{"id":"https://openalex.org/W2736216151","doi":"https://doi.org/10.18632/oncotarget.19217","title":"PTEN loss detection in prostate cancer: comparison of PTEN immunohistochemistry and PTEN FISH in a large retrospective prostatectomy cohort","display_name":"PTEN loss detection in prostate cancer: comparison of PTEN immunohistochemistry and PTEN FISH in a large retrospective prostatectomy cohort","publication_year":2017,"publication_date":"2017-07-10","ids":{"openalex":"https://openalex.org/W2736216151","doi":"https://doi.org/10.18632/oncotarget.19217","mag":"2736216151","pmid":"https://pubmed.ncbi.nlm.nih.gov/29029453"},"language":"en","primary_location":{"id":"doi:10.18632/oncotarget.19217","doi":"https://doi.org/10.18632/oncotarget.19217","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19217","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18632/oncotarget.19217","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008552473","display_name":"Tamara Levin Lotan","orcid":"https://orcid.org/0000-0002-0494-9067","observed_orcids":["https://orcid.org/0000-0002-0494-9067"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara L. Lotan","raw_affiliation_strings":["Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA","Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088886744","display_name":"Asmus Heumann","orcid":"https://orcid.org/0009-0001-5542-579X","observed_orcids":["https://orcid.org/0009-0001-5542-579X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Asmus Heumann","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062979282","display_name":"Sebastian Dwertmann Rico","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Dwertmann Rico","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077295537","display_name":"Jessica L Hicks","orcid":"https://orcid.org/0000-0001-7885-3319","observed_orcids":["https://orcid.org/0000-0001-7885-3319"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Hicks","raw_affiliation_strings":["Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088656778","display_name":"Kristen Lecksell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Lecksell","raw_affiliation_strings":["Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085320118","display_name":"Christina Koop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Koop","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021421424","display_name":"Guido Sauter","orcid":"https://orcid.org/0000-0002-9024-4978","observed_orcids":["https://orcid.org/0000-0002-9024-4978"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guido Sauter","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006752837","display_name":"Thorsten Schlomm","orcid":"https://orcid.org/0000-0001-9557-4653","observed_orcids":["https://orcid.org/0000-0001-9557-4653"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210111521","display_name":"Martini-Klinik","ror":"https://ror.org/01vb5ks25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711","https://openalex.org/I4210111521"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten Schlomm","raw_affiliation_strings":["Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","Martini-Klinik Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Martini-Klinik Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711","https://openalex.org/I4210111521"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086499788","display_name":"Ronald Simon","orcid":"https://orcid.org/0000-0003-0158-4258","observed_orcids":["https://orcid.org/0000-0003-0158-4258"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ronald Simon","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.8847,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.97647926,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"39","first_page":"65566","last_page":"65576"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pten-loss","display_name":"PTEN loss","score":0.9449999928474426},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/diagnostic-agreement","display_name":"diagnostic agreement","score":0.656000018119812},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.8859999775886536},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.8849999904632568},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/biochemical-recurrence","display_name":"biochemical recurrence","score":0.5740000009536743},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.39800000190734863},{"id":"https://openalex.org/keywords/gleason-grade","display_name":"Gleason grade","score":0.4320000112056732},{"id":"https://openalex.org/keywords/hormone-receptor-status","display_name":"hormone receptor status","score":0.42899999022483826},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9865785837173462},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7068028450012207},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6370358467102051},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.5864534378051758},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5633800625801086},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.5163615942001343},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4922589361667633},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4369683265686035},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.425092875957489},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42037487030029297},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40245839953422546},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3812013566493988},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703825831413269},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12047842144966125},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.05890995264053345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05177423357963562},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18632/oncotarget.19217","doi":"https://doi.org/10.18632/oncotarget.19217","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19217","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},{"id":"pmid:29029453","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29029453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4558434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5630353","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5630353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5630353","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oncotarget","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.18632/oncotarget.19217","doi":"https://doi.org/10.18632/oncotarget.19217","is_oa":true,"landing_page_url":"https://doi.org/10.18632/oncotarget.19217","pdf_url":null,"source":{"id":"https://openalex.org/S126644158","display_name":"Oncotarget","issn_l":"1949-2553","issn":["1949-2553"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncotarget","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1574080856","https://openalex.org/W1578291413","https://openalex.org/W1609049719","https://openalex.org/W1721946128","https://openalex.org/W1825798804","https://openalex.org/W1905250185","https://openalex.org/W1966230453","https://openalex.org/W1969947723","https://openalex.org/W1971081363","https://openalex.org/W1991656527","https://openalex.org/W1991780505","https://openalex.org/W1994847090","https://openalex.org/W2000060994","https://openalex.org/W2004477123","https://openalex.org/W2009087111","https://openalex.org/W2016059982","https://openalex.org/W2018756851","https://openalex.org/W2023011880","https://openalex.org/W2038120654","https://openalex.org/W2044167977","https://openalex.org/W2051025382","https://openalex.org/W2054074987","https://openalex.org/W2078038998","https://openalex.org/W2078576279","https://openalex.org/W2079738717","https://openalex.org/W2107633226","https://openalex.org/W2115921546","https://openalex.org/W2117050434","https://openalex.org/W2141265794","https://openalex.org/W2145655945","https://openalex.org/W2149307190","https://openalex.org/W2155672452","https://openalex.org/W2159715390","https://openalex.org/W2159801541","https://openalex.org/W2160714232","https://openalex.org/W2160971263","https://openalex.org/W2169599916","https://openalex.org/W2173477069","https://openalex.org/W2260123348","https://openalex.org/W2335238283","https://openalex.org/W2385742736","https://openalex.org/W2413955303","https://openalex.org/W2550609039","https://openalex.org/W2552660393"],"related_works":["https://openalex.org/W4255321854","https://openalex.org/W2074517075","https://openalex.org/W3146426108","https://openalex.org/W2884617011","https://openalex.org/W2087724775","https://openalex.org/W3015759778","https://openalex.org/W2088520467","https://openalex.org/W2075763133","https://openalex.org/W2376423713","https://openalex.org/W1583600832"],"abstract_inverted_index":{"//":[0],"Tamara":[1,93],"L.":[2,94],"Lotan":[3],"1,":[4],"2":[5,50],",":[6,10,15,19,23,27,31],"Asmus":[7],"Heumann":[8],"3":[9,14,26,30,39,60],"Sebastian":[11],"Dwertmann":[12],"Rico":[13],"Jessica":[16],"Hicks":[17],"1":[18,22,40],"Kristen":[20],"Lecksell":[21],"Christina":[24],"Koop":[25],"Guido":[28],"Sauter":[29],"Thorsten":[32],"Schlomm":[33],"4,":[34],"5":[35,81],"and":[36,136,160,176,254,289,308],"Ronald":[37],"Simon":[38],"Pathology,":[41,63],"Johns":[42,52],"Hopkins":[43,53],"School":[44,54],"of":[45,55,62,83,164,172,179,195,235,305],"Medicine,":[46,56],"Baltimore,":[47,57],"MD,":[48,58],"USA":[49,59],"Oncology,":[51],"Institute":[61],"University":[64,75,85],"Medical":[65,76,86],"Center":[66,77,87],"Hamburg-Eppendorf,":[67,78,88],"Hamburg,":[68,79,89],"Germany":[69,80,90],"4":[70],"Martini-Klinik":[71],"Prostate":[72],"Cancer":[73],"Center,":[74],"Department":[82],"Urology,":[84],"Correspondence":[91],"to:":[92],"Lotan,":[95],"email:":[96],"tlotan1@jhmi.edu":[97],"Keywords:":[98],"prostatic":[99],"carcinoma,":[100],"PTEN,":[101],"fluorescence":[102,138],"in":[103,128,139,143,220,318],"situ":[104,140],"hybridization,":[105],"immunohistochemistry,":[106],"biomarker":[107,127],"Received:":[108],"April":[109,113],"04,":[110],"2017":[111,115,119],"Accepted:":[112],"27,":[114],"Published:":[116],"July":[117],"10,":[118],"ABSTRACT":[120],"PTEN":[121,133,137,168,173,182,188,198,203,208,231,236,240,261,270,282,292,306,309,316],"deletion":[122,175,190,201,232,237,272,294],"is":[123],"an":[124],"established":[125],"prognostic":[126],"prostate":[129,319],"cancer.":[130,320],"We":[131],"compared":[132],"immunohistochemistry":[134],"(IHC)":[135],"hybridization":[141],"(FISH)":[142],"the":[144,303],"largest":[145],"existing":[146],"radical":[147],"prostatectomy":[148],"cohort":[149],"with":[150,166,181,197,214,229,247,259,276,281,297],"clinical":[151],"follow-up":[152],"data.":[153],"There":[154],"was":[155,212,244,273],"high":[156],"concordance":[157],"between":[158],"IHC":[159,169,186,211,243,307],"FISH:":[161],"93%":[162],"(3098/3330)":[163],"tumors":[165],"intact":[167,260],"showed":[170,187],"absence":[171,234],"gene":[174,189,200,271,293],"66%":[177],"(720/1087)":[178],"cases":[180,196,228,258,280],"protein":[183,204],"loss":[184,205,209,241,283,317],"by":[185,191,206,210,238,242,262,284],"FISH.":[192],"84%":[193],"(447/533)":[194],"homozygous":[199,264,287],"had":[202],"IHC.":[207],"associated":[213,246,275,296],"reduced":[215,248,277,298],"PSA":[216],"recurrence-free":[217],"survival":[218],"(RFS)":[219],"multivariable":[221],"models":[222],"(HR=1.3;":[223],"95%":[224],"CI:":[225],"1.16-1.47).":[226],"Among":[227,257,279],"either":[230],"or":[233],"FISH,":[239],"strongly":[245],"RFS":[249],"on":[250],"univariable":[251],"analysis":[252],"(p=0.0005":[253],"p<0.0001":[255],"respectively).":[256],"IHC,":[263,285],"(p=0.04)":[265],"but":[266],"not":[267],"heterozygous":[268,290],"(p=0.10)":[269],"weakly":[274],"RFS.":[278,299],"both":[286],"(p=0.0044)":[288],"(p=0.0017)":[291],"were":[295],"These":[300],"data":[301],"support":[302],"utility":[304],"FISH":[310],"as":[311],"complementary":[312],"screening":[313],"tools":[314],"for":[315]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}