{"id":"https://openalex.org/W2736553833","doi":"https://doi.org/10.1967/s002449910557","title":"The value of 18FDG PET/CT parameters, hematological parameters and tumor markers in predicting KRAS oncogene mutation in colorectal cancer.","display_name":"The value of 18FDG PET/CT parameters, hematological parameters and tumor markers in predicting KRAS oncogene mutation in colorectal cancer.","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2736553833","doi":"https://doi.org/10.1967/s002449910557","mag":"2736553833","pmid":"https://pubmed.ncbi.nlm.nih.gov/28697193"},"language":"en","primary_location":{"id":"pmid:28697193","doi":"https://doi.org/10.1967/s002449910557","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28697193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hellenic journal of nuclear medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084510032","display_name":"Ali Ozan \u00d6ner","orcid":"https://orcid.org/0000-0001-7487-9044","observed_orcids":["https://orcid.org/0000-0001-7487-9044"]},"institutions":[{"id":"https://openalex.org/I52407163","display_name":"Afyon Kocatepe University","ror":"https://ror.org/03a1crh56","country_code":"TR","type":"education","lineage":["https://openalex.org/I52407163"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ali Ozan Oner","raw_affiliation_strings":["Afyon Kocatepe University Faculty of Medicine, Department of Nuclear Medicine, Afyon, Turkey. afunda12@gmail.com","Afyon Kocatepe University Faculty of Medicine, Department of Nuclear Medicine, Afyon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Afyon Kocatepe University Faculty of Medicine, Department of Nuclear Medicine, Afyon, Turkey. afunda12@gmail.com","institution_ids":["https://openalex.org/I52407163"]},{"raw_affiliation_string":"Afyon Kocatepe University Faculty of Medicine, Department of Nuclear Medicine, Afyon, Turkey","institution_ids":["https://openalex.org/I52407163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025115833","display_name":"Evrim S\u00fcrer Budak","orcid":"https://orcid.org/0000-0002-8318-0785","observed_orcids":["https://orcid.org/0000-0002-8318-0785"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evrim Surer Budak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046214989","display_name":"\u015eenay Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0002-1457-7957","observed_orcids":["https://orcid.org/0000-0002-1457-7957","https://orcid.org/0000-0002-1078-7973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Senay Y\u0131ld\u0131r\u0131m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077954387","display_name":"Funda Armagan Aydin","orcid":"https://orcid.org/0000-0002-5484-9435","observed_orcids":["https://orcid.org/0000-0002-5484-9435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Funda Ayd\u0131n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072439844","display_name":"Cem Sezer","orcid":"https://orcid.org/0000-0002-7592-5345","observed_orcids":["https://orcid.org/0000-0002-7592-5345"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cem Sezer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6544,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.69128484,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"20","issue":"2","first_page":"160","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.7728999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0430000014603138,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/fdg-pet-ct","display_name":"FDG PET/CT","score":0.8790000081062317},{"id":"https://openalex.org/keywords/suvmax","display_name":"SUVmax","score":0.9359999895095825},{"id":"https://openalex.org/keywords/metabolic-tumor-volume","display_name":"metabolic tumor volume","score":0.9980000257492065},{"id":"https://openalex.org/keywords/total-lesion-glycolysis","display_name":"total lesion glycolysis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.8889999985694885},{"id":"https://openalex.org/keywords/platelet-to-lymphocyte-ratio","display_name":"platelet-to-lymphocyte ratio","score":1.0},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ca19-9","display_name":"CA19-9","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7319999933242798},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.75}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.9236912131309509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7435908317565918},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7287667989730835},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6511484384536743},{"id":"https://openalex.org/C199374082","wikidata":"https://www.wikidata.org/wiki/Q907080","display_name":"Standardized uptake value","level":3,"score":0.576907217502594},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.5186589956283569},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4767383337020874},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4744863510131836},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.440085232257843},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43593692779541016},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.3465864658355713},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.1634737253189087},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:28697193","doi":"https://doi.org/10.1967/s002449910557","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28697193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hellenic journal of nuclear medicine","raw_type":"Journal Article"},{"id":"mag:2736553833","doi":"https://doi.org/10.1967/s002449910557","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28697193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2332268904","https://openalex.org/W4323293773","https://openalex.org/W3031697961","https://openalex.org/W2924111937","https://openalex.org/W3173441807","https://openalex.org/W4213311661","https://openalex.org/W2280498124","https://openalex.org/W4396805549","https://openalex.org/W4405781039","https://openalex.org/W2603377993"],"abstract_inverted_index":{"OBJECTIVE:":[0],"In":[1,130],"this":[2],"study":[3],"we":[4,226],"investigated":[5],"the":[6,38,50,107,135,187,190],"predictive":[7],"value":[8,13,177,185],"of":[9,40,52,63,83,186],"maximum":[10],"standardized":[11],"uptake":[12],"(SUVmax),":[14],"metabolic":[15],"tumor":[16,99,243],"volume":[17],"(MTV),":[18],"total":[19,62],"lesion":[20],"glycolysis":[21],"(TLG),":[22],"neutrophils/lymphocytes":[23],"ratio":[24,27],"(NLR),":[25],"platelets/lymphocytes":[26],"(PLR),":[28],"carcinoembryonic":[29],"antigen":[30,34],"(CEA)":[31],"and":[32,79,98,106,112,124,158,207,259],"carbohydrate":[33],"(CA":[35],"19-9)":[36,103],"in":[37,49,54,134,141,165,221],"prediction":[39],"KRAS":[41,84,113,136,166,204,229,260],"gene":[42,137,205,230],"mutation":[43,81,115],"which":[44],"plays":[45],"an":[46],"important":[47],"role":[48],"choice":[51],"treatment":[53],"colorectal":[55,68,224],"cancer":[56,69],"patients.":[57],"SUBJECTS":[58],"AND":[59],"METHODS:":[60],"A":[61],"55":[64],"cases":[65,132,143],"with":[66,223],"untreated":[67],"who":[70],"had":[71],"undergone":[72],"both":[73],"PET/CT":[74,89,233],"examinations":[75],"for":[76],"initial":[77],"staging":[78],"also":[80,197],"analysis":[82,123,150,196],"oncogene":[85,114,167],"were":[86,104,138,145],"studied.":[87],"Fluorine-18-FDG":[88],"parameters":[90,95,111,234,239],"(SUVmax,":[91,235],"MTV,":[92,154,209,236],"TLG),":[93,237],"hematological":[94,238],"(NLR,":[96,240],"PLR),":[97],"markers":[100],"(CEA,":[101],"CA":[102,159,214,245],"recorded":[105],"relationship":[108],"between":[109,203,257],"these":[110],"was":[116],"evaluated":[117],"using":[118,232],"receiver":[119],"operating":[120],"characteristics":[121],"(ROC)":[122],"multiple":[125],"logistic":[126,194],"regression":[127,195],"analysis.":[128],"RESULTS:":[129],"20":[131],"mutations":[133,144,164,206,231],"detected,":[139],"while":[140],"35":[142],"not":[146,162,199,252],"observed":[147,219],"(wild-type).":[148],"ROC":[149],"revealed":[151],"that":[152,220],"SUVmax,":[153,208],"TLG,":[155,210],"NLR,":[156,211],"PLR,":[157,212],"19-9":[160,215],"could":[161],"predict":[163,228],"(P=0.600,":[168],"0.263,":[169],"0.214,":[170],"0.057,":[171],"0.104,":[172],"0.189,":[173],"respectively)":[174],"although":[175],"CEA":[176,258],"showed":[178],"signi..cant":[179],"difference":[180],"(P=0.031)":[181],"but":[182,251],"without":[183],"high":[184],"area":[188],"under":[189],"curve":[191],"(0.676).":[192],"Multivariate":[193],"did":[198],"show":[200],"significant":[201,250],"association":[202,255],"CEA,":[213],"values.":[216],"CONCLUSION:":[217],"We":[218,247],"patients":[222],"cancers,":[225],"cannot":[227],"PLR)":[241],"or":[242],"marker":[244],"19-9.":[246],"detected":[248],"a":[249],"very":[253],"strong":[254],"only":[256],"mutations.":[261]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2017-07-31T00:00:00"}
