{"id":"https://openalex.org/W2735356102","doi":"https://doi.org/10.1167/iovs.16-21365","title":"Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study","display_name":"Corneal Wound Repair After Rose Bengal and Green Light Crosslinking: Clinical and Histologic Study","publication_year":2017,"publication_date":"2017-07-12","ids":{"openalex":"https://openalex.org/W2735356102","doi":"https://doi.org/10.1167/iovs.16-21365","mag":"2735356102","pmid":"https://pubmed.ncbi.nlm.nih.gov/28700779"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.16-21365","doi":"https://doi.org/10.1167/iovs.16-21365","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.16-21365","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/936360/i1552-5783-58-9-3471.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/936360/i1552-5783-58-9-3471.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042441129","display_name":"Patricia Gallego\u2010Mu\u00f1oz","orcid":"https://orcid.org/0000-0002-1826-8123","observed_orcids":["https://orcid.org/0000-0002-1826-8123"]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Gallego-Mu\u00f1oz","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, GIR de T\u00e9cnicas \u00d3pticas para el Diagn\u00f3stico, Universidad de Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, GIR de T\u00e9cnicas \u00d3pticas para el Diagn\u00f3stico, Universidad de Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037407847","display_name":"Luc\u00eda Ibar\u00e9s-Fr\u00edas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luc\u00eda Ibares-Fr\u00edas","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, GIR de T\u00e9cnicas \u00d3pticas para el Diagn\u00f3stico, Universidad de Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, GIR de T\u00e9cnicas \u00d3pticas para el Diagn\u00f3stico, Universidad de Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elvira Lorenzo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elvira Lorenzo","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, GIR de T\u00e9cnicas \u00d3pticas para el Diagn\u00f3stico, Universidad de Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, GIR de T\u00e9cnicas \u00d3pticas para el Diagn\u00f3stico, Universidad de Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048647453","display_name":"Susana C. Marcos","orcid":"https://orcid.org/0000-0001-5511-1697","observed_orcids":["https://orcid.org/0000-0001-5511-1697","https://orcid.org/0000-0002-7995-5146"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210087660","display_name":"Instituto de \u00d3ptica \"Daza de Vald\u00e9s\"","ror":"https://ror.org/002zef647","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210087660"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Susana Marcos","raw_affiliation_strings":["Instituto de \u00d3ptica, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de \u00d3ptica, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210087660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036455205","display_name":"Pablo P\u00e9rez\u2010Merino","orcid":"https://orcid.org/0000-0003-3591-7567","observed_orcids":["https://orcid.org/0000-0003-3591-7567"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210087660","display_name":"Instituto de \u00d3ptica \"Daza de Vald\u00e9s\"","ror":"https://ror.org/002zef647","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210087660"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pablo Per\u00e9z-Merino","raw_affiliation_strings":["Instituto de \u00d3ptica, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de \u00d3ptica, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210087660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079675033","display_name":"N\u00e1ndor B\u00e9k\u00e9si","orcid":"https://orcid.org/0000-0001-7532-9589","observed_orcids":["https://orcid.org/0000-0001-7532-9589"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210087660","display_name":"Instituto de \u00d3ptica \"Daza de Vald\u00e9s\"","ror":"https://ror.org/002zef647","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210087660"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nandor Bekesi","raw_affiliation_strings":["Instituto de \u00d3ptica, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de \u00d3ptica, Consejo Superior de Investigaciones Cient\u00edficas, Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210087660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033699079","display_name":"Irene E. Kochevar","orcid":"https://orcid.org/0000-0002-3763-3923","observed_orcids":["https://orcid.org/0000-0002-3763-3923"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene E. Kochevar","raw_affiliation_strings":["Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032342377","display_name":"Carmen Mart\u00ednez\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0002-9533-6169","observed_orcids":["https://orcid.org/0000-0002-9533-6169"]},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"M. Carmen Mart\u00ednez-Garc\u00eda","raw_affiliation_strings":["Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, GIR de T\u00e9cnicas \u00d3pticas para el Diagn\u00f3stico, Universidad de Valladolid, Valladolid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Biolog\u00eda Celular, Histolog\u00eda y Farmacolog\u00eda, GIR de T\u00e9cnicas \u00d3pticas para el Diagn\u00f3stico, Universidad de Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5032342377"],"corresponding_institution_ids":["https://openalex.org/I108103353"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":3.777,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.93197914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"9","first_page":"3471","last_page":"3471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.6122999787330627,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.6122999787330627,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.35690000653266907,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corneal-cross-linking","display_name":"corneal cross-linking","score":0.8629999756813049},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.9729999899864197},{"id":"https://openalex.org/keywords/corneal-de-epithelialization","display_name":"corneal de-epithelialization","score":0.9010000228881836},{"id":"https://openalex.org/keywords/keratocyte-loss","display_name":"keratocyte loss","score":0.8799999952316284},{"id":"https://openalex.org/keywords/myofibroblast-differentiation","display_name":"myofibroblast differentiation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.8550000190734863},{"id":"https://openalex.org/keywords/corneal-stiffness","display_name":"corneal stiffness","score":0.6759999990463257},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2780898351","wikidata":"https://www.wikidata.org/wiki/Q11350933","display_name":"Rose bengal","level":2,"score":0.9310280084609985},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.7787504196166992},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.775134265422821},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6923612952232361},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.5838483572006226},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.5294427871704102},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.48577049374580383},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.4710383713245392},{"id":"https://openalex.org/C2778015030","wikidata":"https://www.wikidata.org/wiki/Q410922","display_name":"Fluorescein","level":3,"score":0.4452284872531891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4268415868282318},{"id":"https://openalex.org/C2780918802","wikidata":"https://www.wikidata.org/wiki/Q25091543","display_name":"Repopulation","level":4,"score":0.4267883896827698},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42098867893218994},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.40429267287254333},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3299367427825928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3226366639137268},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25639864802360535},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.18749430775642395},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.18338117003440857},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10374242067337036},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012395","descriptor_name":"Rose Bengal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D065306","descriptor_name":"Corneal Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1167/iovs.16-21365","doi":"https://doi.org/10.1167/iovs.16-21365","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.16-21365","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/936360/i1552-5783-58-9-3471.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmid:28700779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28700779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:hispana.mcu.es:54600503","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.16-21365","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:uvadoc.uva.es:10324/45096","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.16-21365","pdf_url":"https://uvadoc.uva.es/bitstream/10324/45096/1/Corneal-wound-repair.pdf","source":{"id":"https://openalex.org/S4306401553","display_name":"UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108103353","host_organization_name":"Universidad de Valladolid","host_organization_lineage":["https://openalex.org/I108103353"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digital.csic.es:10261/163347","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/163347","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:dnet:uvadoc______::9a610618857207128b356fcd8eff0517","doi":null,"is_oa":true,"landing_page_url":"http://uvadoc.uva.es/handle/10324/45096","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1167/iovs.16-21365","doi":"https://doi.org/10.1167/iovs.16-21365","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.16-21365","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/936360/i1552-5783-58-9-3471.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2735356102.pdf","grobid_xml":"https://content.openalex.org/works/W2735356102.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W4313777","https://openalex.org/W21782368","https://openalex.org/W50202540","https://openalex.org/W1565416402","https://openalex.org/W1966684193","https://openalex.org/W1974232226","https://openalex.org/W1977818531","https://openalex.org/W1984288164","https://openalex.org/W1990198787","https://openalex.org/W1990526183","https://openalex.org/W1992386723","https://openalex.org/W1999366378","https://openalex.org/W2002733942","https://openalex.org/W2012048276","https://openalex.org/W2012467780","https://openalex.org/W2013413310","https://openalex.org/W2019255253","https://openalex.org/W2029429157","https://openalex.org/W2048254581","https://openalex.org/W2061829653","https://openalex.org/W2065537338","https://openalex.org/W2069814568","https://openalex.org/W2071116121","https://openalex.org/W2078061793","https://openalex.org/W2089336980","https://openalex.org/W2089488785","https://openalex.org/W2091786991","https://openalex.org/W2097392264","https://openalex.org/W2128532429","https://openalex.org/W2146834218","https://openalex.org/W2150023663","https://openalex.org/W2152064409","https://openalex.org/W2152754613","https://openalex.org/W2156553577","https://openalex.org/W2170663581","https://openalex.org/W2178027623","https://openalex.org/W2282979770","https://openalex.org/W2313580324","https://openalex.org/W2332380251","https://openalex.org/W2338809038","https://openalex.org/W2369818751","https://openalex.org/W2412356912","https://openalex.org/W2464877844","https://openalex.org/W2608929622"],"related_works":["https://openalex.org/W2896467184","https://openalex.org/W2464877844","https://openalex.org/W2156553577","https://openalex.org/W2560338881","https://openalex.org/W2765677996","https://openalex.org/W4410776652","https://openalex.org/W4386497996","https://openalex.org/W1728612043","https://openalex.org/W21782368","https://openalex.org/W7204174734"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"evaluate":[2],"corneal":[3,127],"wound":[4],"healing":[5,210],"after":[6,91,139,144,214,222],"treatment":[7,73,231],"with":[8,51,228],"a":[9],"new":[10],"collagen":[11],"crosslinking":[12],"protocol":[13],"using":[14],"rose":[15,53],"bengal":[16,54],"dye":[17],"and":[18,58,85,96,107,122,157,167,175,184,233],"green":[19,61],"light":[20,62],"(RGX).":[21,68],"Methods:":[22],"One":[23],"cornea":[24,244],"of":[25,120,125,188,199],"20":[26],"New":[27],"Zealand":[28],"rabbits":[29],"was":[30,137,150,191,202],"de-epithelialized":[31],"(DE)":[32],"in":[33,39,172,212],"an":[34],"8-mm":[35],"diameter":[36],"circle":[37],"and,":[38],"another":[40],"group":[41],"(n":[42],"=":[43],"25),":[44],"the":[45,126,153,158,173,189,200],"DE":[46,145,168,183,223],"corneas":[47,213],"were":[48,79,89,114,129],"then":[49,143],"stained":[50],"0.1%":[52],"for":[55,65,242],"2":[56,179],"minutes":[57,67],"exposed":[59],"to":[60,110,152,219],"(532":[63],"nm)":[64],"7":[66],"The":[69,77,209],"contralateral":[70],"eyes":[71],"without":[72],"acted":[74],"as":[75],"controls.":[76],"animals":[78],"clinically":[80],"followed":[81],"including":[82],"fluorescein":[83],"staining":[84],"pachymetry.":[86],"Healing":[87],"events":[88],"analyzed":[90],"euthanasia":[92],"at":[93,178,193,205],"2,":[94],"30,":[95,195],"60":[97,206],"days.":[98,180,207],"Cell":[99,148,170],"death":[100,149],"(TUNEL":[101],"assay),":[102],"cell":[103,108,197],"proliferation":[104,171],"(5-bromo-2'-deoxyuridine":[105],"incorporation),":[106],"differentiation":[109],"myofibroblasts":[111],"(\u03b1-SMA":[112],"labeling)":[113],"carried":[115],"out.":[116],"In":[117,181],"addition,":[118],"loss":[119],"keratocytes":[121],"subsequent":[123],"repopulation":[124,198],"stroma":[128,176,201],"quantified":[130],"on":[131,236],"hematoxylin-eosin-stained":[132],"sections.":[133],"Results:":[134],"Wound":[135],"closure":[136],"slower":[138],"RGX":[140,166,185,215,238],"(4.4":[141],"days)":[142],"(3.3":[146],"days).":[147],"restricted":[151],"anterior":[154],"central":[155],"stroma,":[156],"cellular":[159],"decrease":[160],"did":[161],"not":[162,203],"differ":[163],"significantly":[164],"between":[165],"corneas.":[169],"epithelium":[174,190],"appeared":[177],"both":[182],"corneas,":[186],"recovery":[187],"complete":[192,204],"day":[194],"although":[196],"Conclusions:":[208],"response":[211],"is":[216],"very":[217],"similar":[218],"that":[220],"observed":[221],"alone,":[224],"suggesting":[225],"that,":[226],"along":[227],"its":[229],"short":[230],"time":[232],"limited":[234],"effect":[235],"keratocytes,":[237],"displays":[239],"good":[240],"potential":[241],"clinical":[243],"stiffening.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-21T00:00:00"}