{"id":"https://openalex.org/W2736620779","doi":"https://doi.org/10.18203/2320-1770.ijrcog20173441","title":"Clinicopathological and therapeutic features of metaplastic carcinoma of the breast: a study of 15 cases","display_name":"Clinicopathological and therapeutic features of metaplastic carcinoma of the breast: a study of 15 cases","publication_year":2017,"publication_date":"2017-07-25","ids":{"openalex":"https://openalex.org/W2736620779","doi":"https://doi.org/10.18203/2320-1770.ijrcog20173441","mag":"2736620779"},"language":"en","primary_location":{"id":"doi:10.18203/2320-1770.ijrcog20173441","doi":"https://doi.org/10.18203/2320-1770.ijrcog20173441","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2320-1770.ijrcog20173441","pdf_url":"https://www.ijrcog.org/index.php/ijrcog/article/download/2467/2613","source":{"id":"https://openalex.org/S2764444635","display_name":"International Journal of Reproduction Contraception Obstetrics and Gynecology","issn_l":"2320-1770","issn":["2320-1770","2320-1789"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Reproduction, Contraception, Obstetrics and Gynecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ijrcog.org/index.php/ijrcog/article/download/2467/2613","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055515388","display_name":"Hasna Salhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Hasna Salhi","raw_affiliation_strings":["Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089754024","display_name":"Olfa Ja\u00efdane","orcid":"https://orcid.org/0000-0002-8157-0544","observed_orcids":["https://orcid.org/0000-0002-8157-0544"]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Olfa Jaidane","raw_affiliation_strings":["Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047843041","display_name":"Olfa El Amine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Olfa El Amine","raw_affiliation_strings":["Department of Pathology, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076254680","display_name":"Mohamed Ayadi","orcid":"https://orcid.org/0000-0001-7574-2795","observed_orcids":["https://orcid.org/0000-0001-7574-2795"]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Med Malek Ayadi","raw_affiliation_strings":["Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045119647","display_name":"Jamel Ben Hassouna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Jamel Ben Hassouna","raw_affiliation_strings":["Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024872975","display_name":"Tarek Ben Dhieb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Tarek Ben Dhieb","raw_affiliation_strings":["Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013909355","display_name":"Monia Hechiche","orcid":"https://orcid.org/0000-0002-1344-7472","observed_orcids":["https://orcid.org/0000-0002-1344-7472"]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Monia Hechiche","raw_affiliation_strings":["Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043024368","display_name":"Amor Gammoudi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Gammoudi Amor","raw_affiliation_strings":["Department of Pathology, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079179961","display_name":"Khaled Rahal","orcid":"https://orcid.org/0000-0002-6093-4257","observed_orcids":["https://orcid.org/0000-0002-6093-4257"]},"institutions":[{"id":"https://openalex.org/I4210090597","display_name":"Institut Salah-Aza\u00efz","ror":"https://ror.org/00brjxm92","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210090597"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Khaled Rahal","raw_affiliation_strings":["Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncological Surgery, Salah Azaiez Institute, Tunis 1006, Tunisia","institution_ids":["https://openalex.org/I4210090597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210090597"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"8","first_page":"3219","last_page":"3219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metaplastic-breast-carcinoma","display_name":"metaplastic breast carcinoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/carcinosarcoma","display_name":"carcinosarcoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sarcomatoid-carcinoma","display_name":"sarcomatoid carcinoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/radical-mastectomy","display_name":"radical mastectomy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/postoperative-radiotherapy","display_name":"postoperative radiotherapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.8090000152587891},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.8230000138282776},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.6549999713897705},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2776047466","wikidata":"https://www.wikidata.org/wiki/Q6823150","display_name":"Metaplastic carcinoma","level":4,"score":0.8675935864448547},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8516848683357239},{"id":"https://openalex.org/C2778938455","wikidata":"https://www.wikidata.org/wiki/Q5038170","display_name":"Carcinosarcoma","level":3,"score":0.6547813415527344},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5588247776031494},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5398352146148682},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.48762574791908264},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.46161210536956787},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45685794949531555},{"id":"https://openalex.org/C2777757722","wikidata":"https://www.wikidata.org/wiki/Q848318","display_name":"Mastectomy","level":4,"score":0.43298637866973877},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40976113080978394},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34234732389450073},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32082441449165344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29289960861206055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18203/2320-1770.ijrcog20173441","doi":"https://doi.org/10.18203/2320-1770.ijrcog20173441","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2320-1770.ijrcog20173441","pdf_url":"https://www.ijrcog.org/index.php/ijrcog/article/download/2467/2613","source":{"id":"https://openalex.org/S2764444635","display_name":"International Journal of Reproduction Contraception Obstetrics and Gynecology","issn_l":"2320-1770","issn":["2320-1770","2320-1789"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Reproduction, Contraception, Obstetrics and Gynecology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18203/2320-1770.ijrcog20173441","doi":"https://doi.org/10.18203/2320-1770.ijrcog20173441","is_oa":true,"landing_page_url":"https://doi.org/10.18203/2320-1770.ijrcog20173441","pdf_url":"https://www.ijrcog.org/index.php/ijrcog/article/download/2467/2613","source":{"id":"https://openalex.org/S2764444635","display_name":"International Journal of Reproduction Contraception Obstetrics and Gynecology","issn_l":"2320-1770","issn":["2320-1770","2320-1789"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322697004","host_organization_name":"Medip Academy","host_organization_lineage":["https://openalex.org/P4322697004"],"host_organization_lineage_names":["Medip Academy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Reproduction, Contraception, Obstetrics and Gynecology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2736620779.pdf","grobid_xml":"https://content.openalex.org/works/W2736620779.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1835459135","https://openalex.org/W1945470089","https://openalex.org/W1969181991","https://openalex.org/W1970419458","https://openalex.org/W1986870690","https://openalex.org/W2027797732","https://openalex.org/W2028778537","https://openalex.org/W2032894034","https://openalex.org/W2035366252","https://openalex.org/W2036934183","https://openalex.org/W2036985141","https://openalex.org/W2052882948","https://openalex.org/W2059303218","https://openalex.org/W2096006212","https://openalex.org/W2102136315","https://openalex.org/W2119372724","https://openalex.org/W2138585603","https://openalex.org/W2142105383","https://openalex.org/W2157285286","https://openalex.org/W2315414183","https://openalex.org/W2340301267","https://openalex.org/W2411236386"],"related_works":["https://openalex.org/W4392634314","https://openalex.org/W2983760598","https://openalex.org/W2338859202","https://openalex.org/W2072248176","https://openalex.org/W3146885899","https://openalex.org/W2416790530","https://openalex.org/W2340301267","https://openalex.org/W4310796876","https://openalex.org/W4200376657","https://openalex.org/W3175421290"],"abstract_inverted_index":{"Background:":[0],"Metaplastic":[1],"carcinoma":[2,52,123,209],"of":[3,13,35,50,53,99,116,120,127,175,187,222,229],"the":[4,54,237],"breast":[5,55,208],"is":[6,38,210,234],"a":[7,11,27,160,213,219,226],"rare":[8,43],"entity":[9,30],"containing":[10],"mixture":[12],"malignant":[14],"epithelial":[15],"and":[16,62,69,124,195,225],"mesenchymal":[17],"elements.":[18],"The":[19,33,96,138],"World":[20],"Health":[21],"Organization":[22],"only":[23],"recognized":[24],"it":[25],"as":[26],"distinct":[28],"pathological":[29],"since":[31],"2000.":[32],"aim":[34],"this":[36,42,205],"study":[37],"to":[39,79,90,146],"better":[40],"characterize":[41],"disease.Methods:":[44],"We":[45,64],"reviewed":[46],"retrospectively":[47],"15":[48],"cases":[49,115,119,126],"metaplastic":[51,207],"treated":[56],"in":[57,102,154,166],"our":[58],"institute":[59],"between":[60],"1994":[61],"2015.":[63],"analyzed":[65],"clinical,":[66],"histological,":[67],"therapeutic":[68],"evolutive":[70],"data.Results:":[71],"All":[72],"patients":[73,170,181],"were":[74,113,133,152,182],"females":[75],"ranging":[76],"from":[77,88],"29":[78],"75":[80],"years":[81],"old":[82],"(median,":[83,93,192],"50).":[84],"Tumor":[85],"size":[86,216],"ranged":[87],"20":[89,176],"150":[91],"mm":[92],"72":[94],"mm).":[95],"Treatment":[97],"consisted":[98],"radical":[100],"mastectomy":[101],"14":[103],"cases,":[104],"often":[105],"combined":[106],"with":[107,184,200,236],"post-operative":[108],"radiation":[109],"and/or":[110],"chemotherapy.":[111],"There":[112],"8":[114],"carcinosarcoma,":[117],"4":[118],"spindle":[121],"cell":[122,129],"3":[125,167],"squamous":[128],"carcinoma.":[130],"Follow-up":[131],"data":[132],"available":[134],"on":[135,204],"12":[136],"patients.":[137,168],"median":[139,173],"follow-up":[140],"was":[141,198],"47":[142,193],"months":[143,177],"(range,":[144,178],"10":[145],"146":[147],"months).":[148],"Definitive":[149],"nodal":[150,223],"metastases":[151,164,224],"identified":[153],"6":[155],"cases.":[156],"One":[157],"patient":[158,197],"developed":[159],"local":[161],"recurrence.":[162],"Extranodal":[163],"occurred":[165],"Three":[169],"died":[171],"at":[172,217],"interval":[174],"13-30).":[179],"Eight":[180],"alive":[183,199],"no":[185],"evidence":[186],"recurrent":[188],"or":[189],"metastatic":[190,201],"disease":[191],"months)":[194],"one":[196],"disease.Conclusions:":[202],"Based":[203],"series,":[206],"characterized":[211],"by":[212],"large":[214],"tumor":[215],"presentation,":[218],"low":[220],"frequency":[221],"high":[227],"proportion":[228],"triple":[230],"negativity.":[231],"Our":[232],"series":[233],"consistent":[235],"literature.":[238]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2017-07-31T00:00:00"}