{"id":"https://openalex.org/W2736010163","doi":"https://doi.org/10.1002/jbio.201700028","title":"Developing Raman spectroscopy as a diagnostic tool for label\u2010free antigen detection","display_name":"Developing Raman spectroscopy as a diagnostic tool for label\u2010free antigen detection","publication_year":2017,"publication_date":"2017-07-12","ids":{"openalex":"https://openalex.org/W2736010163","doi":"https://doi.org/10.1002/jbio.201700028","mag":"2736010163","pmid":"https://pubmed.ncbi.nlm.nih.gov/28700142"},"language":"en","primary_location":{"id":"doi:10.1002/jbio.201700028","doi":"https://doi.org/10.1002/jbio.201700028","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbio.201700028","pdf_url":null,"source":{"id":"https://openalex.org/S47864364","display_name":"Journal of Biophotonics","issn_l":"1864-063X","issn":["1864-063X","1864-0648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biophotonics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039026953","display_name":"Aaran T. Lewis","orcid":"https://orcid.org/0000-0001-5373-7231","observed_orcids":["https://orcid.org/0000-0001-5373-7231"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Aaran T. Lewis","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-5373-7231","affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006559172","display_name":"Riana Gaifulina","orcid":"https://orcid.org/0000-0003-3927-3471","observed_orcids":["https://orcid.org/0000-0003-3927-3471"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Riana Gaifulina","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015673151","display_name":"Naomi Guppy","orcid":"https://orcid.org/0000-0003-1004-3605","observed_orcids":["https://orcid.org/0000-0003-1004-3605"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Naomi J Guppy","raw_affiliation_strings":["UCL-Advanced Diagnostics, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL-Advanced Diagnostics, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112789250","display_name":"Martin Isabelle","orcid":"https://orcid.org/0009-0002-7995-0342","observed_orcids":["https://orcid.org/0009-0002-7995-0342"]},"institutions":[{"id":"https://openalex.org/I4210148984","display_name":"Gloucestershire Royal Hospital","ror":"https://ror.org/05gh5ar80","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802266942","https://openalex.org/I4210148984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Isabelle","raw_affiliation_strings":["Biophotonics Research Unit, Gloucester Royal Hospitals NHS Foundation Trust, Gloucestershire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophotonics Research Unit, Gloucester Royal Hospitals NHS Foundation Trust, Gloucestershire, UK","institution_ids":["https://openalex.org/I4210148984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054925512","display_name":"Jennifer Dorney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Dorney","raw_affiliation_strings":["School of Physics and Astronomy, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025554672","display_name":"Gavin Rhys Lloyd","orcid":"https://orcid.org/0000-0001-7989-6695","observed_orcids":["https://orcid.org/0000-0001-7989-6695"]},"institutions":[{"id":"https://openalex.org/I4210148984","display_name":"Gloucestershire Royal Hospital","ror":"https://ror.org/05gh5ar80","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802266942","https://openalex.org/I4210148984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gavin R. Lloyd","raw_affiliation_strings":["Biophotonics Research Unit, Gloucester Royal Hospitals NHS Foundation Trust, Gloucestershire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophotonics Research Unit, Gloucester Royal Hospitals NHS Foundation Trust, Gloucestershire, UK","institution_ids":["https://openalex.org/I4210148984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011340913","display_name":"Manuel Rodriguez\u2010Justo","orcid":"https://orcid.org/0000-0001-5007-1761","observed_orcids":["https://orcid.org/0000-0001-5007-1761","https://orcid.org/0000-0002-4741-3473"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Manuel Rodriguez\u2010Justo","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036568222","display_name":"Catherine A. Kendall","orcid":"https://orcid.org/0000-0002-7705-853X","observed_orcids":["https://orcid.org/0000-0002-7705-853X"]},"institutions":[{"id":"https://openalex.org/I4210148984","display_name":"Gloucestershire Royal Hospital","ror":"https://ror.org/05gh5ar80","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802266942","https://openalex.org/I4210148984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine Kendall","raw_affiliation_strings":["Biophotonics Research Unit, Gloucester Royal Hospitals NHS Foundation Trust, Gloucestershire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biophotonics Research Unit, Gloucester Royal Hospitals NHS Foundation Trust, Gloucestershire, UK","institution_ids":["https://openalex.org/I4210148984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088796043","display_name":"Nicholas Stone","orcid":"https://orcid.org/0000-0001-5603-3731","observed_orcids":["https://orcid.org/0000-0001-5603-3731"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas Stone","raw_affiliation_strings":["School of Physics and Astronomy, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058291543","display_name":"Geraint M. H. Thomas","orcid":"https://orcid.org/0000-0003-4035-7832","observed_orcids":["https://orcid.org/0000-0003-4035-7832"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geraint M. Thomas","raw_affiliation_strings":["Department of Cell and Developmental Biology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039026953"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":3370,"currency":"USD","value_usd":3370},"apc_paid":null,"fwci":0.2937,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.54211858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11212","display_name":"Cultural Heritage Materials Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1204","display_name":"Archeology (arts and humanities)"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/raman-spectroscopy","display_name":"Raman spectroscopy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/immunohistochemistry-comparison","display_name":"immunohistochemistry comparison","score":0.9300000071525574},{"id":"https://openalex.org/keywords/colonic-tissue","display_name":"colonic tissue","score":0.8209999799728394},{"id":"https://openalex.org/keywords/formalin-fixed-paraffin-embedded-tissue","display_name":"formalin-fixed paraffin-embedded tissue","score":0.902999997138977},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"principal component analysis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/desmin","display_name":"desmin","score":0.6899999976158142},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.9950000047683716},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mucin-glycoproteins","display_name":"mucin glycoproteins","score":0.8960000276565552},{"id":"https://openalex.org/keywords/tissue-composition","display_name":"tissue composition","score":0.4729999899864197},{"id":"https://openalex.org/keywords/antibody-free-detection","display_name":"antibody-free detection","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7556086182594299},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6642502546310425},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4964452385902405},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.48982951045036316},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.48206597566604614},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.43419113755226135},{"id":"https://openalex.org/C21269302","wikidata":"https://www.wikidata.org/wiki/Q7243098","display_name":"Primary and secondary antibodies","level":3,"score":0.4335872530937195},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4334907531738281},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.41172677278518677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37644290924072266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3425474762916565},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.22454246878623962},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1966751515865326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10750278830528259},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06957533955574036},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.06819018721580505}],"mesh":[{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005557","descriptor_name":"Formaldehyde","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013059","descriptor_name":"Spectrum Analysis, Raman","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016612","descriptor_name":"Paraffin Embedding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016707","descriptor_name":"Tissue Fixation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1002/jbio.201700028","doi":"https://doi.org/10.1002/jbio.201700028","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jbio.201700028","pdf_url":null,"source":{"id":"https://openalex.org/S47864364","display_name":"Journal of Biophotonics","issn_l":"1864-063X","issn":["1864-063X","1864-0648"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biophotonics","raw_type":"journal-article"},{"id":"pmid:28700142","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28700142","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biophotonics","raw_type":"Journal Article"},{"id":"pmh:oai:ore.exeter.ac.uk:10871/28678","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10871/28678","pdf_url":null,"source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1565532","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1565532/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biophotonics , 11 (2) , Article e201700028. (2018)","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/29734742","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/journal_contribution/Developing_Raman_Spectroscopy_as_a_Diagnostic_Tool_for_Label-free_Antigen_Detection_/29734742","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:rde.openrepository.com:11287/620437","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11287/620437","pdf_url":null,"source":{"id":"https://openalex.org/S4306401891","display_name":"Royal Devon and Exeter Research Repository (Royal Devon and Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801242002","host_organization_name":"Royal Devon and Exeter Hospital","host_organization_lineage":["https://openalex.org/I2801242002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4703095218","display_name":"A Chemical Imaging Platform for Discovery Biosciences (CIP-DB).","funder_award_id":"BB/R013667/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320335087","display_name":"Innovate UK","ror":"https://ror.org/05ar5fy68"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1491750590","https://openalex.org/W1812948675","https://openalex.org/W1955210431","https://openalex.org/W1968871412","https://openalex.org/W1982632301","https://openalex.org/W1999045001","https://openalex.org/W2008885546","https://openalex.org/W2013238628","https://openalex.org/W2019916133","https://openalex.org/W2024437068","https://openalex.org/W2039222020","https://openalex.org/W2049817126","https://openalex.org/W2062528602","https://openalex.org/W2076945421","https://openalex.org/W2077440316","https://openalex.org/W2080774554","https://openalex.org/W2084652933","https://openalex.org/W2096906555","https://openalex.org/W2099348322","https://openalex.org/W2115390024","https://openalex.org/W2142647038","https://openalex.org/W2144692208","https://openalex.org/W2147567454","https://openalex.org/W2163932563","https://openalex.org/W2412014446","https://openalex.org/W2479757744","https://openalex.org/W2514303014","https://openalex.org/W2575712535","https://openalex.org/W2601378842","https://openalex.org/W2917837889","https://openalex.org/W4238768614"],"related_works":["https://openalex.org/W2113883062","https://openalex.org/W1967067999","https://openalex.org/W7052571561","https://openalex.org/W2962414008","https://openalex.org/W2110958082","https://openalex.org/W2142647038","https://openalex.org/W2514303014","https://openalex.org/W2582052168","https://openalex.org/W1977182656","https://openalex.org/W1988534186"],"abstract_inverted_index":{"For":[0],"several":[1,110],"decades,":[2],"a":[3,27,79,123,179],"multitude":[4],"of":[5,11,29,40,82,117,125,172],"studies":[6],"have":[7,33],"documented":[8],"the":[9,36,52,59,73,115,162,168,183],"ability":[10],"Raman":[12,85],"spectroscopy":[13],"(RS)":[14],"to":[15,24,44,51,113,131],"differentiate":[16],"between":[17,58,159],"tissue":[18,45,94,177],"types":[19],"and":[20,99,134,137,148,161],"identify":[21],"pathological":[22],"changes":[23,48,175],"tissues":[25],"in":[26,176,178],"range":[28,81],"diseases.":[30,83],"Furthermore,":[31],"spectroscopists":[32],"illustrated":[34],"that":[35,61,127,154,167],"technique":[37,169],"is":[38,62,72,156,170],"capable":[39,171],"detecting":[41,173],"disease-specific":[42],"alterations":[43],"before":[46],"morphological":[47],"become":[49],"apparent":[50],"pathologist.":[53],"This":[54],"study":[55],"draws":[56],"comparisons":[57],"information":[60],"obtainable":[63],"using":[64,90],"RS":[65,160],"alongside":[66],"immunohistochemistry":[67],"(IHC),":[68],"since":[69],"histological":[70],"examination":[71],"current":[74],"GOLD":[75],"standard":[76],"for":[77,185],"diagnosing":[78],"wide":[80],"Here,":[84],"spectral":[86,100],"maps":[87],"were":[88,107,140],"generated":[89],"formalin-fixed,":[91],"paraffin-embedded":[92],"colonic":[93],"sections":[95],"from":[96,102],"healthy":[97],"patients":[98],"signatures":[101,126],"principal":[103],"components":[104],"analysis":[105],"(PCA)":[106],"compared":[108],"with":[109,142],"IHC":[111,163],"markers":[112,164],"confirm":[114],"validity":[116],"their":[118,138],"localizations.":[119],"PCA":[120],"loadings":[121],"identified":[122],"number":[124],"could":[128],"be":[129],"assigned":[130],"muscle,":[132],"DNA":[133],"mucin":[135],"glycoproteins":[136],"distributions":[139],"confirmed":[141],"antibodies":[143],"raised":[144],"against":[145],"anti-Desmin,":[146],"anti-Ki67":[147],"anti-MUC2,":[149],"respectively.":[150],"The":[151],"comparison":[152],"confirms":[153],"there":[155],"excellent":[157],"correlation":[158],"used,":[165],"demonstrating":[166],"compositional":[174],"label-free":[180],"manner,":[181],"eliminating":[182],"need":[184],"antibodies.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-07-21T00:00:00"}
