{"id":"https://openalex.org/W2735344772","doi":"https://doi.org/10.1038/ni.3796","title":"\u03b1-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","display_name":"\u03b1-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","publication_year":2017,"publication_date":"2017-07-17","ids":{"openalex":"https://openalex.org/W2735344772","doi":"https://doi.org/10.1038/ni.3796","mag":"2735344772","pmid":"https://pubmed.ncbi.nlm.nih.gov/28714978"},"language":"en","primary_location":{"id":"doi:10.1038/ni.3796","doi":"https://doi.org/10.1038/ni.3796","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ni.3796","pdf_url":null,"source":{"id":"https://openalex.org/S41063453","display_name":"Nature Immunology","issn_l":"1529-2908","issn":["1529-2908","1529-2916"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lirias.kuleuven.be/handle/123456789/668100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Pu-Ste Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pu-Ste Liu","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Haiping Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Haiping Wang","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100781902","display_name":"Xiaoyun Li","orcid":"https://orcid.org/0000-0003-0000-9171","observed_orcids":["https://orcid.org/0000-0003-0000-9171"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Xiaoyun Li","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091705594","display_name":"Tung Hui Chao","orcid":"https://orcid.org/0000-0003-3641-4996","observed_orcids":["https://orcid.org/0000-0003-3641-4996"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tung Chao","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089048513","display_name":"Tony Teav","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tony Teav","raw_affiliation_strings":["Metabolomics Unit, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolomics Unit, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043655789","display_name":"Stefan Christen","orcid":"https://orcid.org/0000-0002-2121-8215","observed_orcids":["https://orcid.org/0000-0002-2121-8215"]},"institutions":[{"id":"https://openalex.org/I4210092815","display_name":"VIB-KU Leuven Center for Cancer Biology","ror":"https://ror.org/00eyng893","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210092815","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Stefan Christen","raw_affiliation_strings":["Laboratory of Cellular Metabolism and Metabolic Regulation, Center for Cancer Biology, VIB, Leuven, Belgium","Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Metabolism and Metabolic Regulation, Center for Cancer Biology, VIB, Leuven, Belgium","institution_ids":["https://openalex.org/I4210092815"]},{"raw_affiliation_string":"Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042790504","display_name":"Giusy Di Conza","orcid":"https://orcid.org/0000-0003-1353-5867","observed_orcids":["https://orcid.org/0000-0003-1353-5867"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Giusy Di Conza","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075569778","display_name":"Wan-Chen Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Wan-Chen Cheng","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069713085","display_name":"Chih\u2010Hung Chou","orcid":"https://orcid.org/0000-0001-5714-1718","observed_orcids":["https://orcid.org/0000-0001-5714-1718"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Hung Chou","raw_affiliation_strings":["Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan","Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055612686","display_name":"Magdal\u00e9na Vav\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0003-1999-1388","observed_orcids":["https://orcid.org/0000-0003-1999-1388"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Magdalena Vavakova","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005905090","display_name":"Charlotte Muret","orcid":"https://orcid.org/0000-0003-0465-0118","observed_orcids":["https://orcid.org/0000-0003-0465-0118"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Charlotte Muret","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008325337","display_name":"Koen Debackere","orcid":"https://orcid.org/0000-0002-7701-326X","observed_orcids":["https://orcid.org/0000-0002-7701-326X"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Koen Debackere","raw_affiliation_strings":["Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium","Laboratory of Tumor Inflammation and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Laboratory of Tumor Inflammation and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005112202","display_name":"Massimiliano Mazzone","orcid":"https://orcid.org/0000-0001-8824-4015","observed_orcids":["https://orcid.org/0000-0001-8824-4015"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Massimiliano Mazzone","raw_affiliation_strings":["Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium","Laboratory of Tumor Inflammation and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Laboratory of Tumor Inflammation and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040277769","display_name":"Hsien\u2010Da Huang","orcid":"https://orcid.org/0000-0003-2857-7023","observed_orcids":["https://orcid.org/0000-0003-2857-7023"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsien-Da Huang","raw_affiliation_strings":["Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan","Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsin-Chu, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043975935","display_name":"Sarah\u2010Maria Fendt","orcid":"https://orcid.org/0000-0001-6018-9296","observed_orcids":["https://orcid.org/0000-0001-6018-9296"]},"institutions":[{"id":"https://openalex.org/I4210092815","display_name":"VIB-KU Leuven Center for Cancer Biology","ror":"https://ror.org/00eyng893","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210092815","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sarah-Maria Fendt","raw_affiliation_strings":["Laboratory of Cellular Metabolism and Metabolic Regulation, Center for Cancer Biology, VIB, Leuven, Belgium","Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular Metabolism and Metabolic Regulation, Center for Cancer Biology, VIB, Leuven, Belgium","institution_ids":["https://openalex.org/I4210092815"]},{"raw_affiliation_string":"Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077405324","display_name":"Julijana Ivani\u0161evi\u0107","orcid":"https://orcid.org/0000-0001-8267-2705","observed_orcids":["https://orcid.org/0000-0001-8267-2705"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Julijana Ivanisevic","raw_affiliation_strings":["Metabolomics Unit, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8267-2705","affiliations":[{"raw_affiliation_string":"Metabolomics Unit, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036489378","display_name":"Ping\u2010Chih Ho","orcid":"https://orcid.org/0000-0003-3078-3774","observed_orcids":["https://orcid.org/0000-0003-3078-3774"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Ping-Chih Ho","raw_affiliation_strings":["Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","Ludwig Lausanne Branch, Epalinges, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3078-3774","affiliations":[{"raw_affiliation_string":"Department of Fundamental Oncology, Faculty of Biology and Medicine, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Ludwig Lausanne Branch, Epalinges, Switzerland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036489378"],"corresponding_institution_ids":["https://openalex.org/I97565354"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":26.9656,"has_fulltext":false,"cited_by_count":1331,"citation_normalized_percentile":{"value":0.99881962,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"18","issue":"9","first_page":"985","last_page":"994"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-ketoglutarate","display_name":"alpha-ketoglutarate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/glutamine-metabolism","display_name":"glutamine metabolism","score":0.8560000061988831},{"id":"https://openalex.org/keywords/glutaminolysis","display_name":"glutaminolysis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9169999957084656},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.9879999756813049},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/jmjd3","display_name":"JMJD3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.9319999814033508},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.8840000033378601},{"id":"https://openalex.org/keywords/endotoxin-tolerance","display_name":"endotoxin tolerance","score":0.968999981880188},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C2778160063","wikidata":"https://www.wikidata.org/wiki/Q1532402","display_name":"Glutaminolysis","level":4,"score":0.9333662390708923},{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.8237497210502625},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.8225506544113159},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6726616621017456},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6472805738449097},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5678862929344177},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5372424721717834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5197991132736206},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4963412880897522},{"id":"https://openalex.org/C109549099","wikidata":"https://www.wikidata.org/wiki/Q24773687","display_name":"Glutaminase","level":4,"score":0.42804473638534546},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30024945735931396},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.211288720369339},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.13855406641960144},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07498815655708313},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.05446222424507141},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007656","descriptor_name":"Ketoglutaric Acids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007656","descriptor_name":"Ketoglutaric Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010085","descriptor_name":"Oxidative Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019802","descriptor_name":"Succinic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047369","descriptor_name":"Chromatin Immunoprecipitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/ni.3796","doi":"https://doi.org/10.1038/ni.3796","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ni.3796","pdf_url":null,"source":{"id":"https://openalex.org/S41063453","display_name":"Nature Immunology","issn_l":"1529-2908","issn":["1529-2908","1529-2916"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Immunology","raw_type":"journal-article"},{"id":"pmid:28714978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28714978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature immunology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/203537","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/203537","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:iris.unito.it:2318/1841242","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/1841242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/668100","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/668100","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Immunology, vol. 18 (9), (985-994)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:serval.unil.ch:BIB_CA3F4F3BEF1D","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_CA3F4F3BEF1D","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature immunology, vol. 18, no. 9, pp. 985-994","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/668100","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/668100","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Immunology, vol. 18 (9), (985-994)","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1171241794","https://openalex.org/W1548584275","https://openalex.org/W1550446004","https://openalex.org/W1972476556","https://openalex.org/W1980266334","https://openalex.org/W1989090840","https://openalex.org/W1990396303","https://openalex.org/W1993197717","https://openalex.org/W1994313430","https://openalex.org/W2003878114","https://openalex.org/W2006226224","https://openalex.org/W2019750161","https://openalex.org/W2028743750","https://openalex.org/W2038781914","https://openalex.org/W2062927905","https://openalex.org/W2068793888","https://openalex.org/W2076272449","https://openalex.org/W2084885369","https://openalex.org/W2087814592","https://openalex.org/W2089141914","https://openalex.org/W2089532303","https://openalex.org/W2090406819","https://openalex.org/W2105068355","https://openalex.org/W2105724560","https://openalex.org/W2111846773","https://openalex.org/W2120262777","https://openalex.org/W2129261650","https://openalex.org/W2133536768","https://openalex.org/W2135272175","https://openalex.org/W2140876277","https://openalex.org/W2159560463","https://openalex.org/W2165127856","https://openalex.org/W2175283362","https://openalex.org/W2206617731","https://openalex.org/W2254672185","https://openalex.org/W2287265171","https://openalex.org/W2296531152","https://openalex.org/W2468925656","https://openalex.org/W2503851771","https://openalex.org/W2504379340","https://openalex.org/W2510836433","https://openalex.org/W2522038806","https://openalex.org/W2530547043","https://openalex.org/W2534854440","https://openalex.org/W2557169014","https://openalex.org/W2739174192"],"related_works":["https://openalex.org/W3151949117","https://openalex.org/W4223891747","https://openalex.org/W4224287258","https://openalex.org/W4386247556","https://openalex.org/W2622814797","https://openalex.org/W2107756617","https://openalex.org/W2180770854","https://openalex.org/W4404075043","https://openalex.org/W7167510110","https://openalex.org/W2897481181"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":252},{"year":2025,"cited_by_count":221},{"year":2024,"cited_by_count":201},{"year":2023,"cited_by_count":158},{"year":2022,"cited_by_count":143},{"year":2021,"cited_by_count":128},{"year":2020,"cited_by_count":109},{"year":2019,"cited_by_count":62},{"year":2018,"cited_by_count":46},{"year":2017,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2017-07-21T00:00:00"}
