{"id":"https://openalex.org/W2735601992","doi":"https://doi.org/10.1136/bmjopen-2017-016028","title":"Optimal cut points of plasma and urine neutrophil gelatinase-associated lipocalin for the prediction of acute kidney injury among critically ill adults: retrospective determination and clinical validation of a prospective multicentre study","display_name":"Optimal cut points of plasma and urine neutrophil gelatinase-associated lipocalin for the prediction of acute kidney injury among critically ill adults: retrospective determination and clinical validation of a prospective multicentre study","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W2735601992","doi":"https://doi.org/10.1136/bmjopen-2017-016028","mag":"2735601992","pmid":"https://pubmed.ncbi.nlm.nih.gov/28698338","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5726065"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2017-016028","doi":"https://doi.org/10.1136/bmjopen-2017-016028","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2017-016028","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/7/7/e016028.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/7/7/e016028.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025868173","display_name":"Kristen M. Tecson","orcid":"https://orcid.org/0000-0002-6732-8698","observed_orcids":["https://orcid.org/0000-0002-6732-8698"]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]},{"id":"https://openalex.org/I4405274104","display_name":"Baylor Scott & White Research Institute","ror":"https://ror.org/012z4f430","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160418","https://openalex.org/I4405274104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen M Tecson","raw_affiliation_strings":["Baylor Heart and Vascular Institute, Dallas, Texas, USA","Baylor Scott & White Research Institute, Dallas, Texas, USA","Texas A&M College of Medicine Health Science Center, Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Heart and Vascular Institute, Dallas, Texas, USA","institution_ids":["https://openalex.org/I2802366037"]},{"raw_affiliation_string":"Baylor Scott & White Research Institute, Dallas, Texas, USA","institution_ids":["https://openalex.org/I4405274104"]},{"raw_affiliation_string":"Texas A&M College of Medicine Health Science Center, Dallas, Texas, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036508869","display_name":"Elisabeth Erhardtsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272658","display_name":"BioPorto (Denmark)","ror":"https://ror.org/04gs2nx18","country_code":"DK","type":"company","lineage":["https://openalex.org/I4405272658"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Elisabeth Erhardtsen","raw_affiliation_strings":["BiPorto Diagnostics A/S, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BiPorto Diagnostics A/S, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4405272658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035177079","display_name":"Peter M Eriksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272658","display_name":"BioPorto (Denmark)","ror":"https://ror.org/04gs2nx18","country_code":"DK","type":"company","lineage":["https://openalex.org/I4405272658"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter M Eriksen","raw_affiliation_strings":["BiPorto Diagnostics A/S, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BiPorto Diagnostics A/S, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4405272658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001506348","display_name":"Ahmed Osama Gaber","orcid":"https://orcid.org/0000-0002-0743-4974","observed_orcids":["https://orcid.org/0000-0002-0743-4974","https://orcid.org/0000-0002-9444-3202"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Osama Gaber","raw_affiliation_strings":["Houston Methodist Hospital, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Hospital, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009922159","display_name":"Michael J. Germain","orcid":"https://orcid.org/0000-0001-7481-2421","observed_orcids":["https://orcid.org/0000-0001-7481-2421"]},"institutions":[{"id":"https://openalex.org/I1338449461","display_name":"Baystate Medical Center","ror":"https://ror.org/01q2nz307","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1338449461"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Germain","raw_affiliation_strings":["Baystate Medical Center, Springfield, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baystate Medical Center, Springfield, Massachusetts, USA","institution_ids":["https://openalex.org/I1338449461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082775963","display_name":"Ladan Golestaneh","orcid":"https://orcid.org/0000-0003-1848-582X","observed_orcids":["https://orcid.org/0000-0003-1848-582X"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ladan Golestaneh","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031562051","display_name":"Mar\u00eda \u00c1ngeles Lavoria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405272658","display_name":"BioPorto (Denmark)","ror":"https://ror.org/04gs2nx18","country_code":"DK","type":"company","lineage":["https://openalex.org/I4405272658"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Maria de los Angeles Lavoria","raw_affiliation_strings":["BiPorto Diagnostics A/S, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BiPorto Diagnostics A/S, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4405272658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006737510","display_name":"Linda W. Moore","orcid":"https://orcid.org/0000-0003-2519-5150","observed_orcids":["https://orcid.org/0000-0003-2519-5150"]},"institutions":[{"id":"https://openalex.org/I1295876152","display_name":"Houston Methodist","ror":"https://ror.org/027zt9171","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295876152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda W Moore","raw_affiliation_strings":["Houston Methodist Hospital, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Houston Methodist Hospital, Houston, Texas, USA","institution_ids":["https://openalex.org/I1295876152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008382551","display_name":"Peter Andrew McCullough","orcid":"https://orcid.org/0000-0002-0997-6355","observed_orcids":["https://orcid.org/0000-0002-0997-6355"]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]},{"id":"https://openalex.org/I4210156176","display_name":"Baylor Jack and Jane Hamilton Heart and Vascular Hospital","ror":"https://ror.org/054bx8w47","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210156176","https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter A McCullough","raw_affiliation_strings":["Baylor Heart and Vascular Institute, Dallas, Texas, USA","Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas, USA","Baylor University Medical Center, Dallas, Texas, USA","Texas A&M College of Medicine Health Science Center, Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Heart and Vascular Institute, Dallas, Texas, USA","institution_ids":["https://openalex.org/I2802366037"]},{"raw_affiliation_string":"Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas, USA","institution_ids":["https://openalex.org/I4210156176"]},{"raw_affiliation_string":"Baylor University Medical Center, Dallas, Texas, USA","institution_ids":["https://openalex.org/I2802366037"]},{"raw_affiliation_string":"Texas A&M College of Medicine Health Science Center, Dallas, Texas, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008382551"],"corresponding_institution_ids":["https://openalex.org/I2802366037","https://openalex.org/I4210156176"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":4.8375,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.95200577,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"7","first_page":"e016028","last_page":"e016028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8889999985694885},{"id":"https://openalex.org/keywords/plasma-ngal","display_name":"plasma NGAL","score":0.699999988079071},{"id":"https://openalex.org/keywords/urine-ngal","display_name":"urine NGAL","score":0.9359999895095825},{"id":"https://openalex.org/keywords/persistent-acute-kidney-injury","display_name":"persistent acute kidney injury","score":0.6330000162124634},{"id":"https://openalex.org/keywords/critically-ill-adults","display_name":"critically ill adults","score":0.699999988079071},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.8880000114440918},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/aki-severity-staging","display_name":"AKI severity staging","score":0.3610000014305115},{"id":"https://openalex.org/keywords/edta-plasma","display_name":"EDTA plasma","score":0.4659999907016754},{"id":"https://openalex.org/keywords/heparinized-plasma","display_name":"heparinized plasma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/aki-risk-stratification","display_name":"AKI risk stratification","score":0.3269999921321869},{"id":"https://openalex.org/keywords/aki-mortality","display_name":"AKI mortality","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9652730226516724},{"id":"https://openalex.org/C2909801038","wikidata":"https://www.wikidata.org/wiki/Q18028489","display_name":"Neutrophil gelatinase-associated lipocalin","level":3,"score":0.7956328392028809},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7950297594070435},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.62115478515625},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.567184567451477},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5417019724845886},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.5209175944328308},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.47300225496292114},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4729984402656555},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4265348017215729},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.411375492811203},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.3443857431411743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071068","descriptor_name":"Lipocalin-2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000071068","descriptor_name":"Lipocalin-2","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1136/bmjopen-2017-016028","doi":"https://doi.org/10.1136/bmjopen-2017-016028","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2017-016028","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/7/7/e016028.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4646884","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5726065","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28698338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28698338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5726065","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5726065/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmh:oai:open-archive.highwire.org:bmjopen:7/7/e016028","doi":null,"is_oa":false,"landing_page_url":"http://bmjopen.bmj.com/cgi/content/short/7/7/e016028","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2017-016028","doi":"https://doi.org/10.1136/bmjopen-2017-016028","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2017-016028","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/7/7/e016028.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313206","display_name":"Baystate Health","ror":"https://ror.org/02x011m46"},{"id":"https://openalex.org/F4320319137","display_name":"BioPorto","ror":"https://ror.org/04gs2nx18"},{"id":"https://openalex.org/F4320333841","display_name":"Houston Methodist Research Institute","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2735601992.pdf","grobid_xml":"https://content.openalex.org/works/W2735601992.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W64255601","https://openalex.org/W1499722362","https://openalex.org/W1968969423","https://openalex.org/W1969398085","https://openalex.org/W1985518230","https://openalex.org/W2026274122","https://openalex.org/W2043449104","https://openalex.org/W2055129064","https://openalex.org/W2105114108","https://openalex.org/W2109531898","https://openalex.org/W2124451906","https://openalex.org/W2142822179","https://openalex.org/W2143262001","https://openalex.org/W2148152947","https://openalex.org/W2169504018","https://openalex.org/W2281050964","https://openalex.org/W2320095373","https://openalex.org/W2320835511","https://openalex.org/W2566478702"],"related_works":["https://openalex.org/W1974928847","https://openalex.org/W2149948764","https://openalex.org/W2158659030","https://openalex.org/W4396921139","https://openalex.org/W3042235131","https://openalex.org/W2116803132","https://openalex.org/W3080727728","https://openalex.org/W2122055706","https://openalex.org/W2004487153","https://openalex.org/W1537715458"],"abstract_inverted_index":{"OBJECTIVES:":[0],"To":[1],"determine":[2],"the":[3,89,93,97,127,146,242],"optimal":[4,128,181],"threshold":[5],"of":[6,99,256],"blood":[7],"and":[8,23,53,62,114,140,144,200,219,228],"urine":[9,63,141,229],"neutrophil":[10],"gelatinase-associated":[11],"lipocalin":[12],"(NGAL)":[13],"to":[14,17,26,75,184],"predict":[15,76,185],"moderate":[16,25],"severe":[18,27],"acute":[19],"kidney":[20],"injury":[21],"(AKI)":[22],"persistent":[24,100,118,186,238],"AKI":[28,79,113,125,189,240],"lasting":[29],"at":[30,96],"least":[31],"48":[32],"consecutive":[33],"hours,":[34],"as":[35,235,237],"defined":[36],"by":[37,81],"an":[38],"adjudication":[39],"panel.":[40],"METHODS:":[41],"A":[42],"multicentre":[43],"prospective":[44],"observational":[45],"study":[46],"enrolled":[47],"intensive":[48],"care":[49],"unit":[50],"(ICU)":[51],"patients":[52],"recorded":[54],"daily":[55],"ethylenediaminetetraacetic":[56],"acid":[57],"(EDTA)":[58],"plasma,":[59],"heparin":[60,136],"plasma":[61,133,137],"NGAL.":[64],"We":[65,87],"used":[66],"natural":[67],"log-transformed":[68],"NGAL":[69,94,129,182,230],"in":[70,131,241,253],"a":[71,249],"logistic":[72],"regression":[73],"model":[74],"stage":[77,101,111,119,123,187,232],"2/3":[78,102,112,120,124,188,233,239],"(defined":[80],"Kidney":[82],"Disease":[83],"International":[84],"Global":[85],"Organization).":[86],"performed":[88],"same":[90],"analysis":[91],"using":[92,248],"value":[95,156,160],"start":[98],"AKI.":[103,121],"RESULTS:":[104],"Of":[105],"245":[106],"subjects,":[107],"33":[108],"(13.5%)":[109],"developed":[110,117],"25":[115],"(10.2%)":[116],"Predicting":[122],"revealed":[126],"cutoffs":[130,183],"EDTA":[132],"(142.0":[134],"ng/mL),":[135],"(148.3":[138],"ng/mL)":[139,143],"(78.0":[142],"yielded":[145],"following":[147],"decision":[148,246],"statistics:":[149],"sensitivity":[150],"(SN)=78.8%,":[151],"specificity":[152],"(SP)=73.0%,":[153],"positive":[154],"predictive":[155,159],"(PPV)=31.3%,":[157],"negative":[158],"(NPV)=95.7%,":[161],"diagnostic":[162],"accuracy":[163],"(DA)=73.8%":[164],"(EDTA":[165,194,210],"plasma);":[166,173],"SN=72.7%,":[167],"SP=73.8%,":[168],"PPV=30.4%,":[169],"NPV=94.5%,":[170],"DA=73.7%":[171],"(heparin":[172,198,217],"SN=69.7%,":[174],"SP=76.8%,":[175],"PPV=32.9%,":[176],"NPV=94%,":[177],"DA=75.8%":[178],"(urine).":[179,225],"The":[180],"were":[190],"similar:":[191],"148.3":[192],"ng/mL":[193,197,202],"plasma),":[195,211],"169.6":[196],"plasma)":[199,218],"79.0":[201],"(urine)":[203],"yielding:":[204],"SN=84.0%,":[205],"SP=73.5%,":[206],"PPV=26.6%,":[207],"NPV=97.6,":[208],"DA=74.6%":[209],"SN=84%,":[212],"SP=76.1%,":[213],"PPV=26.8%,":[214],"NPV=96.5%,":[215],"DA=76.1%":[216],"SN=75%,":[220],"SP=75.8%,":[221],"PPV=26.1,":[222],"NPV=96.4%,":[223],"DA=75.7%":[224],"CONCLUSION:":[226],"Blood":[227],"predicted":[231],"AKI,":[234],"well":[236],"ICU":[243],"with":[244],"acceptable":[245],"statistics":[247],"single":[250],"cut":[251],"point":[252],"each":[254],"type":[255],"specimen.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-07-21T00:00:00"}