{"id":"https://openalex.org/W2735129554","doi":"https://doi.org/10.1111/imb.12329","title":"Analysis of cytochrome P450 contribution to evolved plant toxin resistance in Drosophila sechellia","display_name":"Analysis of cytochrome P450 contribution to evolved plant toxin resistance in Drosophila sechellia","publication_year":2017,"publication_date":"2017-07-13","ids":{"openalex":"https://openalex.org/W2735129554","doi":"https://doi.org/10.1111/imb.12329","mag":"2735129554","pmid":"https://pubmed.ncbi.nlm.nih.gov/28703934"},"language":"en","primary_location":{"id":"doi:10.1111/imb.12329","doi":"https://doi.org/10.1111/imb.12329","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imb.12329","pdf_url":null,"source":{"id":"https://openalex.org/S137961447","display_name":"Insect Molecular Biology","issn_l":"0962-1075","issn":["0962-1075","1365-2583"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019098957","display_name":"Rubye Dimitri Peyser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100538780","display_name":"Wesleyan University","ror":"https://ror.org/05h7xva58","country_code":"US","type":"education","lineage":["https://openalex.org/I100538780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. D. Peyser","raw_affiliation_strings":["Department of Biology, Wesleyan University, Middletown, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Wesleyan University, Middletown, CT, USA","institution_ids":["https://openalex.org/I100538780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052591011","display_name":"Stephen Lanno","orcid":"https://orcid.org/0000-0002-4992-8462","observed_orcids":["https://orcid.org/0000-0002-4992-8462"]},"institutions":[{"id":"https://openalex.org/I100538780","display_name":"Wesleyan University","ror":"https://ror.org/05h7xva58","country_code":"US","type":"education","lineage":["https://openalex.org/I100538780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. Lanno","raw_affiliation_strings":["Department of Biology, Wesleyan University, Middletown, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Wesleyan University, Middletown, CT, USA","institution_ids":["https://openalex.org/I100538780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071395303","display_name":"Serena J. E. Shimshak","orcid":"https://orcid.org/0000-0001-9146-0480","observed_orcids":["https://orcid.org/0000-0001-9146-0480"]},"institutions":[{"id":"https://openalex.org/I100538780","display_name":"Wesleyan University","ror":"https://ror.org/05h7xva58","country_code":"US","type":"education","lineage":["https://openalex.org/I100538780"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. J. Shimshak","raw_affiliation_strings":["Department of Biology, Wesleyan University, Middletown, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Wesleyan University, Middletown, CT, USA","institution_ids":["https://openalex.org/I100538780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064925364","display_name":"Joseph D. Coolon","orcid":"https://orcid.org/0000-0003-1591-9418","observed_orcids":["https://orcid.org/0000-0003-1591-9418"]},"institutions":[{"id":"https://openalex.org/I100538780","display_name":"Wesleyan University","ror":"https://ror.org/05h7xva58","country_code":"US","type":"education","lineage":["https://openalex.org/I100538780"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. D. Coolon","raw_affiliation_strings":["Department of Biology, Wesleyan University, Middletown, CT, USA"],"raw_orcid":"https://orcid.org/0000-0003-1591-9418","affiliations":[{"raw_affiliation_string":"Department of Biology, Wesleyan University, Middletown, CT, USA","institution_ids":["https://openalex.org/I100538780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064925364"],"corresponding_institution_ids":["https://openalex.org/I100538780"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":null,"fwci":1.005,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.73514815,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"26","issue":"6","first_page":"715","last_page":"720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10135","display_name":"Insect-Plant Interactions and Control","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drosophila-sechellia","display_name":"Drosophila sechellia","score":0.9890000224113464},{"id":"https://openalex.org/keywords/morinda-citrifolia","display_name":"Morinda citrifolia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/toxin-resistance","display_name":"toxin resistance","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mixed-function-oxidase","display_name":"mixed function oxidase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/octanoic-acid","display_name":"octanoic acid","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hexanoic-acid","display_name":"hexanoic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/insect-plant-interactions","display_name":"plant-insect interactions","score":0.5799999833106995},{"id":"https://openalex.org/keywords/dietary-specialization","display_name":"dietary specialization","score":0.5400000214576721},{"id":"https://openalex.org/keywords/insecticide-resistance","display_name":"insecticide resistance","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9004658460617065},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6416320204734802},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5832642912864685},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5704390406608582},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5515664219856262},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.5391547679901123},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.5245112180709839},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4826091527938843},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.4750012159347534},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.41014888882637024},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2293320596218109},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17097413539886475}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002208","descriptor_name":"Caproates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002210","descriptor_name":"Caprylates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/imb.12329","doi":"https://doi.org/10.1111/imb.12329","is_oa":false,"landing_page_url":"https://doi.org/10.1111/imb.12329","pdf_url":null,"source":{"id":"https://openalex.org/S137961447","display_name":"Insect Molecular Biology","issn_l":"0962-1075","issn":["0962-1075","1365-2583"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect Molecular Biology","raw_type":"journal-article"},{"id":"pmid:28703934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28703934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1637114904","https://openalex.org/W1974939545","https://openalex.org/W1983617242","https://openalex.org/W1986007748","https://openalex.org/W2002604364","https://openalex.org/W2002976697","https://openalex.org/W2017548405","https://openalex.org/W2021408415","https://openalex.org/W2032132551","https://openalex.org/W2033048136","https://openalex.org/W2034849909","https://openalex.org/W2037025856","https://openalex.org/W2046747589","https://openalex.org/W2047970275","https://openalex.org/W2049932020","https://openalex.org/W2051477192","https://openalex.org/W2059124931","https://openalex.org/W2075419296","https://openalex.org/W2079498128","https://openalex.org/W2080895359","https://openalex.org/W2086955153","https://openalex.org/W2097518385","https://openalex.org/W2098086227","https://openalex.org/W2110228002","https://openalex.org/W2117895297","https://openalex.org/W2129509890","https://openalex.org/W2147583598","https://openalex.org/W2151725228","https://openalex.org/W2153326142","https://openalex.org/W2153947426","https://openalex.org/W2158974157","https://openalex.org/W2159116844","https://openalex.org/W2335888624","https://openalex.org/W3147894994","https://openalex.org/W3152018431","https://openalex.org/W4298112560"],"related_works":["https://openalex.org/W6911047794","https://openalex.org/W2936047800","https://openalex.org/W2147583598","https://openalex.org/W3091772897","https://openalex.org/W4300646269","https://openalex.org/W1896813130","https://openalex.org/W1934133349","https://openalex.org/W1637114904","https://openalex.org/W6967273650","https://openalex.org/W2908977997"],"abstract_inverted_index":{"Drosophila":[0,55,62],"sechellia":[1,53],"is":[2,38,123,161,167],"a":[3,109],"dietary":[4],"specialist":[5],"species":[6],"of":[7,24,34,41,79,130],"fruit":[8,23],"fly":[9],"that":[10,155],"has":[11],"evolved":[12,100,136],"resistance":[13,37,75,102,114,137,165,173],"to":[14,115,138],"the":[15,22,39,47,77,80,87,116,128,139],"toxic":[16],"secondary":[17],"defence":[18],"compounds":[19],"produced":[20],"by":[21],"its":[25,120],"preferred":[26],"host":[27,121],"plant":[28,122],"Morinda":[29],"citrifolia.":[30],"The":[31],"genetic":[32],"basis":[33],"adult":[35],"toxin":[36,74,101,172],"result":[40],"evolution":[42],"at":[43],"five":[44],"loci":[45],"across":[46],"genome.":[48],"Genetic":[49],"mapping":[50],"between":[51],"D.":[52,112,175],"and":[54,57,150],"simulans":[56],"subsequent":[58],"functional":[59],"studies":[60],"in":[61,73,86,99,103,111,119,135,144,163,170,174],"melanogaster":[63],"have":[64],"identified":[65],"candidate":[66],"genes":[67,81],"potentially":[68],"underlying":[69],"one":[70],"locus":[71],"involved":[72,82,162,169],"but":[76],"remainder":[78],"are":[83,96],"unknown.":[84,124],"Genes":[85],"mixed":[88],"function":[89],"oxidase":[90],"or":[91],"cytochrome":[92,131,157],"P450":[93,132,158],"gene":[94],"family":[95],"frequently":[97],"utilized":[98],"insects,":[104],"yet":[105],"whether":[106],"they":[107],"play":[108],"role":[110,129],"sechellia's":[113],"toxins":[117,142],"found":[118,143,154],"Here":[125],"we":[126],"test":[127],"enzymatic":[133,159],"activity":[134,160],"two":[140],"primary":[141],"M.":[145],"citrifolia":[146],"fruit:":[147],"octanoic":[148],"acid":[149],"hexanoic":[151],"acid.":[152],"We":[153],"although":[156],"basal":[164],"it":[166],"not":[168],"derived":[171],"sechellia.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2017-07-21T00:00:00"}
