{"id":"https://openalex.org/W2736445985","doi":"https://doi.org/10.1159/000470812","title":"The Contribution of Adult Hippocampal Neurogenesis to the Progression of Psychiatric Disorders","display_name":"The Contribution of Adult Hippocampal Neurogenesis to the Progression of Psychiatric Disorders","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2736445985","doi":"https://doi.org/10.1159/000470812","mag":"2736445985","pmid":"https://pubmed.ncbi.nlm.nih.gov/28738394"},"language":"en","primary_location":{"id":"doi:10.1159/000470812","doi":"https://doi.org/10.1159/000470812","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000470812","pdf_url":null,"source":{"id":"https://openalex.org/S4210204830","display_name":"Modern trends in psychiatry","issn_l":"2504-0464","issn":["2504-0464","2504-124X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Trends in Psychiatry","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2617259790","display_name":"Neuroprogression in Psychiatric Disorders"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057830583","display_name":"Rachel A. Kohman","orcid":"https://orcid.org/0000-0002-9737-3668","observed_orcids":["https://orcid.org/0000-0002-9737-3668"]},"institutions":[{"id":"https://openalex.org/I153901656","display_name":"University of North Carolina Wilmington","ror":"https://ror.org/02t0qr014","country_code":"US","type":"education","lineage":["https://openalex.org/I153901656"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Kohman","raw_affiliation_strings":["Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, and","institution_ids":["https://openalex.org/I153901656"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053942773","display_name":"Justin S. Rhodes","orcid":"https://orcid.org/0000-0002-4871-4331","observed_orcids":["https://orcid.org/0000-0002-4871-4331"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I2801919071","display_name":"University of Illinois System","ror":"https://ror.org/05e94g991","country_code":"US","type":"education","lineage":["https://openalex.org/I2801919071"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin S. Rhodes","raw_affiliation_strings":["Department of Psychology, The Beckman Institute, University of Illinois, Urbana, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, The Beckman Institute, University of Illinois, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I2801919071"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6364,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.87283237,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"31","issue":null,"first_page":"124","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-hippocampal-neurogenesis","display_name":"adult hippocampal neurogenesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.8870000243186951},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.6610000133514404},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.890999972820282},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.5260000228881836},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.8999999761581421},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.800000011920929},{"id":"https://openalex.org/keywords/drug-abuse","display_name":"drug abuse","score":0.7160000205039978},{"id":"https://openalex.org/keywords/neurogenesis-regulation","display_name":"neurogenesis regulation","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.9866111278533936},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5698047280311584},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5453668236732483},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.509407103061676},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4483986794948578},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.41002407670021057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32299816608428955}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000470812","doi":"https://doi.org/10.1159/000470812","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000470812","pdf_url":null,"source":{"id":"https://openalex.org/S4210204830","display_name":"Modern trends in psychiatry","issn_l":"2504-0464","issn":["2504-0464","2504-124X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Trends in Psychiatry","raw_type":"book-chapter"},{"id":"pmid:28738394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28738394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern trends in pharmacopsychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":196,"referenced_works":["https://openalex.org/W49700401","https://openalex.org/W644076287","https://openalex.org/W1499680307","https://openalex.org/W1503164232","https://openalex.org/W1514204750","https://openalex.org/W1532177691","https://openalex.org/W1576581762","https://openalex.org/W1670625131","https://openalex.org/W1912010215","https://openalex.org/W1919947890","https://openalex.org/W1963940970","https://openalex.org/W1964173716","https://openalex.org/W1966804691","https://openalex.org/W1968019821","https://openalex.org/W1968840425","https://openalex.org/W1969352530","https://openalex.org/W1971233916","https://openalex.org/W1973429276","https://openalex.org/W1973861157","https://openalex.org/W1974776346","https://openalex.org/W1980166225","https://openalex.org/W1981907384","https://openalex.org/W1981964751","https://openalex.org/W1982528484","https://openalex.org/W1982754908","https://openalex.org/W1983706324","https://openalex.org/W1984567634","https://openalex.org/W1984665282","https://openalex.org/W1985438873","https://openalex.org/W1985952195","https://openalex.org/W1987604172","https://openalex.org/W1995188451","https://openalex.org/W1995538780","https://openalex.org/W1995582623","https://openalex.org/W1995915605","https://openalex.org/W1996484852","https://openalex.org/W1996588072","https://openalex.org/W1997472265","https://openalex.org/W1997591796","https://openalex.org/W1999615939","https://openalex.org/W2001997781","https://openalex.org/W2002648221","https://openalex.org/W2005382874","https://openalex.org/W2005775138","https://openalex.org/W2009525838","https://openalex.org/W2010180821","https://openalex.org/W2010484804","https://openalex.org/W2012346622","https://openalex.org/W2014141862","https://openalex.org/W2014559245","https://openalex.org/W2017139152","https://openalex.org/W2017773565","https://openalex.org/W2018487237","https://openalex.org/W2019492885","https://openalex.org/W2021551531","https://openalex.org/W2021897449","https://openalex.org/W2023295081","https://openalex.org/W2023343492","https://openalex.org/W2026672146","https://openalex.org/W2027132385","https://openalex.org/W2027147751","https://openalex.org/W2027276122","https://openalex.org/W2027953236","https://openalex.org/W2029991969","https://openalex.org/W2030156843","https://openalex.org/W2030396834","https://openalex.org/W2030667276","https://openalex.org/W2030772288","https://openalex.org/W2032923944","https://openalex.org/W2033206554","https://openalex.org/W2034630933","https://openalex.org/W2037577798","https://openalex.org/W2041104744","https://openalex.org/W2041706711","https://openalex.org/W2042755650","https://openalex.org/W2042899905","https://openalex.org/W2045656102","https://openalex.org/W2047460164","https://openalex.org/W2047643883","https://openalex.org/W2050379506","https://openalex.org/W2050508296","https://openalex.org/W2051173215","https://openalex.org/W2052154927","https://openalex.org/W2054552572","https://openalex.org/W2054865354","https://openalex.org/W2059093737","https://openalex.org/W2059332720","https://openalex.org/W2060709606","https://openalex.org/W2062808587","https://openalex.org/W2064323269","https://openalex.org/W2064470291","https://openalex.org/W2066027939","https://openalex.org/W2067856703","https://openalex.org/W2068080380","https://openalex.org/W2068607973","https://openalex.org/W2069153421","https://openalex.org/W2069338913","https://openalex.org/W2069785065","https://openalex.org/W2072895093","https://openalex.org/W2073068789","https://openalex.org/W2073557931","https://openalex.org/W2076509578","https://openalex.org/W2079006359","https://openalex.org/W2079335806","https://openalex.org/W2079676087","https://openalex.org/W2079781508","https://openalex.org/W2080605751","https://openalex.org/W2082377187","https://openalex.org/W2084017889","https://openalex.org/W2087953568","https://openalex.org/W2088601627","https://openalex.org/W2089059900","https://openalex.org/W2089159998","https://openalex.org/W2089949016","https://openalex.org/W2092245844","https://openalex.org/W2092257713","https://openalex.org/W2092499931","https://openalex.org/W2092669597","https://openalex.org/W2093539347","https://openalex.org/W2093541378","https://openalex.org/W2094050668","https://openalex.org/W2096582296","https://openalex.org/W2097408153","https://openalex.org/W2097740790","https://openalex.org/W2098234649","https://openalex.org/W2099516158","https://openalex.org/W2099713879","https://openalex.org/W2099867701","https://openalex.org/W2101446581","https://openalex.org/W2101898118","https://openalex.org/W2102082974","https://openalex.org/W2102181001","https://openalex.org/W2103379504","https://openalex.org/W2104019762","https://openalex.org/W2107965376","https://openalex.org/W2108476653","https://openalex.org/W2112772389","https://openalex.org/W2114999955","https://openalex.org/W2119471783","https://openalex.org/W2120811265","https://openalex.org/W2121021142","https://openalex.org/W2123263640","https://openalex.org/W2125244470","https://openalex.org/W2129579709","https://openalex.org/W2133518193","https://openalex.org/W2133565799","https://openalex.org/W2133748952","https://openalex.org/W2135890562","https://openalex.org/W2136108338","https://openalex.org/W2136801447","https://openalex.org/W2140980734","https://openalex.org/W2141701184","https://openalex.org/W2142302489","https://openalex.org/W2145235967","https://openalex.org/W2145944042","https://openalex.org/W2146316688","https://openalex.org/W2147909291","https://openalex.org/W2148239264","https://openalex.org/W2148764339","https://openalex.org/W2149537438","https://openalex.org/W2149677176","https://openalex.org/W2150056340","https://openalex.org/W2151400960","https://openalex.org/W2152820394","https://openalex.org/W2153533547","https://openalex.org/W2153779995","https://openalex.org/W2154042029","https://openalex.org/W2154653323","https://openalex.org/W2154908600","https://openalex.org/W2158151282","https://openalex.org/W2159040523","https://openalex.org/W2161120457","https://openalex.org/W2163997417","https://openalex.org/W2166192872","https://openalex.org/W2166667138","https://openalex.org/W2167272363","https://openalex.org/W2167314970","https://openalex.org/W2169145097","https://openalex.org/W2172266256","https://openalex.org/W2181290496","https://openalex.org/W2194319389","https://openalex.org/W2206955164","https://openalex.org/W2262588230","https://openalex.org/W2283257267","https://openalex.org/W2291635547","https://openalex.org/W2292881981","https://openalex.org/W2317061589","https://openalex.org/W2341485965","https://openalex.org/W2342965781","https://openalex.org/W2415131480","https://openalex.org/W2419501979","https://openalex.org/W2507998393","https://openalex.org/W2513485137","https://openalex.org/W2515897135","https://openalex.org/W2522618573","https://openalex.org/W2791952348"],"related_works":["https://openalex.org/W2087430590","https://openalex.org/W2003229273","https://openalex.org/W4416453360","https://openalex.org/W2144186309","https://openalex.org/W2027706716","https://openalex.org/W140650021","https://openalex.org/W2790136269","https://openalex.org/W3072015068","https://openalex.org/W2325107033","https://openalex.org/W7096506658"],"abstract_inverted_index":{"New":[0],"neurons":[1,121,191],"are":[2,67,81,92,150,168],"continuously":[3],"formed":[4],"in":[5,41,122,143,171,197],"the":[6,10,31,34,42,62,74,86,110,113,116,157,172,200],"adult":[7,58],"hippocampus":[8],"of":[9,20,33,47,65,77,112,119,156,185,189,202],"human,":[11],"nonhuman":[12],"primate,":[13],"and":[14,53,69,83,100,129,165,199],"rodent":[15],"throughout":[16],"life":[17,36],"though":[18],"rates":[19],"neurogenesis":[21,66,78,103,144],"precipitously":[22],"decline":[23],"with":[24,94],"age":[25,80],"to":[26,98,109,126,180,192],"near":[27],"zero":[28],"levels":[29],"at":[30],"end":[32],"natural":[35],"span.":[37],"Since":[38],"its":[39],"discovery":[40],"1960s,":[43],"a":[44,106,132,151,154],"large":[45],"number":[46],"studies":[48],"have":[49],"documented":[50],"numerous":[51],"environmental":[52],"genetic":[54],"factors":[55,159],"which":[56,167],"regulate":[57],"neurogenesis.":[59],"Chief":[60,72],"among":[61,73],"positive":[63],"regulators":[64,76],"exercise":[68],"antidepressant":[70],"drugs.":[71],"negative":[75],"besides":[79],"stress":[82,99],"inflammation.":[84],"To":[85],"extent":[87],"that":[88,145],"many":[89],"psychiatric":[90,148],"disorders":[91],"comorbid":[93],"or":[95,153],"causally":[96],"related":[97],"inflammation,":[101,166],"decreased":[102],"could":[104],"be":[105,127,176],"partial":[107],"contributor":[108],"pathophysiology":[111],"disorders.":[114,173],"However,":[115],"functional":[117,195],"significance":[118,196],"new":[120,190],"behavior":[123,198],"has":[124],"yet":[125],"established":[128],"is":[130,138],"currently":[131],"hotly":[133],"debated":[134],"topic.":[135],"Therefore,":[136],"it":[137],"not":[139],"clear":[140],"whether":[141],"changes":[142],"occur":[146],"alongside":[147],"illnesses":[149],"cause":[152],"consequence":[155],"mediating":[158],"such":[160],"as":[161],"stress,":[162],"drug":[163],"abuse,":[164],"complexly":[169],"involved":[170],"It":[174],"will":[175],"important":[177],"moving":[178],"forward":[179],"use":[181],"modern":[182],"technologies":[183],"capable":[184],"instantaneously":[186],"inactivating":[187],"cohorts":[188],"test":[193],"their":[194],"etiology":[201],"mental":[203],"illnesses.":[204]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-31T00:00:00"}