{"id":"https://openalex.org/W2735316730","doi":null,"title":"Using Bioengineering Approaches to Generate a Three-Dimensional Human Induced Pluripotent Stem-Cell Based Model of Alzheimer's Disease","display_name":"Using Bioengineering Approaches to Generate a Three-Dimensional Human Induced Pluripotent Stem-Cell Based Model of Alzheimer's Disease","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2735316730","mag":"2735316730"},"language":"en","primary_location":{"id":"pmh:item:44440","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.44440","pdf_url":"http://hdl.handle.net/2286/R.I.44440","source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masters Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2286/R.I.44440","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rachel A. Lundeen","orcid":"https://orcid.org/0000-0002-4219-3942","observed_orcids":["https://orcid.org/0000-0002-4219-3942"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rachel A. Lundeen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4219-3942","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9394999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/human-induced-pluripotent-stem-cells","display_name":"human induced pluripotent stem cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/three-dimensional-cell-models","display_name":"three-dimensional cell models","score":0.7609999775886536},{"id":"https://openalex.org/keywords/in-vitro-disease-model","display_name":"in vitro disease model","score":0.6610000133514404},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/brain-microenvironment","display_name":"brain microenvironment","score":0.9190000295639038},{"id":"https://openalex.org/keywords/disease-pathophysiology","display_name":"disease pathophysiology","score":0.8259999752044678},{"id":"https://openalex.org/keywords/bioengineering","display_name":"bioengineering","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8213006854057312},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5200516581535339},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5102005004882812},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4376993477344513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4331135153770447},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4162401556968689},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2691458463668823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2660645842552185},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20787599682807922},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1467750072479248},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12509793043136597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05674991011619568}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:item:44440","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.44440","pdf_url":"http://hdl.handle.net/2286/R.I.44440","source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masters Thesis"},{"id":"mag:2735316730","doi":null,"is_oa":false,"landing_page_url":"https://keep.lib.asu.edu/_flysystem/fedora/c7/179386/Lundeen_asu_0010N_16877.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:item:44440","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2286/R.I.44440","pdf_url":"http://hdl.handle.net/2286/R.I.44440","source":{"id":"https://openalex.org/S4306400254","display_name":"Arizona State University Library Digital Repository (Arizona State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55732556","host_organization_name":"Arizona State University","host_organization_lineage":["https://openalex.org/I55732556"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Masters Thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2735316730.pdf","grobid_xml":"https://content.openalex.org/works/W2735316730.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1553983967","https://openalex.org/W1602494991","https://openalex.org/W1830876320","https://openalex.org/W1869426160","https://openalex.org/W2010251891","https://openalex.org/W2018744859","https://openalex.org/W2027009370","https://openalex.org/W2031880534","https://openalex.org/W2040949523","https://openalex.org/W2069121057","https://openalex.org/W2088714934","https://openalex.org/W2097391583","https://openalex.org/W2101889783","https://openalex.org/W2129085204","https://openalex.org/W2136623897","https://openalex.org/W2138977668","https://openalex.org/W2139406641","https://openalex.org/W2156464135","https://openalex.org/W2158173241","https://openalex.org/W2161722802","https://openalex.org/W2218734510","https://openalex.org/W2234898823","https://openalex.org/W2282335838","https://openalex.org/W2343099476","https://openalex.org/W2400335073","https://openalex.org/W2411409053","https://openalex.org/W3014251530"],"related_works":["https://openalex.org/W3018167987","https://openalex.org/W2968048785","https://openalex.org/W2797335531","https://openalex.org/W2539184623","https://openalex.org/W3168894127","https://openalex.org/W2936397629","https://openalex.org/W6998592358","https://openalex.org/W3147459158","https://openalex.org/W4382024070","https://openalex.org/W4206313362"],"abstract_inverted_index":{"abstract:":[0],"The":[1],"pathophysiology":[2,110],"of":[3,23,35,41,85,99,108,115],"Alzheimer\u2019s":[4],"disease":[5,25,58],"(AD)":[6],"remains":[7],"difficult":[8],"to":[9,18,64,67,94],"precisely":[10],"ascertain":[11],"in":[12,87],"part":[13],"because":[14],"animal":[15],"models":[16,40,98],"fail":[17],"fully":[19],"recapitulate":[20],"many":[21,61],"aspects":[22],"the":[24,33,36,81,86,106,113],"and":[26,83],"postmortem":[27],"studies":[28],"do":[29,77],"not":[30,78],"allow":[31],"for":[32],"study":[34],"pathophysiology.":[37],"In":[38],"vitro":[39],"AD":[42,100,109],"generated":[43],"with":[44],"patient":[45],"derived":[46],"human":[47],"induced":[48],"pluripotent":[49],"stem":[50],"cells":[51],"(hiPSCs)":[52],"could":[53],"provide":[54],"new":[55],"insight":[56],"into":[57],"mechanisms.":[59],"Although":[60],"protocols":[62],"exist":[63],"differentiate":[65],"hiPSCs":[66],"neurons,":[68],"standard":[69],"practice":[70],"relies":[71],"on":[72],"two-dimensional":[73],"(2-D)":[74],"systems,":[75],"which":[76,103],"accurately":[79],"mimic":[80],"complexity":[82],"architecture":[84],"vivo":[88],"brain":[89],"microenvironment.":[90],"This":[91],"research":[92],"aims":[93],"create":[95],"three-dimensional":[96],"(3-D)":[97],"using":[101],"hiPSCs,":[102],"would":[104],"enhance":[105],"understanding":[107],"thereby,":[111],"enabling":[112],"generation":[114],"effective":[116],"therapeutics.":[117]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2017-07-21T00:00:00"}
