{"id":"https://openalex.org/W2737463560","doi":"https://doi.org/10.1126/science.aan0063","title":"Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading","display_name":"Bidirectional eukaryotic DNA replication is established by quasi-symmetrical helicase loading","publication_year":2017,"publication_date":"2017-07-20","ids":{"openalex":"https://openalex.org/W2737463560","doi":"https://doi.org/10.1126/science.aan0063","mag":"2737463560","pmid":"https://pubmed.ncbi.nlm.nih.gov/28729513","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5608077"},"language":"en","primary_location":{"id":"doi:10.1126/science.aan0063","doi":"https://doi.org/10.1126/science.aan0063","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.aan0063","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2737463560"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5608077","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076346374","display_name":"Gideon Coster","orcid":"https://orcid.org/0000-0002-1449-6655","observed_orcids":["https://orcid.org/0000-0002-1449-6655"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gideon Coster","raw_affiliation_strings":["Francis Crick Institute, London NW1 1AT, UK"],"raw_orcid":"https://orcid.org/0000-0002-1449-6655","affiliations":[{"raw_affiliation_string":"Francis Crick Institute, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029333589","display_name":"John F.X. Diffley","orcid":"https://orcid.org/0000-0001-5184-7680","observed_orcids":["https://orcid.org/0000-0001-5184-7680"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"John F. X. Diffley","raw_affiliation_strings":["Francis Crick Institute, London NW1 1AT, UK"],"raw_orcid":"https://orcid.org/0000-0001-5184-7680","affiliations":[{"raw_affiliation_string":"Francis Crick Institute, London NW1 1AT, UK","institution_ids":["https://openalex.org/I2801081054"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029333589"],"corresponding_institution_ids":["https://openalex.org/I2801081054"],"apc_list":null,"apc_paid":null,"fwci":4.7167,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.96422468,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"357","issue":"6348","first_page":"314","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8295999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.10649999976158142,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minichromosome-maintenance-complex","display_name":"minichromosome maintenance complex","score":0.8109999895095825},{"id":"https://openalex.org/keywords/origin-recognition-complex","display_name":"origin recognition complex","score":0.9940000176429749},{"id":"https://openalex.org/keywords/replication-origins","display_name":"origin of replication","score":0.722000002861023},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.47600001096725464},{"id":"https://openalex.org/keywords/eukaryotic-dna-replication","display_name":"eukaryotic DNA replication","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.9126830101013184},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7008557915687561},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5851048231124878},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4704897403717041},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.4554542899131775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43216073513031006},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.42096567153930664},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.41598063707351685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37870389223098755},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3434292674064636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.337510347366333},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33033430576324463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1432439684867859},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.09494161605834961},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018741","descriptor_name":"Replication Origin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051738","descriptor_name":"Origin Recognition Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064110","descriptor_name":"Minichromosome Maintenance Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1126/science.aan0063","doi":"https://doi.org/10.1126/science.aan0063","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.aan0063","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:28729513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28729513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4683927","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5608077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5608077","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5608077/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Science","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/12770084","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Bidirectional_eukaryotic_DNA_replication_is_established_by_quasi-symmetrical_helicase_loading/12770084","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4683927","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5608077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2285112744","display_name":null,"funder_award_id":"award302601","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3191184554","display_name":null,"funder_award_id":"award302602","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G3587896766","display_name":null,"funder_award_id":"10668","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G3626482146","display_name":"How the eukaryotic replicative DNA helicase is loaded and activated.","funder_award_id":"106252/Z/14/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G4790349251","display_name":null,"funder_award_id":"10066","funder_id":"https://openalex.org/F4320312060","funder_display_name":"Francis Crick Institute"},{"id":"https://openalex.org/G5254712420","display_name":null,"funder_award_id":"FC001066","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8307290461","display_name":null,"funder_award_id":"15669","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312060","display_name":"Francis Crick Institute","ror":"https://ror.org/04tnbqb63"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1970732313","https://openalex.org/W1973552624","https://openalex.org/W1993824205","https://openalex.org/W1995958788","https://openalex.org/W2007214324","https://openalex.org/W2012144576","https://openalex.org/W2016864528","https://openalex.org/W2038801143","https://openalex.org/W2038946742","https://openalex.org/W2044440192","https://openalex.org/W2047998400","https://openalex.org/W2049171516","https://openalex.org/W2057556482","https://openalex.org/W2059594509","https://openalex.org/W2064234837","https://openalex.org/W2071019833","https://openalex.org/W2090081894","https://openalex.org/W2098337100","https://openalex.org/W2099487576","https://openalex.org/W2105413529","https://openalex.org/W2112429774","https://openalex.org/W2127043939","https://openalex.org/W2137724028","https://openalex.org/W2142294062","https://openalex.org/W2147163870","https://openalex.org/W2171460421","https://openalex.org/W2473838984","https://openalex.org/W2578571972"],"related_works":["https://openalex.org/W2071019833","https://openalex.org/W2991537080","https://openalex.org/W4226212695","https://openalex.org/W6995536518","https://openalex.org/W2468347790","https://openalex.org/W6987014745","https://openalex.org/W3042458246","https://openalex.org/W2099487576","https://openalex.org/W4393166797","https://openalex.org/W4404754578"],"abstract_inverted_index":{"Bidirectional":[0],"replication":[1,5,51,129],"from":[2],"eukaryotic":[3],"DNA":[4,18,50,55],"origins":[6,52],"requires":[7,63],"the":[8,29,82,125],"loading":[9,23,42,62,93,105],"of":[10,28,65,77,106,127],"two":[11,66,70],"ring-shaped":[12],"minichromosome":[13],"maintenance":[14],"(MCM)":[15],"helicases":[16],"around":[17],"in":[19,94,99,130],"opposite":[20],"orientations.":[21],"MCM":[22,41,61,92,108,114],"is":[24,43],"orchestrated":[25],"by":[26,110],"binding":[27,64,72],"origin":[30,97],"recognition":[31],"complex":[32],"(ORC)":[33],"to":[34,57,69,88],"DNA,":[35],"but":[36,80],"how":[37],"ORC":[38,67,71,111],"coordinates":[39],"symmetrical":[40],"unclear.":[44],"We":[45,101],"used":[46],"natural":[47],"budding":[48],"yeast":[49],"and":[53,96,112,132],"synthetic":[54],"sequences":[56],"show":[58],"that":[59,103],"efficient":[60],"molecules":[68],"sites.":[73],"The":[74],"relative":[75],"orientation":[76],"these":[78],"sites,":[79],"not":[81],"distance":[83],"between":[84],"them,":[85],"was":[86],"found":[87],"be":[89],"critical":[90],"for":[91,124],"vitro":[95],"function":[98],"vivo.":[100],"propose":[102],"quasi-symmetrical":[104],"individual":[107],"hexamers":[109,118],"directed":[113],"translocation":[115],"into":[116],"double":[117],"acts":[119],"as":[120],"a":[121],"unifying":[122],"mechanism":[123],"establishment":[126],"bidirectional":[128],"archaea":[131],"eukaryotes.":[133]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":4}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2017-07-31T00:00:00"}