{"id":"https://openalex.org/W2736453173","doi":"https://doi.org/10.1002/cbin.10824","title":"Runx3 inhibits melanoma cell migration through regulation of cell shape change","display_name":"Runx3 inhibits melanoma cell migration through regulation of cell shape change","publication_year":2017,"publication_date":"2017-07-12","ids":{"openalex":"https://openalex.org/W2736453173","doi":"https://doi.org/10.1002/cbin.10824","mag":"2736453173","pmid":"https://pubmed.ncbi.nlm.nih.gov/28699302"},"language":"en","primary_location":{"id":"doi:10.1002/cbin.10824","doi":"https://doi.org/10.1002/cbin.10824","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbin.10824","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Zhang","raw_affiliation_strings":["The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037012760","display_name":"Linghui Wang","orcid":"https://orcid.org/0000-0003-2492-7364","observed_orcids":["https://orcid.org/0000-0003-2492-7364"]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linghui Wang","raw_affiliation_strings":["The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075079503","display_name":"Xianlu Zeng","orcid":"https://orcid.org/0000-0002-2655-4197","observed_orcids":["https://orcid.org/0000-0002-2655-4197"]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianlu Zeng","raw_affiliation_strings":["The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009223026","display_name":"Takashi Fujita","orcid":"https://orcid.org/0000-0001-7417-3551","observed_orcids":["https://orcid.org/0000-0001-7417-3551"]},"institutions":[{"id":"https://openalex.org/I135768898","display_name":"Ritsumeikan University","ror":"https://ror.org/0197nmd03","country_code":"JP","type":"education","lineage":["https://openalex.org/I135768898","https://openalex.org/I4390039241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Fujita","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Molecular Toxicology Lab, Ritsumeikan University, Shiga 525-8577, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Molecular Toxicology Lab, Ritsumeikan University, Shiga 525-8577, Japan","institution_ids":["https://openalex.org/I135768898"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100662798","display_name":"Wenguang Liu","orcid":"https://orcid.org/0000-0002-4216-2070","observed_orcids":["https://orcid.org/0000-0002-4216-2070"]},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenguang Liu","raw_affiliation_strings":["The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin 130024, China","institution_ids":["https://openalex.org/I184983240"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075079503","https://openalex.org/A5100662798"],"corresponding_institution_ids":["https://openalex.org/I184983240"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.3152,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.50354445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"41","issue":"9","first_page":"1048","last_page":"1055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.17970000207424164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx3","display_name":"RUNX3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cell-morphology-changes","display_name":"cell shape changes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/stress-fiber-formation","display_name":"stress fiber formation","score":0.902999997138977},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.996999979019165},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.996999979019165},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8450000286102295},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.8799999952316284}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8310099840164185},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.7419074177742004},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.7377462387084961},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.641983687877655},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.6017453074455261},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5949928164482117},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4523348808288574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44224244356155396},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4387945830821991},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43176132440567017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35029464960098267},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.22838029265403748},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07615470886230469}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022001","descriptor_name":"Focal Adhesions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022001","descriptor_name":"Focal Adhesions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050677","descriptor_name":"Core Binding Factor Alpha 3 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbin.10824","doi":"https://doi.org/10.1002/cbin.10824","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbin.10824","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},{"id":"pmid:28699302","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28699302","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1214686688","display_name":"Molecular mechanisms of hair follicle formation by Runx family proteins","funder_award_id":"15K07980","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6730518825","display_name":"\u80bf\u7624\u7ec6\u80de\u5206\u6ccc\u56e0\u5b50CXCL1\u548cCXCL2\u8bf1\u5bfc\u9ad3\u6e90\u7956\u7ec6\u80de\u5206\u5316mo-MDSC\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81670095","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8156020483","display_name":"mo-MDSC\u5728\u80bf\u7624\u8f6c\u79fb\u524d\u751f\u6001\u4f4d\u5f62\u6210\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u7814\u7a76","funder_award_id":"81372288","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W181317606","https://openalex.org/W1484875081","https://openalex.org/W1503876730","https://openalex.org/W1884210385","https://openalex.org/W1914408012","https://openalex.org/W1967948255","https://openalex.org/W1971124483","https://openalex.org/W1978228345","https://openalex.org/W1979038578","https://openalex.org/W1995668305","https://openalex.org/W2004563109","https://openalex.org/W2007798124","https://openalex.org/W2008063578","https://openalex.org/W2025316386","https://openalex.org/W2031735540","https://openalex.org/W2047446272","https://openalex.org/W2050136398","https://openalex.org/W2050612706","https://openalex.org/W2058910072","https://openalex.org/W2076480857","https://openalex.org/W2087624790","https://openalex.org/W2090935417","https://openalex.org/W2108713158","https://openalex.org/W2108770100","https://openalex.org/W2118263932","https://openalex.org/W2119204417","https://openalex.org/W2119542428","https://openalex.org/W2127767223","https://openalex.org/W2132868514","https://openalex.org/W2141870702","https://openalex.org/W2142796088","https://openalex.org/W2148454908","https://openalex.org/W2154465669","https://openalex.org/W2161923095","https://openalex.org/W2163802608","https://openalex.org/W2167744079","https://openalex.org/W2169818143","https://openalex.org/W2538172560","https://openalex.org/W2553084674","https://openalex.org/W2555205955"],"related_works":["https://openalex.org/W3131887257","https://openalex.org/W2018712322","https://openalex.org/W2046842139","https://openalex.org/W2107192912","https://openalex.org/W2515950542","https://openalex.org/W2318844540","https://openalex.org/W2154998222","https://openalex.org/W2054953791","https://openalex.org/W2119204417","https://openalex.org/W1505083232"],"abstract_inverted_index":{"The":[0],"transcription":[1],"factor":[2],"Runx3":[3,26,44,88,102,126,141],"is":[4,13,174],"a":[5,117],"known":[6],"tumor":[7],"suppressor":[8],"gene,":[9],"and":[10,31,56,60,72,76,157,180],"its":[11],"expression":[12,27],"frequently":[14],"lost":[15],"in":[16,37,46,90],"melanoma.":[17],"However,":[18],"the":[19,23,51,68,83,87,98,101,111,125,132,168],"potential":[20],"contribution":[21],"of":[22,25,70,100,131],"loss":[24],"to":[28,58,146],"melanoma":[29,48,92,112,133,148,178],"development":[30,179],"progression":[32],"remains":[33],"unclear.":[34],"In":[35,80],"this":[36],"vitro":[38],"study,":[39],"we":[40],"demonstrated":[41],"that":[42,121,140,170],"ectopic":[43],"re-expression":[45,89],"B16-F10":[47,91],"cells":[49,93,113],"changed":[50],"cell":[52,84,95,104,128,144,149,171],"shape":[53,85,105,129,145,172],"from":[54],"elongated":[55],"branched":[57],"spread":[59],"unbranched,":[61],"which":[62],"enhanced":[63],"stress":[64,154],"fiber":[65,155],"formation,":[66],"increased":[67],"number":[69],"mature":[71],"fibrillar":[73],"focal":[74],"adhesions,":[75],"up-regulated":[77],"fibronectin":[78,122],"expression.":[79],"association":[81],"with":[82,177],"change,":[86],"inhibited":[94],"migration.":[96],"Moreover,":[97],"phenotype":[99],"induced":[103,127],"change":[106,130,173],"was":[107],"partially":[108],"resembled":[109],"when":[110],"were":[114],"cultured":[115],"on":[116],"fibronectin-coated":[118],"coverslip,":[119],"suggesting":[120],"may":[123,142],"mediate":[124],"cells.":[134],"Taken":[135],"together,":[136],"our":[137],"findings":[138],"suggest":[139],"regulate":[143],"inhibit":[147],"migration":[150],"partly":[151],"through":[152],"enhancing":[153],"formation":[156],"ECM":[158],"protein":[159],"production.":[160],"Our":[161],"present":[162],"study":[163],"provides":[164],"further":[165],"evidence":[166],"for":[167],"idea":[169],"potentially":[175],"correlated":[176],"progression.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2017-07-31T00:00:00"}