{"id":"https://openalex.org/W2735633262","doi":"https://doi.org/10.7150/thno.18914","title":"Therapeutic Effect of Astroglia-like Mesenchymal Stem Cells Expressing Glutamate Transporter in a Genetic Rat Model of Depression","display_name":"Therapeutic Effect of Astroglia-like Mesenchymal Stem Cells Expressing Glutamate Transporter in a Genetic Rat Model of Depression","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2735633262","doi":"https://doi.org/10.7150/thno.18914","mag":"2735633262","pmid":"https://pubmed.ncbi.nlm.nih.gov/28819456","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5558562"},"language":"en","primary_location":{"id":"doi:10.7150/thno.18914","doi":"https://doi.org/10.7150/thno.18914","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.18914","pdf_url":"https://www.thno.org/v07p2690.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.thno.org/v07p2690.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036686524","display_name":"Amit Shwartz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Amit Shwartz","raw_affiliation_strings":["The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006830815","display_name":"Oshra Betzer","orcid":"https://orcid.org/0000-0002-4429-7024","observed_orcids":["https://orcid.org/0000-0002-4429-7024"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Oshra Betzer","raw_affiliation_strings":["Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel","Leslie Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"Leslie Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015310483","display_name":"Noam Kronfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Noam Kronfeld","raw_affiliation_strings":["The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081610776","display_name":"Gila Kazimirsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gila Kazimirsky","raw_affiliation_strings":["The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041474889","display_name":"Simona Cazacu","orcid":"https://orcid.org/0000-0002-6085-4177","observed_orcids":["https://orcid.org/0000-0002-6085-4177"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simona Cazacu","raw_affiliation_strings":["Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA 48202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA 48202","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000219160","display_name":"Susan Finniss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Finniss","raw_affiliation_strings":["Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA 48202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA 48202","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101883790","display_name":"Hae Kyung Lee","orcid":"https://orcid.org/0000-0002-9560-862X","observed_orcids":["https://orcid.org/0000-0002-9560-862X"]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hae Kyung Lee","raw_affiliation_strings":["Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA 48202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA 48202","institution_ids":["https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108487650","display_name":"Menachem Motiei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Menachem Motiei","raw_affiliation_strings":["Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089420958","display_name":"Shani Yael Dagan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Shani Yael Dagan","raw_affiliation_strings":["The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039004884","display_name":"Rachela Popovtzer","orcid":"https://orcid.org/0000-0002-3585-348X","observed_orcids":["https://orcid.org/0000-0002-3585-348X"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rachela Popovtzer","raw_affiliation_strings":["Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071979955","display_name":"Chaya Brodie","orcid":"https://orcid.org/0000-0002-7551-2735","observed_orcids":["https://orcid.org/0000-0002-7551-2735"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["IL","US"],"is_corresponding":false,"raw_author_name":"Chaya Brodie","raw_affiliation_strings":["Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA 48202","The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA 48202","institution_ids":["https://openalex.org/I2803043754"]},{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088336881","display_name":"Gal Yadid","orcid":"https://orcid.org/0000-0002-4379-8505","observed_orcids":["https://orcid.org/0000-0002-4379-8505"]},"institutions":[{"id":"https://openalex.org/I13955877","display_name":"Bar-Ilan University","ror":"https://ror.org/03kgsv495","country_code":"IL","type":"education","lineage":["https://openalex.org/I13955877"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Gal Yadid","raw_affiliation_strings":["Leslie Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel","The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leslie Susan Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]},{"raw_affiliation_string":"The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel","institution_ids":["https://openalex.org/I13955877"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088336881"],"corresponding_institution_ids":["https://openalex.org/I13955877"],"apc_list":{"value":2500,"currency":"AUD","value_usd":1671},"apc_paid":{"value":2500,"currency":"AUD","value_usd":1671},"fwci":4.4005,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95584639,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":"10","first_page":"2690","last_page":"2703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.27730000019073486,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.07850000262260437,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.7839999794960022},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9380000233650208},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.9079999923706055},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.878000020980835},{"id":"https://openalex.org/keywords/flinders-sensitive-line-rats","display_name":"Flinders Sensitive Line rats","score":0.7429999709129333},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cell-tracking","display_name":"cell tracking","score":0.6850000023841858},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7120000123977661},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/glial-pathology","display_name":"glial pathology","score":0.625},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.6919339895248413},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6167552471160889},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5652446150779724},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5246781706809998},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4929940402507782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3757903575897217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37105029821395874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3653693199157715},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3241894245147705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25655597448349},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06573954224586487}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045506","descriptor_name":"Therapeutic Uses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.7150/thno.18914","doi":"https://doi.org/10.7150/thno.18914","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.18914","pdf_url":"https://www.thno.org/v07p2690.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5558562","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5558562","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Text"},{"id":"pmid:28819456","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28819456","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7150/thno.18914","doi":"https://doi.org/10.7150/thno.18914","is_oa":true,"landing_page_url":"https://doi.org/10.7150/thno.18914","pdf_url":"https://www.thno.org/v07p2690.pdf","source":{"id":"https://openalex.org/S2482500137","display_name":"Theranostics","issn_l":"1838-7640","issn":["1838-7640"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317973","host_organization_name":"Ivyspring International Publisher","host_organization_lineage":["https://openalex.org/P4310317973"],"host_organization_lineage_names":["Ivyspring International Publisher"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Theranostics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2735633262.pdf","grobid_xml":"https://content.openalex.org/works/W2735633262.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W4710707","https://openalex.org/W69781432","https://openalex.org/W254805310","https://openalex.org/W1600024584","https://openalex.org/W1877874306","https://openalex.org/W1914011667","https://openalex.org/W1954747488","https://openalex.org/W1968497578","https://openalex.org/W1971437356","https://openalex.org/W1973125755","https://openalex.org/W1976392245","https://openalex.org/W1978891587","https://openalex.org/W1979008433","https://openalex.org/W1980599856","https://openalex.org/W1980628301","https://openalex.org/W1983617759","https://openalex.org/W1991062038","https://openalex.org/W1993254026","https://openalex.org/W1994631286","https://openalex.org/W2002731409","https://openalex.org/W2008565079","https://openalex.org/W2009963449","https://openalex.org/W2012394652","https://openalex.org/W2012549032","https://openalex.org/W2017524562","https://openalex.org/W2019154525","https://openalex.org/W2019860362","https://openalex.org/W2020525105","https://openalex.org/W2022333056","https://openalex.org/W2023983678","https://openalex.org/W2025005051","https://openalex.org/W2026021191","https://openalex.org/W2027527237","https://openalex.org/W2035000104","https://openalex.org/W2035015498","https://openalex.org/W2036433444","https://openalex.org/W2041899662","https://openalex.org/W2043898918","https://openalex.org/W2044473166","https://openalex.org/W2048211160","https://openalex.org/W2048595403","https://openalex.org/W2054291254","https://openalex.org/W2055716589","https://openalex.org/W2058103199","https://openalex.org/W2058745128","https://openalex.org/W2060966174","https://openalex.org/W2061967972","https://openalex.org/W2067535960","https://openalex.org/W2071904806","https://openalex.org/W2078477176","https://openalex.org/W2080836866","https://openalex.org/W2083217982","https://openalex.org/W2083850312","https://openalex.org/W2084269334","https://openalex.org/W2089694151","https://openalex.org/W2090457936","https://openalex.org/W2096045982","https://openalex.org/W2098459519","https://openalex.org/W2099749043","https://openalex.org/W2100639321","https://openalex.org/W2103218986","https://openalex.org/W2104417933","https://openalex.org/W2105089616","https://openalex.org/W2105434751","https://openalex.org/W2106647511","https://openalex.org/W2109334244","https://openalex.org/W2110921107","https://openalex.org/W2120947452","https://openalex.org/W2121651624","https://openalex.org/W2127985653","https://openalex.org/W2136433713","https://openalex.org/W2137296158","https://openalex.org/W2140699994","https://openalex.org/W2142133036","https://openalex.org/W2146772921","https://openalex.org/W2149038956","https://openalex.org/W2150002111","https://openalex.org/W2151785656","https://openalex.org/W2159417266","https://openalex.org/W2219697440","https://openalex.org/W2221267861","https://openalex.org/W2313713230","https://openalex.org/W2318039332","https://openalex.org/W2327690312","https://openalex.org/W2342356818","https://openalex.org/W2345236994","https://openalex.org/W2394853042","https://openalex.org/W2402385618","https://openalex.org/W2416755357","https://openalex.org/W2518933576","https://openalex.org/W4243547149","https://openalex.org/W4250535441","https://openalex.org/W4299381670","https://openalex.org/W4300887218"],"related_works":["https://openalex.org/W2033713094","https://openalex.org/W2043713804","https://openalex.org/W7037515383","https://openalex.org/W2036693001","https://openalex.org/W3021896357","https://openalex.org/W2058745128","https://openalex.org/W2911145260","https://openalex.org/W2977483878","https://openalex.org/W1979623781","https://openalex.org/W2609998541"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2,35],"proposed":[3],"that":[4,24,176,221],"abnormal":[5],"glutamatergic":[6,28],"neurotransmission":[7],"and":[8,18,64,104,109,134,137,159,173,203,208,235],"glial":[9,201],"pathology":[10],"play":[11],"an":[12],"important":[13],"role":[14],"in":[15,53,196,213,228,239],"the":[16,98,113,152,177,184,188,214,240],"etiology":[17],"manifestation":[19],"of":[20,26,58,62,66,75,106,179,187,200,206,216],"depression.It":[21],"was":[22],"postulated":[23],"restoration":[25],"normal":[27],"transmission,":[29],"by":[30,151,230],"enhancing":[31],"glutamate":[32,77,233],"uptake,":[33],"may":[34],"a":[36,129,190],"beneficial":[37],"effect":[38],"on":[39],"depression.We":[40],"examined":[41],"this":[42],"hypothesis":[43],"using":[44],"unique":[45],"human":[46],"glial-like":[47],"mesenchymal":[48],"stem":[49],"cells":[50,99],"(MSCs),":[51],"which":[52,87],"addition":[54],"to":[55,60,71,123,165,183],"inherent":[56],"properties":[57],"migration":[59,108],"regions":[61],"injury":[63],"secretion":[65,238],"neurotrophic":[67],"factors,":[68],"were":[69,95,120,140,210],"differentiated":[70],"express":[72],"high":[73],"levels":[74,205],"functional":[76],"transporters":[78],"(excitatory":[79],"amino":[80],"acid":[81],"transporters;":[82],"EAAT).Additionally,":[83],"gold":[84],"nanoparticles":[85],"(GNPs),":[86],"serve":[88],"as":[89,163],"contrast":[90],"agents":[91],"for":[92,100,132],"CT":[93],"imaging,":[94,167],"loaded":[96],"into":[97],"non-invasive,":[101],"real-time":[102],"imaging":[103],"tracking":[105],"MSC":[107],"final":[110],"location":[111],"within":[112],"brain.MSC-EAAT":[114],"(2\u00d710":[115],"5":[116],";":[117],"10":[118],"\u03bcl)":[119],"administered":[121],"(i.c.v.)":[122],"Flinder":[124],"Sensitive":[125],"Line":[126],"rats":[127,142],"(FSLs),":[128],"genetic":[130],"model":[131],"depression,":[133,197],"longitudinal":[135],"behavioral":[136],"molecular":[138],"changes":[139,195],"monitored.FSL":[141],"treated":[143],"with":[144],"MSC-EAAT":[145],"showed":[146,175],"attenuated":[147],"depressive-like":[148,225],"behaviors":[149],"(measured":[150],"forced":[153],"swim":[154],"test,":[155],"novelty":[156],"exploration":[157],"test":[158],"sucrose":[160],"self-administration":[161],"paradigm),":[162],"compared":[164],"controls.CT":[166],"Flame":[168],"Atomic":[169],"Absorption":[170],"Spectroscopy":[171],"analysis":[172],"immunohistochemistry":[174],"majority":[178],"MSCs":[180],"homed":[181],"specifically":[182],"dentate":[185],"gyrus":[186],"hippocampus,":[189],"region":[191],"showing":[192],"structural":[193],"brain":[194],"including":[198],"loss":[199],"cells.mRNA":[202],"protein":[204],"EAAT1":[207],"BDNF":[209],"significantly":[211],"elevated":[212],"hippocampus":[215],"MSC-EAAT-treated":[217],"FSLs.Our":[218],"findings":[219],"indicate":[220],"MSC-EAATs":[222],"effectively":[223],"improve":[224],"manifestations,":[226],"possibly":[227],"part":[229],"increasing":[231],"both":[232],"uptake":[234],"neurotropic":[236],"factor":[237],"hippocampus.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-21T00:00:00"}