{"id":"https://openalex.org/W2736246487","doi":"https://doi.org/10.1152/ajpendo.00075.2017","title":"Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men","display_name":"Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men","publication_year":2017,"publication_date":"2017-07-11","ids":{"openalex":"https://openalex.org/W2736246487","doi":"https://doi.org/10.1152/ajpendo.00075.2017","mag":"2736246487","pmid":"https://pubmed.ncbi.nlm.nih.gov/28698282","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5792144"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00075.2017","doi":"https://doi.org/10.1152/ajpendo.00075.2017","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00075.2017","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC5792144","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074929020","display_name":"Katya B. Rubinow","orcid":"https://orcid.org/0000-0002-6505-5657","observed_orcids":["https://orcid.org/0000-0002-6505-5657"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Katya B. Rubinow","raw_affiliation_strings":["Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;","Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;"],"raw_orcid":"https://orcid.org/0000-0002-6505-5657","affiliations":[{"raw_affiliation_string":"Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002414635","display_name":"Jing H. Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing H. Chao","raw_affiliation_strings":["Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053256029","display_name":"Derek K. Hagman","orcid":"https://orcid.org/0000-0003-2877-2304","observed_orcids":["https://orcid.org/0000-0003-2877-2304"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Hagman","raw_affiliation_strings":["The Fred Hutchinson Cancer Research Center, Seattle, Washington; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fred Hutchinson Cancer Research Center, Seattle, Washington; and","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066606742","display_name":"Mario Kratz","orcid":"https://orcid.org/0000-0003-2660-8033","observed_orcids":["https://orcid.org/0000-0003-2660-8033"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mario Kratz","raw_affiliation_strings":["Department of Nutrition and Department of Environmental Toxicology, University of California-Davis, Davis, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Department of Environmental Toxicology, University of California-Davis, Davis, California","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089769656","display_name":"Brian Van Yserloo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Van Yserloo","raw_affiliation_strings":["Department of Surgery, University of Washington School of Medicine, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Washington School of Medicine, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033681410","display_name":"Nilesh W. Gaikwad","orcid":"https://orcid.org/0000-0002-4087-3266","observed_orcids":["https://orcid.org/0000-0002-4087-3266"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilesh W. Gaikwad","raw_affiliation_strings":["Department of Nutrition and Department of Environmental Toxicology, University of California-Davis, Davis, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition and Department of Environmental Toxicology, University of California-Davis, Davis, California","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017240945","display_name":"John Kenneth Amory","orcid":"https://orcid.org/0000-0002-7419-435X","observed_orcids":["https://orcid.org/0000-0002-7419-435X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John K. Amory","raw_affiliation_strings":["Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101630226","display_name":"Stephanie T. Page","orcid":"https://orcid.org/0000-0002-6959-6389","observed_orcids":["https://orcid.org/0000-0002-6959-6389"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie T. Page","raw_affiliation_strings":["Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;","Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Research in Reproduction and Contraception, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Diabetes Institute, Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, Washington;","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074929020"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":1.0701,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77124757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"313","issue":"5","first_page":"E528","last_page":"E539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-steroids","display_name":"sex steroids","score":0.921999990940094},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.8320000171661377},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.949999988079071},{"id":"https://openalex.org/keywords/adipose-tissue-immune-cells","display_name":"adipose tissue immune cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/adipose-tissue-macrophages","display_name":"adipose tissue macrophages","score":0.8799999952316284},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/male-hypogonadism","display_name":"male hypogonadism","score":0.9079999923706055},{"id":"https://openalex.org/keywords/acyline","display_name":"acyline","score":0.675000011920929},{"id":"https://openalex.org/keywords/gnrh-antagonist","display_name":"GnRH antagonist","score":0.8840000033378601},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.5170000195503235},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.9230921268463135},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8615114688873291},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8337147235870361},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6583383083343506},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5844154953956604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49855470657348633},{"id":"https://openalex.org/C2779938979","wikidata":"https://www.wikidata.org/wiki/Q422812","display_name":"Sex steroid","level":4,"score":0.45867404341697693},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4421055316925049},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.333251416683197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28146156668663025},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.16219568252563477},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12047842144966125}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011966","descriptor_name":"Receptors, LHRH","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039521","descriptor_name":"CD11c Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajpendo.00075.2017","doi":"https://doi.org/10.1152/ajpendo.00075.2017","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00075.2017","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5155879","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5792144","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5792144","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5792144","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Endocrinol Metab","raw_type":"Text"},{"id":"pmid:28698282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28698282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5155879","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5792144","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1203555382","display_name":"Dose-response relationship between circulating and prostatic androgens in men","funder_award_id":"5r01ag037603-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1964883604","display_name":null,"funder_award_id":"R01-AG-037603","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6518910007","display_name":"Men's Reproductive Health Research at the University of Washington","funder_award_id":"K12HD053984","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000881174","display_name":"Diabetes Research Center","funder_award_id":"P30DK017047","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000920257","display_name":"Diabetes, Obesity and Metabolism Training Program","funder_award_id":"T32DK007247","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":89,"referenced_works":["https://openalex.org/W1500142735","https://openalex.org/W1577577364","https://openalex.org/W1667402504","https://openalex.org/W1863098067","https://openalex.org/W1964971241","https://openalex.org/W1968573181","https://openalex.org/W1971003548","https://openalex.org/W1984508788","https://openalex.org/W1985061586","https://openalex.org/W1991309264","https://openalex.org/W1991374761","https://openalex.org/W1999861795","https://openalex.org/W2000467286","https://openalex.org/W2001118572","https://openalex.org/W2002967738","https://openalex.org/W2003583183","https://openalex.org/W2003729023","https://openalex.org/W2003819161","https://openalex.org/W2004181696","https://openalex.org/W2004316716","https://openalex.org/W2008295589","https://openalex.org/W2008869160","https://openalex.org/W2026457264","https://openalex.org/W2027085157","https://openalex.org/W2027264386","https://openalex.org/W2028122319","https://openalex.org/W2037725361","https://openalex.org/W2041695244","https://openalex.org/W2044574130","https://openalex.org/W2045688706","https://openalex.org/W2049679461","https://openalex.org/W2054591290","https://openalex.org/W2058461615","https://openalex.org/W2060067888","https://openalex.org/W2064899968","https://openalex.org/W2073593141","https://openalex.org/W2076633494","https://openalex.org/W2078940124","https://openalex.org/W2088983332","https://openalex.org/W2098140119","https://openalex.org/W2098214350","https://openalex.org/W2101328621","https://openalex.org/W2102076625","https://openalex.org/W2102179430","https://openalex.org/W2103435859","https://openalex.org/W2104919541","https://openalex.org/W2107786108","https://openalex.org/W2111061353","https://openalex.org/W2118553855","https://openalex.org/W2119283349","https://openalex.org/W2120071870","https://openalex.org/W2121845219","https://openalex.org/W2122779261","https://openalex.org/W2124384011","https://openalex.org/W2124967115","https://openalex.org/W2134463235","https://openalex.org/W2136024338","https://openalex.org/W2141671471","https://openalex.org/W2142563833","https://openalex.org/W2143055774","https://openalex.org/W2143079083","https://openalex.org/W2145690342","https://openalex.org/W2145697808","https://openalex.org/W2149120265","https://openalex.org/W2149332882","https://openalex.org/W2155279970","https://openalex.org/W2158171063","https://openalex.org/W2159081962","https://openalex.org/W2160140561","https://openalex.org/W2160581228","https://openalex.org/W2163660677","https://openalex.org/W2166289344","https://openalex.org/W2169664798","https://openalex.org/W2170535351","https://openalex.org/W2175576992","https://openalex.org/W2192099069","https://openalex.org/W2208778639","https://openalex.org/W2259577452","https://openalex.org/W2264199913","https://openalex.org/W2290750036","https://openalex.org/W2299822073","https://openalex.org/W2320443657","https://openalex.org/W2349392032","https://openalex.org/W2395409092","https://openalex.org/W2411657503","https://openalex.org/W2412044945","https://openalex.org/W2504837934","https://openalex.org/W2508933622","https://openalex.org/W2593574278"],"related_works":["https://openalex.org/W3011365805","https://openalex.org/W2069954919","https://openalex.org/W2978523530","https://openalex.org/W2070191401","https://openalex.org/W2092105206","https://openalex.org/W2149154502","https://openalex.org/W4402141597","https://openalex.org/W2404462206","https://openalex.org/W7099050675","https://openalex.org/W2018430241"],"abstract_inverted_index":{"Male":[0],"hypogonadism":[1],"results":[2],"in":[3,5,11,20,40,124,133,165,173,195,200,217,230,237,268],"changes":[4,229,236],"body":[6],"composition":[7],"characterized":[8],"by":[9],"increases":[10,216],"fat":[12],"mass.":[13],"Resident":[14],"immune":[15,47,113,250],"cells":[16,160,221],"influence":[17],"energy":[18],"metabolism":[19],"adipose":[21,45,101,111,162,177,218,238,248],"tissue":[22,46,102,112,178,219,239,249],"and":[23,108,110,117,151,198,222,235],"could":[24,262],"promote":[25],"increased":[26,265],"adiposity":[27],"through":[28],"paracrine":[29],"effects.":[30],"We":[31],"hypothesized":[32],"that":[33,261],"manipulation":[34],"of":[35,58,63,75,136,176],"circulating":[36],"sex":[37,210,232,243],"steroid":[38,211,233,244],"levels":[39,120,234,245],"healthy":[41],"men":[42],"would":[43],"alter":[44],"cell":[48,251],"populations.":[49,252],"Subjects":[50],"(":[51],"n":[52],"=":[53,139,142,146,149,154,157,182,185,204,207],"44":[54],"men,":[55],"19\u201355":[56],"yr":[57],"age)":[59],"received":[60],"4":[61],"wk":[62],"treatment":[64],"with":[65,72,96,131,171,215],"the":[66,134,174],"gonadotropin-releasing":[67],"hormone":[68],"receptor":[69],"antagonist":[70],"acyline":[71],"daily":[73],"administration":[74],"1)":[76],"placebo":[77],"gel,":[78,89],"2)":[79],"1.25":[80],"g":[81,87,93],"testosterone":[82,88,94,127,197],"gel":[83,95],"(1.62%),":[84],"3)":[85],"5":[86,92],"or":[90],"4)":[91],"an":[97],"aromatase":[98],"inhibitor.":[99],"Subcutaneous":[100],"biopsies":[103],"were":[104,121,226],"performed":[105],"at":[106],"baseline":[107],"end-of-treatment,":[109],"cells,":[114],"gene":[115,240],"expression,":[116],"intra-adipose":[118],"estrogen":[119],"quantified.":[122],"Change":[123,164],"serum":[125,166,196,231],"total":[126],"level":[128,168],"correlated":[129,169],"inversely":[130,170],"change":[132,172,194,199],"number":[135,175],"CD3+":[137],"(\u03b2":[138,145,153,181,203],"\u22120.36,":[140],"P":[141,148,156,184,206],"0.04),":[143,150],"CD4+":[144],"\u22120.34,":[147,183],"CD8+":[152],"\u22120.33,":[155],"0.05)":[158],"T":[159,220],"within":[161],"tissue.":[163],"17\u03b2-estradiol":[167],"macrophages":[179],"(ATMs)":[180],"0.05).":[186],"A":[187],"negative":[188],"association":[189],"also":[190],"was":[191,213],"found":[192,227],"between":[193,228],"CD11c+":[201],"ATMs":[202],"\u22120.41,":[205],"0.01).":[208],"Overall,":[209],"deprivation":[212],"associated":[214],"ATMs.":[223],"No":[224],"associations":[225],"expression.":[241],"Circulating":[242],"may":[246],"regulate":[247],"These":[253],"exploratory":[254],"findings":[255],"highlight":[256],"a":[257],"possible":[258],"novel":[259],"mechanism":[260],"contribute":[263],"to":[264],"metabolic":[266],"risk":[267],"hypogonadal":[269],"men.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-21T00:00:00"}