{"id":"https://openalex.org/W2736294334","doi":null,"title":"Identification and functional analysis of gene expression changes in acute myeloid leukaemia.","display_name":"Identification and functional analysis of gene expression changes in acute myeloid leukaemia.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2736294334","mag":"2736294334"},"language":"en","primary_location":{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/65057","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/65057","pdf_url":"http://hdl.handle.net/2440/65057","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2440/65057","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061012183","display_name":"Chung Hoow Kok","orcid":"https://orcid.org/0000-0002-3181-7852","observed_orcids":["https://orcid.org/0000-0002-3181-7852"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chung Hoow Kok","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3181-7852","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5061012183"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.6340000033378601},{"id":"https://openalex.org/keywords/cd123","display_name":"CD123","score":0.8130000233650208},{"id":"https://openalex.org/keywords/akt-mtor-signaling-pathway","display_name":"Akt/mTOR signaling","score":0.7730000019073486},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9210000038146973},{"id":"https://openalex.org/keywords/gadd45a","display_name":"GADD45A","score":0.9100000262260437},{"id":"https://openalex.org/keywords/differentiation-block","display_name":"differentiation block","score":0.6119999885559082},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.578000009059906},{"id":"https://openalex.org/keywords/connectivity-map","display_name":"Connectivity Map","score":0.6520000100135803},{"id":"https://openalex.org/keywords/inv-16","display_name":"inv(16)","score":0.7760000228881836},{"id":"https://openalex.org/keywords/mll-translocation","display_name":"MLL translocation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C2993296363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukaemia","level":2,"score":0.7890875339508057},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6108874082565308},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47685110569000244},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4754840135574341},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4582350552082062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40782204270362854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38437017798423767},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37528741359710693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33474767208099365},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.05849611759185791}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/65057","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/65057","pdf_url":"http://hdl.handle.net/2440/65057","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2736294334","doi":null,"is_oa":false,"landing_page_url":"https://digital.library.adelaide.edu.au/dspace/bitstream/2440/65057/9/01front.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/65057","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/65057","pdf_url":"http://hdl.handle.net/2440/65057","source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311773","display_name":"Women and Children's Health Research Institute","ror":"https://ror.org/03e04kk51"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2736294334.pdf","grobid_xml":"https://content.openalex.org/works/W2736294334.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1486705501","https://openalex.org/W1516797134","https://openalex.org/W1518200090","https://openalex.org/W1528682116","https://openalex.org/W1963718146","https://openalex.org/W1972892706","https://openalex.org/W1973489569","https://openalex.org/W1976021347","https://openalex.org/W1980401099","https://openalex.org/W1982130774","https://openalex.org/W1983757156","https://openalex.org/W1990030298","https://openalex.org/W1991479256","https://openalex.org/W1991509879","https://openalex.org/W1992390929","https://openalex.org/W1996172186","https://openalex.org/W1996840524","https://openalex.org/W2001614713","https://openalex.org/W2001871974","https://openalex.org/W2004608668","https://openalex.org/W2006752284","https://openalex.org/W2009886857","https://openalex.org/W2011477466","https://openalex.org/W2011585726","https://openalex.org/W2013546240","https://openalex.org/W2014737409","https://openalex.org/W2014970302","https://openalex.org/W2018699543","https://openalex.org/W2019530874","https://openalex.org/W2030257185","https://openalex.org/W2030371558","https://openalex.org/W2033196054","https://openalex.org/W2035521247","https://openalex.org/W2036161897","https://openalex.org/W2040950977","https://openalex.org/W2045166052","https://openalex.org/W2051974375","https://openalex.org/W2059150276","https://openalex.org/W2072870454","https://openalex.org/W2076426515","https://openalex.org/W2080461863","https://openalex.org/W2081302041","https://openalex.org/W2086338749","https://openalex.org/W2089910118","https://openalex.org/W2093708765","https://openalex.org/W2093769888","https://openalex.org/W2095247586","https://openalex.org/W2102450081","https://openalex.org/W2112364188","https://openalex.org/W2114242622","https://openalex.org/W2123202958","https://openalex.org/W2132032809","https://openalex.org/W2137774959","https://openalex.org/W2149011343","https://openalex.org/W2152333235","https://openalex.org/W2164751825","https://openalex.org/W2307098563","https://openalex.org/W2329654917","https://openalex.org/W2411380396"],"related_works":["https://openalex.org/W89619966","https://openalex.org/W2049482339","https://openalex.org/W2165392081","https://openalex.org/W2154742235","https://openalex.org/W7095200137","https://openalex.org/W2591535566","https://openalex.org/W2620947741","https://openalex.org/W2096340973","https://openalex.org/W2111486257","https://openalex.org/W7071404078"],"abstract_inverted_index":{"Acute":[0],"Myeloid":[1],"Leukaemia":[2],"(AML)":[3],"is":[4,17,43,108,136,248,302],"a":[5,127,150,191],"malignant":[6],"blood":[7],"cancer":[8],"characterised":[9],"by":[10,149,157,259],"uncontrolled":[11],"growth":[12,125,187,283],"of":[13,22,70,84,100,113,141,153,172,197,212,219,236,246,285,304],"leukaemic":[14,151],"blasts.":[15],"This":[16],"associated":[18,44,57,162,279],"with":[19,34,45,58,163,202,207,280,293,311,320],"constitutive":[20,82],"activation":[21],"key":[23],"signalling":[24],"molecules":[25],"such":[26],"as":[27,80],"AKT,":[28],"ERK1/2,":[29],"STAT5":[30],"and":[31,33,68,92,115,126,139,145,156,188,190,215,222,228,239,253,277,297,332,339],"NF\uf06bB":[32],"aberrant":[35,118],"transcription":[36],"factor":[37,95],"activity,":[38],"which":[39,182,247],"in":[40,78,110,129,133,181,193,256],"many":[41],"cases":[42,292],"characteristic":[46],"chromosomal":[47,295],"translocations.":[48],"Aberrant":[49],"receptor":[50,72,96,107],"signaling":[51,61,120,143],"can":[52],"constitutively":[53],"activate":[54],"the":[55,59,85,101,116,137,142,158,173,210,213,234,254,260,269,274,281,305,329],"pathways":[56,144,217,278],"above":[60],"molecules.":[62],"For":[63,165],"example,":[64],"autocrine":[65],"interleukin-3":[66],"(IL-3),":[67],"over-expression":[69],"IL-3":[71,91],"alpha":[73],"(IL3RA/CD123)":[74],"have":[75,324],"been":[76,267],"found":[77],"AML,":[79],"has":[81,204,266],"phosphorylation":[83],"common":[86,109],"beta":[87],"subunit":[88],"(hBc)":[89],"for":[90,224,250,337],"granulocyte-macrophage":[93],"colony-stimulating":[94],"(GMR).":[97],"Also":[98],"mutation":[99],"FMS-like":[102],"tyrosine":[103],"kinase":[104],"3":[105],"(FLT3)":[106],"AML":[111,291,334,342],"(~30%":[112],"patients)":[114],"resultant":[117],"FLT3":[119,159],"contributes":[121],"to":[122,209,272,317],"enhanced":[123],"survival,":[124],"block":[128,192,255],"differentiation.":[130,194,229],"A":[131,263],"focus":[132,265],"this":[134,198],"thesis":[135],"identification":[138],"dissection":[140],"downstream":[146,218],"genes":[147],"activated":[148,160,261],"mutant":[152],"GMR":[154],"(GMR-V449E)":[155],"mutants":[161,184],"AML.":[164,286],"these":[166,183,220],"studies":[167],"we":[168,231,289],"make":[169],"extensive":[170],"use":[171,196,301],"murine":[174],"bi-potential":[175],"myeloid":[176],"cell":[177,225,251],"line":[178],"model":[179],"FDB-1":[180],"induce":[185],"factorindependent":[186],"survival":[189,227,252],"The":[195],"experimental":[199],"approach":[200],"together":[201,310],"bioinformatics":[203],"provided":[205],"leads":[206],"regard":[208],"role":[211,235],"AKT/mTOR":[214],"ERK":[216],"receptors,":[221],"important":[223,249],"proliferation,":[226],"Additionally,":[230],"focused":[232],"on":[233,341],"the\\nGrowth":[237],"Arrest":[238],"DNA":[240],"Damage":[241],"45a":[242],"(Gadd45a)":[243],"gene,":[244],"repression":[245],"differentiation":[257],"induced":[258],"mutants.":[262],"second":[264],"extending":[268],"bioinformatic":[270],"approaches":[271],"define":[273,318],"gene":[275,314],"expression":[276,315],"abnormal":[282],"characteristics":[284],"In":[287],"particular,":[288],"studied":[290],"numerical":[294],"abnormalities":[296],"translocation":[298,335],"events.":[299],"Extensive":[300],"made":[303],"Connectivity":[306],"Map":[307],"(CMAP)":[308],"resource":[309],"publicly":[312],"available":[313],"datasets":[316],"agents":[319],"antileukaemic":[321],"potential.":[322],"We":[323],"tested":[325],"drugs,":[326],"selected":[327],"using":[328],"inv(16)":[330],"(CBFB-MYH11)":[331],"MLL":[333],"signatures,":[336],"specificity":[338],"sensitivity":[340],"patient":[343],"samples.":[344]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2017-07-21T00:00:00"}