268437","https://openalex.org/W2090494147","https://openalex.org/W2090786449","https://openalex.org/W2092161253","https://openalex.org/W2092333889","https://openalex.org/W2093137226","https://openalex.org/W2093536495","https://openalex.org/W2093579074","https://openalex.org/W2093865462","https://openalex.org/W2095178743","https://openalex.org/W2097224767","https://openalex.org/W2097246425","https://openalex.org/W2098084836","https://openalex.org/W2098432187","https://openalex.org/W2099172067","https://openalex.org/W2099938481","https://openalex.org/W2100229458","https://openalex.org/W2101177020","https://openalex.org/W2101189282","https://openalex.org/W2101832306","https://openalex.org/W2102732638","https://openalex.org/W2102764003","https://openalex.org/W2102932734","https://openalex.org/W2103802132","https://openalex.org/W2105281461","https://openalex.org/W2105464829","https://openalex.org/W2105556163","https://openalex.org/W2106132583","https://openalex.org/W2106232291","https://openalex.org/W2106239124","https://openalex.org/W2106945734","https://openalex.org/W2107188441","https://openalex.org/W2107749930","https://openalex.org/W2108045530","https://openalex.org/W2109124959","https://openalex.org/W2109204917","https://openalex.org/W2109751281","https://openalex.org/W2109931549","https://openalex.org/W2110161909","https://openalex.org/W2110309669","https://openalex.org/W2110381465","https://openalex.org/W2110671968","https://openalex.org/W2110716288","https://openalex.org/W2111260918","https://openalex.org/W2111359040","https://openalex.org/W2111695773","https://openalex.org/W2112296339","https://openalex.org/W2112546054","https://openalex.org/W2112639947","https://openalex.org/W2112876622","https://openalex.org/W2114799524","https://openalex.org/W2116692899","https://openalex.org/W2117740937","https://openalex.org/W2118001355","https://openalex.org/W2118320694","https://openalex.org/W2118364979","https://openalex.org/W2118537722","https://openalex.org/W2118647619","https://openalex.org/W2118888785","https://openalex.org/W2119847138","https://openalex.org/W2120987396","https://openalex.org/W2121381066","https://openalex.org/W2123260081","https://openalex.org/W2124270882","https://openalex.org/W2124394465","https://openalex.org/W2125020009","https://openalex.org/W2126659405","https://openalex.org/W2127082703","https://openalex.org/W2127404676","https://openalex.org/W2127685726","https://openalex.org/W2128009173","https://openalex.org/W2128417270","https://openalex.org/W2128759062","https://openalex.org/W2129319296","https://openalex.org/W2129442719","https://openalex.org/W2129651659","https://openalex.org/W2129932872","https://openalex.org/W2130259551","https://openalex.org/W2130506001","https://openalex.org/W2131091045","https://openalex.org/W2131188831","https://openalex.org/W2131761283","https://openalex.org/W2132034333","https://openalex.org/W2132282141","https://openalex.org/W2132444008","https://openalex.org/W2133369735","https://openalex.org/W2133483324","https://openalex.org/W2133692384","https://openalex.org/W2134181802","https://openalex.org/W2135218342","https://openalex.org/W2135649725","https://openalex.org/W2136110758","https://openalex.org/W2136437831","https://openalex.org/W2136648580","https://openalex.org/W2136749452","https://openalex.org/W2136977064","https://openalex.org/W2137374406","https://openalex.org/W2137594178","https://openalex.org/W2138529156","https://openalex.org/W2139246666","https://openalex.org/W2139620037","https://openalex.org/W2139977061","https://openalex.org/W2140542253","https://openalex.org/W2140734388","https://openalex.org/W2140912924","https://openalex.org/W2141398361","https://openalex.org/W2142684817","https://openalex.org/W2143498880","https://openalex.org/W2144361201","https://openalex.org/W2144694464","https://openalex.org/W2144950102","https://openalex.org/W2145049340","https://openalex.org/W2145243874","https://openalex.org/W2145295873","https://openalex.org/W2145508988","https://openalex.org/W2145584783","https://openalex.org/W2146277683","https://openalex.org/W2147065714","https://openalex.org/W2147077080","https://openalex.org/W2147126871","https://openalex.org/W2147921405","https://openalex.org/W2148178789","https://openalex.org/W2148579227","https://openalex.org/W2148704093","https://openalex.org/W2148715682","https://openalex.org/W2149217958","https://openalex.org/W2149375241","https://openalex.org/W2149765059","https://openalex.org/W2149928606","https://openalex.org/W2150403025","https://openalex.org/W2150486685","https://openalex.org/W2150763544","https://openalex.org/W2151603470","https://openalex.org/W2151901780","https://openalex.org/W2152620027","https://openalex.org/W2152678942","https://openalex.org/W2152786092","https://openalex.org/W2152793674","https://openalex.org/W2153920820","https://openalex.org/W2154334154","https://openalex.org/W2154497749","https://openalex.org/W2155229523","https://openalex.org/W2155368883","https://openalex.org/W2155991561","https://openalex.org/W2156643487","https://openalex.org/W2156710432","https://openalex.org/W2157069655","https://openalex.org/W2157712520","https://openalex.org/W2158749909","https://openalex.org/W2159185426","https://openalex.org/W2159772427","https://openalex.org/W2160174559","https://openalex.org/W2160331835","https://openalex.org/W2160425277","https://openalex.org/W2161208630","https://openalex.org/W2161741847","https://openalex.org/W2163570329","https://openalex.org/W2163646754","https://openalex.org/W2164783799","https://openalex.org/W2164874258","https://openalex.org/W2164915072","https://openalex.org/W2165292104","https://openalex.org/W2165880492","https://openalex.org/W2166243539","https://openalex.org/W2167366928","https://openalex.org/W2167778863","https://openalex.org/W2169406601","https://openalex.org/W2169601765","https://openalex.org/W2169979990","https://openalex.org/W2170240282","https://openalex.org/W2170685307","https://openalex.org/W2170700544","https://openalex.org/W2170831273","https://openalex.org/W2170832326","https://openalex.org/W2171459379","https://openalex.org/W2171583504","https://openalex.org/W2172039135","https://openalex.org/W2218395858","https://openalex.org/W2252569787","https://openalex.org/W2321120966","https://openalex.org/W2412926973","https://openalex.org/W2413643247","https://openalex.org/W2439604628","https://openalex.org/W2470599311","https://openalex.org/W2740094458","https://openalex.org/W3098989474","https://openalex.org/W4313347910","https://openalex.org/W4313347961"],"related_works":["https://openalex.org/W6990210862","https://openalex.org/W1573862239","https://openalex.org/W2093927964","https://openalex.org/W2082295598","https://openalex.org/W2020128177","https://openalex.org/W2078125300","https://openalex.org/W2167382963","https://openalex.org/W2047711008","https://openalex.org/W2958336691","https://openalex.org/W1942926563"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,10,16,47,56,86,93,167,193,271,278],"the":[3,14,26,54,60,91,272,275],"innate":[4],"immune":[5,49],"system":[6],"and":[7,51,76,132,140,173,182,201,207,218,230,248,265],"in":[8,13,40,79,90,102,149,187],"particular":[9],"dendritic":[11,87,258],"cells,":[12],"\\nestablishment":[15],"chronic":[17,57],"hepatitis":[18,73,94],"C":[19,74,95],"has":[20],"been":[21],"studied":[22],"quite":[23],"extensively":[24],"over":[25],"\\nlast":[27],"few":[28],"years":[29],"but":[30],"controversy":[31],"remains":[32],"as":[33],"to":[34,44,53,81,107,119,156,162],"whether":[35],"a":[36,83,100],"potential":[37,165],"virus-induced":[38],"\\ndefect":[39,121],"DC":[41,66,105,150,172,205,224,246,280],"function":[42],"leads":[43],"sub-optimal":[45],"initiation":[46],"adaptive":[48],"\\nresponses":[50],"finally":[52],"establishment":[55],"infection.":[58,96],"In":[59],"present":[61,148],"\\nthesis":[62],"we":[63,122,235,266],"examined":[64],"monocyte-derived":[65],"(MDDC),":[67],"generated":[68],"from":[69],"patients":[70,221],"with":[71],"\\nchronic":[72],"(CHC),":[75],"healthy":[77],"subjects":[78],"order":[80],"gain":[82],"better":[84],"\\nunderstanding":[85],"cell":[88,259],"functions":[89,225],"setting":[92],"We":[97,159,254],"\\ninitially":[98],"observed":[99,267],"defect":[101],"CHC":[103],"patients\u2019":[104],"capacity":[106,277],"stimulate":[108],"\u2018na\u00efve\u2019":[109],"CD4+":[110,251],"\\nT-cells":[111],"into":[112],"proliferation.":[113],"Investigating":[114],"for":[115,164],"factors":[116],"potentially":[117],"contributing":[118],"this":[120,279],"demonstrated":[123],"that":[124,237],"HCV":[125,130,138,141,179,183,194,197,263],"genome":[126],"(both":[127],"positive":[128],"strand":[129,137],"RNA":[131],"\\nthe":[133,188],"replicative":[134],"intermediate":[135],"negative":[136],"RNA)":[139],"protein":[142,184],"products":[143],"\\n(HCV":[144],"core":[145,198],"protein)":[146],"are":[147],"without":[151],"though":[152],"any":[153],"obvious":[154],"correlation":[155],"\\nDC":[157],"functions.":[158],"further":[160],"proccedeed":[161],"investigate":[163],"influence":[166],"\\nother,":[168],"host-related,":[169],"parameters":[170],"on":[171,204,274],"tested":[174,256],"liver":[175],"fibrosis,":[176],"ethanol":[177,202],"\\nconsumption,":[178],"viraemia":[180,195],"levels":[181],"products\u2019":[185],"concentration":[186,200],"serum":[189],"demonstarting":[190],"significant":[191],"influences":[192],"/":[196],"\\nserum":[199],"consumption":[203],"functional":[206],"phenotypic":[208],"\\noutput.":[209],"After":[210],"successful":[211],"antiviral":[212,238],"treatment":[213,239],"(with":[214],"pegylated":[215],"interferon":[216],"\u03b1":[217],"\\nribavirin)":[219],"our":[220],"restored":[222],"their":[223],"(allostimulatory":[226],"capacity,":[227],"HCV-specific":[228],"\\nimmune-reactivity":[229],"IL-12production).":[231],"Performing":[232],"\u2018cross-over\u2019":[233],"\\nexperiments":[234],"suggest":[236],"exerted":[240],"its":[241],"effect":[242,270],"by":[243],"improving":[244],"\\nmainly":[245],"capacities":[247],"not":[249],"effector":[250],"T-cell":[252],"reactivity.":[253],"also":[255],"\\nplasmacytoid":[257],"cytokine":[260],"output":[261],"after":[262],"infection":[264],"\\na":[268],"controversial":[269],"virus":[273],"Th1-skewing":[276],"subset.":[281]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-07-31T00:00:00"}